메뉴 건너뛰기




Volumn 35, Issue 6, 2015, Pages 1357-1365

Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages: Relevance in the Context of Atherosclerosis

Author keywords

arachidonic acid; liver X receptor; macrophages; n 3 polyunsaturated fatty acid

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; ACYL COENZYME A DESATURASE 2; ACYL COENZYME A SYNTHASE LONG CHAIN FAMILY MEMBER 3; APOLIPOPROTEIN E; ARACHIDONIC ACID; DIMETHYL SULFOXIDE; DOCOSAHEXAENOIC ACID; ENZYME; FATTY ACID ELONGASE 5; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; UNSATURATED FATTY ACID;

EID: 84933039116     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.305539     Document Type: Article
Times cited : (53)

References (43)
  • 2
    • 84867031028 scopus 로고    scopus 로고
    • Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
    • Spann NJ, Garmire LX, McDonald JG, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012;151:138-152. doi: 10.1016/j.cell.2012.06.054.
    • (2012) Cell , vol.151 , pp. 138-152
    • Spann, N.J.1    Garmire, L.X.2    McDonald, J.G.3
  • 3
    • 77955170550 scopus 로고    scopus 로고
    • Nuclear receptors and inflammation control: Molecular mechanisms and pathophysiological relevance
    • Huang W, Glass CK. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol. 2010;30:1542-1549. doi: 10.1161/ATVBAHA.109.191189.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1542-1549
    • Huang, W.1    Glass, C.K.2
  • 4
    • 84858796689 scopus 로고    scopus 로고
    • Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
    • Calkin AC, Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat Rev Mol Cell Biol. 2012;13:213-224. doi: 10.1038/nrm3312.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 213-224
    • Calkin, A.C.1    Tontonoz, P.2
  • 5
    • 0037458568 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure
    • Sun Y, Hao M, Luo Y, Liang CP, Silver DL, Cheng C, Maxfield FR, Tall AR. Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure. J Biol Chem. 2003;278:5813-5820. doi: 10.1074/jbc.M208687200.
    • (2003) J Biol Chem , vol.278 , pp. 5813-5820
    • Sun, Y.1    Hao, M.2    Luo, Y.3    Liang, C.P.4    Silver, D.L.5    Cheng, C.6    Maxfield, F.R.7    Tall, A.R.8
  • 6
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory elementbinding protein-1c
    • Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory elementbinding protein-1c. J Biol Chem. 2002;277:9520-9528. doi: 10.1074/jbc. M111421200.
    • (2002) J Biol Chem , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 10
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282:743-751. doi: 10.1074/jbc.M605023200.
    • (2007) J Biol Chem , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 12
    • 0345098365 scopus 로고    scopus 로고
    • The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse
    • Chisholm JW, Hong J, Mills SA, Lawn RM. The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003;44:2039-2048. doi: 10.1194/jlr.M300135-JLR200.
    • (2003) J Lipid Res , vol.44 , pp. 2039-2048
    • Chisholm, J.W.1    Hong, J.2    Mills, S.A.3    Lawn, R.M.4
  • 14
    • 34249682775 scopus 로고    scopus 로고
    • Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: Liver X receptor-mediated lipotoxicity in pancreatic beta-cells
    • Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, Lee KM, Park KG, Lee IK, Kim JB. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 2007;56:1534-1543. doi: 10.2337/db06-1059.
    • (2007) Diabetes , vol.56 , pp. 1534-1543
    • Choe, S.S.1    Choi, A.H.2    Lee, J.W.3    Kim, K.H.4    Chung, J.J.5    Park, J.6    Lee, K.M.7    Park, K.G.8    Lee, I.K.9    Kim, J.B.10
  • 18
    • 2142756699 scopus 로고    scopus 로고
    • LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1
    • Wang Y, Kurdi-Haidar B, Oram JF. LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1. J Lipid Res. 2004;45:972-980. doi: 10.1194/jlr. M400011-JLR200.
    • (2004) J Lipid Res , vol.45 , pp. 972-980
    • Wang, Y.1    Kurdi-Haidar, B.2    Oram, J.F.3
  • 20
    • 51549107903 scopus 로고    scopus 로고
    • Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008;134:933-944. doi: 10.1016/j. cell.2008.07.048.
    • (2008) Cell , vol.134 , pp. 933-944
    • Cao, H.1    Gerhold, K.2    Mayers, J.R.3    Wiest, M.M.4    Watkins, S.M.5    Hotamisligil, G.S.6
  • 21
    • 0035932990 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
    • Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci U S A. 2001;98:6027-6032. doi: 10.1073/pnas.111138698.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6027-6032
    • Ou, J.1    Tu, H.2    Shan, B.3    Luk, A.4    Debose-Boyd, R.A.5    Bashmakov, Y.6    Goldstein, J.L.7    Brown, M.S.8
  • 22
    • 18544388579 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    • Yoshikawa T, Shimano H, Yahagi N, et al. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem. 2002;277:1705-1711. doi: 10.1074/jbc.M105711200.
    • (2002) J Biol Chem , vol.277 , pp. 1705-1711
    • Yoshikawa, T.1    Shimano, H.2    Yahagi, N.3
  • 23
