Characterization of the immune inflammatory profile in obese asthmatic children

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 14, Issue 3, 2014, Pages 187-195

  Magrone, Thea ^a   Simone, Maria ^a   Altamura, Maria ^a   Munno, Irene ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Adiponectin; Adipose tissue; Asthma; Children; Cytokine; Leptin; Obesity; Resistin; Visfatin

Indexed keywords

ADIPONECTIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; ASTHMA; BLOOD SAMPLING; BODY MASS; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFLAMMATION; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; OBESITY;

EID: 84924334504     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/1871530314666140526095211     Document Type: Article

References (46)

1. Liu, P.C.; Kieckhefer, G.M. and Gau, B.S. (2013) A systematic review of the association between obesity and asthma in children. J. Adv. Nurs., 69, 1446-1465.
2. Papoutsakis, C.; Priftis, K.N.; Drakouli, M.; Prifti, S.; Konstantaki, E.; Chondronikola, M.; Antonogeorgos, G. and Matziou, V. (2013) Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. J. Acad. Nutr. Diet., 113, 77-105.
3. Farah, C.S. and Salome, C.M. (2012) Asthma and obesity: a known association but unknown mechanism. Respirology., 17, 412-421.
4. Peters, J.I.; McKinney, J.M.; Smith, B.; Wood, P.; Forkner, E. and Galbreath, A.D. (2011) Impact of obesity in asthma: evidence from a large prospective disease management study. Ann. Allergy Asthma Immunol., 106, 30-35.
5. Brüske, I.; Flexeder, C. and Heinrich, J. (2014) Body mass index and the incidence of asthma in children. Curr. Opin. Allergy Clin. Immunol., 14, 155-160.
6. Ahmad, N.; Biswas, S.; Bae, S.; Meado, K.E.; Huang, R. and Singh, K.P. (2009) Association between obesity and asthma in US children and adolescents. J. Asthma, 46, 642-646.
7. Lugogo, N.L.; Kraft, M. and Dixon, A.E. (2010) Does obesity produce a distinct asthma phenotype? J. Appl. Physiol. (1985), 108, 729-734.
8. Jensen, M.E.; Collins C.E.; Gibson, P.G. and Wood, L.G. (2011) The obesity phenotype in children with asthma. Paediatr. Respir. Rev., 12, 152-159.
9. van Veen, I.H.; Ten Brinke, A.; Sterk, P.J.; Rabe, K.F. and Bel, E.H. (2008) Airway inflammation in obese and nonobese patients with difficult-to-treat asthma. Allergy., 63, 570-574.
10. Sutherland, E.R. (2014) Linking obesity and asthma. Ann. N. Y. Acad. Sci., [Epub ahead of print].
11. Wellen, K.E. and Hotamisligil, G.S. (2003) Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest., 112, 1785- 1788.
12. Heilbronn, L.K. and Campbell, L.V. (2008) Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des., 14, 1225-1230.
13. Itoh, M.; Suganami, T.; Hachiya, R. and Ogawa, Y. (2011) Adipose tissue remodeling as homeostatic inflammation. Int. J. Inflam., 2011, 720926.
14. Galic, S.; Oakhill, J.S. and Steinberg, G.R. (2010) Adipose tissue as an endocrine organ. Mol. Cell. Endocrinol., 316, 129-139.
15. Trzeciak-Ryczek, A.; Tokarz-Deptuła, B. and Deptuła, W. (2011) Adipocytokines affecting the immune system-selected data. Centr. Eur. J. Immunol., 36, 92-94.
