Synthesis of a C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine monomer enabling the convergent construction of symmetrical and non-symmetrical dimeric analogs

Tetrahedron Letters

Volumn 56, Issue 30, 2015, Pages 4512-4515

  Kolakowski, Robert V ^a   Young, Thomas D ^a   Howard, Philip W ^b   Jeffrey, Scott C ^a   Senter, Peter D ^a  

^a SEATTLE GENETICS INC   (United States)

^b ADC Products Ltd QMB Innovation Centre   (United Kingdom)

Author keywords

Anti cancer; Antibody drug conjugates; Drug linker; Payloads; Pyrrolobenzodiazepines

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; DRUG ANTIBODY; MONOMER; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYCLIZATION; DESS MARTIN OXIDATION; DIMERIZATION; DNA CROSS LINKING; DRUG CONJUGATION; DRUG SYNTHESIS; IC50; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; SWERN OXIDATION;

EID: 84932197119     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2015.05.116     Document Type: Article

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