A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration

Hepatology

Volumn 58, Issue 6, 2013, Pages 2176-2187

  Lin, Tao ^a   Ibrahim, Wessam ^a   Peng, Cheng Yuan ^b,c   Finegold, Milton J ^d,e   Tsai, Robert Y L ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d TEXAS CHILDREN S HOSPITAL   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CARBON TETRACHLORIDE; NUCLEOSTEMIN; PROTEIN; RAD51 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; NUCLEAR PROTEIN; NUCLEOSTEMIN PROTEIN, MOUSE; RAD51AP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BILE DUCT DISEASE; CELL ACTIVATION; CELL DEATH; CELL DEGENERATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; GENOME; HYPERPLASIA; LIVER CELL; LIVER CELL DAMAGE; LIVER DEVELOPMENT; LIVER REGENERATION; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PERINATAL PERIOD; PRIORITY JOURNAL; STEM CELL; ANIMAL; BILE DUCT; DEFICIENCY; DNA REPLICATION; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; INTOXICATION; LIVER; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BILE DUCTS; CARBON TETRACHLORIDE POISONING; CARRIER PROTEINS; DNA DAMAGE; DNA REPLICATION; GENOME; HEPATOCYTES; HYPERPLASIA; LIVER; LIVER REGENERATION; MICE; NUCLEAR PROTEINS;

EID: 84888302849     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26600     Document Type: Article

References (29)

1. Saintigny Y, Delacote F, Vares G, Petitot F, Lambert S, Averbeck D, Lopez BS. Characterization of homologous recombination induced by replication inhibition in mammalian cells. EMBO J 2001;20:3861-3870.
2. Petermann E, Helleday T. Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol 2010;11:683-687.
3. Helleday T. Amplifying tumour-specific replication lesions by DNA repair inhibitors-a new era in targeted cancer therapy. Eur J Cancer 2008;44:921-927.
4. Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010;40:179-204.
5. Tsai RY, McKay RD. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev 2002;16:2991-3003.
6. Tsai RY, Meng L. Nucleostemin: a latecomer with new tricks. Int J Biochem Cell Biol 2009;41:2122-2124.
7. Zhu Q, Yasumoto H, Tsai RY. Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability. Mol Cell Biol 2006;26:9279-9290.
8. Qu J, Bishop JM. Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency. J Cell Biol 2012;197:731-745.
9. Lin T, Meng L, Li Y, Tsai RY. Tumor-initiating function of nucleostemin-enriched mammary tumor cells. Cancer Res 2010;70:9444-9452.
10. Maki N, Takechi K, Sano S, Tarui H, Sasai Y, Agata K. Rapid accumulation of nucleostemin in nucleolus during newt regeneration. Dev Dyn 2007;236:941-950.
11. Siddiqi S, Gude N, Hosoda T, Muraski J, Rubio M, Emmanuel G, et al. Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res 2008;103:89-97.
12. Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, et al. Nucleostemin in injury-induced liver regeneration. Stem Cells Dev 2012;21:3044-3054.
13. Hsu JK, Lin T, Tsai RY. Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1. J Cell Biol 2012;197:613-624.
14. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305-315.
15. Weisend CM, Kundert JA, Suvorova ES, Prigge JR, Schmidt EE. Cre activity in fetal albCre mouse hepatocytes: utility for developmental studies. Genesis 2009;47:789-792.
16. Farley FW, Soriano P, Steffen LS, Dymecki SM. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 2000;28:106-110.
17. Meng L, Lin T, Tsai RY. Nucloplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival. J Cell Sci 2008;121:4037-4046.
18. Podhorecka M, Skladanowski A, Bozko P. H2AX phosphorylation: its role in DNA damage response and cancer therapy. J Nucleic Acids 2011;2011:1-9.
19. Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 2013;494:247-250.
20. Malato Y, Naqvi S, Schurmann N, Ng R, Wang B, Zape J, et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest 2011;121:4850-4860.
21. Tsuzuki T, Fujii Y, Sakumi K, Tominaga Y, Nakao K, Sekiguchi M, et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci U S A 1996;93:6236-6240.
22. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 2010;107:1437-1442.
23. Endo Y, Zhang M, Yamaji S, Cang Y. Genetic abolishment of hepatocyte proliferation activates hepatic stem cells. PLoS One 2012;7:e31846.
24. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, et al. TWEAK induces liver progenitor cell proliferation. J Clin Invest 2005;115:2330-2340.
25. Benhamouche S, Curto M, Saotome I, Gladden AB, Liu CH, Giovannini M, McClatchey AI. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev 2010;24:1718-1730.
26. Braeuning A, Singh Y, Rignall B, Buchmann A, Hammad S, Othman A, et al. Phenotype and growth behavior of residual beta-catenin-positive hepatocytes in livers of beta-catenin-deficient mice. Histochem Cell Biol 2010;134:469-481.
27. Sekine S, Ogawa R, Kanai Y. Hepatomas with activating Ctnnb1 mutations in "Ctnnb1-deficient" livers: a tricky aspect of a conditional knockout mouse model. Carcinogenesis 2011;32:622-628.
28. Thompson MD, Wickline ED, Bowen WB, Lu A, Singh S, Misse A, Monga SP. Spontaneous repopulation of beta-catenin null livers with beta-catenin-positive hepatocytes after chronic murine liver injury. Hepatology 2011;54:1333-1343.
29. Wang EY, Yeh SH, Tsai TF, Huang HP, Jeng YM, Lin WH, et al. Depletion of beta-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. Proc Natl Acad Sci U S A 2011;108:18384-18389.