-
1
-
-
0022551060
-
Histone hyperacetylation: Its effects on nucleosome conformation and stability
-
Ausio J and van Holde KE: Histone hyperacetylation: its effects on nucleosome conformation and stability. Biochemistry 25: 1421-1428, 1986.
-
(1986)
Biochemistry
, vol.25
, pp. 1421-1428
-
-
Ausio, J.1
Van Holde, K.E.2
-
2
-
-
0024003456
-
A direct link between core histone acetylation and transcriptionally active chromatin
-
Hebbes TR, Thorne AW and Crane-Robinson C: A direct link between core histone acetylation and transcriptionally active chromatin. EMBO 7: 1395-1402, 1988.
-
(1988)
EMBO
, vol.7
, pp. 1395-1402
-
-
Hebbes, T.R.1
Thorne, A.W.2
Crane-Robinson, C.3
-
3
-
-
0027465862
-
A positive role for histone acetylation in transcription factor access to nucleosomal DNA
-
Lee DY, Hayes JJ, Pruss D and Wolffe A: A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72: 73-84, 1993.
-
(1993)
Cell
, vol.72
, pp. 73-84
-
-
Lee, D.Y.1
Hayes, J.J.2
Pruss, D.3
Wolffe, A.4
-
4
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD and Von Hoff DD: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997 15: 2403-2413, 1997.
-
(1997)
J Clin Oncol
, vol.1997
, Issue.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
Green, M.R.4
Rothenberg, M.L.5
Modiano, M.R.6
Cripps, M.C.7
Portenoy, R.K.8
Storniolo, A.M.9
Tarassoff, P.10
Nelson, R.11
Dorr, F.A.12
Stephens, C.D.13
Von Hoff, D.D.14
-
5
-
-
34547897023
-
Histone deacetylases and cancer
-
Glozak MA and Seto E: Histone deacetylases and cancer. Oncogene 26: 5420-5432, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
6
-
-
41149147248
-
Histone deacetylase inhibitors: A novel class of anti-cancer agents on its way to the market
-
Körner M and Tibes U: Histone deacetylase inhibitors: a novel class of anti-cancer agents on its way to the market. Prog Med Chem 46: 205-280, 2008.
-
(2008)
Prog Med Chem
, vol.46
, pp. 205-280
-
-
Körner, M.1
Tibes, U.2
-
7
-
-
26444459387
-
Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells
-
Kothapalli N, Sarath G and Zempleni J: Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells. J Nutr 135: 2337-2342, 2005.
-
(2005)
J Nutr
, vol.135
, pp. 2337-2342
-
-
Kothapalli, N.1
Sarath, G.2
Zempleni, J.3
-
8
-
-
84903581670
-
Targeting histone deacetylases for cancer therapy: From molecular mechanisms to clinical implications
-
Li Z and Zhu WG: Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications. Int J Biol Sci 10: 757-770, 2014.
-
(2014)
Int J Biol Sci
, vol.10
, pp. 757-770
-
-
Li, Z.1
Zhu, W.G.2
-
9
-
-
33744484789
-
Histone deacetylase inhibitors: A novel target of anticancer therapy
-
review
-
Kouraklis G and Theocharis S: Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep 15: 489-494, 2006.
-
(2006)
Oncol Rep
, vol.15
, pp. 489-494
-
-
Kouraklis, G.1
Theocharis, S.2
-
11
-
-
77955581767
-
Histone deacetylase inhibitors: Advancing therapeutic strategies in hematological and solid malignancies
-
Ellis L and Pili R: Histone deacetylase inhibitors: Advancing therapeutic strategies in hematological and solid malignancies. Pharmaceuticals (Basel) 3: 2441-2469, 2010.
-
(2010)
Pharmaceuticals (Basel)
, vol.3
, pp. 2441-2469
-
-
Ellis, L.1
Pili, R.2
-
12
-
-
0037444803
-
Histone deacetylases (HDACs): Characterization of the classical HDAC family
-
de Ruijter AJ, van Gennip AH, Caron HN, Kemp S and van Kuilenburg AB: Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370: 737-749, 2003.
