MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7

Laboratory Investigation

Volumn 95, Issue 7, 2015, Pages 781-789

  Yu, Fujun ^a   Guo, Yong ^a   Chen, Bicheng ^a   Dong, Peihong ^a   Zheng, Jianjian ^a  

^a THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; COLLAGEN TYPE 1; MICRORNA; MICRORNA 17; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; COLLAGEN; MIRN17 MICRORNA, HUMAN; MIRN17 MICRORNA, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL ACTIVATION; CELL CYCLE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DRUG TARGETING; FIBROGENESIS; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; LUCIFERASE ASSAY; MALE; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL; WESTERN BLOTTING; ANIMAL; CASE CONTROL STUDY; CELL LINE; LIVER CIRRHOSIS, EXPERIMENTAL; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CASE-CONTROL STUDIES; CELL LINE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; COLLAGEN; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICRORNAS; RATS; RATS, SPRAGUE-DAWLEY; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84933060092     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.58     Document Type: Article

References (38)

1. Sun X, He Y, Ma TT et al. Participation of miR-200a in TGF-beta1-mediated hepatic stellate cell activation. Mol Cell Biochem 2014;388: 11-23.
2. He Y, Huang C, Sun X et al. MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal 2012;24:1923-1930.
3. Wei J, Feng L, Li Z et al. MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling. Biomed Pharmacother 2013;67:387-392.
4. Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 2010;7:425-436.
5. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008;88:125-172.
6. Dooley S, Delvoux B, Streckert M et al. Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 2001;502:4-10.
7. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115:209-218.
8. Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009;136:642-655.
9. Schickel R, Boyerinas B, Park SM et al. MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 2008;27:5959-5974.
10. Zhao J, Tang N, Wu K et al. MiR-21 Simultaneously Regulates ERK1 Signaling in HSC Activation and Hepatocyte EMT in Hepatic Fibrosis. PLoS One 2014;9:e108005.
11. Sekiya Y, Ogawa T, Yoshizato K et al. Suppression of hepatic stellate cell activation by microRNA-29b. Biochem Biophys Res Commun 2011;412:74-79.
12. Zheng J, Wu C, Lin Z et al. Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNAmediated control of DNA methylation-a novel mechanism suppressing liver fibrosis. FEBS J. 2014;281:88-103.
13. Olive V, Jiang I, He L. mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol 2010;42:1348-1354.
14. Yang F, Yin Y, Wang F et al. miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology 2010;51: 1614-1623.
15. Shan SW, Fang L, Shatseva T et al. Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways. J Cell Sci 2013;126: 1517-1530.
16. Zheng J, Dong P, Gao S et al. High expression of serum miR-17-5p associated with poor prognosis in patients with hepatocellular carcinoma. Hepatogastroenterology 2013;60:549-552.
17. Yao QY, Xu BL, Wang JY et al. Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med 2012;12:156.
18. Zheng J, Wu C, Lin Z et al. Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNAmediated control of DNA methylation-a novel mechanism suppressing liver fibrosis. FEBS J 2014;281:88-103.
19. Dai W, Zhao J, Tang N et al. MicroRNA-155 attenuates activation of hepatic stellate cell by simultaneously preventing EMT process and ERK1 signalling pathway. Liver Int 2014;35:1234-1243.
20. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-1108.
21. Tu X, Zhang H, Zhang J et al. MicroRNA-101 suppresses liver fibrosis by targeting the TGFbeta signalling pathway. J Pathol 2014;234:46-59.
22. Lin J, Chen A. Activation of peroxisome proliferator-activated receptorgamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest 2008;88:529-540.
23. Chen X, Ba Y, Ma L et al. Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008;18:997-1006.
24. Fang C, Zhu DX, Dong HJ et al. Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma. Ann Hematol 2012;91: 553-559.
25. He Y, Huang C, Zhang SP et al. The potential of microRNAs in liver fibrosis. Cell Signal 2012;24:2268-2272.
26. Bian EB, Huang C, Wang H et al. Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol Lett 2014;224:175-185.
27. Friedman SL. Liver fibrosis: from mechanisms to treatment. Gastroenterol Clin Biol 2007;31:812-814.
28. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584.
29. Dooley S, Hamzavi J, Ciuclan L et al. Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology 2008;135:642-659.
30. Xia H, Ooi LL, Hui KM. MicroRNA-216a/217-induced epithelialmesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology 2013;58:629-641.
31. Glenisson W, Castronovo V, Waltregny D. Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim Biophys Acta 2007;1773:1572-1582.
32. Matsumura N, Huang Z, Mori S et al. Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res 2011;21:74-82.
33. Garzon R, Liu S, Fabbri M et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 2009;113:6411-6418.
34. Zheng J, Wu C, Lin Z et al. Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNAmediated control of DNA methylation-a novel mechanism suppressing liver fibrosis. FEBS J 2014;281:88-103.
35. Ogawa T, Enomoto M, Fujii H et al. MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Gut 2012;61:1600-1609.
36. Weber JA, Baxter DH, Zhang S et al. The microRNA spectrum in 12 body fluids. Clin Chem 2010;56:1733-1741.
37. Waidmann O, Koberle V, Brunner F et al. Serum microRNA-122 predicts survival in patients with liver cirrhosis. PLoS One 2012;7:e45652.
38. Huang CF, Sun CC, Zhao F et al. miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis. J Gastroenterol 2014;50:480-490.