Opioid system genes in alcoholism: A case-control study in Croatian population

Neuropeptides

Volumn 47, Issue 5, 2013, Pages 315-319

  Cupic, B ^a   Stefulj, J ^a   Zapletal, E ^a   Matosic, A ^b   Bordukalo Niksic, T ^a   Cicin Sain, L ^a   Gabrilovac, J ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

Author keywords

Alcohol dependence; Cloninger typology; OPRK1; OPRM1; PDYN; POMC; Single nucleotide polymorphism

Indexed keywords

BETA ENDORPHIN; DYNORPHIN; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; OPIATE RECEPTOR; PRODYNORPHIN; PROOPIOMELANOCORTIN;

ADULT; AGED; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROATIA; GENE FREQUENCY; GENETIC REGULATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALCOHOL DEPENDENCE; CLONINGER TYPOLOGY; OPRK1; OPRM1; PDYN; POMC; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ALCOHOLISM; CASE-CONTROL STUDIES; CROATIA; ENKEPHALINS; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PRO-OPIOMELANOCORTIN; PROTEIN PRECURSORS; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; YOUNG ADULT;

EID: 84886954196     PISSN: 01434179     EISSN: 15322785     Source Type: Journal    
DOI: 10.1016/j.npep.2013.08.002     Document Type: Article

References (44)

