메뉴 건너뛰기




Volumn 141, Issue 5, 2015, Pages 839-849

Cytokine-induced killer (CIK) cells in cancer immunotherapy: report of the international registry on CIK cells (IRCC)

Author keywords

Cancer treatment; CIK; Clinical trials; Cytokine induced killer cells; Immunotherapy; International registry

Indexed keywords

ADULT; ADVERSE EFFECTS; AGED; CYTOKINE INDUCED KILLER CELL; FEMALE; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; INTERNATIONAL COOPERATION; MALE; MIDDLE AGED; NEOPLASMS; PROCEDURES; QUALITY OF LIFE; REGISTER; TREATMENT OUTCOME; VERY ELDERLY;

EID: 84931449915     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1864-3     Document Type: Article
Times cited : (117)

References (70)
  • 1
    • 84878057342 scopus 로고    scopus 로고
    • Short-term curative efficacy of autologous cytokine induced killer cells combined with low-dose IL-2 regimen containing immune enhancement by thymic peptide in elderly patients with B-cell chronic lymphocytic leukemia
    • COI: 1:CAS:528:DC%2BC38XhvVSgsr%2FP, PID: 22739156
    • Cai LL, Yang Y, Yang B et al (2012) Short-term curative efficacy of autologous cytokine induced killer cells combined with low-dose IL-2 regimen containing immune enhancement by thymic peptide in elderly patients with B-cell chronic lymphocytic leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:564–570
    • (2012) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.20 , pp. 564-570
    • Cai, L.L.1    Yang, Y.2    Yang, B.3
  • 2
    • 64249142143 scopus 로고    scopus 로고
    • Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes
    • COI: 1:CAS:528:DC%2BD1MXkslOjtb0%3D, PID: 19375652
    • Franceschetti M, Pievani A, Borleri G et al (2009) Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes. Exp Hematol 37:616–628
    • (2009) Exp Hematol , vol.37 , pp. 616-628
    • Franceschetti, M.1    Pievani, A.2    Borleri, G.3
  • 3
    • 84899116386 scopus 로고    scopus 로고
    • Autologous tumor lysate-pulsed dendritic cell immunotherapy with cytokine-induced killer cells improves survival in gastric and colorectal cancer patients
    • PID: 24699863
    • Gao D, Li C, Xie X et al (2014) Autologous tumor lysate-pulsed dendritic cell immunotherapy with cytokine-induced killer cells improves survival in gastric and colorectal cancer patients. PLoS One 9:e93886
    • (2014) PLoS One , vol.9 , pp. e93886
    • Gao, D.1    Li, C.2    Xie, X.3
  • 4
    • 0033536068 scopus 로고    scopus 로고
    • Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
    • COI: 1:CAS:528:DyaK1MXks1Wktro%3D, PID: 10359807
    • Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T (1999) Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. PNAS 96:6879–6884
    • (1999) PNAS , vol.96 , pp. 6879-6884
    • Groh, V.1    Rhinehart, R.2    Secrist, H.3    Bauer, S.4    Grabstein, K.H.5    Spies, T.6
  • 5
    • 79955835802 scopus 로고    scopus 로고
    • Efficacy of transcatheter arterial chemoembolization combined with cytokine-induced killer cell therapy on hepatocellular carcinoma: a comparative study
    • PID: 20109346
    • Hao MZ, Lin HL, Chen Q, Ye YB, Chen QZ, Chen MS (2010) Efficacy of transcatheter arterial chemoembolization combined with cytokine-induced killer cell therapy on hepatocellular carcinoma: a comparative study. Chin J Cancer 29:172–177
    • (2010) Chin J Cancer , vol.29 , pp. 172-177
    • Hao, M.Z.1    Lin, H.L.2    Chen, Q.3    Ye, Y.B.4    Chen, Q.Z.5    Chen, M.S.6
  • 6
    • 78751628167 scopus 로고    scopus 로고
    • Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC)
    • COI: 1:STN:280:DC%2BC3M3jtFelsQ%3D%3D, PID: 20407789
    • Hontscha C, Borck Y, Zhou H, Messmer D, Schmidt-Wolf IGH (2011) Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol 137:305–310
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 305-310
    • Hontscha, C.1    Borck, Y.2    Zhou, H.3    Messmer, D.4    Schmidt-Wolf, I.G.H.5
  • 7
    • 66049104798 scopus 로고    scopus 로고
    • Preliminary assessment of immune reconstitution after autologous peripheral hematopoietic stem cell transplantation (AHSCT)
    • COI: 1:CAS:528:DC%2BD2sXhtlWhur7L, PID: 16965687
