The aetiology of pharyngotonsillitis in adolescents and adults - Fusobacterium necrophorum is commonly found

Clinical Microbiology and Infection

Volumn 21, Issue 3, 2015, Pages 263.e1-263.e7

  Hedin, K ^a,b   Bieber, L ^c   Lindh, M ^d   Sundqvist, M ^e  

^a LUND UNIVERSITY   (Sweden)

^b Kronoberg County Council   (Sweden)

^c CENTRAL HOSPITAL   (Sweden)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^e ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Aetiology; Centor score; Pharyngotonsillitis; Primary healthcare

Indexed keywords

ANTIBODY;

ADOLESCENT; ADOLESCENT DISEASE; ADULT; ADULT DISEASE; ARTICLE; ASYMPTOMATIC DISEASE; BETA HEMOLYTIC STREPTOCOCCUS; BLOOD SAMPLING; CASE CONTROL STUDY; CENTOR SCORE; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; DISEASE ASSESSMENT; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; FEMALE; FUSOBACTERIUM INFECTION; FUSOBACTERIUM NECROPHORUM; GROUP A STREPTOCOCCAL INFECTION; HUMAN; INFLUENZA B; INFLUENZA VIRUS B; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MICROBIOLOGICAL EXAMINATION; MYCOPLASMA PNEUMONIAE; PATHOGENESIS; PHARYNGOTONSILLITIS; PRIMARY HEALTH CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY VIRUS; STREPTOCOCCUS GROUP A; THROAT CULTURE; TONSILLITIS; FUSOBACTERIUM INFECTIONS; MICROBIOLOGY; MIDDLE AGED; PHARYNGITIS; RISK FACTOR; SWEDEN; VIROLOGY; YOUNG ADULT;

CHLAMYDOPHILA PNEUMONIAE; FUSOBACTERIUM NECROPHORUM; HUMAN HERPESVIRUS 4; INFLUENZA B VIRUS; MYCOPLASMA PNEUMONIAE; STREPTOCOCCUS SP. 'GROUP A';

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; FEMALE; FUSOBACTERIUM INFECTIONS; FUSOBACTERIUM NECROPHORUM; HUMANS; MALE; MIDDLE AGED; PHARYNGITIS; PROSPECTIVE STUDIES; RISK FACTORS; SWEDEN; TONSILLITIS; YOUNG ADULT;

EID: 84932127272     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2014.08.020     Document Type: Article

References (28)

