Does the mass spectrometer define the marker? A comparison of global metabolite profiling data generated simultaneously via UPLC-MS on two different mass spectrometers

Analytical Chemistry

Volumn 82, Issue 19, 2010, Pages 8226-8234

  Gika, Helen G ^a   Theodoridis, Georgios A ^a   Earll, Mark ^b   Snyder, Rodney W ^c   Sumner, Susan J ^c   Wilson, Ian D ^d  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Umetrics UK   (United Kingdom)

^c RTI INTERNATIONAL   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL GROUPS; BIO-MARKER DISCOVERY; DATA ANALYSIS; DATA EXTRACTION; DATA SETS; DISCRIMINANT ANALYSIS MODEL; GENERAL PATTERNS; INTERLABORATORY COMPARISON; LINEAR ION TRAP; METABOLITE PROFILES; METABOLITE PROFILING; MULTIVARIATE STATISTICAL ANALYSIS; PARTIAL LEAST SQUARES; QUADRUPOLES; RAT URINE; STATISTICAL ANALYSIS; TIME-OF-FLIGHT MASS SPECTROMETERS; TRIPLE QUADRUPOLE;

DATA REDUCTION; DISCRIMINANT ANALYSIS; INLET FLOW; IONS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES;

MULTIVARIANT ANALYSIS;

BIOLOGICAL MARKER; ISONIAZID;

ANIMAL; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTRUMENTATION; METABOLOME; METHODOLOGY; PRINCIPAL COMPONENT ANALYSIS; RAT; STATISTICAL MODEL; URINE;

ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ISONIAZID; METABOLOME; MODELS, STATISTICAL; PRINCIPAL COMPONENT ANALYSIS; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77957318734     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1016612     Document Type: Article

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