메뉴 건너뛰기




Volumn 17, Issue 7, 2015, Pages

From Glomerular Endothelium to Podocyte Pathobiology in Preeclampsia: a Paradigm Shift

Author keywords

Glomerulus; Kidney; Podocyte; Preeclampsia; sFLT 1; VEGF

Indexed keywords

DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84931269156     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-015-0566-9     Document Type: Review
Times cited : (11)

References (85)
  • 1
    • 84893345544 scopus 로고    scopus 로고
    • Pre-eclampsia increases the risk of postpartum haemorrhage: a nationwide cohort study in the Netherlands
    • von Schmidt auf Altenstadt JF, Hukkelhoven CW, van Roosmalen J, Bloemenkamp KW. Pre-eclampsia increases the risk of postpartum haemorrhage: a nationwide cohort study in the Netherlands. PLoS ONE. 2013;8(12):e81959. doi:10.1371/journal.pone.0081959.
    • (2013) PLoS ONE , vol.8 , Issue.12 , pp. 81959
  • 2
    • 33645737208 scopus 로고    scopus 로고
    • WHO analysis of causes of maternal death: a systematic review
    • PID: 16581405
    • Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006;367(9516):1066–74.
    • (2006) Lancet , vol.367 , Issue.9516 , pp. 1066-1074
    • Khan, K.S.1    Wojdyla, D.2    Say, L.3    Gulmezoglu, A.M.4    Van Look, P.F.5
  • 3
    • 84914691455 scopus 로고    scopus 로고
    • Hypertensive disorders of pregnancy: a systematic review of international clinical practice guidelines
    • PID: 25436639
    • Gillon TE, Pels A, von Dadelszen P, MacDonell K, Magee LA. Hypertensive disorders of pregnancy: a systematic review of international clinical practice guidelines. PLoS ONE. 2014;9(12):e113715. doi:10.1371/journal.pone.0113715.
    • (2014) PLoS ONE , vol.9 , Issue.12 , pp. 113715
    • Gillon, T.E.1    Pels, A.2    von Dadelszen, P.3    MacDonell, K.4    Magee, L.A.5
  • 4
    • 84882284305 scopus 로고    scopus 로고
    • Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study
    • COI: 1:CAS:528:DC%2BC3sXhs1Krs7%2FO, PID: 23906160
    • Myers JE, Kenny LC, McCowan LM, Chan EH, Dekker GA, Poston L, et al. Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study. Bjog. 2013;120(10):1215–23.
    • (2013) Bjog , vol.120 , Issue.10 , pp. 1215-1223
    • Myers, J.E.1    Kenny, L.C.2    McCowan, L.M.3    Chan, E.H.4    Dekker, G.A.5    Poston, L.6
  • 5
    • 84890549167 scopus 로고    scopus 로고
    • Renal function in normal and disordered pregnancy
    • COI: 1:CAS:528:DC%2BC3sXhvV2ku7%2FP, PID: 24247824
    • Hussein W, Lafayette RA. Renal function in normal and disordered pregnancy. Curr Opin Nephrol Hypertens. 2014;23(1):46–53.
    • (2014) Curr Opin Nephrol Hypertens , vol.23 , Issue.1 , pp. 46-53
    • Hussein, W.1    Lafayette, R.A.2
  • 6
    • 70449312639 scopus 로고
    • Glomerular capillary endotheliosis in toxemia of pregnancy
    • COI: 1:STN:280:DyaF3c3gtlyqsg%3D%3D, PID: 13833162
    • Spargo B, McCartney CP, Winemiller R. Glomerular capillary endotheliosis in toxemia of pregnancy. Arch Pathol. 1959;68:593–9.
    • (1959) Arch Pathol , vol.68 , pp. 593-599
    • Spargo, B.1    McCartney, C.P.2    Winemiller, R.3
  • 7
    • 0242524976 scopus 로고    scopus 로고
    • Preeclamptic nephropathy—an endothelial lesion. A morphological study with a review of the literature
    • COI: 1:STN:280:DyaK1c3gvFGltw%3D%3D, PID: 9550195
    • Gartner HV, Sammoun A, Wehrmann M, Grossmann T, Junghans R, Weihing C. Preeclamptic nephropathy—an endothelial lesion. A morphological study with a review of the literature. Eur J Obstet Gynecol Reprod Biol. 1998;77(1):11–27.
    • (1998) Eur J Obstet Gynecol Reprod Biol , vol.77 , Issue.1 , pp. 11-27
    • Gartner, H.V.1    Sammoun, A.2    Wehrmann, M.3    Grossmann, T.4    Junghans, R.5    Weihing, C.6
  • 8
    • 0019151490 scopus 로고
    • Correlations between glomerular epithelial changes and proteinuria in different glomerular diseases. [Italian]
    • Cagnoli L, Casanova S, Pasquali S. Correlations between glomerular epithelial changes and proteinuria in different glomerular diseases. [Italian]. Minerva Nefrol. 1980;27(1):155–8.
    • (1980) Minerva Nefrol , vol.27 , Issue.1 , pp. 155-158
    • Cagnoli, L.1    Casanova, S.2    Pasquali, S.3
  • 9
    • 84883267600 scopus 로고    scopus 로고
    • Preeclampsia is associated with the presence of transcriptionally active placental fragments in the maternal lung
    • COI: 1:CAS:528:DC%2BC3sXht1Oqt7%2FO, PID: 23817495
    • Buurma AJ, Penning ME, Prins F, Schutte JM, Bruijn JA, Wilhelmus S, et al. Preeclampsia is associated with the presence of transcriptionally active placental fragments in the maternal lung. Hypertension. 2013;62(3):608–13.
    • (2013) Hypertension , vol.62 , Issue.3 , pp. 608-613
    • Buurma, A.J.1    Penning, M.E.2    Prins, F.3    Schutte, J.M.4    Bruijn, J.A.5    Wilhelmus, S.6
  • 10
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • COI: 1:CAS:528:DC%2BD3sXhvFentbc%3D, PID: 12618519
    • Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111(5):649–58.
    • (2003) J Clin Invest , vol.111 , Issue.5 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3    Lim, K.H.4    Li, J.5    Mondal, S.6
  • 11
    • 33744985816 scopus 로고    scopus 로고
    • Soluble endoglin contributes to the pathogenesis of preeclampsia
    • COI: 1:CAS:528:DC%2BD28XltlOjtrs%3D, PID: 16751767
    • Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12(6):642–9.
    • (2006) Nat Med , vol.12 , Issue.6 , pp. 642-649
    • Venkatesha, S.1    Toporsian, M.2    Lam, C.3    Hanai, J.4    Mammoto, T.5    Kim, Y.M.6
  • 12
    • 0037631361 scopus 로고    scopus 로고
    • Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
    • COI: 1:CAS:528:DC%2BD3sXislGrsrg%3D, PID: 12538598
    • Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A, et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem. 2003;278(15):12605–8.
