메뉴 건너뛰기




Volumn 11, Issue 4, 2015, Pages 807-821

Can we trust untargeted metabolomics? Results of the metabo-ring initiative, a large-scale, multi-instrument inter-laboratory study

(38)  Martin, Jean Charles a,b,c   Maillot, Matthieu a,b,c   Mazerolles, Gérard d   Verdu, Alexandre e   Lyan, Bernard f,g   Migné, Carole f,g   Defoort, Catherine a,b,c   Canlet, Cecile h   Junot, Christophe i   Guillou, Claude j   Manach, Claudine f,g   Jabob, Daniel k   Bouveresse, Delphine Jouan Rimbaud l,m   Paris, Estelle l,m   Pujos Guillot, Estelle f,g   Jourdan, Fabien h   Giacomoni, Franck f,g   Courant, Frédérique o   Favé, Gaëlle a,b,c   Le Gall, Gwenaëlle p   more..

a INSERM   (France)
c INSERM   (France)
d SPO   (France)
e BRUKER   (France)

Author keywords

Inter laboratory; Mass spectrometry; Metabolic fingerprinting; Nuclear magnetic resonance; Untargeted metabolomics

Indexed keywords

ALANINE; CALCITRIOL; GLUTAMINE; GLYCINE; LACTIC ACID; THREONINE; VITAMIN D;

EID: 84931575490     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-014-0740-0     Document Type: Article
Times cited : (94)

References (47)
  • 2
    • 74449088783 scopus 로고    scopus 로고
    • Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics
    • COI: 1:CAS:528:DC%2BD1MXhsFGrurfO, PID: 20376177
    • Allwood, J. W., Erban, A., de Koning, S., Dunn, W. B., Luedemann, A., Lommen, A., et al. (2009). Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics. Metabolomics,5(4), 479–496.
    • (2009) Metabolomics , vol.5 , Issue.4 , pp. 479-496
    • Allwood, J.W.1    Erban, A.2    de Koning, S.3    Dunn, W.B.4    Luedemann, A.5    Lommen, A.6
  • 3
    • 77955559089 scopus 로고    scopus 로고
    • Development of near infrared sensors: Detection of influential factors by the AComDim method
    • COI: 1:CAS:528:DC%2BC3cXhtVektL%2FF, PID: 20708110
    • Amat, S., Dupuy, N., Kister, J., & Rutledge, D. N. (2010). Development of near infrared sensors: Detection of influential factors by the AComDim method. Analytica Chimica Acta,675(1), 16–23.
    • (2010) Analytica Chimica Acta , vol.675 , Issue.1 , pp. 16-23
    • Amat, S.1    Dupuy, N.2    Kister, J.3    Rutledge, D.N.4
  • 4
    • 84857872088 scopus 로고    scopus 로고
    • Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling
    • COI: 1:CAS:528:DC%2BC38XpvVyitQ%3D%3D, PID: 22304021
    • Benton, H. P., Want, E., Keun, H. C., Amberg, A., Plumb, R. S., Goldfain-Blanc, F., et al. (2012). Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling. Analytical Chemistry,84(5), 2424–2432.
    • (2012) Analytical Chemistry , vol.84 , Issue.5 , pp. 2424-2432
    • Benton, H.P.1    Want, E.2    Keun, H.C.3    Amberg, A.4    Plumb, R.S.5    Goldfain-Blanc, F.6
  • 7
    • 84878253693 scopus 로고    scopus 로고
    • A novel fasting blood test for insulin resistance and prediabetes
    • PID: 23439165
    • Cobb, J., Gall, W., Adam, K. P., Nakhle, P., Button, E., Hathorn, J., et al. (2013). A novel fasting blood test for insulin resistance and prediabetes. J Diabetes Sci Technol,7(1), 100–110.
    • (2013) J Diabetes Sci Technol , vol.7 , Issue.1 , pp. 100-110
    • Cobb, J.1    Gall, W.2    Adam, K.P.3    Nakhle, P.4    Button, E.5    Hathorn, J.6
  • 8
    • 61949104171 scopus 로고    scopus 로고
    • Normalization of urinary drug concentrations with specific gravity and creatinine
    • COI: 1:CAS:528:DC%2BD1MXlvFantA%3D%3D, PID: 19161663
    • Cone, E. J., Caplan, Y. H., Moser, F., Robert, T., Shelby, M. K., & Black, D. L. (2009). Normalization of urinary drug concentrations with specific gravity and creatinine. Journal of Analytical Toxicology,33(1), 1–7.
