메뉴 건너뛰기




Volumn 347, Issue 2, 2014, Pages 183-190

Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer

Author keywords

Combination therapy; HDAC inhibitors; Histone deacetylases; Pancreatic cancer

Indexed keywords

BORTEZOMIB; CAPECITABINE; DACINOSTAT; ENTINOSTAT; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; GEFITINIB; GEMCITABINE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; IRINOTECAN; MOCETINOSTAT; PANOBINOSTAT; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; TACEDINALINE; VALPROIC ACID; VORINOSTAT;

EID: 84898406503     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.02.012     Document Type: Review
Times cited : (48)

References (110)
  • 4
    • 67349117952 scopus 로고    scopus 로고
    • Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy
    • Rivera F., López-Tarruella S., Vega-Villegas M.E., Salcedo M. Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy. Cancer Treat. Rev. 2009, 35:335-339.
    • (2009) Cancer Treat. Rev. , vol.35 , pp. 335-339
    • Rivera, F.1    López-Tarruella, S.2    Vega-Villegas, M.E.3    Salcedo, M.4
  • 5
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore M.J., Goldstein D., Hamm J., Figer A., Hecht J.R., Gallinger S., Au H.J., Murawa P., Walde D., Wolff R.A. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007, 25:1960-1966.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6    Au, H.J.7    Murawa, P.8    Walde, D.9    Wolff, R.A.10
  • 8
    • 80051519812 scopus 로고    scopus 로고
    • Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells
    • Ito T., Kojima T., Yamaguchi H., Kyuno D., Kimura Y., Imamura M., Takasawa A., Murata M., Tanaka S., Hirata K. Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells. J. Cell. Biochem. 2011, 112:1761-1772.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 1761-1772
    • Ito, T.1    Kojima, T.2    Yamaguchi, H.3    Kyuno, D.4    Kimura, Y.5    Imamura, M.6    Takasawa, A.7    Murata, M.8    Tanaka, S.9    Hirata, K.10
  • 9
    • 77953169001 scopus 로고    scopus 로고
    • MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
    • Giovannetti E., Funel N., Peters G.J., Del Chiaro M., Erozenci L.A., Vasile E., Leon L.G., Pollina L.E., Groen A., Falcone A. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res. 2010, 70:4528-4538.
    • (2010) Cancer Res. , vol.70 , pp. 4528-4538
    • Giovannetti, E.1    Funel, N.2    Peters, G.J.3    Del Chiaro, M.4    Erozenci, L.A.5    Vasile, E.6    Leon, L.G.7    Pollina, L.E.8    Groen, A.9    Falcone, A.10
  • 10
    • 79960309513 scopus 로고    scopus 로고
    • Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma
    • Vincent A., Omura N., Hong S.-M., Jaffe A., Eshleman J., Goggins M. Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma. Clin. Cancer Res. 2011, 17:4341-4354.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4341-4354
    • Vincent, A.1    Omura, N.2    Hong, S.-M.3    Jaffe, A.4    Eshleman, J.5    Goggins, M.6
  • 11
    • 84898472897 scopus 로고    scopus 로고
    • Road to early detection of pancreatic cancer: attempts to utilize epigenetic biomarkers
    • Fukushige S., Horii A. Road to early detection of pancreatic cancer: attempts to utilize epigenetic biomarkers. Cancer Lett. 2012.
    • (2012) Cancer Lett.
    • Fukushige, S.1    Horii, A.2
  • 12
    • 77954354936 scopus 로고    scopus 로고
    • Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels
    • Li A., Omura N., Hong S.-M., Vincent A., Walter K., Griffith M., Borges M., Goggins M. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 2010, 70:5226-5237.
    • (2010) Cancer Res. , vol.70 , pp. 5226-5237
    • Li, A.1    Omura, N.2    Hong, S.-M.3    Vincent, A.4    Walter, K.5    Griffith, M.6    Borges, M.7    Goggins, M.8
  • 14
    • 79961187284 scopus 로고    scopus 로고
    • Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development
    • Zhang S., Hao J., Xie F., Hu X., Liu C., Tong J., Zhou J., Wu J., Shao C. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis 2011, 32:1183-1189.