16. Masaki, T.; Chiba, S.; Tatsukawa, H.; Yasuda, T.; Noguchi, H.; Seike, M. and Yoshimatsu, H. (2004) Adiponectin protects LPSinduced liver injury through modulation of TNF-llin KK-Ay obese mice. Hepatology, 40, 177-184.
17. Kumada, M.; Kihara, S.; Ouchi, N.; Kobayashi, H.; Okamoto, Y.; Ohashi, K.; Maeda, K.; Nagaretani, H.; Kishida, K.; Maeda, N.; Nagasawa, A.; Funahashi, T. and Matsuzawa, Y. (2004) Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation, 109, 2046-2049.
18. Wolf, A.M.; Wolf, D.; Rumpold, H.; Enrich, B. and Tilg, H. (2004) Adiponectin induces the anti-inflammatory cytokines IL-10 and IL- 1RA in human leukocytes. Biochem. Biophys. Res. Commun., 323, 630-635.
19. Wulster-Radcliffe, M.C.; Ajuwon, K.M.; Wang, J.; Christian, J.A. and Spurlock, M.E. (2004) Adiponectin differentially regulates cytokines in porcine macrophages. Biochem. Biophys. Res. Commun., 316, 924-929.
20. Stastny, J.; Bienertova-Vasku, J. and Vasku, A. (2012) Visfatin and its role in obesity development. Diabetes Metab. Syndr., 6, 120-124.
21. Jia, S.H.; Li, Y.; Parodo, J.; Kapus, A.; Fan, L.; Rotstein, O.D. and Marshall, J.C. (2004) Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J. Clin. Invest., 113, 1318-1327.
22. Park, H.K. and Ahima, R.S. (2013) Resistin in rodents and humans. Diabetes Metab. J., 37, 404-414.
23. Fang, C.; Meng, Q.; Wu, H.; Eid, G.; Zhang, G.; Zhang, X.; Yang, S.; Huang, K.; Lee, T.H.; Corrigan, C.J. and Ying, S. (2012) Resistin-like molecule-β is a human airway remodelling mediator. Eur. Respir. J., 39, 458-466.
24. Jamaluddin, M.S.; Weakley, S.M.; Yao, Q. and Chen, C. (2012) Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br. J. Pharmacol., 165, 622-632.
25. Gelfand, E.W. and Dakhama, A. (2006) CD8+ T lymphocytes and leukotriene B4: novel interactions in the persistence and progression of asthma. J. Allergy Clin. Immunol., 117, 577-582.
26. Shore, S.A. (2008) Obesity and asthma: possible mechanisms. J. Allergy Clin. Immunol., 121, 1087-1093.
27. Kim, K.W.; Shin, Y.H.; Lee, K.E.; Sohn, M.H. and Kim, K.E. (2008) Relationship between adipokines and manifestations of childhood asthma. Pediatr. Allergy Immunol., 19, 535-540.
28. Tanju, A.; Cekmez, F.; Aydinoz, S.; Karademir, F.; Suleymanoglu, S. and Gocmen, I. (2011) Association between clinical severity of childhood asthma and serum leptin levels. Indian J. Pediatr., 78, 291-295.
29. Rzehak, P.; Wijga, A.H.; Keil, T.; Eller, E.; Bindslev-Jensen, C.; Smit, H.A.; Weyler, J.; Dom, S.; Sunyer, J.; Mendez, M.; Torrent, M.; Vall, O.; Bauer, C.P.; Berdel, D.; Schaaf, B.; Chen, C.M.; Bergstrom, A.; Fantini, M.P.; Mommers, M.; Wahn, U.; Lau, S. and Heinrich, J. (2013) Body mass index trajectory classes and incident asthma in childhood: results from 8 European Birth Cohorts-a Global Allergy and Asthma European Network initiative. J. Allergy Clin. Immunol., 131, 1528-1536.
30. Yin, J.; Quinn, S.; Dwyer, T.; Ponsonby, A.L. and Jones, G. (2012) Maternal diet, breastfeeding and adolescent body composition: a 16-year prospective study. Eur. J. Clin. Nutr., 66, 1329-1334.