-
(2003)
Biochem J
, vol.370
, pp. 737-749
-
-
De Ruijter, A.J.1
Van Gennip, A.H.2
Caron, H.N.3
Kemp, S.4
Van Kuilenburg, A.B.5
-
13
-
-
0036304760
-
Histone deacetylase inhibitors: A new class of potential therapeutic agents for cancer treatment
-
Richon VM and O'Brien JP: Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment. Clin Cancer Res 8: 718-728, 2002.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 718-728
-
-
Richon, V.M.1
O'Brien, J.P.2
-
14
-
-
78650723028
-
Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer
-
Ouaïssi M, Giger U, Sielezneff I, Pirrò N, Sastre B and Ouaissi A: Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer. J Biomed Biotechnol 2011: 315939, 2011.
-
(2011)
J Biomed Biotechnol
, vol.2011
-
-
Ouaïssi, M.1
Giger, U.2
Sielezneff, I.3
Pirrò, N.4
Sastre, B.5
Ouaissi, A.6
-
15
-
-
84895893042
-
The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2
-
Peulen O, Gonzalez A, Peixoto P, Turtoi A, Mottet D, Delvenne P and Castronovo V: The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2. PLoS One 8: e75102, 2013.
-
(2013)
PLoS One
, vol.8
, pp. e75102
-
-
Peulen, O.1
Gonzalez, A.2
Peixoto, P.3
Turtoi, A.4
Mottet, D.5
Delvenne, P.6
Castronovo, V.7
-
17
-
-
77955643796
-
The clinical development of histone deacetylase inhibitors as targeted anticancer drugs
-
Marks PA: The clinical development of histone deacetylase inhibitors as targeted anticancer drugs. Expert Opin Investig Drugs 19: 1049-1066, 2010.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 1049-1066
-
-
Marks, P.A.1
-
19
-
-
49249116407
-
A work in progress: The clinical development of histone deacetylase inhibitors
-
Marsoni S, Damia G and Camboni G: A work in progress: the clinical development of histone deacetylase inhibitors. Epigenetics 3: 164-171, 2008.
-
(2008)
Epigenetics
, vol.3
, pp. 164-171
-
-
Marsoni, S.1
Damia, G.2
Camboni, G.3
-
20
-
-
34248649731
-
The molecular mechanism of HDAC inhibitors in anticancer effects
-
Bi G and Jiang G: The molecular mechanism of HDAC inhibitors in anticancer effects. Cell Mol Immunol 3: 285-290, 2006.
-
(2006)
Cell Mol Immunol
, vol.3
, pp. 285-290
-
-
Bi, G.1
Jiang, G.2
-
21
-
-
67349201377
-
Targeting tumor angiogenesis with histone deacetylase inhibitors
-
Ellis L, Hammers H and Pili R: Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett 280: 145-153, 2009.
-
(2009)
Cancer Lett
, vol.280
, pp. 145-153
-
-
Ellis, L.1
Hammers, H.2
Pili, R.3
-
22
-
-
64249135764
-
Novel agents on the horizon for cancer therapy
-
Ma WW and Adjei AA: Novel agents on the horizon for cancer therapy. CA Cancer J Clin 59: 111-137, 2009.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 111-137
-
-
Ma, W.W.1
Adjei, A.A.2
-
23
-
-
66049111715
-
Histone deacetylase inhibitors as novel anticancer therapeutics
-
Walkinshaw DR and Yang XJ: Histone deacetylase inhibitors as novel anticancer therapeutics. Curr Oncol 15: 237-243, 2008.
-
(2008)
Curr Oncol
, vol.15
, pp. 237-243
-
-
Walkinshaw, D.R.1
Yang, X.J.2
-
24
-
-
84874611509
-
Histone deacetylase inhibitors and pancreatic cancer: Are there any promising clinical trials?
-
Koutsounas I, Giaginis C and Theocharis S: Histone deacetylase inhibitors and pancreatic cancer: Are there any promising clinical trials? World J Gastroenterol 19: 1173-1181, 2013.
-
(2013)
World J Gastroenterol
, vol.19
, pp. 1173-1181
-
-
Koutsounas, I.1
Giaginis, C.2
Theocharis, S.3
-
25
-
-
20444479514
-
Drug insight: Histone deacetylase inhibitors-development of the new targeted anticancer agent suberoylanilide hydroxamic acid
-
Kelly WK and Marks PA: Drug insight: Histone deacetylase inhibitors-development of the new targeted anticancer agent suberoylanilide hydroxamic acid. Nat Clin Pract Oncol 2: 150-157, 2005.
