A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: Longitudinal data from the Danish osteoporosis prevention study

Journal of Bone and Mineral Research

Volumn 18, Issue 4, 2003, Pages 723-729

  Abrahamsen, Bo ^a   Madsen, Jonna Skov ^a   Tofteng, Charlotte Landbo ^b   Stilgren, Lis ^a   Bladbjerg, Else Marie ^c   Kristensen, Søren Risom ^a   Brixen, Kim ^a   Mosekilde, Leif ^d  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

^c ESBJERG HOSPITAL   (Denmark)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Bone mineral density; Fractures; Genetics; Homocysteine metabolism; Menopause; Methylenetetrahydrofolate reductase genotype

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; ESTROFEM; OSTEOCALCIN; TRISEQUENS;

ADULT; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENMARK; DNA POLYMORPHISM; ESTROGEN THERAPY; FEMALE; FRACTURE; GENE; GENOTYPE; HORMONE SUBSTITUTION; HUMAN; HUMAN CELL; LOW BONE MINERAL DENSITY; MAJOR CLINICAL STUDY; MENOPAUSE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; MULTICENTER STUDY; OSTEOLYSIS; OSTEOPOROSIS; POSTMENOPAUSE OSTEOPOROSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

EID: 0042807404     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.4.723     Document Type: Article

References (19)

1. Kelly PJ, Nguyen T, Hopper J, Pocock N, Sambrook P, Eisman J 1993 Changes in axial bone density with age: A twin study. J Bone Miner Res 8:11-17.
2. Kahn SA, Pace JE, Cox ML, Gau DW, Cox SA, Hodkinson HM 1994 Osteoporosis and genetic influence: A three generation study. Postgrad Med J 70:798-800.
3. Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y 2000 Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66:190-194.
4. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH 1996 Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1315:159-162.
5. Madsen JS, Kristensen SR, Klitgaard NA, Bladbjerg EM, Abrahamsen B, Stilgren L, Jespersen J 2002 Effect of long-term hormone replacement therapy on plasma homocysteine in postmenopausal women: A randomized controlled study. Am J Obstet Gynecol 187:33-39.
6. Mosekilde L, Hermann AP, Beck-Nielsen H, Charles P, Nielsen SP, Sorensen OH 1999 The Danish Osteoporosis Prevention Study (DOPS): Project design and inclusion of 2000 normal perimenopausal women. Maturitas 31:207-219.
7. Vestergaard P, Hermann AP, Abrahamsen B, Gram J, Kolthoff NU, Eiken P 1997 Improving compliance with hormonal replacement therapy in primary osteoporosis prevention. Maturitas 28: 137-145.
8. Abrahamsen B, Hansen TB, Jensen LB, Hermann AP, Eiken P 1997 Site of osteodensitometry in perimenopausal women: Correlation and limits of agreement between anatomic regions. J Bone Miner Res 12:1471-1479.
9. Mosekilde LE, Beck-Nielsen H, Sørensen OH, Nielsen SP, Charles P, Vestergaard P, Hermann AP, Gram J, Hansen TB, Abrahamsen B, Ebbesen EN, Stilgren L, Jensen LB, Brot C, Hansen B, Tofteng CL, Eiken P, Kolthoff N 2000 Hormonal replacement therapy reduces forearm fracture incidence in recent postmenopausal women-results of the Danish Osteoporosis Prevention Study. Maturitas 36:181-193.
10. Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y 1997 Genetic polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 95:2032-2036.
11. Grant SF, Reid DM, Blake G, Herd R, Fogelman I, Ralston SH 1996 Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat Genet 14:203-205.
12. Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FE, Grant SF, Hofman A, van Leeuwen JP, Pols HA, Ralston SH 1998 Relation of alleles of the collagen type lalphal gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338:1016-1021.
13. Langdahl BL, Ralston SH, Grant SFA, Eriksen EF 1998 An Sp1 binding site polymorphism in the COL1A1 gene predicts osteoporotic fractures in both men and women. J Bone Miner Res 13: 1384-1389.
14. Brenton DP 1977 Skeletal abnormalities in homocystinuria. Postgrad Med J 53:488-496.
15. Finkelstein J 1998 The metabolism of homocysteine: Pathways and regulation. Eur J Paediatr Nuerol 157:S40-S44.
16. Goyette P, Sumner JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG, Rozen R 1994 Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification. Nat Genet 7:195-200.
17. Goyette P, Pai A, Milos R, Frosst P, Tran P, Chen Z, Chan M, Rozen R 1998 Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 9:652-656.
18. Goyette P, Christensen B, Rosenblatt DS, Rozen R 1996 Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR. Am J Hum Genet 59:1268-1275.
19. Jørgensen HL, Madsen JS, Madsen B, Saleh MMA, Abrahamsen B, Fenger M, Lauritzen JB 2002 Association of a common allelic polymorphism (C617T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 71:386-392.