31. Cacciari, E.; Milani, S.; Balsamo, A.; Spada, E.; Bona, G.; Cavallo, L.; Cerutti, F.; Gargantini, L.; Greggio, N.; Tonini, G. and Cicognani, A. (2006) Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J. Endocrinol. Invest., 29, 581-593.
32. Cole, T.J.; Bellizzi, M.C.; Flegal, K.M. and Dietz, W.H. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. B.M.J., 320, 1240-1243.
33. Pedersen, S.E.; Hurd, S.S.; Lemanske, R.F. Jr.; Becker, A.; Zar, H.J.; Sly, P.D.; Soto-Quiroz, M.; Wong, G. and Bateman, E.D. (2011) Global strategy for the diagnosis and management of asthma in children 5 years and younger. Pediatr. Pulmonol., 46, 1-17.
34. Miller, M.R.; Hankinson, J.; Brusasco, V.; Burgos, F.; Casaburi, R.; Coates, A.; Crapo, R.; Enright, P.; van der Grinten, C.P.; Gustafsson, P.; Jensen, R.; Johnson, D.C.; MacIntyre, N.; McKay, R.; Navajas, D.; Pedersen, O.F.; Pellegrino, R.; Viegi, G. and Wanger, J. (2005) Standardisation of spirometry. Eur. Respir. J., 26, 319-338.
35. Del Vecchio, M.; Bajetta, E.; Canova, S.; Lotze, M.T.; Wesa, A.; Parmiani, G. and Anichini, A. (2007) Interleukin-12: biological properties and clinical application. Clin. Cancer Res., 13, 4677- 4685.
36. Procaccini, C.; Jirillo, E. and Matarese, G. (2012) Leptin as an immunomodulator. Mol. Aspects Med., 33, 35-45.
37. Kim, Y.; Lee, S.; Kim, Y.S.; Lawler, S.; Gho, Y.S.; Kim, Y.K. and Hwang, H.J. (2013) Regulation of Th1/Th2 cells in asthma development: a mathematical model. Math. Biosci. Eng., 10, 1095- 1133.
38. Michaud, B.; Gouvis-Echraghi, R.; Candon, S.; Couderc, R.; Jais, J.P.; Bach, J.F.; Chatenoud, L. and Just, J. (2014) Quantification of circulating house dust mite-specific IL-4- and IL-13-secreting T cells correlates with rhinitis severity in asthmatic children and varies with the seasons. Clin. Exp. Allergy., 44, 222-230.
39. Youssef, D.M.; Elbehidy, R.M.; Shokry, D.M. and Elbehidy, E.M. (2013) The influence of leptin on Th1/Th2 balance in obese children with asthma. J. Bras. Pneumol., 39, 562-568.
40. Stream, A.R. and Sutherland, E.R. (2012) Obesity and asthma disease phenotypes. Curr. Opin. Allergy Clin. Immunol., 12, 76-81.
41. Barranco, P.; Delgado, J.; Gallego, L.T.; Bobolea, I.; Pedrosa, M.; Garcia de Lorenzo, A. and Quirce, S. (2012) Asthma, obesity and diet. Nutr. Hosp., 27, 138-145.
42. Wulster-Radcliffe, M.C.; Ajuwon, K.M.; Wang, J.; Christian, J.A. and Spurlock, M.E. (2004) Adiponectin differentially regulates cytokines in porcine macrophages. Biochem. Biophys. Res. Commun., 316, 924-929.
43. Herderm C.; Carstensen, M. and Ouwens, D.M. (2013) Antiinflammatory cytokines and risk of type 2 diabetes. Diabetes Obes. Metab., 15, 9-50.
44. Dedoussis, G.V.; Kapiri, A.; Samara, A.; Dimitriadis, D.; Lambert, D.; Pfister, M.; Siest, G. and Visvikis-Siest, S. (2009) Visfatin: the link between inflammation and childhood obesity. Diabetes Care., 32, e71.
45. Yuksel, H.; Sogut, A.; Yilmaz, O.; Onur, E. and Dinc G. (2012) Role of adipokines and hormones of obesity in childhood asthma. Allergy Asthma Immunol. Res., 4, 98-103.
46. Jaleel, A.; Aheed, B.; Jaleel, S.; Majeed, R.; Zuberi, A.; Khan, S.; Ahmed, B.; Shoukat. F. and Hashim, H. (2013) Association of adipokines with obesity in children and adolescents. Biomark. Med., 7, 731-735.