Structure-Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

ChemMedChem

Volumn 8, Issue 2, 2013, Pages 297-312

  Chou, Tsui Fen ^a,c   Li, Kelin ^b   Frankowski, Kevin J ^b   Schoenen, Frank J ^b   Deshaies, Raymond J ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

AAA ATPase; Autophagy; Cancer; Structure activity relationships; Ubiquitin proteasome

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ML 240; ML 241; PROTEASOME; PROTEIN P97; QUINAZOLINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CENTRAL NERVOUS SYSTEM; COLON CANCER; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION PATHWAY; HIGH THROUGHPUT SCREENING; HOMEOSTASIS; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATASES; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN;

EID: 84873838455     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200520     Document Type: Article

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