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Volumn 7, Issue 7, 2015, Pages 475-485

Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

Author keywords

Mitochondria targeted antioxidant; Mitochondrial reactive oxygen species; Wound healing

Indexed keywords

10-(6'-PLASTOQUINONYL)DECYLTRIPHENYLPHOSPHONIUM; ANTIOXIDANT; CADHERIN; CYTOKINE; PLASTOQUINONE; REACTIVE OXYGEN METABOLITE; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84931342218     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100772     Document Type: Article
Times cited : (48)

References (61)
  • 1
  • 2
    • 53249117183 scopus 로고    scopus 로고
    • Oxidative stress in normal and impaired wound repair
    • Schafer M and Werner S. Oxidative stress in normal and impaired wound repair. Pharmacol Res. 2008; 58: 165-171.
    • (2008) Pharmacol Res. , vol.58 , pp. 165-171
    • Schafer, M.1    Werner, S.2
  • 3
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol. 2004; 4: 181-189.
    • (2004) Nat Rev Immunol. , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 4
    • 36849080211 scopus 로고    scopus 로고
    • NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
    • Abid MR, Spokes KC, Shih SC and Aird WC. NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem. 2007; 282: 35373-35385.
    • (2007) J Biol Chem. , vol.282 , pp. 35373-35385
    • Abid, M.R.1    Spokes, K.C.2    Shih, S.C.3    Aird, W.C.4
  • 5
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidasedependent signaling in endothelial cells: role in physiology and pathophysiology
    • Frey RS, Ushio-Fukai M and Malik AB. NADPH oxidasedependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal. 2009; 11: 791-810.
    • (2009) Antioxid Redox Signal. , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 7
    • 84907980823 scopus 로고    scopus 로고
    • C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair
    • Xu S and Chisholm Andrew D. C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair. Developmental Cell. 2014; 31: 48-60.
    • (2014) Developmental Cell. , vol.31 , pp. 48-60
    • Xu, S.1    Chisholm Andrew, D.2
  • 9
    • 0034969250 scopus 로고    scopus 로고
    • Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide
    • Corda S, Laplace C, Vicaut E and Duranteau J. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol. 2001; 24: 762-768.
    • (2001) Am J Respir Cell Mol Biol. , vol.24 , pp. 762-768
    • Corda, S.1    Laplace, C.2    Vicaut, E.3    Duranteau, J.4
  • 10
    • 22144432216 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factorinduced apoptosis: evidence from mitochondria-targeted antioxidants
    • Hughes G, Murphy MP and Ledgerwood EC. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factorinduced apoptosis: evidence from mitochondria-targeted antioxidants. Biochem J. 2005; 389: 83-89.
    • (2005) Biochem J. , vol.389 , pp. 83-89
    • Hughes, G.1    Murphy, M.P.2    Ledgerwood, E.C.3
  • 14
    • 84859483420 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
    • Velarde MC, Flynn JM, Day NU, Melov S and Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012; 4: 3-12.
    • (2012) Aging (Albany NY). , vol.4 , pp. 3-12
    • Velarde, M.C.1    Flynn, J.M.2    Day, N.U.3    Melov, S.4    Campisi, J.5
  • 15
    • 78649820215 scopus 로고    scopus 로고
    • Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice
    • Marrotte EJ, Chen DD, Hakim JS and Chen AF. Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice. J Clin Invest. 2010; 120: 4207-4219.
    • (2010) J Clin Invest. , vol.120 , pp. 4207-4219
    • Marrotte, E.J.1    Chen, D.D.2    Hakim, J.S.3    Chen, A.F.4
  • 18
    • 84902303333 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
    • Gioscia-Ryan RA, LaRocca TJ, Sindler AL, Zigler MC, Murphy MP and Seals DR. Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol. 2014; 592: 2549-2561.
    • (2014) J Physiol. , vol.592 , pp. 2549-2561
    • Gioscia-Ryan, R.A.1    LaRocca, T.J.2    Sindler, A.L.3    Zigler, M.C.4    Murphy, M.P.5    Seals, D.R.6