    • (2003) J Biol Chem , vol.278 , Issue.15 , pp. 12605-12608
    • Sugimoto, H.1    Hamano, Y.2    Charytan, D.3    Cosgrove, D.4    Kieran, M.5    Sudhakar, A.6
  • 13
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • COI: 1:CAS:528:DC%2BD3sXhvFenurs%3D, PID: 12618525
    • Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003;111(5):707–16.
    • (2003) J Clin Invest , vol.111 , Issue.5 , pp. 707-716
    • Eremina, V.1    Sood, M.2    Haigh, J.3    Nagy, A.4    Lajoie, G.5    Ferrara, N.6
  • 14
    • 84896739805 scopus 로고    scopus 로고
    • All anti-vascular endothelial growth factor drugs can induce ‘pre-eclampsia-like syndrome’: a RARe study
    • COI: 1:CAS:528:DC%2BC2cXhslygurw%3D, PID: 24302609
    • Vigneau C, Lorcy N, Dolley-Hitze T, Jouan F, Arlot-Bonnemains Y, Laguerre B, et al. All anti-vascular endothelial growth factor drugs can induce ‘pre-eclampsia-like syndrome’: a RARe study. Nephrol Dial Transplant. 2014;29(2):325–32.
    • (2014) Nephrol Dial Transplant , vol.29 , Issue.2 , pp. 325-332
    • Vigneau, C.1    Lorcy, N.2    Dolley-Hitze, T.3    Jouan, F.4    Arlot-Bonnemains, Y.5    Laguerre, B.6
  • 15
    • 84875718770 scopus 로고    scopus 로고
    • Renal involvement in preeclampsia: similarities to VEGF ablation therapy
    • PID: 21494322
    • Muller-Deile J, Schiffer M. Renal involvement in preeclampsia: similarities to VEGF ablation therapy. J Pregnancy. 2011;2011:176973. doi:10.1155/2011/.
    • (2011) J Pregnancy , vol.2011 , pp. 176973
    • Muller-Deile, J.1    Schiffer, M.2
  • 16
    • 84908895055 scopus 로고    scopus 로고
    • Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of Literature
    • COI: 1:CAS:528:DC%2BC2cXhtlSqs73E, PID: 25087655
    • Usui J, Glezerman IG, Salvatore SP, Chandran CB, Flombaum CD, Seshan SV. Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of Literature. Hum Pathol. 2014;45(9):1918–27.
    • (2014) Hum Pathol , vol.45 , Issue.9 , pp. 1918-1927
    • Usui, J.1    Glezerman, I.G.2    Salvatore, S.P.3    Chandran, C.B.4    Flombaum, C.D.5    Seshan, S.V.6
  • 18
    • 84863738713 scopus 로고    scopus 로고
    • Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus
    • COI: 1:CAS:528:DC%2BC38XhtVyisrrO, PID: 22808199, This study describes an inducible podocyte-specific VEGF-A knockdown mouse model. Podocyte-specific VEGF-A knockdown results in endothelial cell swelling and podocyte foot process effacement in vivo. VEGF-A knockdown also leads to decreased alphaVbeta3 integrin signaling, an integrin essential for the withstanding of mechanical stress by the podocyte
    • Veron D, Villegas G, Aggarwal PK, Bertuccio C, Jimenez J, Velazquez H, et al. Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus. PLoS ONE. 2012;7(7):e40589. doi:10.1371/journal.pone.0040589. This study describes an inducible podocyte-specific VEGF-A knockdown mouse model. Podocyte-specific VEGF-A knockdown results in endothelial cell swelling and podocyte foot process effacement in vivo. VEGF-A knockdown also leads to decreased alphaVbeta3 integrin signaling, an integrin essential for the withstanding of mechanical stress by the podocyte.
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. 40589
    • Veron, D.1    Villegas, G.2    Aggarwal, P.K.3    Bertuccio, C.4    Jimenez, J.5    Velazquez, H.6
  • 19
    • 77957861954 scopus 로고    scopus 로고
    • Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling
    • COI: 1:CAS:528:DC%2BC3cXhtlems7zN, PID: 20688931
    • Sison K, Eremina V, Baelde H, Min W, Hirashima M, Fantus IG, et al. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol. 2010;21(10):1691–701.
    • (2010) J Am Soc Nephrol , vol.21 , Issue.10 , pp. 1691-1701
    • Sison, K.1    Eremina, V.2    Baelde, H.3    Min, W.4    Hirashima, M.5    Fantus, I.G.6
  • 20
    • 32944474182 scopus 로고    scopus 로고
    • VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    • COI: 1:CAS:528:DC%2BD28XhsFKjuro%3D, PID: 16172168
    • Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006;290(2):H560–76.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.2 , pp. 560-576
    • Kamba, T.1    Tam, B.Y.2    Hashizume, H.3    Haskell, A.4    Sennino, B.5    Mancuso, M.R.6
  • 21
    • 84862961855 scopus 로고    scopus 로고
    • Upregulation of sFlt-1 by trophoblasts induces the barrier dysfunction of glomerular endothelial cells
    • COI: 1:CAS:528:DC%2BC3MXhs1ersb%2FM, PID: 22173504
    • Zhao J, Liu H, Du H, Qiao F, Li Y, Shi X, et al. Upregulation of sFlt-1 by trophoblasts induces the barrier dysfunction of glomerular endothelial cells. J Huazhong Univ Sci Technol Med Sci. 2011;31(6):815–8.
    • (2011) J Huazhong Univ Sci Technol Med Sci , vol.31 , Issue.6 , pp. 815-818
    • Zhao, J.1    Liu, H.2    Du, H.3    Qiao, F.4    Li, Y.5    Shi, X.6
  • 22
    • 84931265842 scopus 로고    scopus 로고
    • Podocytes protect glomerular endothelial cells from hypoxic injury via deSUMOylation of HIF-1alpha signaling
    • COI: 1:CAS:528:DC%2BC2cXhvVOnu7nF, PID: 25448415
    • Wang L, Zhang T, Fang M, Shen N, Wang D, Teng J, et al. Podocytes protect glomerular endothelial cells from hypoxic injury via deSUMOylation of HIF-1alpha signaling. Int J Biochem Cell Biol. 2015;58:17–27.