    • (2011) Carcinogenesis , vol.32 , pp. 1183-1189
    • Zhang, S.1    Hao, J.2    Xie, F.3    Hu, X.4    Liu, C.5    Tong, J.6    Zhou, J.7    Wu, J.8    Shao, C.9
  • 17
    • 79955678223 scopus 로고    scopus 로고
    • Developing histone deacetylase inhibitors as anti-cancer therapeutics
    • Venugopal B., Evans T. Developing histone deacetylase inhibitors as anti-cancer therapeutics. Curr. Med. Chem. 2011, 18:1658-1671.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 1658-1671
    • Venugopal, B.1    Evans, T.2
  • 18
    • 55949111630 scopus 로고    scopus 로고
    • Molecular basis of the anti-cancer effects of histone deacetylase inhibitors
    • Epping M.T., Bernards R. Molecular basis of the anti-cancer effects of histone deacetylase inhibitors. Int. J. Biochem. Cell Biol. 2009, 41:16-20.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 16-20
    • Epping, M.T.1    Bernards, R.2
  • 19
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • Lane A.A., Chabner B.A. Histone deacetylase inhibitors in cancer therapy. J. Clin. Oncol. 2009, 27:5459-5468.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 20
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer 2006, 6:38-51.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 22
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: targeting chromatin modifications
    • Ellis L., Atadja P.W., Johnstone R.W. Epigenetics in cancer: targeting chromatin modifications. Mol. Cancer Ther. 2009, 8:1409-1420.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 23
    • 56049090769 scopus 로고    scopus 로고
    • Acetylation of non-histone proteins modulates cellular signalling at multiple levels
    • Spange S., Wagner T., Heinzel T., Krämer O.H. Acetylation of non-histone proteins modulates cellular signalling at multiple levels. Int. J. Biochem. Cell Biol. 2009, 41:185-198.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 185-198
    • Spange, S.1    Wagner, T.2    Heinzel, T.3    Krämer, O.H.4
  • 24
    • 78649905409 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions
    • Marks P.A. Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim. Biophys. Acta (BBA) - Gene Regul. Mech. 2010, 1799:717-725.
    • (2010) Biochim. Biophys. Acta (BBA) - Gene Regul. Mech. , vol.1799 , pp. 717-725
    • Marks, P.A.1
  • 25
    • 67449127083 scopus 로고    scopus 로고
    • Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications
    • Schrump D.S. Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications. Clin. Cancer Res. 2009, 15:3947-3957.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3947-3957
    • Schrump, D.S.1
  • 29
    • 41149162821 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1 [alpha], histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation
    • Miyake K., Yoshizumi T., Imura S., Sugimoto K., Batmunkh E., Kanemura H., Morine Y., Shimada M. Expression of hypoxia-inducible factor-1 [alpha], histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation. Pancreas 2008, 36:e1-e9.
    • (2008) Pancreas , vol.36
    • Miyake, K.1    Yoshizumi, T.2    Imura, S.3    Sugimoto, K.4    Batmunkh, E.5    Kanemura, H.6    Morine, Y.7    Shimada, M.8
  • 30
    • 67649965963 scopus 로고    scopus 로고
    • Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer
    • Wang W., Gao J., Man X.-H., Li Z.-S., Gong Y.-F. Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer. Oncol. Rep. 2009, 21:1439-1447.
    • (2009) Oncol. Rep. , vol.21 , pp. 1439-1447
    • Wang, W.1    Gao, J.2    Man, X.-H.3    Li, Z.-S.4    Gong, Y.-F.5
  • 31
    • 48149115853 scopus 로고    scopus 로고
    • High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas
    • Ouaissi M., Sielezneff I., Sastre B., Dahan L., Pirrò N. High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas. Ann. Surg. Oncol. 2008, 15:2318-2328.
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 2318-2328
    • Ouaissi, M.1    Sielezneff, I.2    Sastre, B.3    Dahan, L.4    Pirrò, N.5
  • 33
    • 84874688338 scopus 로고    scopus 로고
    • Histone deacetylases as targets for treatment of multiple diseases
    • Tang J., Yan H., Zhuang S. Histone deacetylases as targets for treatment of multiple diseases. Clin. Sci. 2013, 124:651-662.
