Association analysis for corticotropin releasing hormone polymorphisms with the risk of major depressive disorder and the response to antidepressants

Behavioural Brain Research

Volumn 292, Issue , 2015, Pages 116-124

  Chang, Hun Soo ^a   Won, Eunsoo ^b,c,d   Lee, Hwa Young ^a   Ham, Byung Joo ^b,c,d   Lee, Min Soo ^b,c,d  

^a Soonchunhyang University   (South Korea)

^b Korea University   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d College of Medicine   (South Korea)

Author keywords

Antidepressant; Corticotropin releasing hormone; Genetic polymorphism; Major depressive disorder; Treatment outcome

Indexed keywords

ANTIDEPRESSANT AGENT; CORTICOTROPIN RELEASING FACTOR; CITALOPRAM; MIANSERIN; MIRTAZAPINE; PHARMACOLOGICAL BIOMARKER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CRH GENE; DRUG RESPONSE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HAMILTON DEPRESSION RATING SCALE; HAPLOTYPE; HUMAN; LIFE EVENT; LIFE STRESS; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; REMISSION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; ANALOGS AND DERIVATIVES; CASE CONTROL STUDY; DEPRESSIVE DISORDER, MAJOR; DRUG EFFECTS; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; MIDDLE AGED; RISK FACTOR;

ADULT; ANTIDEPRESSIVE AGENTS; BIOMARKERS, PHARMACOLOGICAL; CASE-CONTROL STUDIES; CITALOPRAM; CORTICOTROPIN-RELEASING HORMONE; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIANSERIN; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84933051954     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2015.06.005     Document Type: Article

References (60)