    • (2015) Int J Biochem Cell Biol , vol.58 , pp. 17-27
    • Wang, L.1    Zhang, T.2    Fang, M.3    Shen, N.4    Wang, D.5    Teng, J.6
  • 23
    • 77955870854 scopus 로고    scopus 로고
    • Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease
    • COI: 1:CAS:528:DC%2BC3cXmtVSgtLY%3D, PID: 20375978
    • Veron D, Reidy KJ, Bertuccio C, Teichman J, Villegas G, Jimenez J, et al. Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease. Kidney Int. 2010;77(11):989–99.
    • (2010) Kidney Int , vol.77 , Issue.11 , pp. 989-999
    • Veron, D.1    Reidy, K.J.2    Bertuccio, C.3    Teichman, J.4    Villegas, G.5    Jimenez, J.6
  • 24
    • 58149343883 scopus 로고    scopus 로고
    • Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice
    • COI: 1:CAS:528:DC%2BD1MXhs1Knt7Y%3D, PID: 18647955
    • Ku CH, White KE, Dei Cas A, Hayward A, Webster Z, Bilous R, et al. Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice. Diabetes. 2008;57(10):2824–33.
    • (2008) Diabetes , vol.57 , Issue.10 , pp. 2824-2833
    • Ku, C.H.1    White, K.E.2    Dei Cas, A.3    Hayward, A.4    Webster, Z.5    Bilous, R.6
  • 25
    • 84856786346 scopus 로고    scopus 로고
    • Nephrotic syndrome unfavorable course correlates with downregulation of podocyte vascular endothelial growth factor receptor (VEGFR)-2
    • COI: 1:CAS:528:DC%2BC38XmvVaqtb8%3D, PID: 22038228
    • Ostalska-Nowicka D, Malinska A, Zabel M, Witkiewicz W, Nowicki M. Nephrotic syndrome unfavorable course correlates with downregulation of podocyte vascular endothelial growth factor receptor (VEGFR)-2. Folia Histochem Cytobiol. 2011;49(3):472–8.
    • (2011) Folia Histochem Cytobiol , vol.49 , Issue.3 , pp. 472-478
    • Ostalska-Nowicka, D.1    Malinska, A.2    Zabel, M.3    Witkiewicz, W.4    Nowicki, M.5
  • 26
    • 77957225604 scopus 로고    scopus 로고
    • Autocrine VEGF-VEGF-R loop on podocytes during glomerulonephritis in humans
    • COI: 1:CAS:528:DC%2BC3cXht1WgsrbI, PID: 20395257
    • Hohenstein B, Colin M, Foellmer C, Amann KU, Brekken RA, Daniel C, et al. Autocrine VEGF-VEGF-R loop on podocytes during glomerulonephritis in humans. Nephrol Dial Transplant. 2010;25(10):3170–80.
    • (2010) Nephrol Dial Transplant , vol.25 , Issue.10 , pp. 3170-3180
    • Hohenstein, B.1    Colin, M.2    Foellmer, C.3    Amann, K.U.4    Brekken, R.A.5    Daniel, C.6
  • 27
    • 81155123707 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes
    • COI: 1:CAS:528:DC%2BC3MXhsVKjsrjN, PID: 21937443
    • Bertuccio C, Veron D, Aggarwal PK, Holzman L, Tufro A. Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes. J Biol Chem. 2011;286(46):39933–44.
    • (2011) J Biol Chem , vol.286 , Issue.46 , pp. 39933-39944
    • Bertuccio, C.1    Veron, D.2    Aggarwal, P.K.3    Holzman, L.4    Tufro, A.5
  • 28
    • 0032015551 scopus 로고    scopus 로고
    • Positionally cloned gene for a novel glomerular protein—nephrin—is mutated in congenital nephrotic syndrome
    • COI: 1:CAS:528:DyaK1cXit1Gisbw%3D, PID: 9660941
    • Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, et al. Positionally cloned gene for a novel glomerular protein—nephrin—is mutated in congenital nephrotic syndrome. Mol Cell. 1998;1(4):575–82.
    • (1998) Mol Cell , vol.1 , Issue.4 , pp. 575-582
    • Kestila, M.1    Lenkkeri, U.2    Mannikko, M.3    Lamerdin, J.4    McCready, P.5    Putaala, H.6
  • 29
    • 33846669530 scopus 로고    scopus 로고
    • Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss
    • COI: 1:CAS:528:DC%2BD2sXjsVOiu7g%3D, PID: 17264876
    • Baelde HJ, Eikmans M, Lappin DW, Doran PP, Hohenadel D, Brinkkoetter PT, et al. Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss. Kidney Int. 2007;71(7):637–45.
    • (2007) Kidney Int , vol.71 , Issue.7 , pp. 637-645
    • Baelde, H.J.1    Eikmans, M.2    Lappin, D.W.3    Doran, P.P.4    Hohenadel, D.5    Brinkkoetter, P.T.6
  • 30
    • 84861125416 scopus 로고    scopus 로고
    • Thilo F, Liu Y, Loddenkemper C, Schuelein R, Schmidt A, Yan Z, et al. VEGF regulates TRPC6 channels in podocytes. Nephrol Dial Transplant. 2012;27(3):921–9. This study investigates the regulatory effect of VEGF on TRPC6, a calcium ion channel found on podocyte foot processes and the slit diaphragms. VEGF165 significantly increases TRPC6 mRNA and protein levels, indicating that VEGF regulates podocyte structure via the expression of TRPC6
    • Thilo F, Liu Y, Loddenkemper C, Schuelein R, Schmidt A, Yan Z, et al. VEGF regulates TRPC6 channels in podocytes. Nephrol Dial Transplant. 2012;27(3):921–9. This study investigates the regulatory effect of VEGF on TRPC6, a calcium ion channel found on podocyte foot processes and the slit diaphragms. VEGF165 significantly increases TRPC6 mRNA and protein levels, indicating that VEGF regulates podocyte structure via the expression of TRPC6.
  • 31
    • 84905514024 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation
    • COI: 1:CAS:528:DC%2BC2cXltVSlurw%3D, PID: 24670409
    • Li SY, Huang PH, Yang AH, Tarng DC, Yang WC, Lin CC, et al. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. Kidney Int. 2014;86(2):358–69.
    • (2014) Kidney Int , vol.86 , Issue.2 , pp. 358-369
    • Li, S.Y.1    Huang, P.H.2    Yang, A.H.3    Tarng, D.C.4    Yang, W.C.5    Lin, C.C.6
  • 32
    • 84923931859 scopus 로고    scopus 로고
    • GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin
    • COI: 1:CAS:528:DC%2BC2MXivVGqtr4%3D, PID: 25012178
    • Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar MG. GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. J Am Soc Nephrol. 2015;26(2):314–27.
