Assessment of microtubule depolymerization property of flavonoids isolated from Tanacetum gracile in breast cancer cells by biochemical and molecular docking approach

Chemico-Biological Interactions

Volumn 239, Issue , 2015, Pages 1-11

  Sinha, Sadhna ^a   Amin, Hina ^b,c   Nayak, Debasis ^b   Bhatnagar, Manisha ^a   Kacker, Puneet ^a   Chakraborty, Souneek ^b   Kitchlu, Surinder ^b   Vishwakarma, Ram ^b   Goswami, Anindya ^b   Ghosal, Sabari ^a  

^a AMITY UNIVERSITY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c BABA GHULAM SHAH BADSHAH UNIVERSITY   (India)

Author keywords

ADMET properties; Antitubulin agent; Flavonoids; Molecular docking; Reactive oxygen species; Tanacetum gracile

Indexed keywords

5 HYDROXY 3,6,7,3',4' PENTAMETHOXYFLAVONE; 5,4' DIHYDROXY 3,6,7,3',4' TETRAMETHOXYFLAVONE; FLAVONOID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; TUBULIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ARTEMETIN; CHRYSOSPLENETIN; COLCHICINE; REACTIVE OXYGEN METABOLITE; TUBULIN MODULATOR;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; ASTERACEAE; BIOCHEMICAL ANALYSIS; BREAST CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; M PHASE CELL CYCLE CHECKPOINT; MASS SPECTROMETRY; MCF 7 CELL LINE; MICROTUBULE ASSEMBLY; MICROTUBULE DEPOLYMERIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TANACETUM GRACILE; UPREGULATION; ANIMAL; BINDING SITE; BLOOD BRAIN BARRIER; BREAST NEOPLASMS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; FEMALE; METABOLISM; MICROTUBULE; PATHOLOGY; PROCEDURES; TANACETUM;

TANACETUM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BINDING SITES; BLOOD-BRAIN BARRIER; BREAST NEOPLASMS; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLAVONOIDS; HUMANS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROTUBULES; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; RATS; REACTIVE OXYGEN SPECIES; TANACETUM; TUBULIN MODULATORS;

EID: 84932601337     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.06.034     Document Type: Article

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