1. De Kloet E.R., Vreugdenhil E., Oitzl M.S., Joels M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 1998, 19:269-301.
2. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000, 23:477-501.
3. Holsboer F., Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr. Rev. 1996, 17:187-205.
4. Meijer O.C., de Kloet E.R. Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity. Crit. Rev. Neurobiol. 1998, 12:1-20.
5. Wolkowitz O.M., Reus V.I., Manfredi F., Ingbar J., Brizendine L., Weingartner H. Ketoconazole administration in hypercortisolemic depression. Am. J. Psychiatry 1993, 150:810-812.
6. Shibahara S., Morimoto Y., Furutani Y., Notake M., Takahashi H., Shimizu S., et al. Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. EMBO J. 1983, 2:775-779.
7. Banki C.M., Bissette G., Arato M., O'Connor L., Nemeroff C.B. CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia. Am. J. Psychiatry 1987, 144:873-877.
8. Lloyd R.B., Nemeroff C.B. The role of corticotropin-releasing hormone in the pathophysiology of depression: therapeutic implications. Curr. Top. Med. Chem. 2011, 11:609-617.
9. Bissette G., Klimek V., Pan J., Stockmeier C., Ordway G. Elevated concentrations of CRF in the locus coeruleus of depressed subjects. Neuropsychopharmacology 2003, 28:1328-1335.
10. Merali Z., Kent P., Du L., Hrdina P., Palkovits M., Faludi G., et al. Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects. Biol. Psychiatry 2006, 59:594-602.
11. Raadsheer F.C., van Heerikhuize J.J., Lucassen P.J., Hoogendijk W.J., Tilders F.J., Swaab D.F. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am. J. Psychiatry 1995, 152:1372-1376.
12. Nemeroff C.B., Bissette G., Akil H., Fink M. Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, beta-endorphin and somatostatin. Br. J. Psychiatry: J. Ment. Sci. 1991, 158:59-63.
13. Veith R.C., Lewis N., Langohr J.I., Murburg M.M., Ashleigh E.A., Castillo S., et al. Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects. Psychiatry Res. 1993, 46:1-8.
14. Plotsky P.M., Thrivikraman K.V., Nemeroff C.B., Caldji C., Sharma S., Meaney M.J. Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology 2005, 30:2192-2204.
15. Heim C., Newport D.J., Bonsall R., Miller A.H., Nemeroff C.B. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am. J. Psychiatry 2001, 158:575-581.
16. Heim C., Newport D.J., Mletzko T., Miller A.H., Nemeroff C.B. The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 2008, 33:693-710.
17. Liu Z., Zhu F., Wang G., Xiao Z., Tang J., Liu W., et al. Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders. Neurosci. Lett. 2007, 414:155-158.
18. Liu Z., Zhu F., Wang G., Xiao Z., Wang H., Tang J., et al. Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression. Neurosci. Lett. 2006, 404:358-362.
19. Papiol S., Arias B., Gasto C., Gutierrez B., Catalan R., Fananas L. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J. Affect. Disord. 2007, 104:83-90.
20. Xiao Z., Liu W., Gao K., Wan Q., Yang C., Wang H., et al. Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population. PLoS ONE 2011, 6:e28733.
21. Ishitobi Y., Nakayama S., Yamaguchi K., Kanehisa M., Higuma H., Maruyama Y., et al. Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012, 159B:429-436.
22. Binder E.B., Salyakina D., Lichtner P., Wochnik G.M., Ising M., Putz B., et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat. Genet. 2004, 36:1319-1325.
23. Zobel A., Schuhmacher A., Jessen F., Hofels S., von Widdern O., Metten M., et al. DNA sequence variants of the FKBP5 gene are associated with unipolar depression. Int. J. Neuropsychopharmacol. 2010, 13:649-660.
24. de Keyzer Y., Lenne F., Auzan C., Jegou S., Rene P., Vaudry H., et al. The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. J. Clin. Invest. 1996, 97:1311-1318. The.
25. Ben-Efraim Y.J., Wasserman D., Wasserman J., Sokolowski M. Family-based study of AVPR1B association and interaction with stressful life events on depression and anxiety in suicide attempts. Neuropsychopharmacology 2013, 38:1504-1511.
26. Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J., et al. Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch. Gen. Psychiatry 2007, 64:1189-1195.
27. van West D., Del-Favero J., Aulchenko Y., Oswald P., Souery D., Forsgren T., et al. A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. Mol. Psychiatry 2004, 9:287-292.
28. Lee H.-Y., Kang R.-H., Han S.-W., Paik J.-W., Chang H.S., Jeong Y.J., et al. Association of glucocorticoid receptor polymorphisms with the susceptibility to major depressive disorder and treatment responses in Korean depressive patients. Acta Neuropsychiatr. 2009, 21:11-17.
29. Chang H.S., Won E.S., Lee H.Y., Ham B.J., Kim Y.G., Lee M.S. The association of proopiomelanocortin polymorphisms with the risk of major depressive disorder and the response to antidepressants via interactions with stressful life events. J. Neural Transm. (Vienna, Austria: 1996) 2015, 122:59-68.