    • (2015) J Am Soc Nephrol , vol.26 , Issue.2 , pp. 314-327
    • Wang, H.1    Misaki, T.2    Taupin, V.3    Eguchi, A.4    Ghosh, P.5    Farquhar, M.G.6
  • 33
    • 84867519785 scopus 로고    scopus 로고
    • Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, et al. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012;151(2):384–99. This study discovered the presence of a podocytal autocrine sFlt-1 loop in vitro and in a mouse model. sFlt-1 knockdown in mice resulted in podocytal flattening, cytoskeletal rearrangements and proteinuria. In vitro, sFlt-1 binds to lipid rafts and co-localizes with nephrin
    • Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, et al. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012;151(2):384–99. This study discovered the presence of a podocytal autocrine sFlt-1 loop in vitro and in a mouse model. sFlt-1 knockdown in mice resulted in podocytal flattening, cytoskeletal rearrangements and proteinuria. In vitro, sFlt-1 binds to lipid rafts and co-localizes with nephrin.
  • 34
    • 34047126908 scopus 로고    scopus 로고
    • Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia
    • COI: 1:CAS:528:DC%2BD2sXjslOgtLg%3D, PID: 17255128
    • Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, et al. Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant. 2007;22(4):1136–43.
    • (2007) Nephrol Dial Transplant , vol.22 , Issue.4 , pp. 1136-1143
    • Garovic, V.D.1    Wagner, S.J.2    Petrovic, L.M.3    Gray, C.E.4    Hall, P.5    Sugimoto, H.6
  • 35
    • 70349290711 scopus 로고    scopus 로고
    • Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia
    • COI: 1:CAS:528:DC%2BD1MXht1Oqtb%2FN, PID: 19528353
    • Zhao S, Gu X, Groome LJ, Wang Y. Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia. Reprod Sci. 2009;16(10):970–9.
    • (2009) Reprod Sci , vol.16 , Issue.10 , pp. 970-979
    • Zhao, S.1    Gu, X.2    Groome, L.J.3    Wang, Y.4
  • 36
    • 79961077457 scopus 로고    scopus 로고
    • Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia
    • COI: 1:CAS:528:DC%2BC3MXhtFCgurrP, PID: 21422051
    • Zhao S, Gu Y, Coates G, Groome LJ, Saleem MA, Mathieson PW, et al. Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia. Reprod Sci. 2011;18(8):772–80.
    • (2011) Reprod Sci , vol.18 , Issue.8 , pp. 772-780
    • Zhao, S.1    Gu, Y.2    Coates, G.3    Groome, L.J.4    Saleem, M.A.5    Mathieson, P.W.6
  • 37
    • 54449091923 scopus 로고    scopus 로고
    • Preeclamptic sera directly induce slit-diaphragm protein redistribution and alter podocyte barrier-forming capacity
    • COI: 1:CAS:528:DC%2BD1cXhsVaisLnK, PID: 18953181
    • Henao DE, Arias LF, Mathieson PW, Ni L, Welsh GI, Bueno JC, et al. Preeclamptic sera directly induce slit-diaphragm protein redistribution and alter podocyte barrier-forming capacity. Nephron Exp Nephrol. 2008;110(3):e73–81.
    • (2008) Nephron Exp Nephrol , vol.110 , Issue.3 , pp. 73-81
    • Henao, D.E.1    Arias, L.F.2    Mathieson, P.W.3    Ni, L.4    Welsh, G.I.5    Bueno, J.C.6
  • 38
    • 84875741945 scopus 로고    scopus 로고
    • Exogenous vascular endothelial growth factor supplementation can restore the podocyte barrier-forming capacity disrupted by sera of preeclamptic women
    • PID: 22639941, In this study human cultured podocytes were exposed to sera from preeclamptic women and healthy pregnant women. Sera from preeclamptic women contained more sFlt-1 and less VEGF and disrupted podocyte barrier-forming capacity. Adding VEGF to these sera attenuated this effect
    • Henao DE, Cadavid AP, Saleem MA. Exogenous vascular endothelial growth factor supplementation can restore the podocyte barrier-forming capacity disrupted by sera of preeclamptic women. J Obstet Gynaecol Res. 2013;39(1):46–52. In this study human cultured podocytes were exposed to sera from preeclamptic women and healthy pregnant women. Sera from preeclamptic women contained more sFlt-1 and less VEGF and disrupted podocyte barrier-forming capacity. Adding VEGF to these sera attenuated this effect.
    • (2013) J Obstet Gynaecol Res , vol.39 , Issue.1 , pp. 46-52
    • Henao, D.E.1    Cadavid, A.P.2    Saleem, M.A.3
  • 39
    • 84874040904 scopus 로고    scopus 로고
    • The podocyte’s response to stress: the enigma of foot process effacement
    • COI: 1:CAS:528:DC%2BC3sXjsFamtLg%3D, PID: 23235479
    • Kriz W, Shirato I, Nagata M, LeHir M, Lemley KV. The podocyte’s response to stress: the enigma of foot process effacement. Am J Physiol Renal Physiol. 2013;304(4):F333–47.
    • (2013) Am J Physiol Renal Physiol , vol.304 , Issue.4 , pp. 333-347
    • Kriz, W.1    Shirato, I.2    Nagata, M.3    LeHir, M.4    Lemley, K.V.5
  • 40
    • 45149133361 scopus 로고    scopus 로고
    • Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells
    • COI: 1:CAS:528:DC%2BD1cXmtVWnurs%3D, PID: 18287402
    • Collino F, Bussolati B, Gerbaudo E, Marozio L, Pelissetto S, Benedetto C, et al. Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells. Am J Physiol Renal Physiol. 2008;294(5):F1185–94.
    • (2008) Am J Physiol Renal Physiol , vol.294 , Issue.5 , pp. 1185-1194
    • Collino, F.1    Bussolati, B.2    Gerbaudo, E.3    Marozio, L.4    Pelissetto, S.5    Benedetto, C.6
  • 41
    • 80051621508 scopus 로고    scopus 로고
    • Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes
    • COI: 1:CAS:528:DC%2BC3MXhtl2gsrfJ, PID: 21849801
    • Eyre J, Burton JO, Saleem MA, Mathieson PW, Topham PS, Brunskill NJ. Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes. Nephron Exp Nephrol. 2011;119(3):e58–66.
    • (2011) Nephron Exp Nephrol , vol.119 , Issue.3 , pp. 58-66
    • Eyre, J.1    Burton, J.O.2    Saleem, M.A.3    Mathieson, P.W.4    Topham, P.S.5    Brunskill, N.J.6
  • 42
    • 84890128050 scopus 로고    scopus 로고
    • Proteinuria in preeclampsia from a podocyte injury perspective
    • COI: 1:CAS:528:DC%2BC3sXhvVGmsLjO, PID: 24214687
    • Henao DE, Saleem MA. Proteinuria in preeclampsia from a podocyte injury perspective. Curr Hypertens Rep. 2013;15(6):600–5.