  • 19
    • 56049120778 scopus 로고    scopus 로고
    • The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharidepeptidoglycan model of sepsis
    • Lowes DA, Thottakam BM, Webster NR, Murphy MP and Galley HF. The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharidepeptidoglycan model of sepsis. Free Radic Biol Med. 2008; 45: 1559-1565.
    • (2008) Free Radic Biol Med. , vol.45 , pp. 1559-1565
    • Lowes, D.A.1    Thottakam, B.M.2    Webster, N.R.3    Murphy, M.P.4    Galley, H.F.5
  • 27
    • 84857029496 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases
    • Skulachev VP. Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases. J Alzheimers Dis. 2012; 28: 283-289.
    • (2012) J Alzheimers Dis. , vol.28 , pp. 283-289
    • Skulachev, V.P.1
  • 30
    • 74549205329 scopus 로고    scopus 로고
    • Validation of anti-aging drugs by treating age-related diseases
    • Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY). 2009; 1: 281-288.
    • (2009) Aging (Albany NY). , vol.1 , pp. 281-288
    • Blagosklonny, M.V.1
  • 33
    • 0029154515 scopus 로고
    • The effects of ageing on cutaneous wound healing in mammals
    • Ashcroft GS, Horan MA and Ferguson MW. The effects of ageing on cutaneous wound healing in mammals. J Anat. 1995; 187: 1-26.
    • (1995) J Anat. , vol.187 , pp. 1-26
    • Ashcroft, G.S.1    Horan, M.A.2    Ferguson, M.W.3
  • 34
    • 0030890616 scopus 로고    scopus 로고
    • Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model
    • Ashcroft GS, Horan MA and Ferguson MW. Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J Invest Dermatol. 1997; 108: 430-437.
    • (1997) J Invest Dermatol. , vol.108 , pp. 430-437
    • Ashcroft, G.S.1    Horan, M.A.2    Ferguson, M.W.3
  • 35
    • 33847084614 scopus 로고    scopus 로고
    • Formation and function of the myofibroblast during tissue repair
    • Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007; 127: 526-537.
    • (2007) J Invest Dermatol. , vol.127 , pp. 526-537
    • Hinz, B.1
  • 36
    • 79960963418 scopus 로고    scopus 로고
    • Mechanisms of pathological scarring: role of myofibroblasts and current developments
    • Sarrazy V, Billet F, Micallef L, Coulomb B and Desmouliere A. Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regen. 2011; 19 Suppl 1:s10-15.
    • (2011) Wound Repair Regen. , vol.19 , pp. s10-15
    • Sarrazy, V.1    Billet, F.2    Micallef, L.3    Coulomb, B.4    Desmouliere, A.5
  • 37
    • 77957824532 scopus 로고    scopus 로고
    • Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing
    • Moulin VJ, Mayrand D, Messier H, Martinez MC, Lopez-Valle CA and Genest H. Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing. J Cell Physiol. 2010; 225: 734-740.
    • (2010) J Cell Physiol. , vol.225 , pp. 734-740
    • Moulin, V.J.1    Mayrand, D.2    Messier, H.3    Martinez, M.C.4    Lopez-Valle, C.A.5    Genest, H.6
  • 38
    • 0031931635 scopus 로고    scopus 로고
    • Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing
    • Ashcroft GS, Horan MA and Ferguson MW. Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest. 1998; 78: 47-58.
    • (1998) Lab Invest. , vol.78 , pp. 47-58
    • Ashcroft, G.S.1    Horan, M.A.2    Ferguson, M.W.3
  • 39
    • 0035725929 scopus 로고    scopus 로고
    • Age-related alterations in the inflammatory response to dermal injury
    • Swift ME, Burns AL, Gray KL and DiPietro LA. Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol. 2001; 117: 1027-1035.
    • (2001) J Invest Dermatol. , vol.117 , pp. 1027-1035
    • Swift, M.E.1    Burns, A.L.2    Gray, K.L.3    DiPietro, L.A.4
  • 40
    • 0031867833 scopus 로고    scopus 로고
    • Cleavage of betacatenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases
    • Herren B, Levkau B, Raines EW and Ross R. Cleavage of betacatenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell. 1998; 9: 1589-1601.
    • (1998) Mol Biol Cell. , vol.9 , pp. 1589-1601
    • Herren, B.1    Levkau, B.2    Raines, E.W.3    Ross, R.4
  • 47
