Association study of POMC variants with body composition measures and nutrient choice

European Journal of Pharmacology

Volumn 660, Issue 1, 2011, Pages 220-225

  Ternouth, Andrew ^a   Brandys, Marek K ^b,c   Van Der Schouw, Yvonne T ^d   Hendriks, Judith ^b   Jansson, John Olov ^e   Collier, David ^a   Adan, Roger A ^b,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Altrecht Mental Health Institute   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

BMI; Gene association; Melanocortine; POMC; Pro opiomelanocortin; Waist hip ratio

Indexed keywords

PROOPIOMELANOCORTIN;

ADULT; AGED; ALCOHOL CONSUMPTION; BODY COMPOSITION; BODY FAT; BODY FAT DISTRIBUTION; BODY WEIGHT; CARBOHYDRATE INTAKE; EXERCISE; FOOD FREQUENCY QUESTIONNAIRE; FOOD INTAKE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HORMONAL REGULATION; HUMAN; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; MALE; NUTRIENT CONCENTRATION; NUTRIENT UPTAKE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTAKE; QUANTITATIVE ANALYSIS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADIPOSE TISSUE; ADULT; AGED; AGED, 80 AND OVER; BODY COMPOSITION; BODY MASS INDEX; FEEDING BEHAVIOR; GENETIC LOCI; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRO-OPIOMELANOCORTIN; REGRESSION ANALYSIS; WAIST-HIP RATIO;

EID: 79955936953     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.112     Document Type: Review

References (41)