    • 59349089822 scopus 로고    scopus 로고
    • Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c
    • Qin Y, Dalen KT, Gustafsson JA, Nebb HI. Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochim Biophys Acta. 2009;1791:140-147. doi: 10.1016/j.bbalip.2008.12.003.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 140-147
    • Qin, Y.1    Dalen, K.T.2    Gustafsson, J.A.3    Nebb, H.I.4
  • 25
    • 84884821893 scopus 로고    scopus 로고
    • NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids
    • Li P, Spann NJ, Kaikkonen MU, et al. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013;155:200-214. doi: 10.1016/j.cell.2013.08.054.
    • (2013) Cell , vol.155 , pp. 200-214
    • Li, P.1    Spann, N.J.2    Kaikkonen, M.U.3
  • 27
    • 77953485038 scopus 로고    scopus 로고
    • Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
    • Weedon-Fekjaer MS, Dalen KT, Solaas K, Staff AC, Duttaroy AK, Nebb HI. Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. J Lipid Res. 2010;51:1886-1896. doi: 10.1194/jlr.M004978.
    • (2010) J Lipid Res , vol.51 , pp. 1886-1896
    • Weedon-Fekjaer, M.S.1    Dalen, K.T.2    Solaas, K.3    Staff, A.C.4    Duttaroy, A.K.5    Nebb, H.I.6
  • 29
    • 0025841905 scopus 로고
    • The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase
    • Voss A, Reinhart M, Sankarappa S, Sprecher H. The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. J Biol Chem. 1991;266:19995-20000.
    • (1991) J Biol Chem , vol.266 , pp. 19995-20000
    • Voss, A.1    Reinhart, M.2    Sankarappa, S.3    Sprecher, H.4
  • 30
    • 0037188553 scopus 로고    scopus 로고
    • Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    • Joseph SB, McKilligin E, Pei L, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002;99:7604-7609. doi: 10.1073/pnas.112059299.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7604-7609
    • Joseph, S.B.1    McKilligin, E.2    Pei, L.3
  • 32
    • 0029953175 scopus 로고    scopus 로고
    • Molecular characterization and expression of rat acyl-CoA synthetase
    • Fujino T, Kang MJ, Suzuki H, Iijima H, Yamamoto T. Molecular characterization and expression of rat acyl-CoA synthetase. J Biol Chem. 1996;271:16748-16752.
    • (1996) J Biol Chem , vol.271 , pp. 16748-16752
    • Fujino, T.1    Kang, M.J.2    Suzuki, H.3    Iijima, H.4    Yamamoto, T.5
  • 33
    • 64149083800 scopus 로고    scopus 로고
    • Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
    • Moon YA, Hammer RE, Horton JD. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J Lipid Res. 2009;50:412-423. doi: 10.1194/jlr.M800383-JLR200.
    • (2009) J Lipid Res , vol.50 , pp. 412-423
    • Moon, Y.A.1    Hammer, R.E.2    Horton, J.D.3
  • 34
    • 0034686664 scopus 로고    scopus 로고
    • Metabolism of highly unsaturated n-3 and n-6 fatty acids
    • Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta. 2000;1486:219-231.
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 219-231
    • Sprecher, H.1
  • 36
    • 34247507175 scopus 로고    scopus 로고
    • Role of liver X receptor, insulin and peroxisome proliferator activated receptor alpha on in vivo desaturase modulation of unsaturated fatty acid biosynthesis
    • Montanaro MA, González MS, Bernasconi AM, Brenner RR. Role of liver X receptor, insulin and peroxisome proliferator activated receptor alpha on in vivo desaturase modulation of unsaturated fatty acid biosynthesis. Lipids. 2007;42:197-210. doi: 10.1007/s11745-006-3006-4.
    • (2007) Lipids , vol.42 , pp. 197-210
    • Montanaro, M.A.1    González, M.S.2    Bernasconi, A.M.3    Brenner, R.R.4
  • 41
    • 54049137639 scopus 로고    scopus 로고
    • Atherosclerosis: Evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    • Merched AJ, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008;22:3595-3606. doi: 10.1096/fj.08-112201.
    • (2008) FASEB J , vol.22 , pp. 3595-3606
    • Merched, A.J.1    Ko, K.2    Gotlinger, K.H.3    Serhan, C.N.4    Chan, L.5
  • 42
    • 84893389416 scopus 로고    scopus 로고
    • Activation of liver X receptor decreases atherosclerosis in Ldlr?/? Mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells
    • Kappus MS, Murphy AJ, Abramowicz S, Ntonga V, Welch CL, Tall AR, Westerterp M. Activation of liver X receptor decreases atherosclerosis in Ldlr?/? mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells. Arterioscler Thromb Vasc Biol. 2014;34:279-284. doi: 10.1161/ATVBAHA.113.302781.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 279-284
    • Kappus, M.S.1    Murphy, A.J.2    Abramowicz, S.3    Ntonga, V.4    Welch, C.L.5    Tall, A.R.6    Westerterp, M.7
  • 43
    • 84893427783 scopus 로고    scopus 로고
    • Liver X receptors and atherosclerosis: It is not all cholesterol
    • Ignatova ID, Schulman IG. Liver X receptors and atherosclerosis: it is not all cholesterol. Arterioscler Thromb Vasc Biol. 2014;34:242-243. doi: 10.1161/ATVBAHA.113.302987.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 242-243
    • Ignatova, I.D.1    Schulman, I.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.