    • (2009) Journal of Analytical Toxicology , vol.33 , Issue.1
    • Cone, E.J.1    Caplan, Y.H.2    Moser, F.3    Robert, T.4    Shelby, M.K.5    Black, D.L.6
  • 9
    • 79959913950 scopus 로고    scopus 로고
    • Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
    • COI: 1:CAS:528:DC%2BC3MXotlCmtL8%3D, PID: 21720319
    • Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., et al. (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols,6(7), 1060–1083.
    • (2011) Nature Protocols , vol.6 , Issue.7 , pp. 1060-1083
    • Dunn, W.B.1    Broadhurst, D.2    Begley, P.3    Zelena, E.4    Francis-McIntyre, S.5    Anderson, N.6
  • 10
    • 0000256876 scopus 로고
    • Le traitement des variables vectorielles
    • Escoufier, Y. (1973). Le traitement des variables vectorielles. Biometrics,29(4), 751–760.
    • (1973) Biometrics , vol.29 , Issue.4 , pp. 751-760
    • Escoufier, Y.1
  • 11
    • 0033982350 scopus 로고    scopus 로고
    • On orthogonal signal correction
    • COI: 1:CAS:528:DC%2BD3cXislyhtg%3D%3D
    • Fearn, T. (2000). On orthogonal signal correction. Chemometrics and Intelligent Laboratory Systems,50(1), 47–52.
    • (2000) Chemometrics and Intelligent Laboratory Systems , vol.50 , Issue.1 , pp. 47-52
    • Fearn, T.1
  • 12
    • 33748067327 scopus 로고    scopus 로고
    • Establishing reporting standards for metabolomic and metabonomic studies: A call for participation
    • COI: 1:CAS:528:DC%2BD28XnvFOktbg%3D, PID: 16901221
    • Fiehn, O., Kristal, B., van Ommen, B., Sumner, L. W., Sansone, S. A., Taylor, C., et al. (2006). Establishing reporting standards for metabolomic and metabonomic studies: A call for participation. OMICS,10(2), 158–163.
    • (2006) OMICS , vol.10 , Issue.2 , pp. 158-163
    • Fiehn, O.1    Kristal, B.2    van Ommen, B.3    Sumner, L.W.4    Sansone, S.A.5    Taylor, C.6
  • 13
    • 44449127629 scopus 로고    scopus 로고
    • Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice
    • COI: 1:CAS:528:DC%2BD1cXmt1Wqurs%3D, PID: 18492843
    • Fleet, J. C., Gliniak, C., Zhang, Z., Xue, Y., Smith, K. B., McCreedy, R., et al. (2008). Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice. Journal of Nutrition,138(6), 1114–1120.
    • (2008) Journal of Nutrition , vol.138 , Issue.6 , pp. 1114-1120
    • Fleet, J.C.1    Gliniak, C.2    Zhang, Z.3    Xue, Y.4    Smith, K.B.5    McCreedy, R.6
  • 14
    • 77957318734 scopus 로고    scopus 로고
    • Does the mass spectrometer define the marker? A comparison of global metabolite profiling data generated simultaneously via UPLC-MS on two different mass spectrometers
    • COI: 1:CAS:528:DC%2BC3cXhtFarsbzO, PID: 20828141
    • Gika, H. G., Theodoridis, G. A., Earll, M., Snyder, R. W., Sumner, S. J., & Wilson, I. D. (2010). Does the mass spectrometer define the marker? A comparison of global metabolite profiling data generated simultaneously via UPLC-MS on two different mass spectrometers. Analytical Chemistry,82(19), 8226–8234.
    • (2010) Analytical Chemistry , vol.82 , Issue.19 , pp. 8226-8234
    • Gika, H.G.1    Theodoridis, G.A.2    Earll, M.3    Snyder, R.W.4    Sumner, S.J.5    Wilson, I.D.6
  • 15
    • 84877102868 scopus 로고    scopus 로고
    • Ultra-high pressure liquid chromatography-mass spectrometry for plant metabolomics: A systematic comparison of high-resolution quadrupole-time-of-flight and single stage Orbitrap mass spectrometers
    • COI: 1:CAS:528:DC%2BC3sXhtVylsA%3D%3D, PID: 23274073
    • Glauser, G., Veyrat, N., Rochat, B., Wolfender, J. L., & Turlings, T. C. (2013). Ultra-high pressure liquid chromatography-mass spectrometry for plant metabolomics: A systematic comparison of high-resolution quadrupole-time-of-flight and single stage Orbitrap mass spectrometers. Journal of Chromatography A,1292, 151–159.