    • (2013) Clin. Sci. , vol.124 , pp. 651-662
    • Tang, J.1    Yan, H.2    Zhuang, S.3
  • 36
    • 49349098483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy[J]
    • Carew J.S., Giles F.J., Nawrocki S.T. Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy[J]. Cancer Lett. 2008, 269:7-17.
    • (2008) Cancer Lett. , vol.269 , pp. 7-17
    • Carew, J.S.1    Giles, F.J.2    Nawrocki, S.T.3
  • 37
    • 84855471990 scopus 로고    scopus 로고
    • HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications
    • Khan O., La Thangue N.B. HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol. Cell Biol. 2011, 90:85-94.
    • (2011) Immunol. Cell Biol. , vol.90 , pp. 85-94
    • Khan, O.1    La Thangue, N.B.2
  • 38
  • 41
    • 84874611509 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?
    • Koutsounas I., Giaginis C., Theocharis S. Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?. World J. Gastroenterol.: WJG 2013, 19:1173.
    • (2013) World J. Gastroenterol.: WJG , vol.19 , pp. 1173
    • Koutsounas, I.1    Giaginis, C.2    Theocharis, S.3
  • 43
    • 84906217157 scopus 로고    scopus 로고
    • Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo
    • Chien W., Lee D.H., Zheng Y., Wuensche P., Alvarez R., Wen D.L., Aribi A.M., Thean S.M., Doan N.B., Said J.W. Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo. Mol. Carcinogen. 2013.
    • (2013) Mol. Carcinogen.
    • Chien, W.1    Lee, D.H.2    Zheng, Y.3    Wuensche, P.4    Alvarez, R.5    Wen, D.L.6    Aribi, A.M.7    Thean, S.M.8    Doan, N.B.9    Said, J.W.10
  • 44
    • 79956198574 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor MGCD0103 synergizes with gemcitabine in human pancreatic cells
    • Sung V., Richard N., Brady H., Maier A., Kelter G., Heise C. Histone deacetylase inhibitor MGCD0103 synergizes with gemcitabine in human pancreatic cells. Cancer Sci. 2011, 102:1201-1207.
    • (2011) Cancer Sci. , vol.102 , pp. 1201-1207
    • Sung, V.1    Richard, N.2    Brady, H.3    Maier, A.4    Kelter, G.5    Heise, C.6
  • 45
    • 84876807758 scopus 로고    scopus 로고
    • Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells
    • Qiao Z., Ren S., Li W., Wang X., He M., Guo Y., Sun L., He Y., Ge Y., Yu Q. Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 2013.
    • (2013) Biochem. Biophys. Res. Commun.
    • Qiao, Z.1    Ren, S.2    Li, W.3    Wang, X.4    He, M.5    Guo, Y.6    Sun, L.7    He, Y.8    Ge, Y.9    Yu, Q.10
  • 46
    • 4444223456 scopus 로고    scopus 로고
    • Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro-and anti-apoptotic genes in pancreatic adenocarcinoma cells
    • Moore P.S., Barbi S., Donadelli M., Costanzo C., Bassi C., Palmieri M., Scarpa A. Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro-and anti-apoptotic genes in pancreatic adenocarcinoma cells. Biochim. Biophys. Acta (BBA) - Mol. Cell Res. 2004, 1693:167-176.
    • (2004) Biochim. Biophys. Acta (BBA) - Mol. Cell Res. , vol.1693 , pp. 167-176
    • Moore, P.S.1    Barbi, S.2    Donadelli, M.3    Costanzo, C.4    Bassi, C.5    Palmieri, M.6    Scarpa, A.7
  • 48
    • 84871273907 scopus 로고    scopus 로고
    • Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer
    • Wang G., He J., Zhao J., Yun W., Xie C., Taub J.W., Azmi A., Mohammad R.M., Dong Y., Kong W. Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer. PLoS ONE 2012, 7:e52095.