    • (2013) Curr Hypertens Rep , vol.15 , Issue.6 , pp. 600-605
    • Henao, D.E.1    Saleem, M.A.2
  • 43
    • 84868192453 scopus 로고    scopus 로고
    • Preeclampsia is characterized by placental complement dysregulation
    • COI: 1:CAS:528:DC%2BC38XhsFagtL7E, PID: 23006730
    • Buurma A, Cohen D, Veraar K, Schonkeren D, Claas FH, Bruijn JA, et al. Preeclampsia is characterized by placental complement dysregulation. Hypertension. 2012;60(5):1332–7.
    • (2012) Hypertension , vol.60 , Issue.5 , pp. 1332-1337
    • Buurma, A.1    Cohen, D.2    Veraar, K.3    Schonkeren, D.4    Claas, F.H.5    Bruijn, J.A.6
  • 44
    • 41349089497 scopus 로고    scopus 로고
    • Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia
    • Lynch AM, Murphy JR, Byers T, Gibbs RS, Neville MC, Giclas PC, et al. Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia. Am J Obstet Gynecol. 2008;198(4):385.e1–9.
    • (2008) Am J Obstet Gynecol , vol.198 , Issue.4 , pp. 1-9
    • Lynch, A.M.1    Murphy, J.R.2    Byers, T.3    Gibbs, R.S.4    Neville, M.C.5    Giclas, P.C.6
  • 46
    • 84914155680 scopus 로고    scopus 로고
    • Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia
    • COI: 1:CAS:528:DC%2BC2cXhsFWhurbF, PID: 24958504
    • Burwick RM, Easter SR, Dawood HY, Yamamoto HS, Fichorova RN, Feinberg BB. Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia. Hypertension. 2014;64(4):833–8.
    • (2014) Hypertension , vol.64 , Issue.4 , pp. 833-838
    • Burwick, R.M.1    Easter, S.R.2    Dawood, H.Y.3    Yamamoto, H.S.4    Fichorova, R.N.5    Feinberg, B.B.6
  • 47
    • 84891594043 scopus 로고    scopus 로고
    • Urinary excretion of C5b-9 in severe preeclampsia: tipping the balance of complement activation in pregnancy
    • COI: 1:CAS:528:DC%2BC2cXisVejtw%3D%3D, PID: 24060886
    • Burwick RM, Fichorova RN, Dawood HY, Yamamoto HS, Feinberg BB. Urinary excretion of C5b-9 in severe preeclampsia: tipping the balance of complement activation in pregnancy. Hypertension. 2013;62(6):1040–5.
    • (2013) Hypertension , vol.62 , Issue.6 , pp. 1040-1045
    • Burwick, R.M.1    Fichorova, R.N.2    Dawood, H.Y.3    Yamamoto, H.S.4    Feinberg, B.B.5
  • 48
    • 84865480216 scopus 로고    scopus 로고
    • Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia
    • COI: 1:CAS:528:DC%2BC38Xht1SitbnF, PID: 22868393
    • Wang W, Irani RA, Zhang Y, Ramin SM, Blackwell SC, Tao L, et al. Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia. Hypertension. 2012;60(3):712–21.
    • (2012) Hypertension , vol.60 , Issue.3 , pp. 712-721
    • Wang, W.1    Irani, R.A.2    Zhang, Y.3    Ramin, S.M.4    Blackwell, S.C.5    Tao, L.6
  • 49
    • 84901728046 scopus 로고    scopus 로고
    • Urinary podocyte excretion and proteinuria in patients treated with antivascular endothelial growth factor therapy for solid tumor malignancies
    • COI: 1:CAS:528:DC%2BC2cXhtFOqt7vJ, PID: 24902997
    • Hayman SR, Calle JC, Jatoi A, Craici IM, Wagner SJ, Weaver AL, et al. Urinary podocyte excretion and proteinuria in patients treated with antivascular endothelial growth factor therapy for solid tumor malignancies. Oncology. 2014;86(5–6):271–8.
    • (2014) Oncology , vol.86 , Issue.5-6 , pp. 271-278
    • Hayman, S.R.1    Calle, J.C.2    Jatoi, A.3    Craici, I.M.4    Wagner, S.J.5    Weaver, A.L.6
  • 50
    • 84927547028 scopus 로고    scopus 로고
    • The value of the urinary protein: creatinine ratio for the detection of significant proteinuria in women with suspected preeclampsia
    • PID: 25737188
    • Bhide A, Rana R, Dhavilkar M, Amodio-Hernandez M, Deshpande D, Caric V. The value of the urinary protein: creatinine ratio for the detection of significant proteinuria in women with suspected preeclampsia. Acta Obstet Gynecol Scand. 2015. doi:10.1111/aogs.12624.
    • (2015) Acta Obstet Gynecol Scand
    • Bhide, A.1    Rana, R.2    Dhavilkar, M.3    Amodio-Hernandez, M.4    Deshpande, D.5    Caric, V.6
  • 51
    • 84908214147 scopus 로고    scopus 로고
    • The role of the podocyte in preeclampsia
    • COI: 1:CAS:528:DC%2BC2cXhs1GnurnL, PID: 25035271
    • Garovic VD. The role of the podocyte in preeclampsia. Clin J Am Soc Nephrol. 2014;9(8):1337–40.
    • (2014) Clin J Am Soc Nephrol , vol.9 , Issue.8 , pp. 1337-1340
    • Garovic, V.D.1
  • 52
    • 21344446946 scopus 로고    scopus 로고
    • Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria
    • COI: 1:CAS:528:DC%2BD2MXls1eiu7c%3D, PID: 15829708
    • Yu D, Petermann A, Kunter U, Rong S, Shankland SJ, Floege J. Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J Am Soc Nephrol. 2005;16(6):1733–41.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.6 , pp. 1733-1741
    • Yu, D.1    Petermann, A.2    Kunter, U.3    Rong, S.4    Shankland, S.J.5    Floege, J.6
  • 54
    • 84878917311 scopus 로고    scopus 로고
    • Podocyturia predates proteinuria and clinical features of preeclampsia: longitudinal prospective study
    • COI: 1:CAS:528:DC%2BC3sXns1GmtLg%3D, PID: 23529165
    • Craici IM, Wagner SJ, Bailey KR, Fitz-Gibbon PD, Wood-Wentz CM, Turner ST, et al. Podocyturia predates proteinuria and clinical features of preeclampsia: longitudinal prospective study. Hypertension. 2013;61(6):1289–96.
