Visfatin and ghrelin: Can they be forthcoming biomarkers or new drug targets for asthma?

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 4, 2015, Pages 6257-6261

  Toru, Ümran ^a   Ayada, Ceylan ^a   Genç, Osman ^a   Şahin, Server ^a   Arık, Özlem ^a   Acat, Murat ^b   Bulut, İsmet ^c   Çetinkaya, Erdoğan ^d  

^a DUMLUPINAR UNIVERSITY   (Turkey)

^b KARABUK UNIVERSITY   (Turkey)

^c Sureyyapasa Chest Diseases and Thoracic Surgery Teaching and Research Hospital   (Turkey)

^d Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital   (Turkey)

Author keywords

Adipokine; Appetite modulating hormone; Asthma; Biomarker; Drug target; Ghrelin; Inflammation; Visfatin

Indexed keywords

GHRELIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;

ADULT; ARTICLE; ASTHMA; BLOOD LEVEL; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; MALE;

EID: 84931275512     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Nakagome K and Nagata M. Pathogenesis of airway inflammation in bronchial asthma. Auris Nasus Larynx 2011; 38:555-563.
2. Fu JJ, McDonald VM, Gibson PG, Simpson JL. Systemic Inflammation in Older Adults with Asthma-COPD Overlap Syndrome. Allergy As-thma Immunol Res 2014; 6: 316-324.
3. Fantuzzi G. Adipose tissue, adipokines, and in­flammation. J Allergy ClinImmunol 2005; 115: 911-919; quiz 920.
4. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic dis­ease. Nat Rev Immunol 2011; 11: 85-97.
5. Ali Assad N and Sood A. Leptin, adiponectin and pulmonary diseases. Biochimie 2012; 94: 2180-2189.
6. Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, Tilg H. Visfatin, an adipocytokine with proinflammatory and im­munomodulating properties. J Immunol 2007; 178: 1748-1758.
7. Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colo­ny-enhancing factor. Mol Cell Biol 1994; 14: 1431-1437.
8. Revollo JR, Körner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S. Nampt/PBEF/Visfatin regulates insulin secre­tion in beta cells as a systemic NAD biosynthet­ic enzyme. Cell Metab 2007; 6: 363-375.
9. Broglio F, Gottero C, Arvat E, Ghigo E. Endocrine and non-endocrine actions of ghrelin. Horm Res 2003; 59: 109-117.
10. Meier U and Gressner AM. Endocrine regula­tion of energy metabolism: review of pathobio­chemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50: 1511-1525.
11. Tschöp M, Smiley DL, Heiman ML. Ghrelin in­duces adiposity in rodents. Nature 2000; 407: 908-913.
12. Erşahın M, Toklu HZ, Erzık C, Akakin D, Tetık S, Sener G, Yeğen BC. Ghrelin alleviates spinal cord injury in rats via its anti-inflammatory ef­fects. Turk Neurosurg 2011; 21: 599-605.
13. Warrington R. Immunotherapy in asthma.Immunotherapy 2010; 2: 711-725.
14. Wellen KE and Hotamisligil GS. Obesity-induced inflammatory changes in adipose tis­sue. J Clin Invest 2003; 112: 1785-1788.
15. Lugogo NL, Bappanad D, Kraft M. Obesity, met­abolic dysregulation and oxidative stress in asthma. Biochim Biophys Acta 2011; 1810: 1120-1126.
16. Hauner H. Secretory factors from human adi­pose tissue and their functional role. Proc Nutr Soc 2005; 64: 163-169.
17. Takizawa H. Cytokines/chemokines and adhe­sion molecules in local inflammatory respons­es of the lung. Drug News Perspect 1998; 11: 611-619.
18. Starr ME, Saito M, Evers BM, Saito H. Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue. J Gerontol A Biol Sci Med Sci 2014; [Epub ahead of print].
19. Ali Z and Ulrik CS. Obesity and asthma: a coin­cidence or a causal relationship? A systematic review. Respir Med 2013; 107: 1287-1300.
20. Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentra­tions of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 2005; 69: 29e35.
21. Beuther DA and Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007; 175: 661-666.
22. Schachter LM, Salome CM, Peat JK, Woolcock AJ. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001; 56: 4-8.
23. Sood A and Shore SA. Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies. J Allergy (Cairo) 2013; 2013: 785835.
24. Tilg H and Moschen AR. Adipocytokines: medi­ators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772-783.
25. Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O. Adipokines: biofac­tors from white adipose tissue. A complex hub among inflammation, metabolism, and immu­nity. Biofactors 2011; 37: 413-420.
26. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307: 426-430.
27. Adeghate E. Visfatin: structure, function and relation to diabetes mellitus and other dys­functions. Curr Med Chem 2008; 15: 1851-1862.
28. Li RZ, Ma Xn, Hu XF, Kang SX, Chen SK, Cianflone K, Lu HL. Elevated visfatin levels in obese children are related to proinflammatory factors. J Pediatr Endocrinol Metab 2013; 26: 111-118.
29. Machura E, Ziora K, Ziora D, Świtęochowska E, Halkiewicz F, Oświęcimska J, Kasperska-Zając A. Serum visfatin levels are decreased in school children with atopic asthma. Neuro Endocrinol Lett 2012; 33: 559-564.
30. Leivo-Korpela S, Lehtimäki L, Hämälainen M, Vuolteenaho K, Kööbi L, Järvenpää R, Kankaanranta H, Saarelainen S, Moilanen E.AdipokinesNUCB2/nesfatin-1 and visfatin as novel inflammatory factors in chronic obstruc­tive pulmonary disease. Mediators In-flamm 2014; 2014: 232167.
31. Matsumoto Y, Toyomasu K, Uchimura N, Ishitake T. Low-molecular-weight adiponectin is more closely associated with episodes of asthma than high-molecular-weight adiponec­tin. Endocr J 2013; 60: 119-125.
32. Magrone T, Simone M, Altamura M, Munno I. Characterization of the Immune Inflammatory Profile in Obese Asthmatic Children. En-docr Metab Immune Disord Drug Targets 2014; 14: 187-195.
33. Dixit VD and Taub DD. Ghrelin and immunity: a young player in an old field. Exp Gerontol 2005; 40: 900-910.
34. Tsaroucha A, Daniil Z, Malli F, Georgoulias P, Minas M, Kostikas K, Bargiota A, Zintzaras E, Gourgoulianis KI. Leptin, adiponectin, and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma 2013; 50: 188-197.
35. Yuksel H, Sogut A, Yilmaz O, Onur E, Dinc G. Role of adipokines and hormones of obesity in childhood asthma. Allergy Asthma Immunol Res 2012; 4: 98-103.