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Volumn 35, Issue 3, 2015, Pages 343-349

Inhibitory effects of parthenolide on the activity of NF-κB in multiple myeloma via targeting TRAF6

Author keywords

nuclear factor B; parthenolide; tumor necrosis factor receptor associated factor 6; ubiquitination

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PARTHENOLIDE; RELA PROTEIN, HUMAN; SESQUITERPENE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

EID: 84931261288     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-015-1435-0     Document Type: Article
Times cited : (16)

References (24)
  • 1
    • 84876730349 scopus 로고    scopus 로고
    • Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXmsVGls7Y%3D, PID: 2353494
    • Fuchs O. Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma. Cardiovasc Hematol Disord Drug Targets, 2013,13(1):16–34
    • (2013) Cardiovasc Hematol Disord Drug Targets , vol.13 , Issue.1 , pp. 16-34
    • Fuchs, O.1
  • 2
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity
    • COI: 1:CAS:528:DC%2BD3cXjs1Gmtro%3D, PID: 1083707
    • Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol, 2000,18:621–663
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 3
    • 84901684523 scopus 로고    scopus 로고
    • NF-kappaB pathways in hematological malignancies
    • COI: 1:CAS:528:DC%2BC2cXotF2gtQ%3D%3D, PID: 2441930
    • Gasparini C, Celeghini C, Monasta L, et al. NF-kappaB pathways in hematological malignancies. Cell Mol Life Sci, 2014,71(11):2083–2102
    • (2014) Cell Mol Life Sci , vol.71 , Issue.11 , pp. 2083-2102
    • Gasparini, C.1    Celeghini, C.2    Monasta, L.3
  • 4
    • 47149099552 scopus 로고    scopus 로고
    • NF-kappaB in the pathogenesis and treatment of multiple myeloma
    • COI: 1:CAS:528:DC%2BD1cXnvFehu74%3D, PID: 1853657
    • Li ZW, Chen H, Campbell RA, et al. NF-kappaB in the pathogenesis and treatment of multiple myeloma. Curr Opin Hematol, 2008,15(4):391–399
    • (2008) Curr Opin Hematol , vol.15 , Issue.4 , pp. 391-399
    • Li, Z.W.1    Chen, H.2    Campbell, R.A.3
  • 5
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXps1art74%3D, PID: 1769280
    • Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell, 2007,12(2):115–130
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3
  • 6
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXps1art78%3D, PID: 1769280
    • Keats JJ, Fonseca R, Chesi M, et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell, 2007,12(2):131–144
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 131-144
    • Keats, J.J.1    Fonseca, R.2    Chesi, M.3
  • 7
    • 23944514626 scopus 로고    scopus 로고
    • Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver
    • Smolinski AT, Pestka JJ. Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. J Inflamm (Lond), 2005,2:6
    • (2005) J Inflamm (Lond) , vol.2 , pp. 6
    • Smolinski, A.T.1    Pestka, J.J.2
  • 8
    • 48449083208 scopus 로고    scopus 로고
    • Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells
    • COI: 1:CAS:528:DC%2BD1MXkslWjt7w%3D, PID: 1851922
    • Pajak B, Gajkowska B, Orzechowski A. Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells. Folia Histochem Cytobiol, 2008,46(2):129–135
    • (2008) Folia Histochem Cytobiol , vol.46 , Issue.2 , pp. 129-135
    • Pajak, B.1    Gajkowska, B.2    Orzechowski, A.3
  • 9
    • 58149355768 scopus 로고    scopus 로고
    • The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine
    • COI: 1:CAS:528:DC%2BD1cXhsV2it7rF, PID: 1908802
    • Hewamana S, Lin TT, Jenkins C, et al. The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. Clin Cancer Res, 2008,14(24):8102–8111
    • (2008) Clin Cancer Res , vol.14 , Issue.24 , pp. 8102-8111
    • Hewamana, S.1    Lin, T.T.2    Jenkins, C.3
