The effect of thalidomide in chicken embryos

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 85, Issue 8, 2009, Pages 725-731

  Stephens, Trent D ^a  

^a Nucl Eng Idaho State University   (United States)

Author keywords

Chick; Defects; Embryo; Limb; Thalidomide

Indexed keywords

2 (2,6 DIOXO 3 PIPERIDINYL)PHTHALIMIDINE; ALCIAN BLUE; RINGER ACETATE; SEPHADEX; THALIDOMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHICKEN; CONTROLLED STUDY; EMBRYO; LIMB DEFECT; LIMB MALFORMATION; LIMB REDUCTION DEFECT; MALFORMATION SYNDROME; NONHUMAN; PRIORITY JOURNAL; STEREOISOMERISM; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CHICK EMBRYO; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTREMITIES; LIMB DEFORMITIES, CONGENITAL; TERATOGENS; THALIDOMIDE;

EID: 68949090176     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20597     Document Type: Article

References (60)

1. Aleksandrov PN, Bogdanova VA, Chernukh AM. 1965a. The teratogenic effect of intermediate products of thalidomide synthesis upon the chick embryo [in Russian]. Farmakol Toksikol. 28:744-747.
2. Aleksandrov PN, Bogdanova VA, Ivanov AI, et al. 1965b. Method of preliminary evaluation of the teratogenic effect of drugs on chick embryos [in Russian]. Vestn Akad Med Nauk SSSR 20:78-81.
3. Aleksandrov PN, Bogdanova VA, Chernukh AM. 1966. Teratogenic action of intermediate products of thalidomide synthesis on chick embryo. Fed Proc Transl Suppl 25:910-912.
4. Bergstrom RM, Erila T, Pirskanen R. 1967. Teratogenic effects of the amino acid leucine in the chicken. Experientia 23:767-768.
5. Brown NA, Fabro S. 1983. The value of animal teratogenicity testing for predicting human risk. Clin Obstet Gynacol 26:467-477.
6. Debock CA, Peters A. 1963. Effect of thalidomide on the development of the chick embryo. Nature 199:1204-1206.
7. Delahunt CS, Lassen LJ. 1964. Thalidomide syndrome in monkeys. Science 146:1300-1305.
8. Dyban AP. 1967. Some current problems of experimental teratology [in Russian]. Vestn Akad Med Nauk SSSR. 22:18-30.
9. Ethmann B. 1964. On the effect of thalidomide on a chick embryo. Klin Wochenschr 42:295-296.
10. Fan QY, Ramakrishna S, Marchi N, et al. 2008. Combined effects of prenatal inhibition of vasculogenesis and neurogenesis on rat brain development. Neurobiol Dis 32:499-509.
11. Field EO, Gibbs JE, Tucker DF, Hellmann K. 1966. Effect of thalidomide on the graft versus host reaction. Nature 211:1308-1310.
12. Franceschini M. 1964. The action of dioxane and thalidomide on growth in organ-type culture of the tibia of the chick embryo [in Italian]. Sperimentale 114:1-17.
13. Franceschini M, Mussa A. 1964. Action of thalidomide on the growth of the chick-embryo tibia in organotypic cultures [in Italian]. Boll Soc Ital Biol Sper. 40:761-763.
14. Geduspan JS, Solursh M. 1992. Cellular contribution of the different regions of the somatopleure to the developing limb. Dev Dyn 195: 177-187. (Pubitemid 23119296)
15. Geduspan JS, Solursh M. 1993. Effects of the mesonephros and insulin-like growth factor I on chondrogenesis of limb explants. Dev Biol 156:500-508. (Pubitemid 23122314)
16. Heger W, Schmahl HJ, Klug S, et al. 1994. Embryotoxic effects of thalidomide derivatives in the non-human primate callithrix jacchus. IV. Teratogenicity of micrograms/kg doses of the EM12 enantiomers Teratog Carcinog Mutagen 14:115-122.
17. Jaffe WP. 1966. Failure of thalidomide to influence homograft immunity in chickens. Vet Rec. 78:883-884.
18. Jurand A. 1966. Early changes in limb buds of chick embryos after thalidomide treatment. J Embryol Exp Morphol 16:289-300.
19. Kemper F. 1962. Thalidomide and development of the chick embryo [in German]. Arzneimittelforschung 12:640-641.
20. Kemper F. 1963. Chick egg embryopathy [in German]. Arzneimittelforschung 13:191-194.
21. Knobloch J, Shaughnessy JD Jr, Rüther U. 2007. Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J 21:1410-1421. (Pubitemid 46684844)
22. Knobloch J, Schmitz I, Götz K, et al. 2008. Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol 28:529-538.
23. Landauer W. 1954. On the chemical production of developmental abnormalities and of phenocopies in chick embryos. J Cell Physiol Suppl 43(Suppl 1):261-305.
24. Lash JW, Saxén L. 1971. Effect of thalidomide on human embryonic tissues. Nature 232:634-635.
25. Lash JW, Saxén L. 1972. Human teratogenesis: in vitro studies on thalidomide-inhibited chondrogenesis. Dev Biol 28:61-70.
26. Lenz W. 1962. Thalidomide and congenital abnormalities. Lancet i:45.
27. Li ZJ, Yang C, Tang FW, et al. 2005. In vitro vasculogenesis and angiogenesis of mouse embryonic stem cells [in Chinese]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:62-66.
28. McBride WB. 1961. Thalidomide and congenital abnormalities. Lancet ii:1358.
29. Merker HJ, Heger W, Sames K, et al. 1988. Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development Arch Toxicol 61:165-179.
30. Naber EC, Largent EJ. 1965. Thalidomide teratogenesis in the developing chick embryo and its relationship to vitamin metabolism. Poult Sci 44:1583-1591.
