Modulatory effects of adiponectin on the polarization of tumor-associated macrophages

International Journal of Cancer

Volumn 137, Issue 4, 2015, Pages 848-858

  Peng, Jiao ^a   Tsang, Julia Y ^b,c   Ho, Derek H ^b   Zhang, Ruizhong ^a,b   Xiao, Haitao ^d   Li, Daxu ^b   Zhu, Jiang ^b   Wang, Fenghua ^a   Bian, Zhaoxiang ^d   Lui, Vincent C ^b   Xu, Aimin ^b   Tam, Paul K ^b   Lamb, Jonathan R ^e   Xia, Huimin ^a   Chen, Yan ^a,b  

^a GUANGZHOU WOMEN AND CHILDREN S MEDICAL CENTER   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

adiponectin; M1 M2 polarization; p38 MAPK; tumor associated macrophages

Indexed keywords

ADIPONECTIN; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; CCL2 PROTEIN, MOUSE; CHEMOKINE CCL2; INTERLEUKIN-10; METFORMIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CANCER GROWTH; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INTRACELLULAR SIGNALING; LEUKOCYTE ACTIVATION; MALE; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHABDOMYOSARCOMA; TUMOR ASSOCIATED LEUKOCYTE; YM1 GENE; ANIMALS; BIOSYNTHESIS; BLOOD; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG EFFECTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETICS; HUMANS; KILLER CELLS, NATURAL; MACROPHAGES; METABOLISM; MICE; PATHOLOGY; SARCOMA; SIGNAL TRANSDUCTION;

ADIPONECTIN; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-10; KILLER CELLS, NATURAL; MACROPHAGES; METFORMIN; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SARCOMA; SIGNAL TRANSDUCTION;

EID: 84931573407     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29485     Document Type: Article

References (41)

1. Mantovani A, Bottazzi B, Colotta F, et al., The origin and function of tumor-associated macrophages. Immunol Today 1992; 13: 265-70.
2. Bingle L, Brown NJ, Lewis CE,. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002; 196: 254-65.
3. Buddingh EP, Kuijjer ML, Duim RA, et al., Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage activating agents. Clin Cancer Res 2011; 17: 2110-9.
4. Watkins SK, Egilmez NK, Suttles J, et al., IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol 2007; 178: 1357-62.
5. Andreu P, Johansson M, Affara NI, et al., Activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell 2010; 17: 121-34.
6. Folco EJ, Rocha VZ, Lopez-Ilasaca M, et al., Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10. J Biol Chem 2009; 284: 25569-75.
7. Kelesidis I, Kelesidis T, Mantzoros CS,. Adiponectin and cancer: a systematic review. Br J Cancer 2006; 94: 1221-5.
8. Perrier S, Jarde T,. Adiponectin, an anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer. Curr Med Chem 2012; 19: 5501-12.
9. Tang CH, Lu ME,. Adiponectin increases motility of human prostate cancer cells via adipoR, p38, AMPK, and NF-kappaB pathways. The Prostate 2009; 69: 1781-9.
10. Ratke J, Niggemann B, Lang K, et al., A novel role of adiponectin: stimulator of human SW480 colon carcinoma cell migration by inducing an autocrine IL-8 and MCP-1 loop. J Cancer Sci Ther 2013; 5: 150-7.
11. Ogunwobi OO, Beales IL,. Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept 2006; 134: 105-13.
12. Han S, Jeong AL, Lee S, et al., Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. J Immunol 2013; 190: 4877-86.
13. Ohashi K, Parker JL, Ouchi N, et al., Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 2010; 285: 6153-60.
14. Peng J, Tsang JY, Li D, et al., Inhibition of TGF-beta signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages. Cancer Lett 2013; 331: 239-49.
15. Saccani A, Schioppa T, Porta C, et al., p50 nuclear Factor-κB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 2006; 66: 11432-40.
16. Bottazzi B, Erba E, Nobili N, et al., A paracrine circuit in the regulation of the proliferation of macrophages infiltrating murine sarcomas. J Immunol 1990; 144: 2409-12.
17. Asgharzadeh S, Salo JA, Ji L, et al., Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. J Clin Oncol 2012; 30: 3525-32.
18. Hao NB, Lu MH, Fan YH, et al., Macrophages in tumor microenvironments and the progression of tumors. Clin Dev Immunol 2012; 2012: 948098
19. Mandal P, Pratt BT, Barnes M, et al., Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J Biol Chem 2011; 286: 13460-9.
20. Lovren F, Pan Y, Quan A, et al., Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages. Am J Physiol Heart Cir Physiol 2010; 299: H656-H63.
21. Maeda N, Shimomura I, Kishida K, et al., Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002; 8: 731-7.
22. Byeon JS, Jeong JY, Kim MJ, et al., Adiponectin and adiponectin receptor in relation to colorectal cancer progression. Int J Cancer 2010; 127: 2758-67.
23. Wei EK, Giovannucci E, Fuchs CS, et al., Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst 2005; 97: 1688-94.
24. Miyoshi Y, Funahashi T, Kihara S, et al., Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 2003; 9: 5699-704.
25. Ishikawa M, Kitayama J, Kazama S, et al., Plasma adiponectin and gastric cancer. Clin Cancer Res 2005; 11: 466-72.
26. Dieudonne MN, Bussiere M, Dos Santos E, et al., Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun 2006; 345: 271-9.
27. Brakenhielm E, Veitonmaki N, Cao R, et al., Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 2004; 101: 2476-81.
28. Roberts DL, Dive C, Renehan AG,. Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 2010; 61: 301-16.
29. Ueno T, Toi M, Saji H, et al., Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res 2000; 6: 3282-9.
30. Biswas SK, Gangi L, Paul S, et al., A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 2006; 107: 2112-22.
31. Gu L, Tseng S, Horner RM, et al., Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 2000; 404: 407-11.
32. Rovin B, Wilmer W, Danne M, et al., The mitogen-activated protein kinase p38 is necessary for interleukin-1β-induced monocyte chemoattractant protein 1 expression by human mesangial cells. Cytokine 1999; 11: 118-26.
33. Goebeler M, Kilian K, Gillitzer R, et al., The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-α-induced expression of monocyte-chemoattractant protein-1 in endothelial cells. Blood 1999; 93: 857-65.
34. Kadowaki T, Yamauchi T, Kubota N, et al., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006; 116: 1784-92.
35. Saccani A, Schioppa T, Porta C, et al., p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 2006; 66: 11432-40.
36. Tang CH, Chiu YC, Tan TW, et al., Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 2007; 179: 5483-92.
37. Yamauchi T, Kamon J, Ito Y, et al., Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423: 762-9.
38. Park HU, Suy S, Danner M, et al., AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther 2009; 8: 733-41.
39. Liu X, Chhipa RR, Pooya S, et al., Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci 2014; 111: E435-E44.
40. Luo Z, Zang M, Guo W,. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol 2010; 6: 457-70.
41. Landskroner-Eiger S, Qian B, Muise ES, et al., Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin Cancer Res 2009; 15: 3265-76.