-
(2005)
Nat Clin Pract Oncol
, vol.2
, pp. 150-157
-
-
Kelly, W.K.1
Marks, P.A.2
-
26
-
-
12444321545
-
Phase I clinical trial of histone deacetylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously
-
Kelly WK, Richon VM, O'Connor O, Curley T, MacGregor-Curtelli B, Tong W, Klang M, Schwartz L, Richardson S, Rosa E, Drobnjak M, Cordon-Cordo C, Chiao JH, Rifkind R, Marks PA and Scher H: Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res 9: 3578-3588, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3578-3588
-
-
Kelly, W.K.1
Richon, V.M.2
O'Connor, O.3
Curley, T.4
MacGregor-Curtelli, B.5
Tong, W.6
Klang, M.7
Schwartz, L.8
Richardson, S.9
Rosa, E.10
Drobnjak, M.11
Cordon-Cordo, C.12
Chiao, J.H.13
Rifkind, R.14
Marks, P.A.15
Scher, H.16
-
27
-
-
77954140840
-
Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells
-
Angst E, Dawson DW, Nguyen A, Park J, Go VL, Reber HA, Hines OJ and Eibl G: Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas 39: 675-679, 2010.
-
(2010)
Pancreas
, vol.39
, pp. 675-679
-
-
Angst, E.1
Dawson, D.W.2
Nguyen, A.3
Park, J.4
Go, V.L.5
Reber, H.A.6
Hines, O.J.7
Eibl, G.8
-
28
-
-
77950814683
-
HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells
-
Schüler S, Fritsche P, Diersch S, Arlt A, Schmid RM, Saur D and Schneider G: HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells. Mol Cancer 9: 80, 2010.
-
(2010)
Mol Cancer
, vol.9
, pp. 80
-
-
Schüler, S.1
Fritsche, P.2
Diersch, S.3
Arlt, A.4
Schmid, R.M.5
Saur, D.6
Schneider, G.7
-
29
-
-
23844486708
-
Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines
-
García-Morales P, Gómez-Martínez A, Carrato A, Martínez-Lacaci I, Barberá VM, Soto JL, Carrasco-García E, Menéndez-Gutierrez MP, Castro-Galache MD, Ferragut JA and Saceda M: Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. Mol Cancer Ther 4: 1222-1230, 2005.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1222-1230
-
-
García-Morales, P.1
Gómez-Martínez, A.2
Carrato, A.3
Martínez-Lacaci, I.4
Barberá, V.M.5
Soto, J.L.6
Carrasco-García, E.7
Menéndez-Gutierrez, M.P.8
Castro-Galache, M.D.9
Ferragut, J.A.10
Saceda, M.11
-
30
-
-
34250200750
-
Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine
-
Donadelli M, Costanzo C, Beghelli S, Scupoli MT, Dandrea M, Bonora A, Piacentini P, Budillon A, Caraglia M, Scarpa A and Palmieri M: Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. Biochim Biophys Acta 1773: 1095-1106, 2007.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1095-1106
-
-
Donadelli, M.1
Costanzo, C.2
Beghelli, S.3
Scupoli, M.T.4
Dandrea, M.5
Bonora, A.6
Piacentini, P.7
Budillon, A.8
Caraglia, M.9
Scarpa, A.10
Palmieri, M.11
-
31
-
-
33747874802
-
Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells
-
Bai J, Demirjian A, Sui J, Marasco W and Callery MP: Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. Biochem Biophys Res Commun 348: 1245-1253, 2006.
-
(2006)
Biochem Biophys Res Commun
, vol.348
, pp. 1245-1253
-
-
Bai, J.1
Demirjian, A.2
Sui, J.3
Marasco, W.4
Callery, M.P.5
-
32
-
-
84906226036
-
Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo
-
Chien W, Lee DH, Zheng Y, Wuensche P, Alvarez R, Wen DL, Aribi AM, Thean SM, Doan NB, Said JW and Koeffler HP: Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo. Mol Carcinog 53: 722-735, 2014.
