The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

FASEB Journal

Volumn 29, Issue 5, 2015, Pages 1653-1662

  Bae, Woo Kyun ^a,c   Kang, Keunsoo ^a,d   Yu, Ji Hoon ^a,e   Yoo, Kyung Hyun ^a   Factor, Valentina M ^b   Kaji, Kosuke ^b   Matter, Matthias ^b   Thorgeirsson, Snorri ^b   Hennighausen, Lothar ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Chonnam National University Medical School   (South Korea)

^d Dankook University   (South Korea)

^e Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

Fibrosis; H3 K27 trimethylation; Liver regeneration

Indexed keywords

CARBON TETRACHLORIDE; HISTONE H3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EZH1; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; EZH1 PROTEIN, MOUSE; EZH2 PROTEIN, MOUSE; HISTONE; MESSENGER RNA; POLYCOMB REPRESSIVE COMPLEX 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DEGENERATION; GENE EXPRESSION; HEPATIC DEGENERATION; HEPATIC PROGENITOR CELL; HISTONE METHYLATION; HOMEOSTASIS; INFLAMMATORY INFILTRATE; LIVER CELL; LIVER DISEASE; LIVER DYSFUNCTION; LIVER FIBROSIS; LIVER NODULE; LIVER REGENERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HIGH THROUGHPUT SEQUENCING; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANIMALS; BIOMARKERS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HISTONES; HOMEOSTASIS; INFLAMMATION; LIVER REGENERATION; MALE; MICE; MICE, KNOCKOUT; POLYCOMB REPRESSIVE COMPLEX 2; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84932630527     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-261537     Document Type: Article

References (28)

1. Sauvageau, M., and Sauvageau, G. (2010) Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7, 299-313
2. Ringrose, L., and Paro, R. (2004) Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu. Rev. Genet. 38, 413-443
3. Margueron, R., and Reinberg, D. (2011) The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349
4. Margueron, R., Li, G., Sarma, K., Blais, A., Zavadil, J., Woodcock, C. L., Dynlacht, B. D., and Reinberg, D. (2008) Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 32, 503-518
5. Ezhkova, E., Lien, W. H., Stokes, N., Pasolli, H. A., Silva, J. M., and Fuchs, E. (2011) EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev. 25, 485-498
6. Ntziachristos, P., Tsirigos, A., Van Vlierberghe, P., Nedjic, J., Trimarchi, T., Flaherty, M. S., Ferres-Marco, D., Da Ros, V., Tang, Z., Siegle, J., Asp, P., Hadler, M., Rigo, I., De Keersmaecker, K., Patel, J., Huynh, T., Utro, F., Poglio, S., Samon, J. B., Paietta, E., Racevskis, J., Rowe, J. M., Rabadan, R., Levine, R. L., Brown, S., Pflumio, F., Dominguez, M., Ferrando, A., and Aifantis, I. (2012) Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat. Med. 18, 298-301
7. Au, S. L., Wong, C. C., Lee, J. M., Fan, D. N., Tsang, F. H., Ng, I. O., and Wong, C. M. (2012) Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology 56, 622-631
8. Xu, K., Wu, Z. J., Groner, A. C., He, H. H., Cai, C., Lis, R. T., Wu, X., Stack, E. C., Loda, M., Liu, T., Xu, H., Cato, L., Thornton, J. E., Gregory, R. I., Morrissey, C., Vessella, R. L., Montironi, R., Magi-Galluzzi, C., Kantoff, P. W., Balk, S. P., Liu, X. S., and Brown, M. (2012) EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 338, 1465-1469
9. Lee, J. M., Lee, J. S., Kim, H., Kim, K., Park, H., Kim, J. Y., Lee, S. H., Kim, I. S., Kim, J., Lee, M., Chung, C. H., Seo, S. B., Yoon, J. B., Ko, E., Noh, D. Y., Kim, K. I., Kim, K. K., and Baek, S. H. (2012) EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol. Cell 48, 572-586
10. Mousavi, K., Zare, H., Wang, A. H., and Sartorelli, V. (2012) Polycomb protein Ezh1 promotes RNA polymerase II elongation. Mol. Cell 45, 255-262
11. Su, I. H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., and Tarakhovsky, A. (2003) Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat. Immunol. 4, 124-131
12. Factor, V. M., Radaeva, S. A., and Thorgeirsson, S. S. (1994) Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am. J. Pathol. 145, 409-422
13. Langmead, B., Trapnell, C., Pop, M., and Salzberg, S. L. (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25
14. Trapnell, C., Roberts, A., Goff, L., Pertea, G., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., and Pachter, L. (2012) Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 7, 562-578
15. Kobayashi, N., Ito, M., Nakamura, J., Cai, J., Gao, C., Hammel, J. M., and Fox, I. J. (2000) Hepatocyte transplantation in rats with decompensated cirrhosis. Hepatology 31, 851-857
16. Zang, C., Schones, D. E., Zeng, C., Cui, K., Zhao, K., and Peng, W. (2009) A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics 25, 1952-1958
17. Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., and Glass, C. K. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589
18. Thorvaldsdóttir, H., Robinson, J. T., and Mesirov, J. P. (2013) Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief. Bioinform. 14, 178-192
19. Yakar, S., Liu, J. L., Stannard, B., Butler, A., Accili, D., Sauer, B., and LeRoith, D. (1999) Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 96, 7324-7329
20. Williams, M. J., Clouston, A. D., and Forbes, S. J. (2014) Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology 146, 349-356
21. Shen, X., Liu, Y., Hsu, Y. J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G. C., and Orkin, S. H. (2008) EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32, 491-502
22. Bardot, E. S., Valdes, V. J., Zhang, J., Perdigoto, C. N., Nicolis, S., Hearn, S. A., Silva, J. M., and Ezhkova, E. (2013) Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells. EMBO J. 32, 1990-2000
23. Jakubowski, A., Ambrose, C., Parr, M., Lincecum, J. M., Wang, M. Z., Zheng, T. S., Browning, B., Michaelson, J. S., Baetscher, M., Wang, B., Bissell, D. M., and Burkly, L. C. (2005) TWEAK induces liver progenitor cell proliferation. J. Clin. Invest. 115, 2330-2340
24. Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C. H., Giovannini, M., and McClatchey, A. I. (2010) Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev. 24, 1718-1730
25. Lin, T., Ibrahim, W., Peng, C. Y., Finegold, M. J., and Tsai, R. Y. (2013) A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration. Hepatology 58, 2176-2187
26. Sherr, C. J., and Roberts, J. M. (2004) Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18, 2699-2711
27. Park, I. K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., and Clarke, M. F. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423, 302-305
28. Molofsky, A. V., Pardal, R., Iwashita, T., Park, I. K., Clarke, M. F., and Morrison, S. J. (2003) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425, 962-967