Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 94, Issue , 2015, Pages 160-169

  Mangal, Sharad ^a   Meiser, Felix ^a   Tan, Geoffrey ^a   Gengenbach, Thomas ^b   Denman, John ^c   Rowles, Matthew R ^d   Larson, Ian ^a   Morton, David A V ^a  

^a MONASH UNIVERSITY   (Australia)

^b CSIRO   (Australia)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^d The University of Melbourne   (Australia)

Author keywords

Inter particle cohesion; l Leucine; Polyvinylpyrrolidone; Spray drying; Surface mapping

Indexed keywords

LEUCINE; POVIDONE; AEROSOL; LUBRICATING AGENT; POWDER;

ARTICLE; BULK POWDER; CRYSTAL STRUCTURE; DRY POWDER; INVERSE GAS CHROMATOGRAPHY; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SHEAR CELL; SOLID STATE; SPRAY DRIED FORMULATION; SPRAY DRYING; SURFACE AREA; SURFACE PROPERTY; TABLET FORMULATION; TIME OF FLIGHT MASS SPECTROMETRY; X RAY PHOTOELECTRON SPECTROSCOPY; X RAY POWDER DIFFRACTION; AEROSOL; CHEMISTRY; CRYSTALLIZATION; DESICCATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINAL CHEMISTRY; PHARMACEUTICS; POWDER; POWDER DIFFRACTION; PROCEDURES; X RAY CRYSTALLOGRAPHY;

AEROSOLS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GAS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DESICCATION; LEUCINE; LUBRICANTS; MASS SPECTROMETRY; MICROSCOPY, ELECTRON, SCANNING; PHOTOELECTRON SPECTROSCOPY; POVIDONE; POWDER DIFFRACTION; POWDERS; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 84931262316     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.04.035     Document Type: Article

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