    • Huang HQ, Cai QC, Shi YX et al (2006) Preliminary assessment of immune reconstitution after autologous peripheral hematopoietic stem cell transplantation (AHSCT). Ai Zheng 25:1023–1028
    • (2006) Ai Zheng , vol.25 , pp. 1023-1028
    • Huang, H.Q.1    Cai, Q.C.2    Shi, Y.X.3
  • 8
    • 57449105089 scopus 로고    scopus 로고
    • A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma
    • PID: 18818130
    • Hui D, Qiang L, Jian W, Ti Z, Da-Lu K (2009) A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma. Dig Liver Dis 41:36–41
    • (2009) Dig Liver Dis , vol.41 , pp. 36-41
    • Hui, D.1    Qiang, L.2    Jian, W.3    Ti, Z.4    Da-Lu, K.5
  • 9
    • 34548801834 scopus 로고    scopus 로고
    • Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study
    • PID: 17606446
    • Introna M, Borleri G, Conti E et al (2007) Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study. Haematologica 92:952–959
    • (2007) Haematologica , vol.92 , pp. 952-959
    • Introna, M.1    Borleri, G.2    Conti, E.3
  • 10
    • 77957749135 scopus 로고    scopus 로고
    • Feasibility and safety of adoptive immunotherapy with CIK cells after cord blood transplantation
    • PID: 20685246
    • Introna M, Pievani A, Borleri G et al (2010) Feasibility and safety of adoptive immunotherapy with CIK cells after cord blood transplantation. Biol Blood Marrow Transplant 16:1603–1607
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 1603-1607
    • Introna, M.1    Pievani, A.2    Borleri, G.3
  • 11
    • 24044554898 scopus 로고    scopus 로고
    • The efficacy of chemotherapy in combination with auto-cytokine-induced killer cells in acute leukemia
    • PID: 15840260
    • Jiang H, Liu KY, Tong CR, Jiang B, Lu DP (2005) The efficacy of chemotherapy in combination with auto-cytokine-induced killer cells in acute leukemia. Zhonghua Nei Ke Za Zhi 44:198–201
    • (2005) Zhonghua Nei Ke Za Zhi , vol.44 , pp. 198-201
    • Jiang, H.1    Liu, K.Y.2    Tong, C.R.3    Jiang, B.4    Lu, D.P.5
  • 12
    • 33745565374 scopus 로고    scopus 로고
    • Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells
    • COI: 1:CAS:528:DC%2BD28XntV2mtrw%3D, PID: 16821594
    • Jiang J, Xu N, Wu C et al (2006) Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells. Anticancer Res 26:2237–2242
    • (2006) Anticancer Res , vol.26 , pp. 2237-2242
    • Jiang, J.1    Xu, N.2    Wu, C.3
  • 13
    • 64249096161 scopus 로고    scopus 로고
    • Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity
    • COI: 1:CAS:528:DC%2BD1MXjsVSjtbs%3D, PID: 19299720
    • Kilinc MO, Gu T, Harden JL, Virtuoso LP, Egilmez NK (2009) Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity. J Immunol 182:4217–4225
    • (2009) J Immunol , vol.182 , pp. 4217-4225
    • Kilinc, M.O.1    Gu, T.2    Harden, J.L.3    Virtuoso, L.P.4    Egilmez, N.K.5
  • 14
    • 36849010673 scopus 로고    scopus 로고
    • Inhibition of human ovarian tumor growth by cytokine-induced killer cells
    • COI: 1:CAS:528:DC%2BD1cXhtFOksrg%3D, PID: 18087816
    • Kim HM, Kang JS, Lim J et al (2007) Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Arch Pharm Res 30:1464–1470
    • (2007) Arch Pharm Res , vol.30 , pp. 1464-1470
    • Kim, H.M.1    Kang, J.S.2    Lim, J.3
  • 15
    • 80053210017 scopus 로고    scopus 로고
    • Adoptive immunotherapy with cytokine-induced killer cells for patients with relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation
    • COI: 1:CAS:528:DC%2BC3MXhsVSksL3O, PID: 21664472
    • Laport GG, Sheehan K, Baker J et al (2011) Adoptive immunotherapy with cytokine-induced killer cells for patients with relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 17:1679–1687
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1679-1687
    • Laport, G.G.1    Sheehan, K.2    Baker, J.3
  • 16
    • 14244263846 scopus 로고    scopus 로고
    • A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma
    • PID: 15744236
    • Leemhuis T, Wells S, Scheffold C, Edinger M, Negrin RS (2005) A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. Biol Blood Marrow Transplant 11:181–187
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 181-187
    • Leemhuis, T.1    Wells, S.2    Scheffold, C.3    Edinger, M.4    Negrin, R.S.5
  • 17
