Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia

Reproductive Sciences

Volumn 18, Issue 8, 2011, Pages 772-780

  Zhao, Shuang ^a   Gu, Yang ^a   Coates, Gregory ^a   Groome, Lynn J ^a   Saleem, Moin A ^b   Mathieson, Peter W ^b   Wang, Yuping ^a  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

nephrin; podocyte; podoplanin; polarity protein; preeclampsia

Indexed keywords

NEPHRIN; PODOPLANIN; POLARITY PROTEIN PARTITIONING DEFECTIVE 3; POLARITY PROTEIN PARTITIONING DEFECTIVE 6; PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO POLARITY; FEMALE; GLOMERULUS BASEMENT MEMBRANE; HUMAN; MALE; PODOCYTE; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BLOTTING, WESTERN; CELL CYCLE PROTEINS; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICROSCOPY, PHASE-CONTRAST; PODOCYTES; PRE-ECLAMPSIA; PREGNANCY;

EID: 79961077457     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719111398145     Document Type: Article

References (27)

1. Gaber LW, Lindheimer MD Hypertensive Disorder in Pregnancy. 2 nd ed. Lindheimer MD Roberts JM Cunningham FG Chesley's, ed. Stanford, Connecticut: Appleton & Lange ; 1999: 231-262.
2. Garovic VD, Wagner SJ, Turner ST, et al Am J Obstet Gynecol. 2007: 320.e321-327.
3. Garovic VD, Wagner SJ, Petrovic LM, et al. Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant. 2007 ; 22 (4). 1136-1143 (Pubitemid 46523429)
4. Zhao S, Gu X, Groome LJ, Wang Y. Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia. Reprod Sci. 2009 ; 16 (10). 970-979
5. Vogelmann SU, Nelson WJ, Myers BD, Lemley KV. Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol. 2003 ; 285 (1). F40 - F48
6. Saleem MA, O'Hare MJ, Reiser J, et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol. 2002 ; 13 (3). 630-638 (Pubitemid 34183927)
7. Doublier S, Salvidio G, Lupia E, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes. 2003 ; 52 (4). 1023-1030 (Pubitemid 36384273)
8. Patrakka J, Tryggvason K. Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun. 2010 ; 386 (1). 164-169
9. Welsh GI, Saleem MA. Nephrin-signature molecule of the glomerular podocyte?. J Pathol. 2010 ; 220 (3). 328-337
10. Huber TB, Benzing T. The slit diaphragm: a signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens. 2005 ; 14 (3). 211-214
11. Harita Y, Kurihara H, Kosako H, et al. Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. J Biol Chem. 2009 ; 284 (13). 8951-8962
12. Shih NY, Li J, Cotran R, Mundel P, Miner JH, Shaw AS. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol. 2001 ; 159 (6). 2303-2308 (Pubitemid 33104283)
13. Jones N, Blasutig IM, Eremina V, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature. 2006 ; 440 (7085). 818-823
14. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol. 2007 ; 17 (9). 428-437 (Pubitemid 47499042)
15. Kestilä M, Lenkkeri U, Männikkö M, et al. Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell. 1998 ; 1 (4). 575-582 (Pubitemid 128374693)
16. Putaala H, Soininen R, Kilpeläinen P, Wartiovaara J, Tryggvason K. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet. 2001 ; 10 (1). 1-8 (Pubitemid 32051561)
17. Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 2006 ; 69 (12). 2131-2147 (Pubitemid 43882099)
18. Aita K, Etoh M, Hamada H, Yokoyama C, Takahashi A, Suzuki T, Hara M, Nagata M. Acute and transient podocyte loss and proteinuria in preeclampsia. Nephron Clin Pract. 2009 ; 112 (2). c65 - c70
19. Hartleben B, Schweizer H, Lübben P, et al. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008 ; 283 (34). 23033-23038
20. Skoberne A, Konieczny A, Schiffer M. Glomerular epithelial cells in the urine: what has to be done to make them worthwhile?. Am J Physiol Renal Physiol. 2009 ; 296 (2). F230 - F241
21. Bariéty J, Bruneval P, Hill GS, Mandet C, Jacquot C, Meyr A. Transdifferentiation of epithelial glomerular cells. J Am Soc Nephrol. 2003 ; 14 (suppl 1). S42 - S47
22. Nagata M, Horita S, Shu Y, Shibata S, Hattori M, Ito K, Watanabe T. Phenotypic characteristics and cyclin-dependent kinase inhibitors repression in hyperplastic epithelial pathology in idiopathic focal segmental glomerulosclerosis. Lab Invest. 2000 ; 80 (6). 869-880 (Pubitemid 30421804)
23. Bariéty J, Nochy D, Mandet C, Jacquot C, Glotz D, Meyrier A. Podocytes undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy. Kidney Int. 1998 ; 53 (4). 918-925 (Pubitemid 28155664)
24. Henao DE, Saleem MA, Cadavid AP. Glomerular disturbances in preeclampsia: disruption between glomerular endothelium and podocyte symbiosis. Hypertens Pregnancy. 2010 ; 29 (1). 10-20
25. Henao DE, Arias LF, Mathieson PW, et al. Preeclamptic sera directly induce slit-diaphragm protein redistribution and alter podocyte barrier-forming capacity. Nephron Exp Nephrol. 2008 ; 110 (3). e73 - e81
26. Collino F, Bussolati B, Gerbaudo E, et al. Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells. Am J Physiol Renal Physiol. 2008 ; 294 (5). F1185-1194
27. Henao DE, Mathieson PW, Saleem MA, Bueno JC, Cadavid A. A novel renal perspective of preeclampsia: a look from the podocyte. Nephrol Dial Transplant. 2007 ; 22 (5). 1477 (Pubitemid 47072243)