    • (2013) Journal of Chromatography A , vol.1292 , pp. 151-159
    • Glauser, G.1    Veyrat, N.2    Rochat, B.3    Wolfender, J.L.4    Turlings, T.C.5
  • 16
    • 34748901177 scopus 로고    scopus 로고
    • Standard reporting requirements for biological samples in metabolomics experiments: Mammalian/in vivo experiments
    • COI: 1:CAS:528:DC%2BD2sXhtFOntbvP
    • Griffin, J. L., Nicholls, A. W., Daykin, C. A., Heald, S., Keun, H. C., Schuppe-Koistinen, I., et al. (2007). Standard reporting requirements for biological samples in metabolomics experiments: Mammalian/in vivo experiments. Metabolomics,3(3), 179–188.
    • (2007) Metabolomics , vol.3 , Issue.3 , pp. 179-188
    • Griffin, J.L.1    Nicholls, A.W.2    Daykin, C.A.3    Heald, S.4    Keun, H.C.5    Schuppe-Koistinen, I.6
  • 17
    • 84873110941 scopus 로고    scopus 로고
    • The effect of LC-MS data preprocessing methods on the selection of plasma biomarkers in fed vs. Fasted rats
    • PID: 24957369
    • Gürdeniz, G., Kristensen, M., Skov, T., & Dragsted, L. O. (2012). The effect of LC-MS data preprocessing methods on the selection of plasma biomarkers in fed vs. Fasted rats. Metabolites,2(1), 77–99.
    • (2012) Metabolites , vol.2 , Issue.1 , pp. 77-99
    • Gürdeniz, G.1    Kristensen, M.2    Skov, T.3    Dragsted, L.O.4
  • 18
    • 43749087841 scopus 로고    scopus 로고
    • Human metabolic phenotype diversity and its association with diet and blood pressure
    • COI: 1:CAS:528:DC%2BD1cXlvV2qtLo%3D, PID: 18425110
    • Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K., Chan, Q., et al. (2008). Human metabolic phenotype diversity and its association with diet and blood pressure. Nature,453(7193), 396–400.
    • (2008) Nature , vol.453 , Issue.7193 , pp. 396-400
    • Holmes, E.1    Loo, R.L.2    Stamler, J.3    Bictash, M.4    Yap, I.K.5    Chan, Q.6
  • 19
    • 3042796936 scopus 로고    scopus 로고
    • A model to estimate influent and effluent concentrations of estradiol, estrone, and ethinylestradiol at sewage treatment works
    • COI: 1:CAS:528:DC%2BD2cXktVeisLk%3D, PID: 15296317
    • Johnson, A. C., & Williams, R. J. (2004). A model to estimate influent and effluent concentrations of estradiol, estrone, and ethinylestradiol at sewage treatment works. Environmental Science and Technology,38(13), 3649–3658.
    • (2004) Environmental Science and Technology , vol.38 , Issue.13 , pp. 3649-3658
    • Johnson, A.C.1    Williams, R.J.2
  • 22
    • 24944444149 scopus 로고    scopus 로고
    • Summary recommendations for standardization and reporting of metabolic analyses
    • COI: 1:CAS:528:DC%2BD2MXlvFegsr4%3D, PID: 16003371
    • Lindon, J. C., Nicholson, J. K., Holmes, E., Keun, H. C., Craig, A., Pearce, J. T., et al. (2005). Summary recommendations for standardization and reporting of metabolic analyses. Nature Biotechnology,23(7), 833–838.
    • (2005) Nature Biotechnology , vol.23 , Issue.7 , pp. 833-838
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3    Keun, H.C.4    Craig, A.5    Pearce, J.T.6
  • 23
    • 84860424898 scopus 로고    scopus 로고
    • Multi-platform characterization of the human cerebrospinal fluid metabolome: A comprehensive and quantitative update
    • COI: 1:CAS:528:DC%2BC38XnsV2ns78%3D, PID: 22546835
    • Mandal, R., Guo, A. C., Chaudhary, K. K., Liu, P., Yallou, F. S., Dong, E., et al. (2012). Multi-platform characterization of the human cerebrospinal fluid metabolome: A comprehensive and quantitative update. Genome Medicine,4(4), 38.