    • 84870975640 scopus 로고    scopus 로고
    • Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study
    • COI: 1:CAS:528:DC%2BC38Xhs1GlsbbO, PID: 22581306
    • Li R, Wang C, Liu L et al (2012) Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study. Cancer Immunol Immunother 61:2125–2133
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 2125-2133
    • Li, R.1    Wang, C.2    Liu, L.3
  • 18
    • 84863722188 scopus 로고    scopus 로고
    • The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies
    • COI: 1:CAS:528:DC%2BC38XhtVSgsb%2FK, PID: 21986635
    • Linn YC, Niam M, Chu S et al (2012a) The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies. Bone Marrow Transplant 47:957–966
    • (2012) Bone Marrow Transplant , vol.47 , pp. 957-966
    • Linn, Y.C.1    Niam, M.2    Chu, S.3
  • 19
    • 84863938333 scopus 로고    scopus 로고
    • A phase I/II clinical trial of autologous cytokine-induced killer cells as adjuvant immunotherapy for acute and chronic myeloid leukemia in clinical remission
    • COI: 1:CAS:528:DC%2BC38XhtVKnsLfJ, PID: 22799277
    • Linn YC, Yong HX, Niam M et al (2012b) A phase I/II clinical trial of autologous cytokine-induced killer cells as adjuvant immunotherapy for acute and chronic myeloid leukemia in clinical remission. Cytotherapy 14:851–859
    • (2012) Cytotherapy , vol.14 , pp. 851-859
    • Linn, Y.C.1    Yong, H.X.2    Niam, M.3
  • 20
    • 84879789536 scopus 로고    scopus 로고
    • Clinical study of autologous cytokine induced killer cell infusion treating for elderly patients with myelodysplastic syndrome
    • PID: 21729572
    • Liu Y, Bao EN, Yang B et al (2011) Clinical study of autologous cytokine induced killer cell infusion treating for elderly patients with myelodysplastic syndrome. Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:787–792
    • (2011) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.19 , pp. 787-792
    • Liu, Y.1    Bao, E.N.2    Yang, B.3
  • 21
    • 84863230396 scopus 로고    scopus 로고
    • Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma
    • COI: 1:CAS:528:DC%2BC38XktVymsrk%3D, PID: 22275504
    • Liu L, Zhang W, Qi X et al (2012) Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma. Clin Cancer Res 18:1751–1759
    • (2012) Clin Cancer Res , vol.18 , pp. 1751-1759
    • Liu, L.1    Zhang, W.2    Qi, X.3
  • 22
    • 84883238502 scopus 로고    scopus 로고
    • Effects of cytokine-induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery
    • COI: 1:CAS:528:DC%2BC3sXhslarsb7L, PID: 24137296
    • Liu H, Song J, Yang Z, Zhang X (2013) Effects of cytokine-induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery. Exp Ther Med 6:953–956
    • (2013) Exp Ther Med , vol.6 , pp. 953-956
    • Liu, H.1    Song, J.2    Yang, Z.3    Zhang, X.4
  • 23
    • 84894478965 scopus 로고    scopus 로고
    • Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment
    • COI: 1:CAS:528:DC%2BC2cXisF2kurc%3D, PID: 24509174
    • Liu J, Li H, Cao S et al (2014) Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment. J Immunother 37:115–122
    • (2014) J Immunother , vol.37 , pp. 115-122
    • Liu, J.1    Li, H.2    Cao, S.3
  • 24
    • 0034948138 scopus 로고    scopus 로고
    • CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells
    • Lopez RD, Waller EK, Lu PH, Negrin RS (2000) CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells. Cancer Immunol Immunother 49:629–640
    • (2000) Cancer Immunol Immunother , vol.49 , pp. 629-640
    • Lopez, R.D.1    Waller, E.K.2    Lu, P.H.3    Negrin, R.S.4
  • 25
    • 0028103808 scopus 로고
    • A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency
    • COI: 1:CAS:528:DyaK2cXlslOmu7k%3D, PID: 7519209
    • Lu PH, Negrin RS (1994) A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol 153:1687–1696
    • (1994) J Immunol , vol.153 , pp. 1687-1696
    • Lu, P.H.1    Negrin, R.S.2
  • 26
    • 84855606037 scopus 로고    scopus 로고
    • Clinical study of autologous cytokine-induced killer cells for the treatment of elderly patients with diffuse large B-cell lymphoma
    • COI: 1:CAS:528:DC%2BC38XlvVeltg%3D%3D, PID: 21913005