1. Albu, J.B., Kovera, A.J., Johnson, J.A., 2000. Fat distribution and health in obesity. Ann. NY Acad. Sci. 904, 491-501.
2. Andersson, N., Strandberg, L., Nilsson, S., Ljungren, O., Karlsson, M.K., Mellstrom, D., Lorentzon, M., Ohlsson, C., Jansson, J., 2009. Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men. Int. J. Obes. (Lond) 33, 525-533.
3. Baker, M., Gaukrodger, N., Mayosi, B.M., Imrie, H., Farrall, M., Watkins, H., Connell, J.M.C., Avery, P.J., Keavney, B., 2005. Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. Diabetes 54, 2492-2496. (Pubitemid 41134281)
4. Bienertova-Vasku, J., Bienert, P., Forejt, M., Tomandl, J., Brazdova, Z., Vasku, A., 2010. Genotype x nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. Br. J. Nutr. 103, 352-359.
5. Bonilla, C., Panguluri, R.K., Taliaferro-Smith, L., Argyropoulos, G., Chen, G., Adeyemo, A.A., Amoah, A., Owusu, S., Acheampong, J., Agyenim-Boateng, K., Eghan, B.A., Oli, J., Okafor, G., Abbiyesuku, F., Johnson, T., Rufus, T., Fasanmade, O., Chen, Y., Collins, F.S., Dunston, G.M., Rotimi, C., Kittles, R.A., 2006. Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans. Int. J. Obes. (Lond) 30, 715-721.
6. Cai, G., Cole, S.A., Bastarrachea, R.A., Bastarrachea-Sosa, R.A., Maccluer, J.W., Blangero, J., Comuzzie, A.G., 2004. Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. Am. J. Clin. Nutr. 80, 1410-1414.
7. Challis, B.G., Pritchard, L.E., Creemers, J.W.M., Delplanque, J., Keogh, J.M., Luan, J., Wareham, N.J., Yeo, G.S.H., Bhattacharyya, S., Froguel, P., White, A., Farooqi, I.S., O'Rahilly, S., 2002. A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum. Mol. Genet. 11, 1997-2004.
8. Chambers, J.C., Elliott, P., Zabaneh, D., Zhang, W., Li, Y., Froguel, P., Balding, D., Scott, J., Kooner, J.S., 2008. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716-718.
9. Chen, Y., Snieder, H., Wang, X., Kaviya, B., McCaffrey, C., Spector, T.D., Carter, N.D., O'Dell, S.D., 2005. Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population. Eur. J. Hum. Genet. 13, 772-780.
10. Comuzzie, A.G., Hixson, J.E., Almasy, L., Mitchell, B.D., Mahaney, M.C., Dyer, T.D., Stern, M.P., MacCluer, J.W., Blangero, J., 1997. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat. Genet. 15, 273-276.
11. de Bakker, P.I.W., Yelensky, R., Pe'er, I., Gabriel, S.B., Daly, M.J., Altshuler, D., 2005. Efficiency and power in genetic association studies. Nat. Genet. 37, 1217-1223.
12. Delplanque, J., Barat-Houari, M., Dina, C., Gallina, P., Clement, K., Guy-Grand, B., Vasseur, F., Boutin, P., Froguel, P., 2000. Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in Caucasian families. Diabetologia 43, 1554-1557. (Pubitemid 32734863)
13. Farooqi, I.S., 2006. Monogenic human obesity syndromes. Prog. Brain Res. 153, 119-125.
14. Farooqi, I.S., Drop, S., Clements, A., Keogh, J.M., Biernacka, J., Lowenbein, S., Challis, B.G., O'Rahilly, S., 2006. Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes 55, 2549-2553. (Pubitemid 44871155)
15. Hagan, M.M., Rushing, P.A., Benoit, S.C., Woods, S.C., Seeley, R.J., 2001. Opioid receptor involvement in the effect of AgRP- (83-132) on food intake and food selection. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, 814-821.
16. Hager, J., Dina, C., Francke, S., Dubois, S., Houari, M., Vatin, V., Vaillant, E., Lorentz, N., Basdevant, A., Clement, K., Guy-Grand, B., Froguel, P., 1998. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat. Genet. 20, 304-308.
17. Heid, I.M., Vollmert, C., Hinney, A., Doring, A., Geller, F., Lowel, H., Wichmann, H., Illig, T., Hebebrand, J., Kronenberg, F., 2005. Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys. J. Med. Genet. 42.
18. Koegler, F.H., Schaffhauser, R.O., Mynatt, R.L., York, D.A., Bray, G.A., 1999. Macronutrient diet intake of the lethal yellow agouti (Ay/a) mouse. Physiol. Behav. 67, 809-812.
19. Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., Gruters, A., 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155-157.