    • (2012) PLoS ONE , vol.7
    • Wang, G.1    He, J.2    Zhao, J.3    Yun, W.4    Xie, C.5    Taub, J.W.6    Azmi, A.7    Mohammad, R.M.8    Dong, Y.9    Kong, W.10
  • 49
    • 84876084668 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in pancreatic cancer
    • Arlt A., Müerköster S.S., Schäfer H. Targeting apoptosis pathways in pancreatic cancer. Cancer Lett. 2013, 332:346-358.
    • (2013) Cancer Lett. , vol.332 , pp. 346-358
    • Arlt, A.1    Müerköster, S.S.2    Schäfer, H.3
  • 50
    • 77955584671 scopus 로고    scopus 로고
    • C-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589
    • Kauh J., Fan S., Xia M., Yue P., Yang L., Khuri F.R., Sun S.-Y. C-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589. PLoS ONE 2010, 5:e10376.
    • (2010) PLoS ONE , vol.5
    • Kauh, J.1    Fan, S.2    Xia, M.3    Yue, P.4    Yang, L.5    Khuri, F.R.6    Sun, S.-Y.7
  • 52
  • 53
    • 67650090545 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: potential in cancer therapy
    • Marks P., Xu W.S. Histone deacetylase inhibitors: potential in cancer therapy. J. Cell Biochem. 2009, 107:600-608.
    • (2009) J. Cell Biochem. , vol.107 , pp. 600-608
    • Marks, P.1    Xu, W.S.2
  • 54
    • 84861679278 scopus 로고    scopus 로고
    • HDAC modulation and cell death in the clinic
    • Dell'Aversana C., Lepore I., Altucci L. HDAC modulation and cell death in the clinic. Exp. Cell Res. 2012, 318:1229-1244.
    • (2012) Exp. Cell Res. , vol.318 , pp. 1229-1244
    • Dell'Aversana, C.1    Lepore, I.2    Altucci, L.3
  • 55
    • 49849103540 scopus 로고    scopus 로고
    • Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
    • Newbold A., Lindemann R.K., Cluse L.A., Whitecross K.F., Dear A.E., Johnstone R.W. Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin. Mol. Cancer Ther. 2008, 7:1066-1079.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1066-1079
    • Newbold, A.1    Lindemann, R.K.2    Cluse, L.A.3    Whitecross, K.F.4    Dear, A.E.5    Johnstone, R.W.6
  • 56
    • 79956125729 scopus 로고    scopus 로고
    • Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737
    • Wiegmans A.P., Alsop A.E., Bots M., Cluse L.A., Williams S.P., Banks K.-M., Ralli R., Scott C.L., Frenzel A., Villunger A. Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737. Cancer Res. 2011, 71:3603-3615.
    • (2011) Cancer Res. , vol.71 , pp. 3603-3615
    • Wiegmans, A.P.1    Alsop, A.E.2    Bots, M.3    Cluse, L.A.4    Williams, S.P.5    Banks, K.-M.6    Ralli, R.7    Scott, C.L.8    Frenzel, A.9    Villunger, A.10
  • 60
    • 33751185927 scopus 로고    scopus 로고
    • Thioredoxin in cancer-role of histone deacetylase inhibitors
    • P.A. Marks, Thioredoxin in cancer-role of histone deacetylase inhibitors, in: Seminars in Cancer Biology, Elsevier, 2006, pp. 436-443.
    • (2006) Seminars in Cancer Biology, Elsevier , pp. 436-443
    • Marks, P.A.1
  • 61
    • 84868318802 scopus 로고    scopus 로고
    • In vivo redox state of Human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)
    • Ungerstedt J., Du Y., Zhang H., Nair D., Holmgren A. In vivo redox state of Human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Free Radical Biol. Med. 2012.
    • (2012) Free Radical Biol. Med.
    • Ungerstedt, J.1    Du, Y.2    Zhang, H.3    Nair, D.4    Holmgren, A.5
  • 63
    • 84880511425 scopus 로고    scopus 로고
    • Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis
    • Wang B., Wang X.-b., Chen L.-y., Huang L., Dong R.-Z. Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis. Biochem. Biophys. Res. Commun. 2013.
    • (2013) Biochem. Biophys. Res. Commun.
