Endotoxemia of metabolic syndrome: A pivotal mediator of meta-inflammation

Metabolic Syndrome and Related Disorders

Volumn 12, Issue 9, 2014, Pages 454-456

  Jialal, Ishwarlal ^a   Rajamani, Uthra ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYLOMICRON; ENDOTOXIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; PATTERN RECOGNITION RECEPTOR; PREBIOTIC AGENT; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 4;

BACTEROIDETES; BODY MASS; CARDIOMETABOLIC RISK; ENDOTOXEMIA; FIRMICUTES; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INTESTINE FLORA; LIPID DIET; MACROPHAGE; METABOLIC SYNDROME X; MONOCYTE; MONONUCLEAR CELL; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SMOKING; WEIGHT REDUCTION; BLOOD; COMPLICATION; DIGESTIVE SYSTEM; MICROBIOLOGY; MICROFLORA; PATHOPHYSIOLOGY; PERMEABILITY;

DIGESTIVE SYSTEM; ENDOTOXEMIA; ENDOTOXINS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; METABOLIC SYNDROME X; MICROBIOTA; PERMEABILITY;

EID: 84931457617     PISSN: 15404196     EISSN: 15578518     Source Type: Journal    
DOI: 10.1089/met.2014.1504     Document Type: Review

References (30)

1. Alexander C, Reitschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res. 2001; 7: 167-202
2. Takeda K. The lipid A receptor. Adv Exp Med Biol. 2010; 667: 53-58
3. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007; 56: 1761-1772
4. Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-dietinduced diabetes in mice through a mechanism associated with endotoxemia. Diabetologia. 2007; 50: 2374-2383
5. Everard A, Cani PD. Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol. 2013; 27: 73-83
6. Shen J, Obin MS, and Zhao L. The gut microbiota, obesity and insulin resistance. Mol Aspects Med. 2013; 34: 39-58
7. Jialal I, Kaur H, Devaraj S. Toll-like receptor status in obesity and metabolic syndrome: A translational perspective. J Clin Endocrinol Metab. 2014; 99: 39-48
8. Nakagomi A, Sasaki M, Ishikawa Y, et al. Upregulation of monocyte tissue factor activity is significantly associated with low-grade chronic inflammation and insulin resistance in patients with metabolic syndrome. Circ J 2010; 74: 572-577
9. Dasu MR, Devaraj S, Park S, et al. Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care. 2010; 33: 861-868
10. Pell JP, Tavernier G, Haw S. A pilot study to explore whether airborne endotoxins play a role in the association between environmental tobacco smoke and non-respiratory, smoking-related diseases. Int. J Epidemiol. 2011; 40: 1128-1129
11. Jialal I, Huet BA, Kaur H, et al. Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Car. 2012; 35: 900-904
12. Chen X, Devaraj S. Monocytes from metabolic syndrome subjects exhibit a proinflammatory M1 phenotype. Metab Syndr Relat Disord. 2014; May 21, epub ahead of print; doi: 10.1089/met.2014.0017
13. Leber B, Tripolt NJ, Blattl D, et al. The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: An open label, randomized pilot study. Eur J Clin Nutr. 2012; 66: 1110-1115
14. Spitzer AL, Harris HW. Statins attenuate sepsis. Surgery. 2006; 139: 283-287
15. Methe H, Kim JO, Kofler S, et al. Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes. Arterioscler Thromb Vasc Biol. 2005; 25: 1439-1445
16. Ghoshal S, Witta J, Zhong J, et al. Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res. 2009; 50: 90-97
17. Erridge C, Attina T, Spickett CM, et al. A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr. 2007; 86: 1286-1292
18. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009; 9: 799-809
19. Ley RE, Backhed F, Turnbaugh P, et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA. 2005; 102: 11070-11075
20. Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: Human gut microbes associated with obesity. Nature. 2006; 444: 1022-1023
21. Duncan SH, Lobley GE, Holtrop G, et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond) 2008; 32: 1720-1724
22. Schwiertz A, Taras D, Schafer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010; 18: 190-195
23. Duncan SH, Belenquer A, Holtrop G, et al. Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol. 2007; 73: 1073-1078
24. Novitsky T. Limitations of the Limulus Amebocyte lysate test in demonstrating circulating lipopolysaccharides. Ann NY Acad Sci. 1998; 851: 416-421
25. Moreno-Navarrete JM, Ortega F, Serino M, et al. Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance. Int J Obes (Lond) 2012; 36: 1442-1449
26. Gonzalez-Quintela A, Alonso M, Campos J, et al. Determinants of serum concentrations of lipopolysaccharidebinding protein (LBP) in adult population: The role of Obesity. PLoS One. 2013; 8: e54600
27. Jialal I, Rajamani U, Huet BA, et al. Circulating pathogen associated molecular pattern-binding proteins and high mobility group box protein 1 in nascent metabolic syndrome: Implications for cellular toll-like receptor activity. Atherosclerosis. 2014; 236: 182-187
28. Adam-Huet B, Devaraj S, Siegel D, et al. Increased adipose tissue insulin resistance in metabolic syndrome: Relationship to circulating adipokines. Metab Syndr Relat Disord. 2014; (in press).
29. Vrieze A, Van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean healthy donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012; 143: 913-916, e917
30. Xiao S, Hei N, Pang, et al. A gut microbiota-Targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol. 2014; 87: 357-367