    • (2012) Genome Medicine , vol.4 , Issue.4 , pp. 38
    • Mandal, R.1    Guo, A.C.2    Chaudhary, K.K.3    Liu, P.4    Yallou, F.S.5    Dong, E.6
  • 24
    • 0037190134 scopus 로고    scopus 로고
    • Chemometric methods for the coupling of spectroscopic techniques and for the extraction of the relevant information contained in the spectral data tables
    • COI: 1:CAS:528:DC%2BD38Xls1Cit7s%3D
    • Mazerolles, G., Devaux, M. F., Dufour, E., Qannari, E. M., & Courcoux, P. (2002). Chemometric methods for the coupling of spectroscopic techniques and for the extraction of the relevant information contained in the spectral data tables. Chemometrics and Intelligent Laboratory Systems,63(1), 57–68.
    • (2002) Chemometrics and Intelligent Laboratory Systems , vol.63 , Issue.1 , pp. 57-68
    • Mazerolles, G.1    Devaux, M.F.2    Dufour, E.3    Qannari, E.M.4    Courcoux, P.5
  • 25
    • 33644837134 scopus 로고    scopus 로고
    • Common components and specific weights analysis: A chemometric method for dealing with complexity of food products
    • COI: 1:CAS:528:DC%2BD28Xit1CjtbY%3D
    • Mazerolles, G., Hanafi, M., Dufour, E., Bertrand, D., & Qannari, E. M. (2006). Common components and specific weights analysis: A chemometric method for dealing with complexity of food products. Chemometrics and Intelligent Laboratory Systems,81(1), 41–49.
    • (2006) Chemometrics and Intelligent Laboratory Systems , vol.81 , Issue.1 , pp. 41-49
    • Mazerolles, G.1    Hanafi, M.2    Dufour, E.3    Bertrand, D.4    Qannari, E.M.5
  • 26
    • 73849129908 scopus 로고    scopus 로고
    • Opinion. (2010). 2020 visions. Nature, 463(7277), 26–32.
    • (2010) 2020 visions. Nature , vol.463 , Issue.7277 , pp. 26-32
  • 27
    • 0015131404 scopus 로고
    • Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography
    • COI: 1:CAS:528:DyaE3MXlsVygsLc%3D
    • Pauling, L., Robinson, A. B., Teranishi, R., & Cary, P. (1971). Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proceedings of the National Academy of Sciences USA,68(10), 2374–2376.
    • (1971) Proceedings of the National Academy of Sciences USA , vol.68 , Issue.10 , pp. 2374-2376
    • Pauling, L.1    Robinson, A.B.2    Teranishi, R.3    Cary, P.4
  • 28
    • 77952090855 scopus 로고    scopus 로고
    • Development and validation of a UPLC/MS method for a nutritional metabolomic study of human plasma
    • COI: 1:CAS:528:DC%2BC3cXlsFSmurc%3D
    • Pereira, H., Martin, J.-F., Joly, C., Sébédio, J.-L., & Pujos-Guillot, E. (2010). Development and validation of a UPLC/MS method for a nutritional metabolomic study of human plasma. Metabolomics,6(2), 207–218.
    • (2010) Metabolomics , vol.6 , Issue.2 , pp. 207-218
    • Pereira, H.1    Martin, J.-F.2    Joly, C.3    Sébédio, J.-L.4    Pujos-Guillot, E.5
  • 30
    • 34249034295 scopus 로고    scopus 로고
    • Proposed reporting requirements for the description of NMR-based metabolomics experiments
    • COI: 1:CAS:528:DC%2BD2sXhtFOntbvE
    • Rubtsov, D. V., Jenkins, H., Ludwig, C., Easton, J., Viant, M. R., Günther, U., et al. (2007). Proposed reporting requirements for the description of NMR-based metabolomics experiments. Metabolomics,3(3), 223–229.
    • (2007) Metabolomics , vol.3 , Issue.3 , pp. 223-229
    • Rubtsov, D.V.1    Jenkins, H.2    Ludwig, C.3    Easton, J.4    Viant, M.R.5    Günther, U.6
  • 31
    • 33845325218 scopus 로고    scopus 로고
    • Metabolomics: The greatest omics of them all?
    • COI: 1:CAS:528:DC%2BD28XhtFChu7jJ, PID: 17134127
    • Ryan, D., & Robards, K. (2006). Metabolomics: The greatest omics of them all? Analytical Chemistry,78(23), 7954–7958.