    • Wang, B.1    Wang, X.-B.2    Chen, L.-Y.3    Huang, L.4    Dong, R.-Z.5
  • 64
    • 67349201377 scopus 로고    scopus 로고
    • Targeting tumor angiogenesis with histone deacetylase inhibitors
    • Ellis L., Hammers H., Pili R. Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett. 2009, 280:145-153.
    • (2009) Cancer Lett. , vol.280 , pp. 145-153
    • Ellis, L.1    Hammers, H.2    Pili, R.3
  • 66
    • 75149157036 scopus 로고    scopus 로고
    • Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors
    • Chen L., Endler A., Shibasaki F. Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors. Exp. Mol. Med. 2009, 41:849-857.
    • (2009) Exp. Mol. Med. , vol.41 , pp. 849-857
    • Chen, L.1    Endler, A.2    Shibasaki, F.3
  • 67
    • 77955581767 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: advancing therapeutic strategies in hematological and solid malignancies
    • Ellis L., Pili R. Histone deacetylase inhibitors: advancing therapeutic strategies in hematological and solid malignancies. Pharmaceuticals 2010, 3:2441-2469.
    • (2010) Pharmaceuticals , vol.3 , pp. 2441-2469
    • Ellis, L.1    Pili, R.2
  • 68
    • 45549101405 scopus 로고    scopus 로고
    • Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7
    • Wang S., Li X., Parra M., Verdin E., Bassel-Duby R., Olson E.N. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc. Nat. Acad. Sci. 2008, 105:7738-7743.
    • (2008) Proc. Nat. Acad. Sci. , vol.105 , pp. 7738-7743
    • Wang, S.1    Li, X.2    Parra, M.3    Verdin, E.4    Bassel-Duby, R.5    Olson, E.N.6
  • 69
    • 33645950778 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: multifunctional anticancer agents
    • Liu T., Kuljaca S., Tee A., Marshall G.M. Histone deacetylase inhibitors: multifunctional anticancer agents. Cancer Treat. Rev. 2006, 32:157-165.
    • (2006) Cancer Treat. Rev. , vol.32 , pp. 157-165
    • Liu, T.1    Kuljaca, S.2    Tee, A.3    Marshall, G.M.4
  • 71
    • 79952264551 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in pancreatic carcinoma
    • Maier H.J., Wirth T., Beug H. Epithelial-mesenchymal transition in pancreatic carcinoma. Cancers (Basel) 2010, 2:2058-2083.
    • (2010) Cancers (Basel) , vol.2 , pp. 2058-2083
    • Maier, H.J.1    Wirth, T.2    Beug, H.3
  • 72
    • 84857055686 scopus 로고    scopus 로고
    • Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
    • Aghdassi A., Sendler M., Guenther A., Mayerle J., Behn C.-O., Heidecke C.-D., Friess H., Büchler M., Evert M., Lerch M.M. Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. Gut 2012, 61:439-448.
    • (2012) Gut , vol.61 , pp. 439-448
    • Aghdassi, A.1    Sendler, M.2    Guenther, A.3    Mayerle, J.4    Behn, C.-O.5    Heidecke, C.-D.6    Friess, H.7    Büchler, M.8    Evert, M.9    Lerch, M.M.10
  • 73
    • 34250810709 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells
    • Kumagai T., Wakimoto N., Yin D., Gery S., Kawamata N., Takai N., Komatsu N., Chumakov A., Imai Y., Koeffler H.P. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. Int. J. Cancer 2007, 121:656-665.
    • (2007) Int. J. Cancer , vol.121 , pp. 656-665
    • Kumagai, T.1    Wakimoto, N.2    Yin, D.3    Gery, S.4    Kawamata, N.5    Takai, N.6    Komatsu, N.7    Chumakov, A.8    Imai, Y.9    Koeffler, H.P.10
  • 77
    • 77952199908 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression
    • Jeon H.W., Lee Y.M. Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression. Mol. Cancer Ther. 2010, 9:1361-1370.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1361-1370
    • Jeon, H.W.1    Lee, Y.M.2
  • 78
    • 0038408486 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion
    • Liu L.-T., Chang H.-C., Chiang L.-C., Hung W.-C. Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. Cancer Res. 2003, 63:3069-3072.