31. Osmundsen JA. 1962. Enigma is found in thalidomide, scientists call drug hard to test on animals. New York Times, Aug 19, 1962. Reprinted in: Hearings before the Committee on Government operations United States Senate; Eighty-seventh Congress Second Session; Agency Coordination Study; Review of Cooperation on Drug Policies among Food and Drug Administration, National Institutes of Health, Veterans' Administration, and other Agencies, August 1 and 9, 1962; Part 2 Supplementary Exhibits. 1963. Washington, DC: U.S. Government Printing Office.
32. Rauen HM, Norpoth K. 1966. Growth stimulation by sibliminal concentrations of growth-inhibiting substances [in German]. Arzneimittelforschung 16:1001-1007.
33. Rickenbacher J. 1963. Experiments with Contergan in chick embryos. Preliminary results [in German] Dtsch Med Wochenschr 88:2252-2260.
34. Ruano Gil D. 1967. The influence of thalidomide on the development of chick embryos cultivated in vitro. Acta Anat (Basel) 66:226-237.
35. Salzgeber B, Salaun J. 1963a. Teratogenic action of thalidomide on the chick embryo, at different stages of development [in French]. C R Hebd Seances Acad Sci 257:273-275.
36. Salzgeber B, Salaun J. 1963b. Malformations of extremities obtained in the chick embryo after treatment by thalidomide [in French]. C R Seances Soc Biol Fil 256:2719-2722.
37. Salzgeber B, Salauen J. 1965. Action of thalidomide on the chick embryo [in French]. J Embryol Exp Morphol 13:159-170.
38. Salzgeber B. 1966. The experimental production of phocomelia in the chick embryo [in French]. Rev Fr Etud Clin Biol. 11:60-68.
39. Savage MP, Hart CE, Riley BB, et al. 1993. Distribution of FGF-2 suggests it has a role in chick limb bud growth. Dev Dyn 198:159-170
40. Schmahl HJ, Dencker L, Plum C, et al. 1996. Stereoselective distribution of the teratogenic thalidomide analogue EM12 in the early embryo of marmoset monkey, Wistar rat and NMRI mouse. Arch Toxicol 70: 749-756 (Pubitemid 26341520)
41. Sevastikoglou JA. 1964. Thalidomide teratogenesis in chicks [in Swedish]. Nord Med 72:853-856.
42. Smith DM, Torres RD, Stephens TD. 1996. Mesonephros has a role in limb development and is related to thalidomide embryopathy. Teratology 54:126-134.
43. Somers GF. 1962. Thalidomide and congenital abnormalities. Lancet 1:912-913.
44. Stanzhevskaia TI. 1966. Characteristics of the pathogenic effect of thalidomide on the various stages of development in the chick embryo [in Russian]. Arkh Anat Gistol Embriol 51:7-12.
45. Stanzhevskaia TI. 1967. Comparison of the teratogenic effect of chloridine and thalidomide on chick embryos [in Russian]. Farmakol Toksikol 30:489-491.
46. Stephens TD, McNulty TR. 1981. Evidence for a metameric pattern in the development of the chick humerus. J Emb Exp Morph 61:191-205. (Pubitemid 11142132)
47. Stephens TD, Beier RLW, Bringhurst DC, Hiatt SR, Prestridge M, Pugmire, DE. 1989. Limbness in the early chick embryo lateral plate. Develop Biol 133. (Pubitemid 19118467)
48. Stephens TD, Spall R, Baker WC, et al. 1991. Axial and paraxial influences on limb morphogenesis. J Morphol 208:367-379.
49. Stephens TD, Baker WC, Cotterell JW, et al. 1993. Evaluation of the chick wing territory as an equipotential self-differentiating system. Dev Dyn 197:157-168.
50. Stephens TD, Bunde CJW, Fillmore BJ. 2000. Mechanismanism of Action in Thalidomide Teratogenesis. Biochemical Pharmacology 59:1489-1499.
51. Stephens TD, Fillmore BJ. 2000. Hypothesis: thalidomide embryopathy-proposed mechanism of action. Teratology 61:189-195. (Pubitemid 30130822)
52. Stephens TD, Brynner R. 2001. Dark remedy: the impact of thalidomide and it revival as a vital medicine. Cambridge, MA: Perseus Books.
53. Strecker TR, Stephens TD. 1983. Peripheral nerves do not play a trophic role in limb skeletal morphogenesis. Teratology 27:159-167.
54. Toivanen A, Markkanen T, Maentyjaervi R, Toivanen P. 1964. Microbiologically determined pantothenic acid and nicotinic acid content of chick embryos after treatment with thalidomide and of rat fetuses, newborns, and placentas from mothers treated with thalidomide. Biochem Pharmacol 13:1489-1497.
55. Tuchmann-Duplessis H. 1972. Teratogenic drug screening. Present procedures and requirements. Teratology 5:271-286.
56. Villa L, Eridani S, Taglioretti D, Valentini R. 1963. Action of thalidomide on the mitotic activity of embryonic blood cells [in Italian]. Ric Sci 2 Ser Pt 2 Rend [B] 35:323-334.
57. Warkany J. 1988. Why I doubted that thalidomide was the cause of the epidemic of limb defects of 1959 to 1961. Teratology 38:217-219. (Pubitemid 18230121)
58. Vorhees CV, Weisenburger WP, Minck DR. 2001. Neurobehavioral teratogenic effects of thalidomide in rats. Neurotoxicol Teratol 23:255-264.
59. Wilson JG. 1979. The evaluation of teratological testing. Teratology 20: 205-212.
60. Williamson AP, Blattner RJ, Lutz HR. 1963. Abnormalities in chick embryos following thalidomide and other insoluble compounds in the amniotic cavity. Proc Soc Exp Biol Med 112:1022-1025.