    • (2013) Hypertension , vol.61 , Issue.6 , pp. 1289-1296
    • Craici, I.M.1    Wagner, S.J.2    Bailey, K.R.3    Fitz-Gibbon, P.D.4    Wood-Wentz, C.M.5    Turner, S.T.6
  • 55
    • 84870253854 scopus 로고    scopus 로고
    • Quantitative polymerase chain reaction-based analysis of podocyturia is a feasible diagnostic tool in preeclampsia
    • COI: 1:CAS:528:DC%2BC38Xhs1GqsrfN, PID: 23090771, In this study a new method for the detection of podocyturia is presented. Urine samples from preeclamptic women, healthy controls and women with gestational hypertension were collected and qPCR for VEGF, podocin and nephrin mRNA was performed. qPCR of these podocyte-specific molecules distinguished preeclamptic patients from healthy and hypertensive controls and is a rapid tool for the detection of podocytes in urine
    • Kelder TP, Penning ME, Uh HW, Cohen D, Bloemenkamp KW, Bruijn JA, et al. Quantitative polymerase chain reaction-based analysis of podocyturia is a feasible diagnostic tool in preeclampsia. Hypertension. 2012;60(6):1538–44. In this study a new method for the detection of podocyturia is presented. Urine samples from preeclamptic women, healthy controls and women with gestational hypertension were collected and qPCR for VEGF, podocin and nephrin mRNA was performed. qPCR of these podocyte-specific molecules distinguished preeclamptic patients from healthy and hypertensive controls and is a rapid tool for the detection of podocytes in urine.
    • (2012) Hypertension , vol.60 , Issue.6 , pp. 1538-1544
    • Kelder, T.P.1    Penning, M.E.2    Uh, H.W.3    Cohen, D.4    Bloemenkamp, K.W.5    Bruijn, J.A.6
  • 56
    • 34250374471 scopus 로고    scopus 로고
    • Role of the VEGF-A signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier
    • Eremina V, Baelde HJ, Quaggin SE. Role of the VEGF-A signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol. 2007;106(2):32–7.
    • (2007) Nephron Physiol , vol.106 , Issue.2 , pp. 32-37
    • Eremina, V.1    Baelde, H.J.2    Quaggin, S.E.3
  • 57
    • 84891596890 scopus 로고    scopus 로고
    • Regulation of placental angiogenesis
    • COI: 1:CAS:528:DC%2BC2cXitVOmsLjI, PID: 23981199
    • Chen DB, Zheng J. Regulation of placental angiogenesis. Microcirculation. 2014;21(1):15–25.
    • (2014) Microcirculation , vol.21 , Issue.1 , pp. 15-25
    • Chen, D.B.1    Zheng, J.2
  • 58
    • 84455208254 scopus 로고    scopus 로고
    • The podocyte as a target for therapies–new and old
    • COI: 1:CAS:528:DC%2BC3MXhs1CqurnI
    • Mathieson PW. The podocyte as a target for therapies–new and old. Nat Rev Nephrol. 2012;8(1):52–6.
    • (2012) Nat Rev Nephrol , vol.8 , Issue.1 , pp. 52-56
    • Mathieson, P.W.1
  • 59
    • 33644801094 scopus 로고    scopus 로고
    • Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins
    • COI: 1:CAS:528:DC%2BD2MXhtFeisL3F, PID: 15987750
    • Wada T, Pippin JW, Marshall CB, Griffin SV, Shankland SJ. Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol. 2005;16(9):2615–25.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.9 , pp. 2615-2625
    • Wada, T.1    Pippin, J.W.2    Marshall, C.B.3    Griffin, S.V.4    Shankland, S.J.5
  • 60
    • 33646133214 scopus 로고    scopus 로고
    • The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases
    • COI: 1:CAS:528:DC%2BD28XjsVWrsLc%3D, PID: 16531978
    • Fujii Y, Khoshnoodi J, Takenaka H, Hosoyamada M, Nakajo A, Bessho F, et al. The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases. Kidney Int. 2006;69(8):1350–9.
    • (2006) Kidney Int , vol.69 , Issue.8 , pp. 1350-1359
    • Fujii, Y.1    Khoshnoodi, J.2    Takenaka, H.3    Hosoyamada, M.4    Nakajo, A.5    Bessho, F.6
  • 61
    • 62549130686 scopus 로고    scopus 로고
    • Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition
    • COI: 1:CAS:528:DC%2BD1MXjs1Whu7k%3D, PID: 19164508
    • Macconi D, Sangalli F, Bonomelli M, Conti S, Condorelli L, Gagliardini E, et al. Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition. Am J Pathol. 2009;174(3):797–807.
    • (2009) Am J Pathol , vol.174 , Issue.3 , pp. 797-807
    • Macconi, D.1    Sangalli, F.2    Bonomelli, M.3    Conti, S.4    Condorelli, L.5    Gagliardini, E.6
  • 62
    • 33744954580 scopus 로고    scopus 로고
    • ACE inhibitors and congenital anomalies
    • COI: 1:CAS:528:DC%2BD28XlsVahtbg%3D, PID: 16760451
    • Friedman JM. ACE inhibitors and congenital anomalies. N Engl J Med. 2006;354(23):2498–500.
    • (2006) N Engl J Med , vol.354 , Issue.23 , pp. 2498-2500
    • Friedman, J.M.1
  • 63
    • 67651089825 scopus 로고    scopus 로고
    • Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy
    • COI: 1:CAS:528:DC%2BD1MXptVamtLY%3D, PID: 19188342
    • Sakurai N, Kuroiwa T, Ikeuchi H, Hiramatsu N, Takeuchi S, Tomioka M, et al. Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy. Nephrol Dial Transplant. 2009;24(8):2378–83.
    • (2009) Nephrol Dial Transplant , vol.24 , Issue.8 , pp. 2378-2383
    • Sakurai, N.1    Kuroiwa, T.2    Ikeuchi, H.3    Hiramatsu, N.4    Takeuchi, S.5    Tomioka, M.6
  • 64
    • 84897673455 scopus 로고    scopus 로고
    • Therapeutic potential of statins and the induction of heme oxygenase-1 in preeclampsia
    • PID: 24503248
    • Ramma W, Ahmed A. Therapeutic potential of statins and the induction of heme oxygenase-1 in preeclampsia. J Reprod Immunol. 2014;101–102:153–60.
    • (2014) J Reprod Immunol , vol.101-102 , pp. 153-160
    • Ramma, W.1    Ahmed, A.2
  • 65
    • 84902238995 scopus 로고    scopus 로고
    • Clinical improvement and successful pregnancy in a preeclamptic patient with antiphospholipid syndrome treated with pravastatin
    • COI: 1:CAS:528:DC%2BC2cXms1Wksrg%3D, PID: 24591337
    • Lefkou E, Mamopoulos A, Fragakis N, Dagklis T, Vosnakis C, Nounopoulos E, et al. Clinical improvement and successful pregnancy in a preeclamptic patient with antiphospholipid syndrome treated with pravastatin. Hypertension. 2014;63(5):e118–9.
