The association of proopiomelanocortin polymorphisms with the risk of major depressive disorder and the response to antidepressants via interactions with stressful life events

Journal of Neural Transmission

Volumn 122, Issue 1, 2015, Pages 59-68

  Chang, Hun Soo ^a   Won, Eun Soo ^b,c   Lee, Hwa Young ^a   Ham, Byung Joo ^b,c   Kim, Yong Gu ^b,c   Lee, Min Soo ^b,c  

^a Soonchunhyang University   (South Korea)

^b Korea University   (South Korea)

^c Korea University College of Medicine   (South Korea)

Author keywords

Antidepressant; Genetic polymorphism; Life stress; Major depressive disorder; Proopiomelanocortin; Treatment outcome

Indexed keywords

ESCITALOPRAM; MIRTAZAPINE; PROOPIOMELANOCORTIN; ANTIDEPRESSIVE AGENTS; PRO-OPIOMELANOCORTIN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HAMILTON DEPRESSION RATING SCALE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MIDDLE AGED; PRIORITY JOURNAL; REMISSION; RISK ASSESSMENT; STRESS; TREATMENT RESPONSE; AGED; COMPLICATION; DEPRESSIVE DISORDER, MAJOR; FOLLOW-UP STUDIES; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENETICS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RISK; STRESS, PSYCHOLOGICAL;

ADULT; AGED; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PRO-OPIOMELANOCORTIN; PSYCHIATRIC STATUS RATING SCALES; RISK; STRESS, PSYCHOLOGICAL;

EID: 84933039172     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-014-1333-9     Document Type: Article

References (51)