-
(2014)
Mol Carcinog
, vol.53
, pp. 722-735
-
-
Chien, W.1
Lee, D.H.2
Zheng, Y.3
Wuensche, P.4
Alvarez, R.5
Wen, D.L.6
Aribi, A.M.7
Thean, S.M.8
Doan, N.B.9
Said, J.W.10
Koeffler, H.P.11
-
33
-
-
84881570005
-
Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies
-
Grassadonia A, Cioffi P, Simiele F, Iezzi L, Zilli M and Natoli C: Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies. Cancers (Basel) 5: 919-942, 2013.
-
(2013)
Cancers (Basel)
, vol.5
, pp. 919-942
-
-
Grassadonia, A.1
Cioffi, P.2
Simiele, F.3
Iezzi, L.4
Zilli, M.5
Natoli, C.6
-
34
-
-
84907546075
-
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome
-
Ouaïssi M, Silvy F, Loncle C, Ferraz da Silva D, Martins Abreu C, Martinez E, Berthézene P, Cadra S, Le Treut YP, Hardwigsen J, Sastre B, Sielezneff I, Benkoel L, Delgrande J, Ouaissi A, Iovanna J, Lombardo D and Mas E: Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome. PLoS One 9: e108520, 2014.
-
(2014)
PLoS One
, vol.9
-
-
Ouaïssi, M.1
Silvy, F.2
Loncle, C.3
Ferraz Da Silva, D.4
Martins Abreu, C.5
Martinez, E.6
Berthézene, P.7
Cadra, S.8
Le Treut, Y.P.9
Hardwigsen, J.10
Sastre, B.11
Sielezneff, I.12
Benkoel, L.13
Delgrande, J.14
Ouaissi, A.15
Iovanna, J.16
Lombardo, D.17
Mas, E.18
-
35
-
-
84898406503
-
Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer
-
Feng W, Zhang B, Cai D and Zou X: Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer. Cancer Lett 347: 183-190, 2014.
-
(2014)
Cancer Lett
, vol.347
, pp. 183-190
-
-
Feng, W.1
Zhang, B.2
Cai, D.3
Zou, X.4
-
36
-
-
84884950651
-
Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas
-
Li J, Bonifati S, Hristov G, Marttila T, Valmary-Degano S, Stanzel S, Schnölzer M, Mougin C, Aprahamian M, Grekova SP, Raykov Z, Rommelaere J and Marchini A: Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas. EMBO Mol Med 5: 1537-1555, 2013.
-
(2013)
EMBO Mol Med
, vol.5
, pp. 1537-1555
-
-
Li, J.1
Bonifati, S.2
Hristov, G.3
Marttila, T.4
Valmary-Degano, S.5
Stanzel, S.6
Schnölzer, M.7
Mougin, C.8
Aprahamian, M.9
Grekova, S.P.10
Raykov, Z.11
Rommelaere, J.12
Marchini, A.13
-
37
-
-
84860283904
-
An epigenetic approach to pancreatic cancer treatment: The prospective role of histone deacetylase inhibitors
-
Tinari N, De Tursi M, Grassadonia A, Zilli M, Stuppia L, Iacobelli S and Natoli C: An epigenetic approach to pancreatic cancer treatment: the prospective role of histone deacetylase inhibitors. Curr Cancer Drug Targets 12: 439-452, 2012.
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 439-452
-
-
Tinari, N.1
De Tursi, M.2
Grassadonia, A.3
Zilli, M.4
Stuppia, L.5
Iacobelli, S.6
Natoli, C.7
-
38
-
-
79951894022
-
Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines
-
Iwahashi S, Ishibashi H, Utsunomiya T, Morine Y, Ochir TL, Hanaoka J, Mori H, Ikemoto T, Imura S and Shimada M: Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines. J Med Invest 58: 106-109, 2011.
-
(2011)
J Med Invest
, vol.58
, pp. 106-109
-
-
Iwahashi, S.1
Ishibashi, H.2
Utsunomiya, T.3
Morine, Y.4
Ochir, T.L.5
Hanaoka, J.6
Mori, H.7
Ikemoto, T.8
Imura, S.9
Shimada, M.10
-
39
-
-
84991442304
-
Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer
-
Paller CJ, Wissing MD, Mendonca J, Sharma A, Kim E, Kim HS, Kortenhorst MS, Gerber S, Rosen M, Shaikh F, Zahurak ML, Rudek MA, Hammers H, Rudin CM, Carducci MA and Kachhap SK: Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer. Cancer Med 3: 1322-1335, 2014.
