Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model

Biotechnology and Bioengineering

Volumn 112, Issue 8, 2015, Pages 1673-1682

  Anand, Padmaja ^a   Fu, Afu ^a   Teoh, Swee H ^a   Luo, Kathy Q ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

3D breast tumor model; Anti cancer drugs; Biosensor; Fluorescence resonance energy transfer (FRET); Real time detection of apoptosis

Indexed keywords

BIOSENSORS; CELL CULTURE; CELL DEATH; CELLS; CHEMICAL ACTIVATION; CURRICULA; CYTOLOGY; DISEASES; DRUG DOSAGE; DRUG THERAPY; ENERGY TRANSFER; FLUORESCENCE; GENE EXPRESSION; NUCLEIC ACIDS; RESONANCE; SOFTWARE ARCHITECTURE; TUMORS;

ANTICANCER DRUG; BREAST TUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION STUDIES; HISTOLOGICAL EXAMINATION; HUMAN BREAST CANCER CELLS; REAL-TIME DETECTION; THREEDIMENSIONAL (3-D);

THREE DIMENSIONAL COMPUTER GRAPHICS;

CASPASE 3; GELATINASE B; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; PACLITAXEL; PLASMID DNA; TRANSCRIPTION FACTOR SOX2; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOSENSOR; BREAST CANCER CELL LINE; BREAST TUMOR; CANCER CHEMOTHERAPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROENCAPSULATION; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT; TUMOR MODEL; TUMOR SPHEROID; UPREGULATION; BIOLOGICAL MODEL; DRUG EFFECTS; GENETIC PROCEDURES; ORGAN CULTURE TECHNIQUE; PROCEDURES; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOSENSING TECHNIQUES; BREAST NEOPLASMS; CELL LINE, TUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES;

EID: 84932199329     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25572     Document Type: Article

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