20. Loos, R.J.F., Katzmarzyk, P.T., Rao, D.C., Rice, T., Leon, A.S., Skinner, J.S., Wilmore, J.H., Rankinen, T., Bouchard, C., 2003. Genome-wide linkage scan for the metabolic syndrome in the HERITAGE family study. J. Clin. Endocrinol. Metab. 88, 5935-5943.
21. Loos, R.J.F., Rankinen, T., Rice, T., Rao, D.C., Leon, A.S., Skinner, J.S., Bouchard, C., Argyropoulos, G., 2005. Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake. Am. J. Clin. Nutr. 82, 1097-1101.
22. Loos, R.J.F., Lindgren, C.M., Li, S., Wheeler, E., Zhao, J.H., Prokopenko, I., Inouye, M., Freathy, R.M., Attwood, A.P., Beckmann, J.S., Berndt, S.I., Bergmann, S., Bennett, A.J., Bingham, S.A., Bochud, M., Brown, M., Cauchi, S., Connell, J.M., Cooper, C., Smith, G.D., Day, I., Dina, C., De, S., Dermitzakis, E.T., Doney, A.S.F., Elliott, K.S., Elliott, P., Evans, D.M., Sadaf Farooqi, I., Froguel, P., Ghori, J., Groves, C.J., Gwilliam, R., Hadley, D., Hall, A.S., Hattersley, A.T., Hebebrand, J., Heid, I.M., Herrera, B., Hinney, A., Hunt, S.E., Jarvelin, M., Johnson, T., Jolley, J.D.M., Karpe, F., Keniry, A., Khaw, K., Luben, R.N., Mangino, M., Marchini, J., McArdle, W.L., McGinnis, R., Meyre, D., Munroe, P.B., Morris, A.D., Ness, A.R., Neville, M.J., Nica, A.C., Ong, K.K., O'Rahilly, S., Owen, K.R., Palmer, C.N.A., Papadakis, K., Potter, S., Pouta, A., Qi, L., Randall, J.C., Rayner, N.W., Ring, S.M., Sandhu, M.S., Scherag, A., Sims, M.A., Song, K., Soranzo, N., Speliotes, E.K., Syddall, H.E., Teichmann, S.A., Timpson, N.J., Tobias, J.H., Uda, M., Ganz Vogel, C.I., Wallace, C., Waterworth, D.M., Weedon, M.N., Willer, C.J., Wraight, V.L., Yuan, X., Zeggini, E., Hirschhorn, J.N., Strachan, D.P., Ouwehand, W.H., Caulfield, M.J., Samani, N.J., Frayling, T.M., Vollenweider, P., Waeber, G., Mooser, V., Deloukas, P., McCarthy, M.I., Wareham, N.J., Barroso, I., 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768-775.
23. Marks, D.L., Boucher, N., Lanouette, C., Perusse, L., Brookhart, G., Comuzzie, A.G., Chagnon, Y.C., Cone, R.D., 2004. Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans. Am. J. Med. Genet. A 126A, 267-271.
24. Muller, M., Grobbee, D.E., den Tonkelaar, I., Lamberts, S.W.J., van, d.S., 2005. Endogenous sex hormones and metabolic syndrome in aging men. J. Clin. Endocrinol. Metab. 90, 2618-2623.
25. Noble, R.E., 2001. Waist-to-hip ratio versus BMI as predictors of cardiac risk in obese adult women. West. J. Med. 174, 240-241.
26. Ocke, M.C., Bueno-de-Mesquita, H.B., Pols, M.A., Smit, H.A., van Staveren, W.A., Kromhout, D., 1997a. The Dutch EPIC food frequency questionnaire. II. Relative validity and reproducibility for nutrients. Int. J. Epidemiol. 26 (Suppl. 1), 49-58.
27. Ocke, M.C., Bueno-de-Mesquita, H.B., Goddijn, H.E., Jansen, A., Pols, M.A., van Staveren, W.A., Kromhout, D., 1997b. The Dutch EPIC food frequency questionnaire. I. Description of the questionnaire, and relative validity and reproducibility for food groups. Int. J. Epidemiol. 26 (Suppl. 1), 37-48.
28. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A.R., Bender, D., Maller, J., Sklar, P., de Bakker, P.I.W., Daly, M.J., Sham, P.C., 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575. doi:10.1086/519795.
29. Rice, T., Rankinen, T., Chagnon, Y.C., Province, M.A., Perusse, L., Leon, A.S., Skinner, J.S., Wilmore, J.H., Bouchard, C., Rao, D.C., 2002. Genomewide linkage scan of resting blood pressure: HERITAGE family study. Health, risk factors, exercise training, and genetics. Hypertension 39, 1037-1043. (Pubitemid 34620120)
30. Samama, P., Rumennik, L., Grippo, J.F., 2003. The melanocortin receptor MCR4 controls fat consumption. Regul. Pept. 113, 85-88.
31. Simonen, R.L., Rankinen, T., Perusse, L., Rice, T., Rao, D.C., Chagnon, Y., Bouchard, C., 2003. Genome-wide linkage scan for physical activity levels in the Quebec family study. Med. Sci. Sports Exerc. 35, 1355-1359.