1. Aperia B, Bergman H, Engelbrektson K, Thoren M, Wetterberg L (1985) Effects of electroconvulsive therapy on neuropsychological function and circulating levels of ACTH, cortisol, prolactin, and TSH in patients with major depressive illness. Acta Psychiatr Scand 72:536–541
2. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571
3. Ben-Efraim YJ, Wasserman D, Wasserman J, Sokolowski M (2013) Family-based study of AVPR1B association and interaction with stressful life events on depression and anxiety in suicide attempts. Neuropsychopharmacol 38:1504–1511. doi:10.1038/npp.2013.49
4. Binder EB, Salyakina D, Lichtner P et al (2004) Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 36:1319–1325. doi:10.1038/ng1479
5. Binder EB, Owens MJ, Liu W et al (2010) Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Arch Gen Psychiatry 67:369–379. doi:10.1001/archgenpsychiatry.2010.18
6. Chowdhury NI, Souza RP, Tiwari AK et al (2014) Investigation of melanocortin system gene variants in antipsychotic-induced weight gain. World J Biol Psychiatry 15:251–258. doi:10.3109/15622975.2013.858827
7. Cupic B, Stefulj J, Zapletal E, Matosic A, Bordukalo-Niksic T, Cicin-Sain L, Gabrilovac J (2013) Opioid system genes in alcoholism: a case-control study in Croatian population. Neuropeptides 47:315–319. doi:10.1016/j.npep.2013.08.002
8. de Keyzer Y, Lenne F, Auzan C et al (1996) The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. J Clin Invest 97:1311–1318. doi:10.1172/jci118547
9. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269–301. doi:10.1210/edrv.19.3.0331
10. Dempster EL, Burcescu I, Wigg K et al (2007) Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch Gen Psychiatry 64:1189–1195. doi:10.1001/archpsyc.64.10.1189
11. Doherty JL, Owen MJ (2014) Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. Genome Med 6:29. doi:10.1186/gm546
12. Du H, Vimaleswaran KS, Angquist L et al (2011) Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change—the DiOGenes study. PLoS One 6:e17436. doi:10.1371/journal.pone.0017436
13. Fang Z, Rajewsky N (2011) The impact of miRNA target sites in coding sequences and in 3′UTRs. PLoS One 6:e18067. doi:10.1371/journal.pone.0018067
14. Forman JJ, Coller HA (2010) The code within the code: microRNAs target coding regions. Cell cycle (Georgetown, Tex) 9:1533-1541
15. Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J (2010) Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 303:47–53
16. Graff M, Ngwa JS, Workalemahu T et al (2013) Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet 22:3597–3607. doi:10.1093/hmg/ddt205
17. Grabe HJ, Schwahn C, Appel K et al (2010) Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population. Am J Med Genet B Neuropsychiatr Genet 153:1483–1493. doi:10.1002/ajmg.b.31131
18. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiat 23:56–62
19. Hayase T, Yamamoto Y, Yamamoto K (2002) Increased immunoreactivity of POMC-derived neuropeptides and immediate-early gene-derived proteins (c-Fos and Egr-1 proteins) as an early step of acute cocaine-induced stressor effects: comparison with the effects of immobilization stress. Nihon Arukoru Yakubutsu Igakkai Zasshi 37:586–596
20. Hedrick PW (1987) Gametic disequilibrium measures: proceed with caution. Genetics 117:331–341
21. Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacol 23:477–501. doi:10.1016/s0893-133x(00)00159-7
22. Holsboer F, Barden N (1996) Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 17:187–205. doi:10.1210/edrv-17-2-187
23. Ishitobi Y, Nakayama S, Yamaguchi K et al (2012) Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet 159b:429–436. doi:10.1002/ajmg.b.32046
24. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B (2005) The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62:529–535. doi:10.1001/archpsyc.62.5.529
25. Kendler KS, Gatz M, Gardner CO, Pedersen NL (2006) A Swedish national twin study of lifetime major depression. Am J Psychiatry 163:109–114
26. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR et al (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289:3095–3105
27. Khan A, Leventhal RM, Khan SR, Brown WA (2002) Severity of depression and response to antidepressants and placebo: an analysis of the Food and Drug Administration database. J Clin Psychopharmacol 22:40–45
28. Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT (2008) Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 5:e45
29. Kuehnen P, Mischke M, Wiegand S et al (2012) An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity. PLoS Genet 8:e1002543. doi:10.1371/journal.pgen.1002543
30. Lee H-Y, Kang R-H, Han S-W, Paik J-W, Chang HS, Jeong YJ, Lee M-S (2009) Association of glucocorticoid receptor polymorphisms with the susceptibility to major depressive disorder and treatment responses in Korean depressive patients. Acta Neuropsychiatrica 21:11–17
31. Liu Z, Zhu F, Wang G et al (2006) Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression. Neurosci Lett 404:358–362. doi:10.1016/j.neulet.2006.06.016
32. Liu Z, Zhu F, Wang G et al (2007) Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders. Neurosci Lett 414:155–158. doi:10.1016/j.neulet.2006.12.013
33. Meijer OC, de Kloet ER (1998) Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity. Crit Rev Neurobiol 12:1–20
34. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD (1992) The cloning of a family of genes that encode the melanocortin receptors. Science (New York, NY) 257:1248–1251
35. Nakanishi S, Inoue A, Kita T, Nakamura M, Chang AC, Cohen SN, Numa S (1979) Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278:423–427
36. Papiol S, Arias B, Gasto C, Gutierrez B, Catalan R, Fananas L (2007) Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J Affect Disord 104:83–90. doi:10.1016/j.jad.2007.02.017
37. Purcell S, Cherny SS, Sham PC (2003) Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149–150
38. Schule C (2007) Neuroendocrinological mechanisms of actions of antidepressant drugs. J Neuroendocrinol 19:213–226. doi:10.1111/j.1365-2826.2006.01516.x
39. Shadrina M, Nikopensius T, Slominsky P et al (2006) Association study of sporadic Parkinson’s disease genetic risk factors in patients from Russia by APEX technology. Neurosci Lett 405:212–216. doi:10.1016/j.neulet.2006.06.066
40. Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978–989. doi:10.1086/319501 S0002-9297(07)61424-4 (pii)
41. Suzuki M, Egashira N, Kajiya H et al (2008) ACTH and alpha-subunit are co-expressed in rare human pituitary corticotroph cell adenomas proposed to originate from ACTH-committed early pituitary progenitor cells. Endocr Pathol 19:17–26. doi:10.1007/s12022-008-9014-6
42. Takahashi A, Mizusawa K (2013) Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance. Front Endocrinol (Lausanne) 4:143. doi:10.3389/fendo.2013.00143
43. Ternouth A, Brandys MK, van der Schouw YT, Hendriks J, Jansson JO, Collier D, Adan RA (2011) Association study of POMC variants with body composition measures and nutrient choice. Eur J Pharmacol 660:220–225. doi:10.1016/j.ejphar.2010.10.112
44. van West D, Del-Favero J, Aulchenko Y et al (2004) A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. Mol Psychiatry 9:287–292. doi:10.1038/sj.mp.4001420
45. Wang F, Gelernter J, Kranzler HR, Zhang H (2012) Identification of POMC exonic variants associated with substance dependence and body mass index. PLoS One 7:e45300. doi:10.1371/journal.pone.0045300
46. Wasserman D, Sokolowski M, Rozanov V, Wasserman J (2008) The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress. Genes Brain Behav 7:14–19. doi:10.1111/j.1601-183X.2007.00310.x
47. Wolkowitz OM, Reus VI, Manfredi F, Ingbar J, Brizendine L, Weingartner H (1993) Ketoconazole administration in hypercortisolemic depression. Am J Psychiatry 150:810–812
48. Wong ML, Kling MA, Munson PJ et al (2000) Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Nat Acad Sci USA 97:325–330
49. Xiao Z, Liu W, Gao K et al (2011) Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population. PLoS One 6:e28733. doi:10.1371/journal.pone.0028733
50. Zhang H, Kranzler HR, Weiss RD et al (2009) Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies. Biol Psychiatry 66:128–136. doi:10.1016/j.biopsych.2008.12.021
51. Zobel A, Schuhmacher A, Jessen F et al (2010) DNA sequence variants of the FKBP5 gene are associated with unipolar depression. Int J Neuropsychopharmacol 13:649–660. doi:10.1017/s1461145709991155