-
(2014)
Cancer Med
, vol.3
, pp. 1322-1335
-
-
Paller, C.J.1
Wissing, M.D.2
Mendonca, J.3
Sharma, A.4
Kim, E.5
Kim, H.S.6
Kortenhorst, M.S.7
Gerber, S.8
Rosen, M.9
Shaikh, F.10
Zahurak, M.L.11
Rudek, M.A.12
Hammers, H.13
Rudin, C.M.14
Carducci, M.A.15
Kachhap, S.K.16
-
40
-
-
84920836032
-
Epigenetic therapy of cancer with histone deacetylase inhibitors
-
Lakshmaiah KC, Jacob LA, Aparna S, Lokanatha D and Saldanha SC: Epigenetic therapy of cancer with histone deacetylase inhibitors. J Cancer Res Ther 10: 469-478, 2014.
-
(2014)
J Cancer Res Ther
, vol.10
, pp. 469-478
-
-
Lakshmaiah, K.C.1
Jacob, L.A.2
Aparna, S.3
Lokanatha, D.4
Saldanha, S.C.5
-
41
-
-
84871273907
-
Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer
-
Wang G, He J, Zhao J, Yun W, Xie C, Taub JW, Azmi A, Mohammad RM, Dong Y, Kong W, Guo Y and Ge Y: Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer. PLoS One 7: e52095, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Wang, G.1
He, J.2
Zhao, J.3
Yun, W.4
Xie, C.5
Taub, J.W.6
Azmi, A.7
Mohammad, R.M.8
Dong, Y.9
Kong, W.10
Guo, Y.11
Ge, Y.12
-
42
-
-
0141954051
-
Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells
-
Donadelli M, Costanzo C, Faggioli L, Scupoli MT, Moore PS, Bassi C, Scarpa A and Palmieri M: Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells. Mol Carcinog 38: 59-69, 2003.
-
(2003)
Mol Carcinog
, vol.38
, pp. 59-69
-
-
Donadelli, M.1
Costanzo, C.2
Faggioli, L.3
Scupoli, M.T.4
Moore, P.S.5
Bassi, C.6
Scarpa, A.7
Palmieri, M.8
-
43
-
-
33646533106
-
SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines
-
Ryu JK, Lee WJ, Lee KH, Hwang JH, Kim YT, Yoon YB and Kim CY: SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. Cancer Lett 237: 143-154, 2006.
-
(2006)
Cancer Lett
, vol.237
, pp. 143-154
-
-
Ryu, J.K.1
Lee, W.J.2
Lee, K.H.3
Hwang, J.H.4
Kim, Y.T.5
Yoon, Y.B.6
Kim, C.Y.7
-
44
-
-
34447307175
-
HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2
-
Schneider G, Reichert M, Saur D, Hamacher R, Fritsch R and Schmid RM: HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. Cell Prolif 40: 522-531, 2007.
-
(2007)
Cell Prolif
, vol.40
, pp. 522-531
-
-
Schneider, G.1
Reichert, M.2
Saur, D.3
Hamacher, R.4
Fritsch, R.5
Schmid, R.M.6
-
45
-
-
4444223456
-
Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells
-
Moore PS, Barbi S, Donadelli M, Costanzo C, Bassi C, Palmieri M and Scarpa A: Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. Biochim Biophys Acta 1693: 167-176, 2004.
-
(2004)
Biochim Biophys Acta
, vol.1693
, pp. 167-176
-
-
Moore, P.S.1
Barbi, S.2
Donadelli, M.3
Costanzo, C.4
Bassi, C.5
Palmieri, M.6
Scarpa, A.7
-
46
-
-
67649200336
-
E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex
-
von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G and Saur D: E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology 137: 361-371, 2009.
