Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors

Anesthesiology

Volumn 122, Issue 4, 2015, Pages 787-794

  Franks, Nicholas P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID; LIGAND GATED ION CHANNEL; PROPOFOL; INTRAVENOUS ANESTHETIC AGENT;

ARTICLE; BINDING AFFINITY; BINDING SITE; CAENORHABDITIS ELEGANS; COMPARATIVE STUDY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANESTHETICS, INTRAVENOUS; ANIMALS; BINDING SITES; HUMANS; LIGAND-GATED ION CHANNELS; MOLECULAR SEQUENCE DATA; PROPOFOL; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84932123482     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000588     Document Type: Article

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