GABAA receptor subtype-selectivity of novel bicuculline derivatives

Current Medicinal Chemistry

Volumn 22, Issue 6, 2015, Pages 771-780

  Ramerstorfer, Joachim ^a   Foppa, Verena ^a   Thiery, Hanna ^a   Hermange, Philippe ^b   Janody, Simon ^b   Berger, Michael L ^a   Dodd, Robert H ^b   Sieghart, Werner ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CNRS   (France)

Author keywords

Benzodiazepine binding site; GABAA receptor; Novel binding site; Novel ligands; Positive modulators; ROD 185

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA6; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; 5 (2 'N BENZYLOXYCARBONYL 1',2' DIHYDRO 1'METHYLISOQUINOLINYL) 2(5H) FURANONE; 5 (2' N BENZYLOXYCARBONYL 1',2 'DIHYDRO 6'BROMOISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 3 CYANOISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 3'METHOXYCARBONYLISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 4' BROMOISOQUINOLYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 5'BROMOISOQUINOLINYL) 2(5H) FURANONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 5'BROMOISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 5'NITROISOQUINOLINYL) 2(5H) FURANONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 5'NITROISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 6' BROMOISOQUINOLINYL) 2(5H) FURANONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDRO 6' BROMOISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDROISOQUINOLINYL) 2(5H) FURANONE; 5 (2' N BENZYLOXYCARBONYL 1',2' DIHYDROISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 1',2',3',4' TETRAHYDRO 5' ISOQUINOLINYL)TETRAHYDROFURAN 2 ONE; 5 (2' N BENZYLOXYCARBONYL 4' BROMO 1',2' DIHYDROISOQUINOLINYL) 2(5H) FURANONE; BENZODIAZEPINE; BICUCULLINE; COMPLEMENTARY DNA; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; PROTEIN BINDING;

ADULT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; HYDROGENATION; IN VITRO STUDY; NONHUMAN; OOCYTE; OVARY FOLLICLE CELL; RAT; VOLTAGE CLAMP TECHNIQUE; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; ELECTROPHYSIOLOGY; ENZYME SPECIFICITY; METABOLISM; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; BICUCULLINE; BINDING SITES; ELECTROPHYSIOLOGICAL PROCESSES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SUBSTRATE SPECIFICITY;

EID: 84931267754     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867321666141106110356     Document Type: Article

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