Healing of massive segmental femoral bone defects in minipigs by allogenic ASCs engineered with FLPo/Frt-based baculovirus vectors

Biomaterials

Volumn 50, Issue 1, 2015, Pages 98-106

  Lin, Chin Yu ^a   Wang, Yao Horng ^b   Li, Kuei Chang ^a   Sung, Li Yu ^a   Yeh, Chia Lin ^a   Lin, Kun Ju ^c,d   Yen, Tzu Chen ^d,e   Chang, Yu Han ^c   Hu, Yu Chen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Adipose derived stem cells; Baculovirus; Gene therapy; Massive bone defects; Minipig; Pre clinical

Indexed keywords

BONE; COMPUTERIZED TOMOGRAPHY; DEFECTS; GENE THERAPY; STEM CELLS;

ADIPOSE DERIVED STEM CELLS; BACULOVIRUS; BONE DEFECT; MINI-PIG; PRE-CLINICAL;

POSITRON EMISSION TOMOGRAPHY;

BACULOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT VASCULOTROPIN; RECOMBINASE; VASCULOTROPIN; DNA POLYMERASE;

ADIPOSE DERIVED STEM CELL; ALLOGENIC ADIPOSE DERIVED STEM CELL TRANSPLANTATION; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACULOVIRIDAE; BACULOVIRUS EXPRESSION SYSTEM; BLOOD CHEMISTRY; BONE DEFECT; CODON; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; FEMORAL BONE DEFECT; FEMUR; FEMUR DIAPHYSIS; FEMUR MALFORMATION; FRACTURE HEALING; GENE EXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MINIPIG; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; VIRAL GENE DELIVERY SYSTEM; ADIPOSE TISSUE; ANIMAL; BIOMECHANICS; BONE DEVELOPMENT; BONE REGENERATION; CELL CULTURE; CYTOLOGY; GENE VECTOR; GENETIC ENGINEERING; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PIG; RADIOGRAPHY; SCINTISCANNING; STEM CELL; TRANSGENE; VASCULARIZATION; WOUND HEALING;

ORYCTOLAGUS CUNICULUS;

ADIPOSE TISSUE; ANIMALS; BACULOVIRIDAE; BASE SEQUENCE; BIOMECHANICAL PHENOMENA; BONE REGENERATION; CELLS, CULTURED; DNA NUCLEOTIDYLTRANSFERASES; FEMUR; GENETIC ENGINEERING; GENETIC VECTORS; OSTEOGENESIS; POSITRON-EMISSION TOMOGRAPHY; STEM CELL TRANSPLANTATION; STEM CELLS; SWINE; SWINE, MINIATURE; TOMOGRAPHY, X-RAY COMPUTED; TRANSGENES; TRANSPLANTATION, HOMOLOGOUS; WOUND HEALING;

EID: 84932624435     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.01.052     Document Type: Article

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