Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women

Geriatrics and Gerontology International

Volumn 14, Issue 4, 2014, Pages 942-946

  Urano, Tomohiko ^a,b   Shiraki, Masataka ^d   Saito, Mitsuru ^c   Sasaki, Noriko ^a,b   Ouchi, Yasuyoshi ^a   Inoue, Satoshi ^a,b,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Research Institute and Practice for Involutional Diseases   (Japan)

^e SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Fracture; Osteoporosis; Single nucleotide polymorphism; SLC25A32

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; CARRIER PROTEIN; DNA; FOLATE TRANSPORTER; SLC25A32 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADULT; ARTICLE; BONE DENSITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLIC ACID BLOOD LEVEL; FRAGILITY FRACTURE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLC25A32 GENE; YOUNG ADULT; BLOOD; FOLLOW UP; FRACTURES, BONE; GENETIC POLYMORPHISM; GENETICS; INCIDENCE; JAPAN; METABOLISM; MIDDLE AGED; PHOTON ABSORPTIOMETRY; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; RISK FACTOR;

ABSORPTIOMETRY, PHOTON; BONE DENSITY; DNA; FEMALE; FOLIC ACID; FOLIC ACID TRANSPORTERS; FOLLOW-UP STUDIES; FRACTURES, BONE; GENOTYPE; HUMANS; INCIDENCE; JAPAN; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POSTMENOPAUSE; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84931827731     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/ggi.12201     Document Type: Article

References (18)

1. Ralston SH, Uitterlinden AG. Genetics of osteoporosis. Endocr Rev 2010; 31: 629-662.
2. Hosoi T. Genetic aspects of osteoporosis. J Bone Miner Metab 2010; 28: 601-607.
3. Petramala L, Acca M, Francucci CM, D'Erasmo E. Hyperhomocysteinemia: a biochemical link between bone and cardiovascular system diseases? J Endocrinol Invest 2009; 32: 10-14.
4. Herrmann M, Peter Schmidt J, Umanskaya N etal. The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review. Clin Chem Lab Med 2007; 45: 1621-1632.
5. Jørgensen HL, Madsen JS, Madsen B etal. Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 2002; 71: 386-392.
6. Abrahamsen B, Madsen JS, Tofteng CL etal. A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study. J Bone Miner Res 2003; 18: 723-729.
7. Shiraki M, Urano T, Kuroda T etal. The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures. J Bone Miner Metab 2008; 26: 595-602.
8. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM etal. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004; 350: 2033-2041.
9. McLean RR, Jacques PF, Selhub J etal. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004; 350: 2042-2049.
10. Titus SA, Moran RG. Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. J Biol Chem 2000; 275: 36811-36817.
11. McCarthy EA, Titus SA, Taylor SM, Jackson-Cook C, Moran RG. A mutation inactivating the mitochondrial inner membrane folate transporter creates a glycine requirement for survival of chinese hamster cells. J Biol Chem 2004; 279: 33829-33836.
12. Urano T, Shiraki M, Yagi H etal. GPR98/Gpr98 gene is involved in the regulation of human and mouse bone mineral density. J Clin Endocrinol Metab 2012; 97: E565-E574.
13. Urano T, Shiraki M, Ouchi Y, Inoue S. Association of circulating sclerostin levels with fat mass and metabolic disease - related markers in Japanese postmenopausal women. J Clin Endocrinol Metab 2012; 97: E1473-E1477.
14. Shiraki M, Kuroda T, Tanaka S, Saito M, Fukunaga M, Nakamura T. Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures. J Bone Miner Metab 2008; 26: 93-100.
15. Shiraki M, Kuroda T, Shiraki Y, Tanaka S, Higuchi T, Saito M. Urinary pentosidine and plasma homocysteine levels at baseline predict future fractures in osteoporosis patients under bisphosphonate treatment. J Bone Miner Metab 2011; 29: 62-70.
16. Tanaka S, Kuroda T, Saito M, Shiraki M. Urinary pentosidine improves risk classification using fracture risk assessment tools for postmenopausal women. J Bone Miner Res 2011; 26: 2778-2784.
17. Wilcken DE, Wang XL, Sim AS, McCredie RM. Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation. Arterioscler Thromb Vasc Biol 1996; 16: 878-882.
18. Trimmer EE. Methylenetetrahydrofolate reductase: biochemical characterization and medical significance. Curr Pharm Des 2013; 19: 2574-2593.