Effects of cytokine-induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery

Experimental and Therapeutic Medicine

Volumn 6, Issue 4, 2013, Pages 953-956

  Liu, Hongxiang ^a   Song, Junmin ^a   Yang, Zhen ^a   Zhang, Xiefu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

CIK cells; FOLFOX4; Gastric cancer; Recurrence rate; Survival rate

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FLUOROURACIL; FOLINATE CALCIUM; OXALIPLATIN; PYRIDOXINE; SEROTONIN ANTAGONIST;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CELL COUNT; CELL THERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE INDUCED KILLER CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NATURAL KILLER CELL; STOMACH CANCER; SURVIVAL RATE;

EID: 84883238502     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1247     Document Type: Article

References (16)

1. Dong S, Li FQ, Zhang Q, Lv KZ, Yang HL, Gao Y and Yu JR: Expression and clinical significance of SHP2 in gastric cancer. J Int Med Res 40: 2083-2089, 2012.
2. Martella B, Cardin F, Lorenzetti R, Terranova C, Amato B and Militello C: Local recurrence of gastric cancer after total gastrectomy: an unusual presentation. BMC Surg 12 (Suppl 1): S28, 2012.
3. Shi SB, Ma TH, Li CH and Tang XY: Effect of maintenance therapy with dendritic cells: cytokine-induced killer cells in patients with advanced non-small cell lung cancer. Tumori 98: 314-319, 2012.
4. Yang XJ, Huang JA, Lei W, Zhu YB and Zhang XG: Antitumor effects of cocultured dendritic cells and cytokine-induced killer cells on lung cancer in vitro and in vivo. Ai Zheng 25: 1329-1333, 2006 (In Chinese).
5. Ma Y, Xu YC, Tang L, Zhang Z, Wang J and Wang HX: Cytokine-induced killer (CIK) cell therapy for patients with hepatocellular carcinoma: efficacy and safety. Exp Hematol Oncol 1: 11, 2012.
6. Basili G, Nesi G, Barchielli A, Manetti A and Biliotti G: Pathologic features and long-term results in early gastric cancer: report of 116 cases 8-13 years after surgery. World J Surg 27: 149-152, 2003.
7. Marrelli D, Roviello F, De Stefano A, Fotia G, Giliberto C, Garosi L and Pinto E: Risk factors for liver metastases after curative surgical procedures for gastric cancer: a prospective study of 208 patients treated with surgical resection. J Am Coll Surg 198: 51-58, 2004.
8. Zhou QM, Wu PH, Zhao M, et al: Short-term curative efficacy of cytokine-induced killer cells combined micro-invasive treatments on hepatocellular carcinoma. Ai Zheng 25: 1414-1418, 2006 (In Chinese).
9. Blattman JN and Greenberg PD: Cancer immunotherapy: a treatment for the masses. Science 305: 200-205, 2004.
10. Shi L, Zhou Q, Wu J, Ji M, Li G, Jiang J and Wu C: Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother 61: 2251-2259, 2012.
11. Rutella S and Locatelli F. Is there a role for cytokine-induced killer cells in cancer immunotherapy? Immunotherapy 4: 867-869, 2012.
12. Sangiolo D. Cytokine induced killer cells as promising immunotherapy for solid tumors. J Cancer 2: 363-368, 2011.
13. Jäkel CE, Hauser S, Rogenhofer S, Müller SC, Brossart P and Schmidt-Wolf, IG: Clinical studies applying cytokine-induced killer cells for the treatment of renal cell carcinoma. Clin Dev Immunol 2012: 473245, 2012.
14. Sangiolo D, Mesiano G, Carnevale-Schianca F, Piacibello W, Aglietta M and Cignetti A: Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin Biol Ther 9: 831-840, 2009.
15. Zhang J, Zhu L, Wei J, Liu L, Yin Y, Gu Y and Shu Y: The effects of cytokine-induced killer cells for the treatment of patients with solid tumors: a clinical retrospective study. J Cancer Res Clin Oncol 138: 1057-1062, 2012.
16. Schlimper C, Hombach AA, Abken H and Schmidt-Wolf IG: Improved activation toward primary colorectal cancer cells by antigen-specific targeting autologous cytokine-induced killer cells. Clin Dev Immunol 2012: 238924, 2012.