    • Lu XC, Yang B, Yu RL et al (2012) Clinical study of autologous cytokine-induced killer cells for the treatment of elderly patients with diffuse large B-cell lymphoma. Cell Biochem Biophys 62:257–265
    • (2012) Cell Biochem Biophys , vol.62 , pp. 257-265
    • Lu, X.C.1    Yang, B.2    Yu, R.L.3
  • 27
    • 79952734945 scopus 로고    scopus 로고
    • Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies
    • COI: 1:CAS:528:DC%2BC3MXjsVyqurY%3D, PID: 21215350
    • Niu Q, Wang W, Li Y et al (2011) Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies. Int Immunopharmacol 11:449–456
    • (2011) Int Immunopharmacol , vol.11 , pp. 449-456
    • Niu, Q.1    Wang, W.2    Li, Y.3
  • 28
    • 0023126984 scopus 로고
    • Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta
    • COI: 1:CAS:528:DyaL2sXitFagu7s%3D, PID: 2435804
    • Ochoa AC, Gromo G, Alter BJ, Sondel PM, Bach FH (1987) Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta. J Immunol 138:2728–2733
    • (1987) J Immunol , vol.138 , pp. 2728-2733
    • Ochoa, A.C.1    Gromo, G.2    Alter, B.J.3    Sondel, P.M.4    Bach, F.H.5
  • 29
    • 84870474547 scopus 로고    scopus 로고
    • Suppression, subversion and escape: the role of regulatory T cells in cancer progression
    • COI: 1:CAS:528:DC%2BC38XhslKrtLrM, PID: 23199321
    • Oleinika K, Nibbs RJ, Graham GJ, Fraser AR (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clin Exp Immunol 171:36–45
    • (2013) Clin Exp Immunol , vol.171 , pp. 36-45
    • Oleinika, K.1    Nibbs, R.J.2    Graham, G.J.3    Fraser, A.R.4
  • 30
    • 67650360317 scopus 로고    scopus 로고
    • Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours: a pilot clinical trial
    • COI: 1:CAS:528:DC%2BD1MXhtlWks7fK, PID: 19294626
    • Olioso P, Giancola R, Di Riti M, Contento A, Accorsi P, Iacone A (2009) Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours: a pilot clinical trial. Hematol Oncol 27:130–139
    • (2009) Hematol Oncol , vol.27 , pp. 130-139
    • Olioso, P.1    Giancola, R.2    Di Riti, M.3    Contento, A.4    Accorsi, P.5    Iacone, A.6
  • 31
    • 84892367840 scopus 로고    scopus 로고
    • The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients
    • PID: 23892527
    • Pan K, Li YQ, Wang W et al (2013) The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients. Ann Surg Oncol 20:4305–4311
    • (2013) Ann Surg Oncol , vol.20 , pp. 4305-4311
    • Pan, K.1    Li, Y.Q.2    Wang, W.3
  • 32
    • 84901764003 scopus 로고    scopus 로고
    • Clinical activity of adjuvant cytokine-induced killer cell immunotherapy in patients with post-mastectomy triple-negative breast cancer
    • Pan K, Guan XX, Li YQ et al (2014) Clinical activity of adjuvant cytokine-induced killer cell immunotherapy in patients with post-mastectomy triple-negative breast cancer. Clin Cancer Res. doi:10.1158/1078-0432.CCR-14-0082
    • (2014) Clin Cancer Res
    • Pan, K.1    Guan, X.X.2    Li, Y.Q.3
  • 33
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    • COI: 1:CAS:528:DC%2BD38XosF2ms7k%3D, PID: 12414645
    • Pende D, Rivera P, Marcenaro S et al (2002) Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res 62:6178–6186
    • (2002) Cancer Res , vol.62 , pp. 6178-6186
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3
  • 34
    • 84455162015 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3- galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells
    • COI: 1:CAS:528:DC%2BC38XhtFaktb4%3D, PID: 22219594
    • Qiu Y, Xu MB, Yun MM et al (2011) Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3- galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells. World J Gastroenterol 17:5260–5266
    • (2011) World J Gastroenterol , vol.17 , pp. 5260-5266
    • Qiu, Y.1    Xu, M.B.2    Yun, M.M.3
  • 35
    • 83755188591 scopus 로고    scopus 로고
    • The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells
    • COI: 1:CAS:528:DC%2BC3MXhs1CitL%2FL, PID: 21973023
    • Rettinger E, Kuçi S, Naumann I, Becker P et al (2012) The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells. Cytotherapy 14:91–103
    • (2012) Cytotherapy , vol.14 , pp. 91-103
    • Rettinger, E.1    Kuçi, S.2    Naumann, I.3    Becker, P.4
  • 36
    • 0033135536 scopus 로고    scopus 로고