    • (2014) Hypertension , vol.63 , Issue.5 , pp. 118-119
    • Lefkou, E.1    Mamopoulos, A.2    Fragakis, N.3    Dagklis, T.4    Vosnakis, C.5    Nounopoulos, E.6
  • 67
    • 84931261174 scopus 로고    scopus 로고
    • Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules
    • PID: 25332898
    • Fukusumi Y, Miyauchi N, Hashimoto T, Saito A, Kawachi H. Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules. World J Nephrol. 2014;3(3):77–84.
    • (2014) World J Nephrol , vol.3 , Issue.3 , pp. 77-84
    • Fukusumi, Y.1    Miyauchi, N.2    Hashimoto, T.3    Saito, A.4    Kawachi, H.5
  • 68
    • 84889004068 scopus 로고    scopus 로고
    • Actin-associated proteins in the pathogenesis of podocyte injury
    • COI: 1:CAS:528:DC%2BC3sXhvFeltb3I
    • He FF, Chen S, Su H, Meng XF, Zhang C. Actin-associated proteins in the pathogenesis of podocyte injury. Curr Genom. 2013;14(7):477–84.
    • (2013) Curr Genom , vol.14 , Issue.7 , pp. 477-484
    • He, F.F.1    Chen, S.2    Su, H.3    Meng, X.F.4    Zhang, C.5
  • 69
    • 84898069665 scopus 로고    scopus 로고
    • Arif E, Rathore YS, Kumari B, Ashish F, Wong HN, Holzman LB, et al. Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem. 2014;289(14):9502–18. This study shows that Neph1 signaling inhibition prevents podocyte damage in vivo and in vitro in PAN and adriamycine renal injury models. Inhibition of Neph1 phosphorylation prevents mislocalization of Neph1 and maintains the normal cytoskeletal structure in podocytes
    • Arif E, Rathore YS, Kumari B, Ashish F, Wong HN, Holzman LB, et al. Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem. 2014;289(14):9502–18. This study shows that Neph1 signaling inhibition prevents podocyte damage in vivo and in vitro in PAN and adriamycine renal injury models. Inhibition of Neph1 phosphorylation prevents mislocalization of Neph1 and maintains the normal cytoskeletal structure in podocytes.
  • 70
    • 77952550133 scopus 로고    scopus 로고
    • Kidney disease after preeclampsia: a systematic review and meta-analysis
    • PID: 20346562
    • McDonald SD, Han Z, Walsh MW, Gerstein HC, Devereaux PJ. Kidney disease after preeclampsia: a systematic review and meta-analysis. Am J Kidney Dis. 2010;55(6):1026–39.
    • (2010) Am J Kidney Dis , vol.55 , Issue.6 , pp. 1026-1039
    • McDonald, S.D.1    Han, Z.2    Walsh, M.W.3    Gerstein, H.C.4    Devereaux, P.J.5
  • 71
    • 84874289366 scopus 로고    scopus 로고
    • Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study
    • PID: 23339156
    • Wang IK, Muo CH, Chang YC, Liang CC, Chang CT, Lin SY, et al. Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study. Cmaj. 2013;185(3):207–13.
    • (2013) Cmaj , vol.185 , Issue.3 , pp. 207-213
    • Wang, I.K.1    Muo, C.H.2    Chang, Y.C.3    Liang, C.C.4    Chang, C.T.5    Lin, S.Y.6
  • 72
    • 84869119307 scopus 로고    scopus 로고
    • Familial factors in the association between preeclampsia and later ESRD
    • PID: 22956264, This large study using the Norwegian Population Registry shows that the increased risk of end-stage renal disease after preeclampsia is not explained by familial aggregation of risk factors, but that the preeclampsia itself probably leads to kidney damage
    • Vikse BE, Irgens LM, Karumanchi SA, Thadhani R, Reisaeter AV, Skjaerven R. Familial factors in the association between preeclampsia and later ESRD. Clin J Am Soc Nephrol. 2012;7(11):1819–26. This large study using the Norwegian Population Registry shows that the increased risk of end-stage renal disease after preeclampsia is not explained by familial aggregation of risk factors, but that the preeclampsia itself probably leads to kidney damage.
    • (2012) Clin J Am Soc Nephrol , vol.7 , Issue.11 , pp. 1819-1826
    • Vikse, B.E.1    Irgens, L.M.2    Karumanchi, S.A.3    Thadhani, R.4    Reisaeter, A.V.5    Skjaerven, R.6
  • 73
    • 49949114457 scopus 로고    scopus 로고
    • Preeclampsia and the risk of end-stage renal disease
    • COI: 1:CAS:528:DC%2BD1cXhtVShur7E, PID: 18716297
    • Vikse BE, Irgens LM, Leivestad T, Skjaerven R, Iversen BM. Preeclampsia and the risk of end-stage renal disease. N Engl J Med. 2008;359(8):800–9.
    • (2008) N Engl J Med , vol.359 , Issue.8 , pp. 800-809
    • Vikse, B.E.1    Irgens, L.M.2    Leivestad, T.3    Skjaerven, R.4    Iversen, B.M.5
  • 74
    • 0036891810 scopus 로고    scopus 로고
    • Podocyte biology and response to injury
    • PID: 12444221
    • Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol. 2002;13(12):3005–15.
    • (2002) J Am Soc Nephrol , vol.13 , Issue.12 , pp. 3005-3015
    • Mundel, P.1    Shankland, S.J.2
  • 75
    • 0035743293 scopus 로고    scopus 로고
    • Urinary podocytes in primary focal segmental glomerulosclerosis
    • COI: 1:CAS:528:DC%2BD3MXnsFSjsL0%3D, PID: 11598401
    • Hara M, Yanagihara T, Kihara I. Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron. 2001;89(3):342–7.
    • (2001) Nephron , vol.89 , Issue.3 , pp. 342-347
    • Hara, M.1    Yanagihara, T.2    Kihara, I.3
  • 76
    • 77957232521 scopus 로고    scopus 로고
    • Previous preeclampsia and risk for progression of biopsy-verified kidney disease to end-stage renal disease
    • PID: 20348149
    • Vikse BE, Hallan S, Bostad L, Leivestad T, Iversen BM. Previous preeclampsia and risk for progression of biopsy-verified kidney disease to end-stage renal disease. Nephrol Dial Transplant. 2010;25(10):3289–96.