    • (2003) Cancer Res. , vol.63 , pp. 3069-3072
    • Liu, L.-T.1    Chang, H.-C.2    Chiang, L.-C.3    Hung, W.-C.4
  • 79
    • 79952158522 scopus 로고    scopus 로고
    • Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer
    • Thurn K.T., Thomas S., Moore A., Munster P.N. Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer. Future Oncol. 2011, 7:263-283.
    • (2011) Future Oncol. , vol.7 , pp. 263-283
    • Thurn, K.T.1    Thomas, S.2    Moore, A.3    Munster, P.N.4
  • 81
    • 33745629366 scopus 로고    scopus 로고
    • Gemcitabine plus CI-994 offers no advantage over gemcitabine alone in the treatment of patients with advanced pancreatic cancer: results of a phase II randomized, double-blind, placebo-controlled, multicenter study
    • Richards D., Boehm K., Waterhouse D., Wagener D., Krishnamurthi S., Rosemurgy A., Grove W., Macdonald K., Gulyas S., Clark M. Gemcitabine plus CI-994 offers no advantage over gemcitabine alone in the treatment of patients with advanced pancreatic cancer: results of a phase II randomized, double-blind, placebo-controlled, multicenter study. Ann. Oncol. 2006, 17:1096-1102.
    • (2006) Ann. Oncol. , vol.17 , pp. 1096-1102
    • Richards, D.1    Boehm, K.2    Waterhouse, D.3    Wagener, D.4    Krishnamurthi, S.5    Rosemurgy, A.6    Grove, W.7    Macdonald, K.8    Gulyas, S.9    Clark, M.10
  • 82
    • 84871407100 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination
    • Millward M., Price T., Townsend A., Sweeney C., Spencer A., Sukumaran S., Longenecker A., Lee L., Lay A., Sharma G. Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. Invest. New Drug 2012, 30:2303-2317.
    • (2012) Invest. New Drug , vol.30 , pp. 2303-2317
    • Millward, M.1    Price, T.2    Townsend, A.3    Sweeney, C.4    Spencer, A.5    Sukumaran, S.6    Longenecker, A.7    Lee, L.8    Lay, A.9    Sharma, G.10
  • 83
    • 59149098431 scopus 로고    scopus 로고
    • A phase I trial of romidepsin in combination with gemcitabine in patients with pancreatic and other advanced solid tumors
    • Doss H., Jones S., Infante J., Spigel D., Willcutt N., Lamar R., Barton J., Keegan M., Burris H. A phase I trial of romidepsin in combination with gemcitabine in patients with pancreatic and other advanced solid tumors. J. Clin. Oncol. 2008, 26:25-67.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 25-67
    • Doss, H.1    Jones, S.2    Infante, J.3    Spigel, D.4    Willcutt, N.5    Lamar, R.6    Barton, J.7    Keegan, M.8    Burris, H.9
  • 84
    • 84863339591 scopus 로고    scopus 로고
    • Phase II study of panobinostat and bortezomib in patients with pancreatic cancer progressing on gemcitabine-based therapy
    • Wang H., Cao Q., Dudek A.Z. Phase II study of panobinostat and bortezomib in patients with pancreatic cancer progressing on gemcitabine-based therapy. Anticancer Res. 2012, 32:1027-1031.
    • (2012) Anticancer Res. , vol.32 , pp. 1027-1031
    • Wang, H.1    Cao, Q.2    Dudek, A.Z.3
  • 86
    • 58149183232 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors
    • de Bono J.S., Kristeleit R., Tolcher A., Fong P., Pacey S., Karavasilis V., Mita M., Shaw H., Workman P., Kaye S. Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors. Clin. Cancer Res. 2008, 14:6663-6673.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6663-6673
    • de Bono, J.S.1    Kristeleit, R.2    Tolcher, A.3    Fong, P.4    Pacey, S.5    Karavasilis, V.6    Mita, M.7    Shaw, H.8    Workman, P.9    Kaye, S.10
  • 88
    • 23644437797 scopus 로고    scopus 로고
    • Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: a randomised phase II trial of the Italian oncology group for clinical research (GOIRC)
    • Di Costanzo F., Carlini P., Doni L., Massidda B., Mattioli R., Iop A., Barletta E., Moscetti L., Recchia F., Tralongo P. Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: a randomised phase II trial of the Italian oncology group for clinical research (GOIRC). Brit. J. Cancer 2005, 93:185-189.
