Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 Histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice

International Journal of Neuropsychopharmacology

Volumn 18, Issue 5, 2015, Pages 1-15

  Subbanna, Shivakumar ^a   Nagre, Nagaraja N ^a   Umapathy, Nagavedi S ^b   Pace, Betty S ^b   Basavarajappa, Balapal S ^a,c,d  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Cannabinoid receptor system; Epigenetics; FASD; Memory loss; Synaptic signaling

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; ALCOHOL; CANNABINOID 1 RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CENTRAL DEPRESSANT AGENT; CREBBP PROTEIN, MOUSE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HISTONE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; CB1R GENE; COGNITIVE DEFECT; CONTROLLED STUDY; EPIGENETICS; EXON; EXPOSURE; FETAL ALCOHOL SYNDROME; GENE DELETION; GTPGAMMAS BINDING ASSAY; HIPPOCAMPUS; HISTONE ACETYLATION; KNOCKOUT MOUSE; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NEOCORTEX; NERVE DEGENERATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR GENE; RECEPTOR UPREGULATION; SOCIAL RECOGNITION TEST; SPATIAL MEMORY; ACETYLATION; AGE; AIDS RELATED COMPLEX; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DEGENERATIVE DISEASE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHOSPHORYLATION; PSYCHOLOGY; SOCIAL BEHAVIOR; UPREGULATION;

ACETYLATION; AGE FACTORS; AIDS-RELATED COMPLEX; ANIMALS; ANIMALS, NEWBORN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CREB-BINDING PROTEIN; EPIGENESIS, GENETIC; ETHANOL; EXONS; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HISTONES; MALE; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOCORTEX; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; RECEPTOR, CANNABINOID, CB1; SOCIAL BEHAVIOR; UP-REGULATION;

EID: 84931269629     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1093/ijnp/pyu028     Document Type: Article

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