    • (2010) Nephrol Dial Transplant , vol.25 , Issue.10 , pp. 3289-3296
    • Vikse, B.E.1    Hallan, S.2    Bostad, L.3    Leivestad, T.4    Iversen, B.M.5
  • 77
    • 84899745049 scopus 로고    scopus 로고
    • Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury
    • PID: 24664365, In this study urine samples from women with preeclampsia and normotensive pregnant women were collected from 24 hours before up to five to eight weeks after delivery. Altough proteinuria normalized postpartum, three out of ten preeclampsia patients still had podocyturia postpartum whereas normotensive women had no podocyturia
    • White WM, Garrett AT, Craici IM, Wagner SJ, Fitz-Gibbon PD, Butters KA, et al. Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury. PLoS ONE. 2014;9(3):e92693. doi:10.1371/journal.pone.0092693. In this study urine samples from women with preeclampsia and normotensive pregnant women were collected from 24 hours before up to five to eight weeks after delivery. Altough proteinuria normalized postpartum, three out of ten preeclampsia patients still had podocyturia postpartum whereas normotensive women had no podocyturia.
    • (2014) PLoS ONE , vol.9 , Issue.3 , pp. 92693
    • White, W.M.1    Garrett, A.T.2    Craici, I.M.3    Wagner, S.J.4    Fitz-Gibbon, P.D.5    Butters, K.A.6
  • 78
    • 59949092665 scopus 로고    scopus 로고
    • Recruitment of podocytes from glomerular parietal epithelial cells
    • COI: 1:CAS:528:DC%2BD1MXjtFCrtLw%3D, PID: 19092119
    • Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, et al. Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol. 2009;20(2):333–43.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.2 , pp. 333-343
    • Appel, D.1    Kershaw, D.B.2    Smeets, B.3    Yuan, G.4    Fuss, A.5    Frye, B.6
  • 79
    • 84906547163 scopus 로고    scopus 로고
    • Extensive podocyte loss triggers a rapid parietal epithelial cell response
    • PID: 24335975
    • Hakroush S, Cebulla A, Schaldecker T, Behr D, Mundel P, Weins A. Extensive podocyte loss triggers a rapid parietal epithelial cell response. J Am Soc Nephrol. 2014;25(5):927–38.
    • (2014) J Am Soc Nephrol , vol.25 , Issue.5 , pp. 927-938
    • Hakroush, S.1    Cebulla, A.2    Schaldecker, T.3    Behr, D.4    Mundel, P.5    Weins, A.6
  • 80
    • 79960109593 scopus 로고    scopus 로고
    • Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis
    • COI: 1:CAS:528:DC%2BC3MXhtVSnsL%2FF, PID: 21719782
    • Smeets B, Kuppe C, Sicking EM, Fuss A, Jirak P, van Kuppevelt TH, et al. Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2011;22(7):1262–74.
    • (2011) J Am Soc Nephrol , vol.22 , Issue.7 , pp. 1262-1274
    • Smeets, B.1    Kuppe, C.2    Sicking, E.M.3    Fuss, A.4    Jirak, P.5    van Kuppevelt, T.H.6
  • 81
    • 84908172739 scopus 로고    scopus 로고
    • Association of preeclampsia with podocyte turnover
    • COI: 1:CAS:528:DC%2BC2cXhs1GnurbP, PID: 25035270, In this study, renal samples from women with preeclampsia and pregnant controls were collected from the nationwide Dutch pathology database PALGA. Endotheliosis was not associated with preeclampsia, but increased podocyte turnover and activation of parietal epithelial cells were
    • Penning ME, Bloemenkamp KW, van der Zon T, Zandbergen M, Schutte JM, Bruijn JA, et al. Association of preeclampsia with podocyte turnover. Clin J Am Soc Nephrol. 2014;9(8):1377–85. In this study, renal samples from women with preeclampsia and pregnant controls were collected from the nationwide Dutch pathology database PALGA. Endotheliosis was not associated with preeclampsia, but increased podocyte turnover and activation of parietal epithelial cells were.
    • (2014) Clin J Am Soc Nephrol , vol.9 , Issue.8 , pp. 1377-1385
    • Penning, M.E.1    Bloemenkamp, K.W.2    van der Zon, T.3    Zandbergen, M.4    Schutte, J.M.5    Bruijn, J.A.6
  • 82
    • 84890516193 scopus 로고    scopus 로고
    • What is personalized medicine: sharpening a vague term based on a systematic literature review
    • PID: 24359531
    • Schleidgen S, Klingler C, Bertram T, Rogowski WH, Marckmann G. What is personalized medicine: sharpening a vague term based on a systematic literature review. BMC Med Ethics. 2013;14:55.
    • (2013) BMC Med Ethics , vol.14 , pp. 55
    • Schleidgen, S.1    Klingler, C.2    Bertram, T.3    Rogowski, W.H.4    Marckmann, G.5
  • 83
    • 77957240409 scopus 로고    scopus 로고
    • Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers
    • COI: 1:CAS:528:DC%2BC3cXhtFKls7nF, PID: 20837882
    • Kenny LC, Broadhurst DI, Dunn W, Brown M, North RA, McCowan L, et al. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension. 2010;56(4):741–9.
    • (2010) Hypertension , vol.56 , Issue.4 , pp. 741-749
    • Kenny, L.C.1    Broadhurst, D.I.2    Dunn, W.3    Brown, M.4    North, R.A.5    McCowan, L.6
  • 84
    • 84878896133 scopus 로고    scopus 로고
    • Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia
    • COI: 1:CAS:528:DC%2BC3sXns1GmtLs%3D, PID: 23547239
    • Myers JE, Tuytten R, Thomas G, Laroy W, Kas K, Vanpoucke G, et al. Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia. Hypertension. 2013;61(6):1281–8.
    • (2013) Hypertension , vol.61 , Issue.6 , pp. 1281-1288
    • Myers, J.E.1    Tuytten, R.2    Thomas, G.3    Laroy, W.4    Kas, K.5    Vanpoucke, G.6
  • 85
    • 84889059279 scopus 로고    scopus 로고
    • A multi-centre phase IIa clinical study of predictive testing for preeclampsia: improved pregnancy outcomes via early detection (IMPROvED)
    • PID: 24314209
    • Navaratnam K, Alfirevic Z, Baker PN, Gluud C, Gruttner B, Kublickiene K, et al. A multi-centre phase IIa clinical study of predictive testing for preeclampsia: improved pregnancy outcomes via early detection (IMPROvED). BMC Pregnancy Childbirth. 2013;13:226.
    • (2013) BMC Pregnancy Childbirth , vol.13 , pp. 226
    • Navaratnam, K.1    Alfirevic, Z.2    Baker, P.N.3    Gluud, C.4    Gruttner, B.5    Kublickiene, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.