A fragment-based ligand screen against part of a large protein machine: The ND1 domains of the AAA+ ATPase p97/VCP

Journal of Biomolecular Screening

Volumn 20, Issue 6, 2015, Pages 788-800

  Chimenti, Michael S ^a   Bulfer, Stacie L ^a   Neitz, R Jeffrey ^a   Renslo, Adam R ^a   Jacobson, Matthew P ^a   James, Thomas L ^a   Arkin, Michelle R ^a   Kelly, Mark J S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AAA+ ATPase p97; fragment based drug design; valosin containing protein (VCP)

Indexed keywords

ADENOSINE TRIPHOSPHATASE; LIGAND; PROTEIN P97; VALOSIN CONTAINING PROTEIN; CDC48 PROTEIN; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; P97 ATPASE; PROTEIN BINDING;

ARTICLE; BINDING SITE; DRUG DESIGN; DRUG STRUCTURE; MOLECULAR CLONING; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PURIFICATION; STOICHIOMETRY; SURFACE PLASMON RESONANCE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROCEDURES; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REPRODUCIBILITY;

ADENOSINE TRIPHOSPHATASES; BINDING SITES; CELL CYCLE PROTEINS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SURFACE PLASMON RESONANCE;

EID: 84931310475     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057115570550     Document Type: Article

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