32. Stolk, R.P., Wink, O., Zelissen, P.M., Meijer, R., van Gils, A.P., Grobbee, D.E., 2001. Validity and reproducibility of ultrasonography for the measurement of intra-abdominal adipose tissue. Int. J. Obes. Relat. Metab. Disord. 25, 1346-1351.
33. Sullivan, P.F., 2007. Spurious genetic associations. Biol. Psychiatry 61, 1121-1126. doi:10.1016/j.biopsych.2006.11.010. (Pubitemid 46669468)
34. Sutton, B.S., Langefeld, C.D., Williams, A.H., Norris, J.M., Saad, M.F., Haffner, S.M., Bowden, D.W., 2005. Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study. Obes. Res. 13, 1491-1498.
35. Suviolahti, E., Ridderstrale, M., Almgren, P., Klannemark, M., Melander, O., Carlsson, E., Carlsson, M., Hedenbro, J., Orho-Melander, M., 2003. Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals. Int. J. Obes. Relat. Metab. Disord. 27, 1204-1211.
36. Voorrips, L.E., Ravelli, A.C., Dongelmans, P.C., Deurenberg, P., Van Staveren, W.A., 1991. A physical activity questionnaire for the elderly. Med. Sci. Sports Exerc. 23, 974-979.
37. Wang, Y., Rimm, E.B., Stampfer, M.J., Willett, W.C., Hu, F.B., 2005. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am. J. Clin. Nutr. 81, 555-563.
38. Wigginton, J.E., Cutler, D.J., Abecasis, G.R., 2005. A note on exact tests of Hardy-Weinberg equilibrium. Am. J. Hum. Genet. 76, 887-893.
39. Willer, C.J., Speliotes, E.K., Loos, R.J., Li, S., Lindgren, C.M., Heid, I.M., Berndt, S.I., Elliott, A.L., Jackson, A.U., Lamina, C., Lettre, G., Lim, N., Lyon, H.N., McCarroll, S.A., Papadakis, K., Qi, L., Randall, J.C., Roccasecca, R.M., Sanna, S., Scheet, P., Weedon, M.N., Wheeler, E., Zhao, J.H., Jacobs, L.C., Prokopenko, I., Soranzo, N., Tanaka, T., Timpson, N.J., Almgren, P., Bennett, A., Bergman, R.N., Bingham, S.A., Bonnycastle, L.L., Brown, M., Burtt, N.P., Chines, P., Coin, L., Collins, F.S., Connell, J.M., Cooper, C., Smith, G.D., Dennison, E.M., Deodhar, P., Elliott, P., Erdos, M.R., Estrada, K., Evans, D.M., Gianniny, L., Gieger, C., Gillson, C.J., Guiducci, C., Hackett, R., Hadley, D., Hall, A.S., Havulinna, A.S., Hebebrand, J., Hofman, A., Isomaa, B., Jacobs, K.B., Johnson, T., Jousilahti, P., Jovanovic, Z., Khaw, K.T., Kraft, P., Kuokkanen, M., Kuusisto, J., Laitinen, J., Lakatta, E.G., Luan, J., Luben, R.N., Mangino, M., McArdle, W.L., Meitinger, T., Mulas, A., Munroe, P.B., Narisu, N., Ness, A.R., Northstone, K., O'Rahilly, S., Purmann, C., Rees, M.G., Ridderstrale, M., Ring, S.M., Rivadeneira, F., Ruokonen, A., Sandhu, M.S., Saramies, J., Scott, L.J., Scuteri, A., Silander, K., Sims, M.A., Song, K., Stephens, J., Stevens, S., Stringham, H.M., Tung, Y.C., Valle, T.T., Van Duijn, C.M., Vimaleswaran, K.S., Vollenweider, P., Waeber, G., Wallace, C., Watanabe, R.M., Waterworth, D.M., Watkins, N., Wellcome Trust Case Control Consortium, Witteman, J.C., Zeggini, E., Zhai, G., Zillikens, M.C., Altshuler, D., Caulfield, M.J., Chanock, S.J., Farooqi, I.S., Ferrucci, L., Guralnik, J.M., Hattersley, A.T., Hu, F.B., Jarvelin, M.R., Laakso, M., Mooser, V., Ong, K.K., Ouwehand, W.H., Salomaa, V., Samani, N.J., Spector, T.D., Tuomi, T., Tuomilehto, J., Uda, M., Uitterlinden, A.G., Wareham, N.J., Deloukas, P., Frayling, T.M., Groop, L.C., Hayes, R.B., Hunter, D.J., Mohlke, K.L., Peltonen, L., Schlessinger, D., Strachan, D.P., Wichmann, H.E., McCarthy, M.I., Boehnke, M., Barroso, I., Abecasis, G.R., Hirschhorn, J.N., Genetic Investigation of ANthropometric Traits Consortium, 2009. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34. doi:10.1038/ng.287.
40. Yaswen, L., Diehl, N., Brennan, M.B., Hochgeschwender, U., 1999. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5, 1066-1070.
41. Yusuf, S., Hawken, S., Ounpuu, S., Bautista, L., Franzosi, M.G., Commerford, P., Lang, C.C., Rumboldt, Z., Onen, C.L., Lisheng, L., Tanomsup, S., Wangai, P., Razak, F., Sharma, A.M., Anand, S.S., 2005. Obesity and the risk ofmyocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366, 1640-1649. (Pubitemid 41552419)