A novel role of adiponectin: Stimulator of human SW480 colon carcinoma cell migration by inducing an autocrine IL-8 and MCP-1 loop

Journal of Cancer Science and Therapy

Volumn 5, Issue 4, 2013, Pages 150-157

  Ratke, Janina ^a   Niggemann, Bernd ^a   Lang, Kerstin ^a   Zänker, Kurt S ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Adiponectin; Cell migration; Colon carcinoma; Signal transduction

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CANCER GROWTH; CELL MIGRATION; COLON CARCINOMA; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OBESITY; PHOSPHORYLATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84878187003     PISSN: None     EISSN: 19485956     Source Type: Journal    
DOI: 10.4172/1948-5956.1000202     Document Type: Article

References (32)

1. Kelesidis I, Kelesidis T, Mantzoros CS (2006) Adiponectin and cancer: a systematic review. Br J Cancer 94: 1221-1225.
2. Chandran M, Phillips SA, Ciaraldi T, Henry RR (2003) Adiponectin: more than just another fat cell hormone? Diabetes Care 26: 2442-2450.
3. Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS (2005) Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst 97: 1688-1694.
4. Michalakis K, Williams CJ, Mitsiades N, Blakeman J, Balafouta-Tselenis S, et al. (2007) Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev 16: 308-313.
5. Dal Maso L, Augustin LS, Karalis A, Talamini R, Franceschi S, et al. (2004) Circulating adiponectin and endometrial cancer risk. J Clin Endocrinol Metab 89: 1160-1163.
6. Karaduman M, Bilici A, Ozet A, Sengul A, Musabak U, et al. (2007) Tissue levels of adiponectin in breast cancer patients. Med Oncol 24: 361-366.
7. Petridou ET, Mitsiades N, Gialamas S, Angelopoulos M, Skalkidou A, et al. (2007) Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies. Oncology 73: 261-269.
8. Ratke J, Entschladen F, Niggemann B, Zänker KS, Lang K (2010) Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways. Endocr Relat Cancer 17: 179-189.
9. Lang K, Drell TL 4th, Lindecke A, Niggemann B, Kaltschmidt C, et al. (2004) Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 112: 231-238.
10. Entschladen F, Drell TL 4th, Lang K, Joseph J, Zaenker KS (2004) Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 5: 254-258.
11. Lang K, Niggemann B, Zanker KS, Entschladen F (2002) Signal processing in migrating T24 human bladder carcinoma cells: role of the autocrine interleukin-8 loop. Int J Cancer 99: 673-680.
12. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
13. Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, et al. (2006) APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 8: 516-523.
14. Mao X, Hong JY, Dong LQ (2006) The adiponectin signaling pathway as a novel pharmacological target. Mini Rev Med Chem 6: 1331-1340.
15. Miyazaki T, Bub JD, Uzuki M, Iwamoto Y (2005) Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3. Biochem Biophys Res Commun 333: 79-87.
16. Tran K, Merika M, Thanos D (1997) Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 17: 5386-5399.
17. Benaitreau D, Dieudonné MN, Dos Santos E, Leneveu MC, Mazancourt PD, et al. (2009) Antiproliferative effects of adiponectin on human trophoblastic cell lines JEG-3 and BeWo. Biol Reprod 80: 1107-1114.
18. Barb D, Williams CJ, Neuwirth AK, Mantzoros CS (2007) Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 86: s858-s866.
19. Bastian P, Posch B, Lang K, Niggemann B, Zaenker KS, et al. (2006) Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes. Mol Cancer Res 4: 411-421.
20. Osaki M, Oshimura M, Ito H (2004) PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9: 667-676.
21. Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, et al. (2008) An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res 68: 1310-1318.
22. Meng F, Liu L, Chin PC, D'Mello SR (2002) Akt is a downstream target of NF-kappa B. J Biol Chem 277: 29674-29680.
23. Ogunwobi OO, Beales IL (2006) Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept 134: 105-113.
24. Rovin BH, Song H (2006) Chemokine induction by the adipocyte-derived cytokine adiponectin. Clin Immunol 120: 99-105.
25. Li A, Varney ML, Singh RK (2001) Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res 7: 3298-3304.
26. Baier PK, Eggstein S, Wolff-Vorbeck G, Baumgartner U, Hopt UT (2005) Chemokines in human colorectal carcinoma. Anticancer Res 25: 3581-3584.
27. Staiger H, Tschritter O, Machann J, Thamer C, Fritsche A, et al. (2003) Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res 11: 368-372.
28. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, et al. (2003) Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 9: 5699-5704.
29. Tang CH, Lu ME (2009) Adiponectin increases motility of human prostate cancer cells via adipoR, p38, AMPK, and NF-kappaB pathways. Prostate 69: 1781-1789.
30. Wanninger J, Neumeier M, Weigert J, Bauer S, Weiss TS, et al. (2009) Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways. Am J Physiol Gastrointest Liver Physiol 297: G611-G618.
31. Haugen F, Drevon CA (2007) Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Endocrinology 148: 5478-5486.
32. Lin HJ, Hsieh FC, Song H, Lin J (2005) Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. Br J Cancer 93: 1372-1381.