CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells

Cancer Immunology, Immunotherapy

Volumn 49, Issue 11, 2000, Pages 629-640

  Lopez, Richard D ^a   Waller, Edmund K ^c   Lu, Pei Hua ^b   Negrin, Robert S ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD56 NCAM; IL 12; Immunotherapy; Monocytes macrophages; T lymphocytes

Indexed keywords

CD3 ANTIGEN; CD56 ANTIGEN; INTERLEUKIN 12; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; CD2 ANTIGEN; LYMPHOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; NERVE CELL ADHESION MOLECULE;

ADOPTIVE IMMUNOTHERAPY; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR CELL; ANTINEOPLASTIC ACTIVITY; CELL ACTIVATION; IMMUNOTHERAPY; MACROPHAGE;

ANIMALS; ANTIGENS, CD2; ANTIGENS, CD3; ANTIGENS, CD56; ANTIGENS, CD58; CELLS, CULTURED; CHO CELLS; CRICETINAE; CYTOTOXICITY, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; MONOCYTES; T-LYMPHOCYTES;

EID: 0034948138     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620000148     Document Type: Article

References (29)

1. + cells: Examination of morphology, functions, T cell receptor rearrangement, and pore-forming protein expression
2. Selective expansion of cytotoxic T lymphocytes with a CD4+ CD56+ surface phenotype and a T helper type I profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus
3. Dissection of the LAK phenomenon: Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis
4. Acquisition of non-MHC restricted cytotoxic function by IL-2 activated thymocytes with an "immature" antigenic phenotype
5. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes
6. Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity
7. Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells
8. A novel population of expanded human CD3+ CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency
9. Generation of MHC-nonrestricted and restricted oncolytic subsets from human bone marrow
10. Major histocompatibility complex-unrestricted cytolytic activity of human T cells
11. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
12. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
13. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
14. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biological effects on T and natural killer cells
15. + T lymphocytes, and NK cells
16. IL-12 augments antigen-dependent proliferation of activated T lymphocoytes
17. The IL-12 receptor. II. Distribution and regulation of receptor expression
18. + T lymphocytes
19. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type I and cytotoxic lymphocytes
20. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
21. Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction
22. An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2
23. Fc receptors for mouse IgG1 on human monocytes: Polymorphisms and role in antibody-induced T cell proliferation
24. T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fcγ receptors for murine IgG2a and inability to cross-link the T3 complex
25. + NK cells
26. CD2 regulates responsiveness of activated T cells to interleukin 12
27. Molecular interaction between CD58 and CD2 counter-receptors mediates the ability of monocytes to augment T cell activation by IL-12
28. Long-term growth of lymphokine-activated killer (LAK) cells: Role of anti-CD3, β-IL-1, interferon-γ, and -β