Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function

Journal of the American Heart Association

Volumn 3, Issue 6, 2014, Pages

  Villalba, Nuria ^a   Sonkusare, Swapnil K ^a   Longden, Thomas A ^a   Tran, Tram L ^a   Sackheim, Adrian M ^a   Nelson, Mark T ^a,b   Wellman, George C ^a   Freeman, Kalev ^a  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cerebral artery; Endothelium derived factors; Myogenic tone; Nitric oxide; Traumatic brain injury; Vascular endothelial function; Vascular reactivity

Indexed keywords

4,5 DIAMINOFLUORESCEIN; CALCIUM ION; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORESCENT DYE; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRIC OXIDE; UNCLASSIFIED DRUG; CALCIUM; ENZYME INHIBITOR; NOS2 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; CEREBRAL ARTERY TONE; CEREBROVASCULAR DISEASE; CEREBROVASCULAR TONE; CONTROLLED STUDY; ENZYME REGULATION; FLUORESCENCE ANALYSIS; GAIN OF FUNCTION MUTATION; MALE; NERVOUS SYSTEM PARAMETERS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE TONE; TRAUMATIC BRAIN INJURY; UPREGULATION; VASOCONSTRICTION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTERIAL PRESSURE; BRAIN ARTERY; BRAIN INJURY; CALCIUM SIGNALING; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; MECHANOTRANSDUCTION; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; ARTERIAL PRESSURE; BRAIN INJURIES; CALCIUM; CALCIUM SIGNALING; CEREBRAL ARTERIES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GUANYLATE CYCLASE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MECHANOTRANSDUCTION, CELLULAR; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UP-REGULATION; VASOCONSTRICTION; VASODILATION;

EID: 84931350240     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.001474     Document Type: Article

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