-
(2009)
Gastroenterology
, vol.137
, pp. 361-371
-
-
Von Burstin, J.1
Eser, S.2
Paul, M.C.3
Seidler, B.4
Brandl, M.5
Messer, M.6
Von Werder, A.7
Schmidt, A.8
Mages, J.9
Pagel, P.10
Schnieke, A.11
Schmid, R.M.12
Schneider, G.13
Saur, D.14
-
47
-
-
38449114690
-
The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells
-
Gahr S, Ocker M, Ganslmayer M, Zopf S, Okamoto K, Hartl A, Leitner S, Hahn EG and Herold C: The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. Int J Oncol 31: 567-576, 2007.
-
(2007)
Int J Oncol
, vol.31
, pp. 567-576
-
-
Gahr, S.1
Ocker, M.2
Ganslmayer, M.3
Zopf, S.4
Okamoto, K.5
Hartl, A.6
Leitner, S.7
Hahn, E.G.8
Herold, C.9
-
48
-
-
33744749272
-
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation
-
Piacentini P, Donadelli M, Costanzo C, Moore PS, Palmieri M and Scarpa A: Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. Virchows Arch 448: 797-804, 2006.
-
(2006)
Virchows Arch
, vol.448
, pp. 797-804
-
-
Piacentini, P.1
Donadelli, M.2
Costanzo, C.3
Moore, P.S.4
Palmieri, M.5
Scarpa, A.6
-
49
-
-
54349084579
-
Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors
-
Haefner M, Bluethner T, Niederhagen M, Moebius C, Wittekind C, Mossner J, Caca K and Wiedmann M: Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors. World J Gastroenterol 14: 3681-3692, 2008.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 3681-3692
-
-
Haefner, M.1
Bluethner, T.2
Niederhagen, M.3
Moebius, C.4
Wittekind, C.5
Mossner, J.6
Caca, K.7
Wiedmann, M.8
-
50
-
-
84872807024
-
Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer
-
Venkannagari S, Fiskus W, Peth K, Atadja P, Hidalgo M, Maitra A and Bhalla KN: Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer. Oncotarget 3: 1416-1427, 2012.
-
(2012)
Oncotarget
, vol.3
, pp. 1416-1427
-
-
Venkannagari, S.1
Fiskus, W.2
Peth, K.3
Atadja, P.4
Hidalgo, M.5
Maitra, A.6
Bhalla, K.N.7
-
51
-
-
84862163445
-
HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA)
-
Mehdi O, Françoise S, Sofia CL, Urs G, Kevin Z, Bernard S, Igor S, Anabela CD, Dominique L, Eric M and Ali O: HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). Pancreatology 12: 146-155, 2012.
-
(2012)
Pancreatology
, vol.12
, pp. 146-155
-
-
Mehdi, O.1
Françoise, S.2
Sofia, C.L.3
Urs, G.4
Kevin, Z.5
Bernard, S.6
Igor, S.7
Anabela, C.D.8
Dominique, L.9
Eric, M.10
Ali, O.11
-
52
-
-
84919494726
-
Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer
-
Wang G, Niu X, Zhang W, Caldwell JT, Edwards H, Chen W, Taub JW, Zhao L and Ge Y: Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer. Cancer Lett 356: 656-668, 2015.
-
(2015)
Cancer Lett
, vol.356
, pp. 656-668
-
-
Wang, G.1
Niu, X.2
Zhang, W.3
Caldwell, J.T.4
Edwards, H.5
Chen, W.6
Taub, J.W.7
Zhao, L.8
Ge, Y.9
-
53
-
-
34250810709
-
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells
-
Kumagai T, Wakimoto N, Yin D, Gery S, Kawamata N, Takai N, Komatsu N, Chumakov A, Imai Y and Koeffler HP: Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. Int J Cancer 121: 656-665, 2007.