    • (2006) Analytical Chemistry , vol.78 , Issue.23 , pp. 7954-7958
    • Ryan, D.1    Robards, K.2
  • 32
    • 74449085466 scopus 로고    scopus 로고
    • Mass-spectrometry-based metabolomics: Limitations and recommendations for future progress with particular focus on nutrition research
    • COI: 1:CAS:528:DC%2BD1MXhsFGrurfL, PID: 20046865
    • Scalbert, A., Brennan, L., Fiehn, O., Hankemeier, T., Kristal, B. S., van Ommen, B., et al. (2009). Mass-spectrometry-based metabolomics: Limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics,5(4), 435–458.
    • (2009) Metabolomics , vol.5 , Issue.4 , pp. 435-458
    • Scalbert, A.1    Brennan, L.2    Fiehn, O.3    Hankemeier, T.4    Kristal, B.S.5    van Ommen, B.6
  • 33
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: A software environment for integrated models of biomolecular interaction networks
    • COI: 1:CAS:528:DC%2BD3sXovFWrtr4%3D, PID: 14597658
    • Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., et al. (2003). Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research,13(11), 2498–2504.
    • (2003) Genome Research , vol.13 , Issue.11 , pp. 2498-2504
    • Shannon, P.1    Markiel, A.2    Ozier, O.3    Baliga, N.S.4    Wang, J.T.5    Ramage, D.6
  • 34
    • 59549100948 scopus 로고    scopus 로고
    • Matrix correlations for high-dimensional data: The modified RV-coefficient
    • COI: 1:CAS:528:DC%2BD1MXhtlOls74%3D, PID: 19073588
    • Smilde, A. K., Kiers, H. A. L., Bijlsma, S., Rubingh, C. M., & van Erk, M. J. (2009). Matrix correlations for high-dimensional data: The modified RV-coefficient. Bioinformatics,25, 401–405.
    • (2009) Bioinformatics , vol.25 , pp. 401-405
    • Smilde, A.K.1    Kiers, H.A.L.2    Bijlsma, S.3    Rubingh, C.M.4    van Erk, M.J.5
  • 35
    • 32444446805 scopus 로고    scopus 로고
    • XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
    • COI: 1:CAS:528:DC%2BD28XitVyqtA%3D%3D, PID: 16448051
    • Smith, C. A., Want, E. J., O’Maille, G., Abagyan, R., & Siuzdak, G. (2006). XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Analytical Chemistry,78(3), 779–787.
    • (2006) Analytical Chemistry , vol.78 , Issue.3 , pp. 779-787
    • Smith, C.A.1    Want, E.J.2    O’Maille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 36
    • 78649735772 scopus 로고    scopus 로고
    • Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting
    • PID: 21085649
    • Suhre, K., Meisinger, C., Doring, A., Altmaier, E., Belcredi, P., Gieger, C., et al. (2010). Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting. PLoS ONE,5(11), e13953.
    • (2010) PLoS ONE , vol.5 , Issue.11 , pp. 13953
    • Suhre, K.1    Meisinger, C.2    Doring, A.3    Altmaier, E.4    Belcredi, P.5    Gieger, C.6
  • 37
    • 34748888866 scopus 로고    scopus 로고
    • Proposed minimum reporting standards for chemical analysis
    • COI: 1:CAS:528:DC%2BD2sXhtFOntbvL, PID: 24039616
    • Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A. T., et al. (2007). Proposed minimum reporting standards for chemical analysis. Metabolomics,3(3), 211–221.
    • (2007) Metabolomics , vol.3 , Issue.3 , pp. 211-221
    • Sumner, L.W.1    Amberg, A.2    Barrett, D.3    Beale, M.H.4    Beger, R.5    Daykin, C.A.T.6
  • 38
    • 60649089559 scopus 로고    scopus 로고
    • Highly sensitive feature detection for high resolution LC/MS
    • PID: 19040729
    • Tautenhahn, R., Bottcher, C., & Neumann, S. (2008). Highly sensitive feature detection for high resolution LC/MS. BMC Bioinformatics,9, 504.
    • (2008) BMC Bioinformatics , vol.9 , pp. 504
    • Tautenhahn, R.1    Bottcher, C.2    Neumann, S.3
  • 39
    • 33847369007 scopus 로고    scopus 로고
    • Chemometrics in metabonomics
    • COI: 1:CAS:528:DC%2BD28XhtlCit7rM, PID: 17269704
    • Trygg, J., Holmes, E., & Lundstedt, T. (2007). Chemometrics in metabonomics. Journal of Proteome Research,6(2), 469–479.