    • Lymphocyte subpopulations in patients with multiple primary tumors
    • COI: 1:STN:280:DyaK1M3jslOlsw%3D%3D, PID: 10223250
    • Robinson E, Segal R, Struminger L, Faraggi D, El’ad-Yarum R, Mekori T (1999) Lymphocyte subpopulations in patients with multiple primary tumors. Cancer 85:2073–2076
    • (1999) Cancer , vol.85 , pp. 2073-2076
    • Robinson, E.1    Segal, R.2    Struminger, L.3    Faraggi, D.4    El’ad-Yarum, R.5    Mekori, T.6
  • 37
    • 0041737499 scopus 로고    scopus 로고
    • Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
    • COI: 1:CAS:528:DC%2BD3sXmsFWkt7w%3D, PID: 12714493
    • Salih HR, Antropius H, Gieseke F et al (2003) Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood 102:1389–1396
    • (2003) Blood , vol.102 , pp. 1389-1396
    • Salih, H.R.1    Antropius, H.2    Gieseke, F.3
  • 38
    • 84924572977 scopus 로고    scopus 로고
    • Adoptive immunotherapy strategies with cytokine-induced killer (CIK) cells in the treatment of hematological malignancies
    • COI: 1:CAS:528:DC%2BC2cXhslyqtbbN, PID: 25196601
    • Schmeel FC, Schmeel LC, Gast SM, Schmidt-Wolf IG (2014) Adoptive immunotherapy strategies with cytokine-induced killer (CIK) cells in the treatment of hematological malignancies. Int J Mol Sci 15:14632–14648
    • (2014) Int J Mol Sci , vol.15 , pp. 14632-14648
    • Schmeel, F.C.1    Schmeel, L.C.2    Gast, S.M.3    Schmidt-Wolf, I.G.4
  • 39
    • 0025856106 scopus 로고
    • Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity
    • COI: 1:CAS:528:DyaK3MXltFamsbY%3D, PID: 1711560
    • Schmidt-Wolf IGH, Negrin RS, Kiem HP, Blume KG, Weissman IL (1991) Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med 174:139–149
    • (1991) J Exp Med , vol.174 , pp. 139-149
    • Schmidt-Wolf, I.G.H.1    Negrin, R.S.2    Kiem, H.P.3    Blume, K.G.4    Weissman, I.L.5
  • 40
    • 0027860412 scopus 로고
    • Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells
    • COI: 1:STN:280:DyaK2c%2Fmt12ltw%3D%3D, PID: 7694868
    • Schmidt-Wolf IGH, Lefterova P, Mehta BA et al (1993) Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells. Exp Hematol 21:1673–1679
    • (1993) Exp Hematol , vol.21 , pp. 1673-1679
    • Schmidt-Wolf, I.G.H.1    Lefterova, P.2    Mehta, B.A.3
  • 42
    • 0032698796 scopus 로고    scopus 로고
    • Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-1 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma
    • COI: 1:CAS:528:DyaK1MXnvFSjsL4%3D, PID: 10576658
    • Schmidt-Wolf IGH, Finke S, Trojaneck B et al (1999) Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-1 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma. Br J Cancer 81:1009–1016
    • (1999) Br J Cancer , vol.81 , pp. 1009-1016
    • Schmidt-Wolf, I.G.H.1    Finke, S.2    Trojaneck, B.3
  • 43
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: an overview of signals, mechanisms and functions
    • COI: 1:CAS:528:DC%2BD2cXhsFKntrk%3D, PID: 14525967
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163–189
    • (2004) J Leukoc Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 44
    • 2342437804 scopus 로고    scopus 로고
    • Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD2cXksFGltrY%3D, PID: 15069715
    • Shi M, Zhang B, Tang ZR et al (2004) Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma. World J Gastroenterol 10:1146–1151
    • (2004) World J Gastroenterol , vol.10 , pp. 1146-1151
    • Shi, M.1    Zhang, B.2    Tang, Z.R.3
  • 45
    • 84870988226 scopus 로고    scopus 로고
    • Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer
    • COI: 1:CAS:528:DC%2BC38XhslKhsbjE, PID: 22674056
    • Shi L, Zhou Q, Wu J et al (2012a) Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother 61:2251–2259
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 2251-2259
    • Shi, L.1    Zhou, Q.2    Wu, J.3
  • 46
    • 84867082350 scopus 로고    scopus 로고
    • Effect of maintenance therapy with dendritic cells: cytokine-induced killer cells in patients with advanced non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC3sXhsV2kurY%3D, PID: 22825506
    • Shi SB, Ma TH, Li CH, Tang XY (2012b) Effect of maintenance therapy with dendritic cells: cytokine-induced killer cells in patients with advanced non-small cell lung cancer. Tumori 98:314–319
