Expression of wingless-type mouse mammary tumor virus integration site family pathway effectors in lymphatic and hepatic metastases of patients with colorectal cancer: Associations with the primary tumor

Oncology Letters

Volumn 10, Issue 2, 2015, Pages 863-868

  Kraus, Sebastian ^a   Vay, Christian ^a   Baldus, Stephan ^a   Knoefel, Wolfram T ^a   Stoecklein, Nikolas H ^a   Vallbohmer, Daniel ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Colorectal cancer; Distant metastases; Primary tumor; Wingless type mouse mammary tumor virus integration site family pathway

Indexed keywords

APC PROTEIN; BETA CATENIN; WNT1 PROTEIN;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER LOCALIZATION; CANCER STAGING; CLINICAL ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LYMPH NODE METASTASIS; MALE; PRIMARY TUMOR; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION; WNT SIGNALING PATHWAY;

EID: 84931298754     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3291     Document Type: Article

References (24)

1. Klaus A and Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Caner 8: 387-398, 2008.
2. Anastas JN and Moon RT: WNT signalling pathways as therapeutic targets in cancer. Nat Rev Caner 13: 11-26, 2013.
3. White BD, Chien AJ and Dawson DW: Dysregulation of Wnt/β-catenin signalling in gastrointestinal cancers. Gastroenterology 142: 219-232, 2012.
4. Papkoff J, Rubinfeld B, Schryver B and Polakis P: Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol Cell Biol 16: 2128-2134, 1996.
5. Korinek V, Barker N, Morin PJ, et al: Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science 275: 1784-1787, 1997.
6. Morin PJ, Sparks AB, Korinek V, et al: Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275: 1787-1790, 1997.
7. Martensson A, Oberg A, Jung A, et al: Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep 17: 447-452, 2007.
8. Wanitsuwan W, Kanngurn S, Boonpipattanapong T, et al: Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers. World J Gastroenterol 14: 6052-6059, 2008.
9. Elzagheid A, Buhmeida A, Korkeila E, et al: Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. World J Gastroenterol 14: 3866-3871, 2008.
10. Brabletz T, Jung A, Reu S, et al: Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 98: 10356-10361, 2001.
11. Brabletz T, Jung A, Hermann K, Günther K, Hohenberger W and Kirchner T: Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 194: 701-704, 1998.
12. Gabbert H, Wagner R, Moll R and Gerharz CD: Tumor dedifferentiation: an important step in tumor invasion. Clin Exp Metastasis 3: 257-279, 1985.
13. Hlubek F, Brabletz T, Budczies J, Pfeiffer S, Jung A and Kirchner T: Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer. Int J Cancer 121: 1941-1948, 2007.
14. Behrens J: The role of Wnt signalling pathway in colorectal tumorigenesis. Biochem Soc Trans 33: 672-675, 2005.
15. Stanczak A, Stec R, Bodnar L, et al: Prognostic significance of Wnt-1, beta-Catenin and E-Cadherin expression in advanced colorectal carcinoma. Pathol Oncol Res 17: 955-963, 2011.
16. Khor TO, Gul YA, Ithnin H and Seow HF: A comparative study of expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma. Int J Colorectal Dis 21: 291-300, 2006.
17. Holcombe RF, Marsh JL, Waterman ML, Lin F, et al: Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. Mol Pathol 55: 220-226, 2002.
18. De A: Wnt/Ca2+ signaling pathway: a brief overview. Acta Biochim Biophys Shanghai 2011; 43: 745-756, 2011.
19. Chen J, Röcken C, Lofton-Day C, Schulz HU, et al: Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. Carcinogenesis 26: 37-43, 2005.
20. Baylin SB and Herman JG: DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16: 168-174, 2000.
21. Wu JM, Fackler MJ, Halushka MK, Molavi DW, et al: Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res 14: 1938-1946, 2008.
22. Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
23. Collins VP, Loeffler RK and Tivey H: Observations on growth rates of human tumors. Am J Roentgenol Radium Ther Nucl Med 76: 988-1000, 1956.
24. Klein CA: Parallel progression of primary tumours and metastases. Nat Rev Cancer 9: 302-312, 2009.