-
(2007)
Int J Cancer
, vol.121
, pp. 656-665
-
-
Kumagai, T.1
Wakimoto, N.2
Yin, D.3
Gery, S.4
Kawamata, N.5
Takai, N.6
Komatsu, N.7
Chumakov, A.8
Imai, Y.9
Koeffler, H.P.10
-
54
-
-
33645737411
-
Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki ST, Carew JS, Pino MS, Highshaw RA, Andtbacka RH, Dunner K Jr, Pal A, Bornmann WG, Chiao PJ, Huang P, Xiong H, Abbruzzese JL and McConkey DJ: Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res 66: 3773-3781, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
Highshaw, R.A.4
Andtbacka, R.H.5
Dunner, K.6
Pal, A.7
Bornmann, W.G.8
Chiao, P.J.9
Huang, P.10
Xiong, H.11
Abbruzzese, J.L.12
McConkey, D.J.13
-
55
-
-
33846327942
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer
-
Arnold NB, Arkus N, Gunn J and Korc M: The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer. Clin Cancer Res 13: 18-26, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 18-26
-
-
Arnold, N.B.1
Arkus, N.2
Gunn, J.3
Korc, M.4
-
56
-
-
76249090605
-
Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer
-
Chun SG, Zhou W and Yee NS: Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol Ther 8: 1328-1339, 2009.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1328-1339
-
-
Chun, S.G.1
Zhou, W.2
Yee, N.S.3
-
57
-
-
84861957148
-
Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer
-
Dovzhanskiy DI, Arnold SM, Hackert T, Oehme I, Witt O, Felix K, Giese N and Werner J: Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer. BMC Cancer 12: 226, 2012.
-
(2012)
BMC Cancer
, vol.12
, pp. 226
-
-
Dovzhanskiy, D.I.1
Arnold, S.M.2
Hackert, T.3
Oehme, I.4
Witt, O.5
Felix, K.6
Giese, N.7
Werner, J.8
-
58
-
-
79956071947
-
Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines
-
Spratlin JL, Pitts TM, Kulikowski GN, Morelli MP, Tentler JJ, Serkova NJ and Eckhardt SG: Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines. Anticancer Res 31: 1093-1103, 2011.
-
(2011)
Anticancer Res
, vol.31
, pp. 1093-1103
-
-
Spratlin, J.L.1
Pitts, T.M.2
Kulikowski, G.N.3
Morelli, M.P.4
Tentler, J.J.5
Serkova, N.J.6
Eckhardt, S.G.7
-
59
-
-
24944504460
-
Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways
-
Natoni F, Diolordi L, Santoni C and Gilardini Montani MS: Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways. Biochim Biophys Acta 1745: 318-329, 2005.
-
(2005)
Biochim Biophys Acta
, vol.1745
, pp. 318-329
-
-
Natoni, F.1
Diolordi, L.2
Santoni, C.3
Gilardini Montani, M.S.4
-
60
-
-
33846239420
-
Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells
-
Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grutzmann R, Saeger HD, Janssen O, Sipos B, Kloppel G and Kalthoff H: Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br J Cancer 96: 73-81, 2007.
-
(2007)
Br J Cancer
, vol.96
, pp. 73-81
-
-
Ammerpohl, O.1
Trauzold, A.2
Schniewind, B.3
Griep, U.4
Pilarsky, C.5
Grutzmann, R.6
Saeger, H.D.7
Janssen, O.8
Sipos, B.9
Kloppel, G.10
Kalthoff, H.11
-
61
-
-
6044264858
-
FR901228, a novel histone deacetylase inhibitor, induces cell cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells
-
Sato N, Ohta T, Kitagawa H, Kayahara M, Ninomiya I, Fushida S, Fujimura T, Nishimura G, Shimizu K and Miwa K: FR901228, a novel histone deacetylase inhibitor, induces cell cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells. Int J Oncol 24: 679-685, 2004.
-
(2004)
Int J Oncol
, vol.24
, pp. 679-685
-
-
Sato, N.1
Ohta, T.2
Kitagawa, H.3
Kayahara, M.4
Ninomiya, I.5
Fushida, S.6
Fujimura, T.7
Nishimura, G.8
Shimizu, K.9
Miwa, K.10
-
62
-
-
70349309923
-
HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA
-
Fritsche P, Seidler B, Schüler S, Schnieke A, Göttlicher M, Schmid RM, Saur D and Schneider G: HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA. Gut 58: 1399-1409, 2009.
-
(2009)
Gut
, vol.58
, pp. 1399-1409
-
-
Fritsche, P.1
Seidler, B.2
Schüler, S.3
Schnieke, A.4
Göttlicher, M.5
Schmid, R.M.6
Saur, D.7
Schneider, G.8
|