    • (2012) Tumori , vol.98 , pp. 314-319
    • Shi, S.B.1    Ma, T.H.2    Li, C.H.3    Tang, X.Y.4
  • 47
    • 77956169022 scopus 로고    scopus 로고
    • Immunotherapy with cytokine-induced killer cells in metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC3cXhtVGrsbfP, PID: 20701541
    • Su X, Zhang L, Jin L et al (2010) Immunotherapy with cytokine-induced killer cells in metastatic renal cell carcinoma. Cancer Biother Radiopharm 25:465–470
    • (2010) Cancer Biother Radiopharm , vol.25 , pp. 465-470
    • Su, X.1    Zhang, L.2    Jin, L.3
  • 48
    • 84887123089 scopus 로고    scopus 로고
    • IL-15 improves the cytotoxicity of cytokine-induced killer cells against leukemia cells by upregulating CD3+CD56+ cells and downregulating regulatory T cells as well as IL-35
    • COI: 1:CAS:528:DC%2BC3sXhs1KjsrbF, PID: 24145357
    • Tao Q, Chen T, Tao L et al (2013) IL-15 improves the cytotoxicity of cytokine-induced killer cells against leukemia cells by upregulating CD3+CD56+ cells and downregulating regulatory T cells as well as IL-35. J Immunother 36:462–467
    • (2013) J Immunother , vol.36 , pp. 462-467
    • Tao, Q.1    Chen, T.2    Tao, L.3
  • 49
    • 80051473403 scopus 로고    scopus 로고
    • Combining cytokine-induced killer cells with vaccination in cancer immunotherapy: more than one plus one?
    • COI: 1:CAS:528:DC%2BC3MXhtVCnsbjP, PID: 21652069
    • Thanendrarajan S, Nowak M, Abken H, Schmidt-Wolf IG (2011) Combining cytokine-induced killer cells with vaccination in cancer immunotherapy: more than one plus one? Leuk Res 35:1136–1142
    • (2011) Leuk Res , vol.35 , pp. 1136-1142
    • Thanendrarajan, S.1    Nowak, M.2    Abken, H.3    Schmidt-Wolf, I.G.4
  • 50
    • 84859570163 scopus 로고    scopus 로고
    • New adoptive immunotherapy strategies for solid tumours with CIK cells
    • COI: 1:CAS:528:DC%2BC38XlsFSrsbg%3D, PID: 22444075
    • Thanendrarajan S, Kim Y, Schmidt-Wolf IGH (2012) New adoptive immunotherapy strategies for solid tumours with CIK cells. Expert Opin Biol Ther 12:565–572
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 565-572
    • Thanendrarajan, S.1    Kim, Y.2    Schmidt-Wolf, I.G.H.3
  • 51
    • 0035204217 scopus 로고    scopus 로고
    • Engineering hematopoietic grafts: purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma
    • COI: 1:STN:280:DC%2BD38%2Fjt1Slsw%3D%3D, PID: 11760085
    • Verneris MR, Ito M, Baker J, Arshi A, Negrin RS, Shizuru JA (2001) Engineering hematopoietic grafts: purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma. Biol Blood Marrow Transplant 7:532–542
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 532-542
    • Verneris, M.R.1    Ito, M.2    Baker, J.3    Arshi, A.4    Negrin, R.S.5    Shizuru, J.A.6
  • 52
    • 1842526956 scopus 로고    scopus 로고
    • Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8 + T cells
    • COI: 1:CAS:528:DC%2BD2cXjsVags70%3D, PID: 15070686
    • Verneris MR, Karami M, Baker J, Jayaswal A, Negrin RS (2004) Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8 + T cells. Blood 103:3065–3072
    • (2004) Blood , vol.103 , pp. 3065-3072
    • Verneris, M.R.1    Karami, M.2    Baker, J.3    Jayaswal, A.4    Negrin, R.S.5
  • 53
    • 0023127374 scopus 로고
    • Suppressor cell function in solid tumor cancer patients
    • Von Roenn J, Harris JE, Braun DP (1987) Suppressor cell function in solid tumor cancer patients. J Clin Oncol 5:150–159
    • (1987) J Clin Oncol , vol.5 , pp. 150-159
    • Von Roenn, J.1    Harris, J.E.2    Braun, D.P.3
  • 54
    • 84874997536 scopus 로고    scopus 로고
    • CIK cells from recurrent or refractory AML patients can be efficiently expanded in vitro and used for reduction of leukemic blasts in vivo
    • COI: 1:CAS:528:DC%2BC3sXktlCrsL0%3D, PID: 23123634
    • Wang Y, Bo J, Dai HR et al (2013) CIK cells from recurrent or refractory AML patients can be efficiently expanded in vitro and used for reduction of leukemic blasts in vivo. Exp Hematol 41:241–252
    • (2013) Exp Hematol , vol.41 , pp. 241-252
    • Wang, Y.1    Bo, J.2    Dai, H.R.3
  • 55
    • 84890952595 scopus 로고    scopus 로고
