Wound healing and longevity: Lessons from long-lived αMUPA mice

Aging

Volumn 7, Issue 3, 2015, Pages 167-176

  Yanai, Hagai ^a   Toren, Dimitri ^a   Vierlinger, Klemens ^b   Hofner, Manuela ^b   Nöhammer, Christa ^b   Chilosi, Marco ^c   Budovsky, Arie ^a   Fraifeld, Vadim E ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b AIT AUSTRIAN INSTITUTE OF TECHNOLOGY   (Austria)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

Aging; Caloric restriction; Gene expression; Growth promoting pathways; Wound healing; MUPA mice

Indexed keywords

UROKINASE;

AGE; ANIMAL; CELL MOTION; FEMALE; FIBROBLAST; GENE EXPRESSION; GENETICS; LONGEVITY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SKIN; TRANSGENIC MOUSE; WOUND HEALING;

AGE FACTORS; ANIMALS; CELL MOVEMENT; FEMALE; FIBROBLASTS; GENE EXPRESSION; LONGEVITY; MICE, TRANSGENIC; SKIN; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; WOUND HEALING;

EID: 84929309744     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100726     Document Type: Article

References (37)

1. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999; 341:738-746.
2. Ferguson MW, O'Kane S. Scar-free healing: From embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004; 359:839-850.
3. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008; 453:314-321.
4. Reid RR, Said HK, Mogford JE, Mustoe TA. The future of wound healing: Pursuing surgical models in transgenic and knockout mice. J Am Coll Surg. 2004; 199:578-585.
5. Shaw TJ, Martin P. Wound repair at a glance. J Cell Sci. 2009; 122:3209-3213.
6. Wong VW, Sorkin M, Glotzbach JP, Longaker MT, Gurtner GC. Surgical approaches to create murine models of human wound healing. J Biomed Biotechnol. 2011; 2011:969618.
7. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003; 83:835-870.
8. Kapetanaki MG, Mora AL, Rojas M. Influence of age on wound healing and fibrosis. J Pathol. 2013; 229:310-322.
9. Gosain A, DiPietro LA. Aging and wound healing. World J Surg. 2004; 28:321-326.
10. Sgonc R, Gruber J. Age-related aspects of cutaneous wound healing: A mini-review. Gerontology. 2013; 59:159-164.
11. Yanai H, Budovsky A, Tacutu R, Fraifeld VE. Is rate of skin wound healing associated with aging or longevity phenotype? Biogerontology. 2011; 12:591-597.
12. Mair W, Dillin A. Aging and survival: The genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008; 77:727-754.
13. Cava E, Fontana L. Will calorie restriction work in humans? Aging (Albany NY). 2013; 5:507-514.
14. Reed MJ, Penn PE, Li Y, Birnbaum R, Vernon RB, Johnson TS, Pendergrass WR, Sage EH, Abrass IB, Wolf NS. Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice. Mech Ageing Dev. 1996; 89:21-43.
15. Roth GS, Kowatch MA, Hengemihle J, Ingram DK, Spangler EL, Johnson LK, Lane MA. Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys. J Gerontol A Biol Sci Med Sci. 1997; 52:B98-102.
16. Hunt ND, Li GD, Zhu M, Miller M, Levette A, Chachich ME, Spangler EL, Allard JS, Hyun DH, Ingram DK, de Cabo R. Effect of calorie restriction and refeeding on skin wound healing in the rat. Age (Dordr). 2012; 34:1453-1458.
17. Miskin R, Tirosh O, Pardo M, Zusman I, Schwartz B, Yahav S, Dubnov G, Kohen R. AlphaMUPA mice: A transgenic model for longevity induced by caloric restriction. Mech Ageing Dev. 2005; 126:255-261.
18. Miskin R, Masos T. Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. J Gerontol A Biol Sci Med Sci. 1997; 52:B118-24.
19. Tirosh O, Aronis A, Zusman I, Kossoy G, Yahav S, Shinder D, Abramovitz R, Miskin R. Mitochondrion-mediated apoptosis is enhanced in long-lived alphaMUPA transgenic mice and calorically restricted wild-type mice. Exp Gerontol. 2003; 38:955-963.
20. Tirosh O, Pardo M, Schwartz B, Miskin R. Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine. Mech Ageing Dev. 2005; 126:1262-1273.
21. Liang CC, Park AY, Guan JL. In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2007; 2:329-333.
22. Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, von Mering C. STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 2009; 37:D412-6.
23. Gardiner DM. Ontogenetic decline of regenerative ability and the stimulation of human regeneration. Rejuvenation Res. 2005; 8:141-153.
24. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69 Suppl 1:S4-9.
25. Blagosklonny MV. Aging is not programmed: Genetic pseudo-program is a shadow of developmental growth. Cell Cycle. 2013; 12:3736-3742.
26. Blagosklonny MV. M(o)TOR of aging: MTOR as a universal molecular hypothalamus. Aging (Albany NY). 2013; 5:490-494.
27. Dilman VM. Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease. Lancet. 1971; 1:1211-1219.
28. Dilman VM, Revskoy SY, Golubev AG. Neuroendocrineontogenetic mechanism of aging: Toward an integrated theory of aging. Int Rev Neurobiol. 1986; 28:89-156.
29. Phipps RP. Atherosclerosis: The emerging role of inflammation and the CD40-CD40 ligand system. Proc Natl Acad Sci U S A. 2000; 97:6930-6932.
30. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999; 340:115-126.
31. Thannickal VJ. Mechanistic links between aging and lung fibrosis. Biogerontology. 2013; 14:609-615.
32. Schafer M, Werner S. Cancer as an overhealing wound: An old hypothesis revisited. Nat Rev Mol Cell Biol. 2008; 9:628-638.
33. Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A. 2009; 106:19352-19357.
34. Gavrilov LA, Gavrilova NS. The reliability theory of aging and longevity. J Theor Biol. 2001; 213:527-545.
35. Rittie L, Fisher GJ. Isolation and culture of skin fibroblasts. Methods Mol Med. 2005; 117:83-98.
36. Schneider CA, Rasband WS, Eliceiri KW. NIH image to ImageJ: 25 years of image analysis. Nat Methods. 2012; 9:671-675.
37. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004; 3:Article3.