    • (2005) Brit. J. Cancer , vol.93 , pp. 185-189
    • Di Costanzo, F.1    Carlini, P.2    Doni, L.3    Massidda, B.4    Mattioli, R.5    Iop, A.6    Barletta, E.7    Moscetti, L.8    Recchia, F.9    Tralongo, P.10
  • 89
    • 73949094909 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer: CALGB 89904
    • Kulke M.H., Tempero M.A., Niedzwiecki D., Hollis D.R., Kindler H.L., Cusnir M., Enzinger P.C., Gorsch S.M., Goldberg R.M., Mayer R.J. Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer: CALGB 89904. J. Clin. Oncol. 2009, 27:5506-5512.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5506-5512
    • Kulke, M.H.1    Tempero, M.A.2    Niedzwiecki, D.3    Hollis, D.R.4    Kindler, H.L.5    Cusnir, M.6    Enzinger, P.C.7    Gorsch, S.M.8    Goldberg, R.M.9    Mayer, R.J.10
  • 90
    • 77950498286 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study
    • Colucci G., Labianca R., Di Costanzo F., Gebbia V., Cartenì G., Massidda B., Dapretto E., Manzione L., Piazza E., Sannicolò M. Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J. Clin. Oncol. 2010, 28:1645-1651.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1645-1651
    • Colucci, G.1    Labianca, R.2    Di Costanzo, F.3    Gebbia, V.4    Cartenì, G.5    Massidda, B.6    Dapretto, E.7    Manzione, L.8    Piazza, E.9    Sannicolò, M.10
  • 91
    • 84861957148 scopus 로고    scopus 로고
    • Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer
    • Dovzhanskiy D.I., Arnold S.M., Hackert T., Oehme I., Witt O., Felix K., Giese N., Werner J. Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer. BMC Cancer 2012, 12:226.
    • (2012) BMC Cancer , vol.12 , pp. 226
    • Dovzhanskiy, D.I.1    Arnold, S.M.2    Hackert, T.3    Oehme, I.4    Witt, O.5    Felix, K.6    Giese, N.7    Werner, J.8
  • 92
    • 64649090292 scopus 로고    scopus 로고
    • Targeting DNA topoisomerase II in cancer chemotherapy
    • Nitiss J.L. Targeting DNA topoisomerase II in cancer chemotherapy. Nat. Rev. Cancer 2009, 9:338-350.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 338-350
    • Nitiss, J.L.1
  • 93
    • 33744749272 scopus 로고    scopus 로고
    • Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation
    • Piacentini P., Donadelli M., Costanzo C., Moore P.S., Palmieri M., Scarpa A. Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. Virchows Arch. 2006, 448:797-804.
    • (2006) Virchows Arch. , vol.448 , pp. 797-804
    • Piacentini, P.1    Donadelli, M.2    Costanzo, C.3    Moore, P.S.4    Palmieri, M.5    Scarpa, A.6
  • 94
    • 79956071947 scopus 로고    scopus 로고
    • Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines
    • Spratlin J., Pitts T., Kulikowski G., Morelli M., Tentler J., Serkova N., Eckhardt S. Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines. Anticancer Res. 2011, 31:1093-1103.
    • (2011) Anticancer Res. , vol.31 , pp. 1093-1103
    • Spratlin, J.1    Pitts, T.2    Kulikowski, G.3    Morelli, M.4    Tentler, J.5    Serkova, N.6    Eckhardt, S.7
  • 95
    • 33747874802 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells
    • Bai J., Demirjian A., Sui J., Marasco W., Callery M.P. Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 2006, 348:1245-1253.