    • Association of myeloid-derived suppressor cells and efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma patients
    • COI: 1:CAS:528:DC%2BC3sXhvFSru7%2FN, PID: 24316555
    • Wang Z, Zhang Y, Liu Y et al (2014) Association of myeloid-derived suppressor cells and efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma patients. J Immunother 37:43–50
    • (2014) J Immunother , vol.37 , pp. 43-50
    • Wang, Z.1    Zhang, Y.2    Liu, Y.3
  • 56
    • 84898884888 scopus 로고    scopus 로고
    • The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma
    • COI: 1:CAS:528:DC%2BC2cXltlyqtrk%3D, PID: 24104501
    • Wei C, Wang W, Pang W et al (2014) The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma. Tumour Biol 35:1997–2007
    • (2014) Tumour Biol , vol.35 , pp. 1997-2007
    • Wei, C.1    Wang, W.2    Pang, W.3
  • 57
    • 80054021524 scopus 로고    scopus 로고
    • Clinical study of autologous cytokine induced killer cells combined with IL-2 for therapy of elderly patients with B-cell malignant lymphoma
    • COI: 1:CAS:528:DC%2BC3MXit1Squr0%3D, PID: 21129269
    • Yang B, Lu XC, Zhu HL et al (2010) Clinical study of autologous cytokine induced killer cells combined with IL-2 for therapy of elderly patients with B-cell malignant lymphoma. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1244–1249
    • (2010) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.18 , pp. 1244-1249
    • Yang, B.1    Lu, X.C.2    Zhu, H.L.3
  • 58
    • 84866265305 scopus 로고    scopus 로고
    • Repeated transfusions of autologous cytokine-induced killer cells for treatment of haematological malignancies in elderly patients: a pilot clinical trial
    • COI: 1:CAS:528:DC%2BC38XhtlemsLvP, PID: 22972689
    • Yang B, Lu XC, Yu RL et al (2012) Repeated transfusions of autologous cytokine-induced killer cells for treatment of haematological malignancies in elderly patients: a pilot clinical trial. Hematol Oncol 30:115–122
    • (2012) Hematol Oncol , vol.30 , pp. 115-122
    • Yang, B.1    Lu, X.C.2    Yu, R.L.3
  • 59
    • 84872488982 scopus 로고    scopus 로고
    • Enhanced antitumor effects of DC-activated CIKs to chemotherapy treatment in a single cohort of advanced non-small-cell lung cancer patients
    • PID: 22744010
    • Yang L, Ren B, Li H et al (2013) Enhanced antitumor effects of DC-activated CIKs to chemotherapy treatment in a single cohort of advanced non-small-cell lung cancer patients. Cancer Immunol Immunother 62:65–73
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 65-73
    • Yang, L.1    Ren, B.2    Li, H.3
  • 60
    • 84892453817 scopus 로고    scopus 로고
    • Treatment of multiple solitary plasmacytomas with cytokine-induced killer cells
    • COI: 1:CAS:528:DC%2BC2cXhtlKhsrc%3D, PID: 24438905
    • Yang B, Wang J, Cai LL et al (2014a) Treatment of multiple solitary plasmacytomas with cytokine-induced killer cells. Cytotherapy 16:278–284
    • (2014) Cytotherapy , vol.16 , pp. 278-284
    • Yang, B.1    Wang, J.2    Cai, L.L.3
  • 61
    • 84903762894 scopus 로고    scopus 로고
    • Clinical study of autologous cytokine induced killer cells combined with chemotherapy for elderly patients with acute myeloid leukemia
    • PID: 24598652
    • Yang Y, Yang B, Cai LL et al (2014b) Clinical study of autologous cytokine induced killer cells combined with chemotherapy for elderly patients with acute myeloid leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 22:58–63
    • (2014) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.22 , pp. 58-63
    • Yang, Y.1    Yang, B.2    Cai, L.L.3
  • 62
    • 84898920952 scopus 로고    scopus 로고
    • A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2cXjtlSjur8%3D, PID: 24337625
    • Yu X, Zhao H, Liu L et al (2014) A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocellular carcinoma. J Clin Immunol 34:194–203
    • (2014) J Clin Immunol , vol.34 , pp. 194-203
    • Yu, X.1    Zhao, H.2    Liu, L.3
  • 63
    • 84869128048 scopus 로고    scopus 로고
    • A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma
    • PID: 23106871
    • Zhan HL, Gao X, Pu XY et al (2012) A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma. Chin Med J 125:3771–3777