1. Andre M., Vernby A., Odenholt I., Lundborg C.S., Axelsson I., Eriksson M., et al. Diagnosis-prescribing surveys in 2000, 2002 and 2005 in Swedish general practice: consultations, diagnosis, diagnostics and treatment choices. Scand J Infect Dis 2008, 40:1-7.
2. Bisno A.L. Acute pharyngitis. NEngl J Med 2001, 344:205-211.
3. Huovinen P., Lahtonen R., Ziegler T., Meurman O., Hakkarainen K., Miettinen A., et al. Pharyngitis in adults: the presence and coexistence of viruses and bacterial organisms. Ann Intern Med 1989, 110:612-616.
4. McIsaac W.J., Goel V., To T., Low D.E. The validity of a sore throat score in family practice. Can Med Assoc J 2000, 163:811-815.
5. Pelucchi C., Grigoryan L., Galeone C., Esposito S., Huovinen P., Little P., et al. Guideline for the management of acute sore throat. Clin Microbiol Infect 2012, 18(Suppl.1):1-28.
6. Lindbaek M., Hoiby E.A., Lermark G., Steinsholt I.M., Hjortdahl P. Clinical symptoms and signs in sore throat patients with large colony variant beta-haemolytic streptococci groups C or G versus group A. Br J Gen Pract 2005, 55:615-619.
7. Carlson P., Renkonen O.V., Kontiainen S. Arcanobacterium haemolyticum and streptococcal pharyngitis. Scand J Infect Dis 1994, 26:283-287.
8. Aronson M.D., Komaroff A.L., Pass T.M., Ervin C.T., Branch W.T. Heterophil antibody in adults with sore throat: frequency and clinical presentation. Ann Intern Med 1982, 96:505-508.
9. Glezen W.P., Clyde W.A., Senior R.J., Sheaffer C.I., Denny F.W. Group A streptococci, mycoplasmas, and viruses associated with acute pharyngitis. JAm Med Assoc 1967, 202:455-460.
10. Esposito S., Blasi F., Bosis S., Droghetti R., Faelli N., Lastrico A., et al. Aetiology of acute pharyngitis: the role of atypical bacteria. JMed Microbiol 2004, 53:645-651.
11. Centor R.M., Witherspoon J.M., Dalton H.P., Brody C.E., Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Making 1981, 1:239-246.
12. Aliyu S.H., Marriott R.K., Curran M.D., Parmar S., Bentley N., Brown N.M., et al. Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice. JMed Microbiol 2004, 53:1029-1035.
13. Jensen A., Hagelskjaer Kristensen L., Prag J. Detection of Fusobacterium necrophorum subsp. funduliforme in tonsillitis in young adults by real-time PCR. Clin Microbiol Infect 2007, 13:695-701.
14. Amess J.A., O'Neill W., Giollariabhaigh C.N., Dytrych J.K. Asix-month audit of the isolation of Fusobacterium necrophorum from patients with sore throat in a district general hospital. Br J Biomed Sci 2007, 64:63-65.
15. Hagelskjaer L.H., Prag J., Malczynski J., Kristensen J.H. Incidence and clinical epidemiology of necrobacillosis, including Lemierre's syndrome, in Denmark 1990-1995. Eur J Clin Microbiol Infect Dis 1998, 17:561-565.
16. Hagelskjaer Kristensen L., Prag J. Lemierre's syndrome and other disseminated Fusobacterium necrophorum infections in Denmark: a prospective epidemiological and clinical survey. Eur J Clin Microbiol Infect Dis 2008, 27:779-789.
17. Kuppalli K., Livorsi D., Talati N.J., Osborn M. Lemierre's syndrome due to Fusobacterium necrophorum. Lancet Infect Dis 2012, 12:808-815.
18. Riordan T. Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome. Clin Microbiol Rev 2007, 20:622-659.
19. Karkos P.D., Asrani S., Karkos C.D., Leong S.C., Theochari E.G., Alexopoulou T.D., et al. Lemierre's syndrome: a systematic review. Laryngoscope 2009, 119:1552-1559.
20. Medical Product Agency Management of pharyngotonsillitis - recommendations. Information från läkemedelsverket 2001, 12:44-70.
21. Bank S., Nielsen H.M., Mathiasen B.H., Leth D.C., Kristensen L.H., Prag J. Fusobacterium necrophorum- detection and identification on a selective agar. Acta Pathol Microbiol Immunol Scand 2010, 118:994-999.
22. Brittain-Long R., Nord S., Olofsson S., Westin J., Anderson L.M., Lindh M. Multiplex real-time PCR for detection of respiratory tract infections. JClin Virol 2008, 41:53-56.
23. Renner B., Mueller C.A., Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res 2012, 61:1041-1052.
24. Bisno A.L., Gerber M.A., Gwaltney J.M., Kaplan E.L., Schwartz R.H. Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America. Clin Infect Dis 2002, 35:113-125.
25. Ludlam H., Howard J., Kingston B., Donachie L., Foulkes J., Guha S., et al. Epidemiology of pharyngeal carriage of Fusobacterium necrophorum. JMed Microbiol 2009, 58:1264-1265.
26. Batty A., Wren M.W., Gal M. Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre's disease. JInfect 2005, 51:299-306.
27. Centor R.M. Expand the pharyngitis paradigm for adolescents and young adults. Ann Intern Med 2009, 151:812-815.
28. Bank S., Christensen K., Kristensen L.H., Prag J. Acost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses. Eur J Clin Microbiol Infect Dis 2013, 32:71-78.