30. Binder E.B., Owens M.J., Liu W., Deveau T.C., Rush A.J., Trivedi M.H., et al. Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Arch. Gen. Psychiatry 2010, 67:369-379.
31. Holliday K.L., Macfarlane G.J., Nicholl B.I., Creed F., Thomson W., McBeth J. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. J. Psychosom. Res. 2010, 68:469-474.
32. Fournier J.C., DeRubeis R.J., Hollon S.D., Dimidjian S., Amsterdam J.D., Shelton R.C., et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA: J. Am. Med. Assoc. 2010, 303:47-53.
33. Khan A., Leventhal R.M., Khan S.R., Brown W.A. Severity of depression and response to antidepressants and placebo: an analysis of the Food and Drug Administration database. J. Clin. Psychopharmacol. 2002, 22:40-45.
34. Kirsch I., Deacon B.J., Huedo-Medina T.B., Scoboria A., Moore T.J., Johnson B.T. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med. 2008, 5:e45.
35. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 1960, 23:56-62.
36. Doherty J.L., Owen M.J. Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. Genome Med. 2014, 6:29.
37. Beck A.T., Ward C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry 1961, 4:561-571.
38. Hedrick P.W. Gametic disequilibrium measures: proceed with caution. Genetics 1987, 117:331-341.
39. Stephens M., Smith N.J., Donnelly P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 2001, 68:978-989.
40. Kendler K.S., Gatz M., Gardner C.O., Pedersen N.L. A Swedish national twin study of lifetime major depression. Am. J. Psychiatry 2006, 163:109-114.
41. Kessler R.C., Berglund P., Demler O., Jin R., Koretz D., Merikangas K.R., et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA: J. Am. Med. Assoc. 2003, 289:3095-3105.
42. Purcell S., Cherny S.S., Sham P.C. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003, 19:149-150.
43. Gu J., Sadler L., Daiger S., Wells D., Wagner M. Dinucleotide repeat polymorphism at the CRH gene. Hum. Mol. Genet. 1993, 2:85.
44. Baerwald C.G., Panayi G.S., Lanchbury J.S. Corticotropin releasing hormone promoter region polymorphisms in rheumatoid arthritis. J. Rheumatol. 1997, 24:215-216.
45. Baerwald C.G., Mok C.C., Tickly M., Lau C.S., Wordsworth B.P., Ollier B., et al. Corticotropin releasing hormone (CRH) promoter polymorphisms in various ethnic groups of patients with rheumatoid arthritis. Z. Rheumatol. 2000, 59:29-34.
46. Fife M., Steer S., Fisher S., Newton J., McKay K., Worthington J., et al. Association of familial and sporadic rheumatoid arthritis with a single corticotropin-releasing hormone genomic region (8q12.3) haplotype. Arthritis Rheum. 2002, 46:75-82.
47. Gonzalez-Gay M.A., Hajeer A.H., Garcia-Porrua C., Dababneh A., Amoli M.M., Botana M.A., et al. Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. J. Rheumatol. 2003, 30:913-917.
48. Malysheva O., Wagner U., Wahle M., Pierer M., Stalla G.K., Baerwald C.G. Hypothalamic-pituitary-adrenal axis stress test in patients with early RA: role of corticotropin-releasing hormone promoter polymorphisms. Ann. Rheum. Dis. 2011, 70:2058-2059.
49. Malysheva O., Wagner U., Wahle M., Stalla G.K., Baerwald C.G. Corticotropin releasing hormone (CRH) response in patients with early rheumatoid arthritis due to polymorphisms in the CRH gene. Clin. Exp. Rheumatol. 2012, 30:421-423.
50. Rosmond R., Chagnon M., Bouchard C., Bjorntorp P. A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. Metabolism 2001, 50:1059-1062.
51. Combi R., Dalpra L., Ferini-Strambi L., Tenchini M.L. Frontal lobe epilepsy and mutations of the corticotropin-releasing hormone gene. Ann. Neurol. 2005, 58:899-904.
52. Wagner U., Wahle M., Moritz F., Hantzschel H., Baerwald C.G. Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro. Horm. Metab. Res. 2006, 38:69-75.
53. Sansoni V., Forcella M., Mozzi A., Fusi P., Ambrosini R., Ferini-Strambi L., et al. Functional characterization of a CRH missense mutation identified in an ADNFLE family. PLoS ONE 2013, 8:e61306.
54. Baerwald C.G., Mok C.C., Fife M.S., Tikly M., Lau C.S., Wordsworth B.P., et al. Distribution of corticotropin-releasing hormone promoter polymorphism in different ethnic groups: evidence for natural selection in human populations. Immunogenetics 1999, 49:894-899.
55. Barr C.S., Dvoskin R.L., Yuan Q., Lipsky R.H., Gupte M., Hu X., et al. CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch. Gen. Psychiatry 2008, 65:934-944.
56. Grabe H.J., Schwahn C., Appel K., Mahler J., Schulz A., Spitzer C., et al. Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010, 153B:1483-1493.
57. Wasserman D., Sokolowski M., Rozanov V., Wasserman J. The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress. Genes Brain Behav. 2008, 7:14-19.
58. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch. Gen. Psychiatry 2005, 62:529-535.
59. Stephen S. Stahl's Essential Psychopharmacology 2013, Cambridge University Press.
60. Cipriani A., Furukawa T.A., Salanti G., Geddes J.R., Higgins J.P., Churchill R., et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 2009, 373:746-758.