    • (2012) Chin Med J , vol.125 , pp. 3771-3777
    • Zhan, H.L.1    Gao, X.2    Pu, X.Y.3
  • 64
    • 84864347928 scopus 로고    scopus 로고
    • The effects of cytokine-induced killer cells for the treatment of patients with solid tumors: a clinical retrospective study
    • COI: 1:CAS:528:DC%2BC38Xnt1ertrg%3D, PID: 22392076
    • Zhang J, Zhu L, Wei J et al (2012) The effects of cytokine-induced killer cells for the treatment of patients with solid tumors: a clinical retrospective study. J Cancer Res Clin Oncol 138:1057–1062
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 1057-1062
    • Zhang, J.1    Zhu, L.2    Wei, J.3
  • 65
    • 84877844118 scopus 로고    scopus 로고
    • Immunotherapy with cytokine-induced killer cells as an adjuvant treatment for advanced gastric carcinoma: a retrospective study of 165 patients
    • COI: 1:CAS:528:DC%2BC3sXnslWltLs%3D, PID: 23506427
    • Zhao H, Fan Y, Li H et al (2013) Immunotherapy with cytokine-induced killer cells as an adjuvant treatment for advanced gastric carcinoma: a retrospective study of 165 patients. Cancer Biother Radiopharm 28:303–309
    • (2013) Cancer Biother Radiopharm , vol.28 , pp. 303-309
    • Zhao, H.1    Fan, Y.2    Li, H.3
  • 66
    • 80054110411 scopus 로고    scopus 로고
    • Dendritic cells combining with cytokine-induced killer cells synergize chemotherapy in patients with late-stage non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC3MXht1SitLjI, PID: 21681372
    • Zhong R, Teng J, Han B, Zhong H (2011) Dendritic cells combining with cytokine-induced killer cells synergize chemotherapy in patients with late-stage non-small cell lung cancer. Cancer Immunol Immunother 60:1497–1502
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1497-1502
    • Zhong, R.1    Teng, J.2    Han, B.3    Zhong, H.4
  • 67
    • 84887202477 scopus 로고    scopus 로고
    • Clinical efficacy of immunotherapy of dendritic cell and cytokine-induced killer cell combined with chemotherapy for treatment of multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXltlCmu70%3D, PID: 23363790
    • Zhong GC, Yan B, Sun Y et al (2012) Clinical efficacy of immunotherapy of dendritic cell and cytokine-induced killer cell combined with chemotherapy for treatment of multiple myeloma. Zhonghua Xue Ye Xue Za Zhi 33:1000–1003
    • (2012) Zhonghua Xue Ye Xue Za Zhi , vol.33 , pp. 1000-1003
    • Zhong, G.C.1    Yan, B.2    Sun, Y.3
  • 68
    • 38049056843 scopus 로고    scopus 로고
    • Short-term curative efficacy of cytokine-induced killer cells combined micro-invasive treatments on hepatocellular carcinoma
    • PID: 17094912
    • Zhou QM, Wu PH, Zhao M et al (2006) Short-term curative efficacy of cytokine-induced killer cells combined micro-invasive treatments on hepatocellular carcinoma. Ai Zheng 25:1414–1418
    • (2006) Ai Zheng , vol.25 , pp. 1414-1418
    • Zhou, Q.M.1    Wu, P.H.2    Zhao, M.3
  • 69
    • 84870949010 scopus 로고    scopus 로고
    • Family haploidentical donor-derived cytokine-induced killer cell biotherapy combined with bortezomib in two patients with relapsed multiple myeloma in a non-allogeneic transplant setting
    • COI: 1:CAS:528:DC%2BC38XhvVWjsLzK, PID: 22734810
    • Zhou X, Zhu J, Sun H, Shao L, Xu M, Guo H (2013) Family haploidentical donor-derived cytokine-induced killer cell biotherapy combined with bortezomib in two patients with relapsed multiple myeloma in a non-allogeneic transplant setting. Leuk Lymphoma 54:209–211
    • (2013) Leuk Lymphoma , vol.54 , pp. 209-211
    • Zhou, X.1    Zhu, J.2    Sun, H.3    Shao, L.4    Xu, M.5    Guo, H.6
  • 70
    • 84885852315 scopus 로고    scopus 로고
    • Efficacy of postoperative adjuvant transfusion of cytokine-induced killer cells combined with chemotherapy in patients with colorectal cancer
    • COI: 1:CAS:528:DC%2BC3sXhtlyisr%2FJ, PID: 23974720
    • Zhu Y, Zhang H, Li Y et al (2013) Efficacy of postoperative adjuvant transfusion of cytokine-induced killer cells combined with chemotherapy in patients with colorectal cancer. Cancer Immunol Immunother 62:1629–1635
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1629-1635
    • Zhu, Y.1    Zhang, H.2    Li, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.