1. Arias A., Feinn R., Kranzler H.R. Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend. 2006, 83:262-268.
2. Arias A.J., Sewell R.A. Pharmacogenetically driven treatments for alcoholism: are we there yet?. CNS Drugs 2012, 26:461-476.
3. Ashenhurst J.R., Bujarski S., Ray L.A. Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. Pharmacol. Biochem. Behav. 2012, 103:253-259.
4. Bart G., Kreek M.J., Ott J., LaForge K.S., Proudnikov D., Pollak L., Heilig M. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 2005, 30:417-422.
5. Bazov I., Kononenko O., Watanabe H., Kuntic V., Sarkisyan D., Taqi M.M., Hussain M.Z., Nyberg F., Yakovleva T., Bakalkin G. The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Addict. Biol. 2013, 18:161-169.
6. Bergen A.W., Kokoszka J., Peterson R., Long J.C., Virkkunen M., Linnoila M., Goldman D. Mu opioid receptor gene variants: lack of association with alcohol dependence. Mol. Psychiatr. 1997, 2:490-494.
7. Bordukalo-Niksic T., Stefulj J., Matosic A., Mokrovic G., Cicin-Sain L. Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism. Psychiat. Res. 2012, 200:1041-1043.
8. Chen D., Liu L., Xiao Y., Peng Y., Yang C., Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug Alcohol Depend. 2012, 123:1-6.
9. Chen Y.C., Prescott C.A., Walsh D., Patterson D.G., Riley B.P., Kendler K.S., Kuo P.H. Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. J. Stud. Alcohol Drugs 2011, 72:752-762.
10. Clarke T.K., Krause K., Li T., Schumann G. An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population. Addict. Biol. 2009, 14:366-370.
11. Cloninger C.R., Sigvardsson S., Bohman M. Type I and Type II alcoholism: an update. Alcohol Health Res. World 1996, 20:18-23.
12. Deb I., Chakraborty J., Gangopadhyay P.K., Choudhury S.R., Das S. Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. J. Neurochem. 2010, 112:486-496.
13. Du Y., Wan Y.J.Y. The interaction of reward genes with environmental factors in contribution to alcoholism in Mexican Americans. Alcohol. Clin. Exp. Res. 2009, 33:2103-2112.
14. Geijer T., Jonsson E., Neiman J., Gyllander A., Sedvall G., Rydberg U., Terenius L. Prodynorphin allelic distribution in Scandinavian chronic alcoholics. Alcohol. Clin. Exp. Res. 1997, 21:1333-1336.
15. Gelernter J., Kranzler H.R. Genetics of alcohol dependence. Hum. Genet. 2009, 126:91-99.
16. Gianoulakis C. Endogenous opioids and addiction to alcohol and other drugs of abuse. Curr. Top. Med. Chem. 2004, 4:39-50.
17. Gianoulakis C., Beliveau D., Angelogianni P., Meaney M., Thavundayil J., Tawar V., Dumas M. Different pituitary beta-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future development of alcoholism. Life Sci. 1989, 45:1097-1109.
18. Gscheidel N., Sander T., Wendel B., Heere P., Schmidt L.G., Rommelspacher H., Hoehe M.R., Samochowiec J. Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence. Pol. J. Pharmacol. 2000, 52:27-31.
19. Heilig M., Goldman D., Berrettini W., O'Brien C.P. Pharmacogenetic approaches to the treatment of alcohol addiction. Nat. Rev. Neurosci. 2011, 12:670-684.
20. Kiefer F., Jimenez-Arriero M.A., Klein O., Diehl A., Rubio G. Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone. Addict. Biol. 2008, 13:124-129.
21. Kim S.A., Kim J.W., Song J.Y., Park S., Lee H.J., Chung J.H. Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol 2004, 34:115-120.
22. Kim S.G., Kim C.M., Kang D.H., Kim Y.J., Byun W.T., Kim S.Y., Park J.M., Kim M.J., Oslin D.W. Association of functional opioid receptor genotypes with alcohol dependence in Koreans. Alcohol. Clin. Exp. Res. 2004, 28:986-990.
23. Kimura M., Higuchi S. Genetics of alcohol dependence. Psychiat. Clin. Neuros. 2011, 65:213-225.
24. Levran O., Yuferov V., Kreek M.J. The genetics of the opioid system and specific drug addictions. Hum. Genet. 2012, 131:823-842.
25. Loh E.W., Fann C.S.J., Chang Y.T., Chang C.J., Cheng A.T.A. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcohol. Clin. Exp. Res. 2004, 28:15-19.
26. Machelska H. Targeting of opioid-producing leukocytes for pain control. Neuropeptides 2007, 41:355-363.
27. Mague S.D., Blendy J.A. OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend. 2010, 108:172-182.
28. Matthes H.W., Maldonado R., Simonin F., Valverde O., Slowe S., Kitchen I., Befort K., Dierich A., Le Meur M., Dolle P., Tzavara E., Hanoune J., Roques B.P., Kieffer B.L. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 1996, 383:819-823.
29. Miranda R., Ray L., Justus A., Meyerson L.A., Knopik V.S., McGeary J., Monti P.M. Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol. Clin. Exp. Res. 2010, 34:112-122.
30. Nishizawa D., Han W., Hasegawa J., Ishida T., Numata Y., Sato T., Kawai A., Ikeda K. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Neuropsychobiology 2006, 53:137-141.
31. Oswald L.M., Wand G.S. Opioids and alcoholism. Physiol. Behav. 2004, 81:339-358.
32. Racz I., Schurmann B., Karpushova A., Reuter M., Cichon S., Montag C., Furst R., Schutz C., Franke P.E., Strohmaier J., Wienker T.F., Terenius L., Osby U., Gunnar A., Maier W., Bilkei-Gorzo A., Nothen M., Zimmer A. The opioid peptides enkephalin and beta-endorphin in alcohol dependence. Biol. Psychiat. 2008, 64:989-997.
33. Rommelspacher H., Smolka M., Schmidt L.G., Samochowiec J., Hoehe M.R. Genetic analysis of the mu-opioid receptor in alcohol-dependent individuals. Alcohol 2001, 24:129-135.
34. Sander T., Gscheidel N., Wendel B., Samochowiec J., Smolka M., Rommelspacher H., Schmidt L.G., Hoehe M.R. Human mu-opioid receptor variation and alcohol dependence. Alcohol. Clin. Exp. Res. 1998, 22:2108-2110.
35. Sauriyal D.S., Jaggi A.S., Singh N. Extending pharmacological spectrum of opioids beyond analgesia: multifunctional aspects in different pathophysiological states. Neuropeptides 2011, 45:175-188.
36. Taqi M.M., Bazov I., Watanabe H., Nyberg F., Yakovleva T., Bakalkin G. Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. Brain Res. 2011, 1385:18-25.
37. Taqi M.M., Bazov I., Watanabe H., Sheedy D., Harper C., Alkass K., Druid H., Wentzel P., Nyberg F., Yakovleva T., Bakalkin G. Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. Addict. Biol. 2011, 16:499-509.
38. Town T., Abdullah L., Crawford F., Schinka J., Ordorica P.I., Francis E., Hughes P., Duara R., Mullan M. Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency. Am. J. Med. Genet. 1999, 88:458-461.
39. Wee S., Koob G.F. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology 2010, 210:121-135.
40. Xuei X., Dick D., Flury-Wetherill L., Tian H.J., Agrawal A., Bierut L., Goate A., Bucholz K., Schuckit M., Nurnberger J., Tischfield J., Kuperman S., Porjesz B., Begleiter H., Foroud T., Edenberg H.J. Association of the kappa-opioid system with alcohol dependence. Mol. Psychiatr. 2006, 11:1016-1024.
41. Xuei X.L., Flury-Wetherill L., Bierut L., Dick D., Nurnberger J., Foroud T., Edenberg H.J. The opioid system in alcohol and drug dependence: family-based association study. Am. J. Med. Genet. B 2007, 144B:877-884.
42. Zadina J.E., Hackler L., Ge L.J., Kastin A.J. A potent and selective endogenous agonist for the mu-opiate receptor. Nature 1997, 386:499-502.
43. Zhang H., Kranzler H.R., Yang B.Z., Luo X., Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol. Psychiat. 2008, 13:531-543.
44. Zollner C., Stein C. Opioids. Handb. Exp. Pharmacol. 2007, 177:31-63.