    • 79952115737 scopus 로고    scopus 로고
    • Cellular senescence controls fibrosis in wound healing
    • Jun JI and Lau LF. Cellular senescence controls fibrosis in wound healing. Aging (Albany NY). 2010; 2: 627-631.
    • (2010) Aging (Albany NY). , vol.2 , pp. 627-631
    • Jun, J.I.1    Lau, L.F.2
  • 48
    • 77956388751 scopus 로고    scopus 로고
    • CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model
    • Lee CH, Shah B, Moioli EK and Mao JJ. CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model. J Clin Invest. 2010; 120: 3340-3349.
    • (2010) J Clin Invest. , vol.120 , pp. 3340-3349
    • Lee, C.H.1    Shah, B.2    Moioli, E.K.3    Mao, J.J.4
  • 49
    • 77955055308 scopus 로고    scopus 로고
    • Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1
    • Shipounova I, Svinareva D, Petrova T, Lyamzaev K, Chernyak B, Drize N and Skulachev V. Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1. Mechanisms of ageing and development. 2010; 131: 415-421.
    • (2010) Mechanisms of ageing and development. , vol.131 , pp. 415-421
    • Shipounova, I.1    Svinareva, D.2    Petrova, T.3    Lyamzaev, K.4    Chernyak, B.5    Drize, N.6    Skulachev, V.7
  • 51
    • 12344313432 scopus 로고    scopus 로고
    • Extracellular regulation of TGFbeta activity in wound repair: growth factor latency as a sensor mechanism for injury
    • Brunner G and Blakytny R. Extracellular regulation of TGFbeta activity in wound repair: growth factor latency as a sensor mechanism for injury. Thromb Haemost. 2004; 92(2):253-261.
    • (2004) Thromb Haemost. , vol.92 , Issue.2 , pp. 253-261
    • Brunner, G.1    Blakytny, R.2
  • 52
    • 34447271736 scopus 로고    scopus 로고
    • Transforming growth factorbeta and fibrosis
    • Verrecchia F and Mauviel A. Transforming growth factorbeta and fibrosis. World J Gastroenterol. 2007; 13: 3056-3062.
    • (2007) World J Gastroenterol. , vol.13 , pp. 3056-3062
    • Verrecchia, F.1    Mauviel, A.2
  • 54
    • 50549090486 scopus 로고    scopus 로고
    • Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
    • Blagosklonny MV. Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res. 2008; 11: 801-808.
    • (2008) Rejuvenation Res. , vol.11 , pp. 801-808
    • Blagosklonny, M.V.1
  • 56
    • 67650602355 scopus 로고    scopus 로고
    • Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
    • Chen WQ, Zhong L, Zhang L, Ji XP, Zhang M, Zhao YX, Zhang C and Zhang Y. Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels. Br J Pharmacol. 2009; 156: 941-951.
    • (2009) Br J Pharmacol. , vol.156 , pp. 941-951
    • Chen, W.Q.1    Zhong, L.2    Zhang, L.3    Ji, X.P.4    Zhang, M.5    Zhao, Y.X.6    Zhang, C.7    Zhang, Y.8
  • 57
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • Blagosklonny MV. Aging: ROS or TOR. Cell Cycle. 2008; 7: 3344-3354.
    • (2008) Cell Cycle. , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 59
    • 84888012439 scopus 로고    scopus 로고
    • Cationic antioxidants as a powerful tool against mitochondrial oxidative stress
    • Skulachev VP. Cationic antioxidants as a powerful tool against mitochondrial oxidative stress. Biochem Biophys Res Commun. 2013; 441: 275-279.
    • (2013) Biochem Biophys Res Commun. , vol.441 , pp. 275-279
    • Skulachev, V.P.1
  • 60
    • 42149154920 scopus 로고    scopus 로고
    • Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells
    • Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D and Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008; 28: 906-912.
    • (2008) Arterioscler Thromb Vasc Biol. , vol.28 , pp. 906-912
    • Chen, C.1    Jamaluddin, M.S.2    Yan, S.3    Sheikh-Hamad, D.4    Yao, Q.5
  • 61
    • 63649157212 scopus 로고    scopus 로고
    • Tube formation: an in vitro matrigel angiogenesis assay
    • Ponce ML. Tube formation: an in vitro matrigel angiogenesis assay. Methods in molecular biology. 2009; 467: 183-188.
    • (2009) Methods in molecular biology. , vol.467 , pp. 183-188
    • Ponce, M.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.