    • (2007) Journal of Proteome Research , vol.6 , Issue.2 , pp. 469-479
    • Trygg, J.1    Holmes, E.2    Lundstedt, T.3
  • 40
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projection to latent structure
    • COI: 1:CAS:528:DC%2BD38XitFClu7c%3D
    • Trygg, J., & Vold, S. (2002). Orthogonal projection to latent structure. Journal of Chemometrics,16, 119–128.
    • (2002) Journal of Chemometrics , vol.16 , pp. 119-128
    • Trygg, J.1    Vold, S.2
  • 41
    • 84871784197 scopus 로고    scopus 로고
    • Comparative analysis of sample preparation methods to handle the complexity of the blood fluid metabolome: When less is more
    • PID: 23190300
    • Tulipani, S., Llorach, R., Urpi-Sarda, M., & Andres-Lacueva, C. (2012). Comparative analysis of sample preparation methods to handle the complexity of the blood fluid metabolome: When less is more. Analytical Chemistry,85(1), 341–348.
    • (2012) Analytical Chemistry , vol.85 , Issue.1 , pp. 341-348
    • Tulipani, S.1    Llorach, R.2    Urpi-Sarda, M.3    Andres-Lacueva, C.4
  • 42
    • 33747019547 scopus 로고    scopus 로고
    • Centering, scaling, and transformations: Improving the biological information content of metabolomics data
    • PID: 16762068
    • van den Berg, R. A., Hoefsloot, H. C., Westerhuis, J. A., Smilde, A. K., & van der Werf, M. J. (2006). Centering, scaling, and transformations: Improving the biological information content of metabolomics data. BMC Genomics,7, 142.
    • (2006) BMC Genomics , vol.7 , pp. 142
    • van den Berg, R.A.1    Hoefsloot, H.C.2    Westerhuis, J.A.3    Smilde, A.K.4    van der Werf, M.J.5
  • 44
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • COI: 1:CAS:528:DC%2BC3MXksVCrsrw%3D, PID: 21475195
    • Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., et al. (2011). Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature,472(7341), 57–63.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3    Koeth, R.4    Levison, B.S.5    DuGar, B.6
  • 45
    • 32444451016 scopus 로고    scopus 로고
    • Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry
    • COI: 1:CAS:528:DC%2BD28XhtFehurs%3D, PID: 16448047
    • Want, E. J., O’Maille, G., Smith, C. A., Brandon, T. R., Uritboonthai, W., Qin, C., et al. (2006). Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Analytical Chemistry,78(3), 743–752.
    • (2006) Analytical Chemistry , vol.78 , Issue.3 , pp. 743-752
    • Want, E.J.1    O’Maille, G.2    Smith, C.A.3    Brandon, T.R.4    Uritboonthai, W.5    Qin, C.6
  • 46
    • 80054885906 scopus 로고    scopus 로고
    • An inter-laboratory comparison demonstrates that [1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection
    • COI: 1:CAS:528:DC%2BC3cXmtlKhs7c%3D, PID: 20526352
    • Ward, J., Baker, J., Miller, S., Deborde, C., Maucourt, M., Biais, B., et al. (2010). An inter-laboratory comparison demonstrates that [1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection. Metabolomics,6(2), 263–273.
    • (2010) Metabolomics , vol.6 , Issue.2 , pp. 263-273
    • Ward, J.1    Baker, J.2    Miller, S.3    Deborde, C.4    Maucourt, M.5    Biais, B.6
  • 47
    • 19544374744 scopus 로고    scopus 로고
    • A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats
    • COI: 1:CAS:528:DC%2BD2MXltVegtbs%3D, PID: 15925248
    • Williams, R. E., Lenz, E. M., Evans, J. A., Wilson, I. D., Granger, J. H., Plumb, R. S., et al. (2005). A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats. Journal of Pharmaceutical and Biomedical Analysis,38(3), 465–471.
    • (2005) Journal of Pharmaceutical and Biomedical Analysis , vol.38 , Issue.3 , pp. 465-471
    • Williams, R.E.1    Lenz, E.M.2    Evans, J.A.3    Wilson, I.D.4    Granger, J.H.5    Plumb, R.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.