    • (2006) Biochem. Biophys. Res. Commun. , vol.348 , pp. 1245-1253
    • Bai, J.1    Demirjian, A.2    Sui, J.3    Marasco, W.4    Callery, M.P.5
  • 97
    • 67449145358 scopus 로고    scopus 로고
    • Rational combinations using HDAC inhibitors
    • Bots M., Johnstone R.W. Rational combinations using HDAC inhibitors. Clin. Cancer Res. 2009, 15:3970-3977.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3970-3977
    • Bots, M.1    Johnstone, R.W.2
  • 98
    • 77955729630 scopus 로고    scopus 로고
    • Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy
    • Wright J.J. Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy. Clin. Cancer Res. 2010, 16:4094-4104.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4094-4104
    • Wright, J.J.1
  • 101
    • 76249090605 scopus 로고    scopus 로고
    • Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer
    • Chun S.G., Zhou W., Yee N.S. Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol. Ther. 2009, 8:1328-1339.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1328-1339
    • Chun, S.G.1    Zhou, W.2    Yee, N.S.3
  • 102
    • 80052600926 scopus 로고    scopus 로고
    • SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
    • Zhao G., Cui J., Zhang J., Qin Q., Chen Q., Yin T., Deng S., Liu Y., Liu L., Wang B. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. Gene Ther. 2011, 18:920-928.
    • (2011) Gene Ther. , vol.18 , pp. 920-928
    • Zhao, G.1    Cui, J.2    Zhang, J.3    Qin, Q.4    Chen, Q.5    Yin, T.6    Deng, S.7    Liu, Y.8    Liu, L.9    Wang, B.10
  • 103
    • 67349157687 scopus 로고    scopus 로고
    • Biomarkers for predicting clinical responses to HDAC inhibitors
    • Stimson L., La Thangue N.B. Biomarkers for predicting clinical responses to HDAC inhibitors. Cancer Lett. 2009, 280:177-183.
    • (2009) Cancer Lett. , vol.280 , pp. 177-183
    • Stimson, L.1    La Thangue, N.B.2
  • 105
    • 67349160499 scopus 로고    scopus 로고
    • HDAC expression and clinical prognosis in human malignancies
    • Weichert W. HDAC expression and clinical prognosis in human malignancies. Cancer Lett. 2009, 280:168-176.
    • (2009) Cancer Lett. , vol.280 , pp. 168-176
    • Weichert, W.1
  • 106
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G., Yang H., Bueso-Ramos C., Ferrajoli A., Cortes J., Wierda W.G., Faderl S., Koller C., Morris G., Rosner G. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008, 111:1060-1066.
    • (2008) Blood , vol.111 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3    Ferrajoli, A.4    Cortes, J.5    Wierda, W.G.6    Faderl, S.7    Koller, C.8    Morris, G.9    Rosner, G.10
  • 108
    • 77950865895 scopus 로고    scopus 로고
    • Potential role of HDAC inhibitors in cancer therapy: Insights into oral squamous cell carcinoma
    • Iglesias-Linares A., Yañez-Vico R.M., González-Moles M.A. Potential role of HDAC inhibitors in cancer therapy: Insights into oral squamous cell carcinoma. J. Oral oncology 2010, 46(5):323-329.
    • (2010) J. Oral oncology , vol.46 , Issue.5 , pp. 323-329
    • Iglesias-Linares, A.1    Yañez-Vico, R.M.2    González-Moles, M.A.3
  • 109
    • 49349098483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy
    • Carew J.S., Giles F.J., Nawrocki S.T. Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy. J. Cancer letters 2008, 269(1):7-17.
    • (2008) J. Cancer letters , vol.269 , Issue.1 , pp. 7-17
    • Carew, J.S.1    Giles, F.J.2    Nawrocki, S.T.3
  • 110
    • 67349285731 scopus 로고    scopus 로고
    • Enhancing the apoptotic and therapeutic effects of HDAC inhibitors
    • Frew A.J., Johnstone R.W., Bolden J.E. Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. J. Cancer letters 2009, 280(2):125-133.
    • (2009) J. Cancer letters , vol.280 , Issue.2 , pp. 125-133
    • Frew, A.J.1    Johnstone, R.W.2    Bolden, J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.