  • 10
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • COI: 1:CAS:528:DC%2BD2MXks12ju74%3D, PID: 1568723
    • Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood, 2005,105(11):4163–4169
    • (2005) Blood , vol.105 , Issue.11 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3
  • 11
    • 58449131932 scopus 로고    scopus 로고
    • Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism
    • COI: 1:CAS:528:DC%2BD1cXhtlyrsLr
    • Kong F, Chen Z, Li Q, et al. Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism. J Huazhong Univ Sci Technolog [Med Sci], 2008,28(5):525–530
    • (2008) J Huazhong Univ Sci Technolog [Med Sci] , vol.28 , Issue.5 , pp. 525-530
    • Kong, F.1    Chen, Z.2    Li, Q.3
  • 12
    • 84883233659 scopus 로고    scopus 로고
    • Parthenolide: from plant shoots to cancer roots
    • COI: 1:CAS:528:DC%2BC3sXptFGjtbw%3D, PID: 2368858
    • Ghantous A, Sinjab A, Herceg Z et al. Parthenolide: from plant shoots to cancer roots. Drug Discov Today, 2013,18(17–18):894–905
    • (2013) Drug Discov Today , vol.18 , Issue.17-18 , pp. 894-905
    • Ghantous, A.1    Sinjab, A.2    Herceg, Z.3
  • 13
    • 0034879173 scopus 로고    scopus 로고
    • The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase
    • COI: 1:CAS:528:DC%2BD3MXmtV2ku7k%3D, PID: 1151422
    • Kwok BH, Koh B, Ndubuisi MI et al. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol, 2001,8(8):759–766
    • (2001) Chem Biol , vol.8 , Issue.8 , pp. 759-766
    • Kwok, B.H.1    Koh, B.2    Ndubuisi, M.I.3
  • 14
    • 7044275192 scopus 로고    scopus 로고
    • Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells
    • COI: 1:CAS:528:DC%2BD2cXhtVWgs73J, PID: 1525648
    • Zhang S, Lin ZN, Yang CF et al. Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis, 2004,25(11):2191–2199
    • (2004) Carcinogenesis , vol.25 , Issue.11 , pp. 2191-2199
    • Zhang, S.1    Lin, Z.N.2    Yang, C.F.3
  • 15
    • 39649125467 scopus 로고    scopus 로고
    • An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
    • COI: 1:CAS:528:DC%2BD1cXot1Wg, PID: 1780469
    • Guzman ML, Rossi RM, Neelakantan S, et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood, 2007,110(13):4427–4435
    • (2007) Blood , vol.110 , Issue.13 , pp. 4427-4435
    • Guzman, M.L.1    Rossi, R.M.2    Neelakantan, S.3
  • 16
    • 78650019223 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies
    • COI: 1:CAS:528:DC%2BC3cXhsFarurnF, PID: 2059418
    • Fuchs O. Transcription factor NF-kappaB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies. Curr Mol Pharmacol, 2010,3(3):98–122
    • (2010) Curr Mol Pharmacol , vol.3 , Issue.3 , pp. 98-122
    • Fuchs, O.1
  • 17
    • 33750443289 scopus 로고    scopus 로고
    • IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
    • COI: 1:CAS:528:DC%2BD28XhtFekt7bJ, PID: 1707232
    • Scheidereit C. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene, 2006,25(51):6685–6705
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6685-6705
    • Scheidereit, C.1
  • 18
    • 77955015392 scopus 로고    scopus 로고
    • Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology
    • COI: 1:CAS:528:DC%2BC3cXpt1Omt74%3D, PID: 2052995
    • Gautheron J, Pescatore A, Fusco F, et al. Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology. Hum Mol Genet, 2010,19(16):3138–3149
    • (2010) Hum Mol Genet , vol.19 , Issue.16 , pp. 3138-3149
    • Gautheron, J.1    Pescatore, A.2    Fusco, F.3
  • 19
    • 41549113466 scopus 로고    scopus 로고
    • Antimyeloma effects of a sesquiterpene lactone parthenolide
    • COI: 1:CAS:528:DC%2BD1cXjtleju7s%3D, PID: 1834718
    • Suvannasankha A, Crean CD, Shanmugam R et al. Antimyeloma effects of a sesquiterpene lactone parthenolide. Clin Cancer Res, 2008,14(6):1814–1822
    • (2008) Clin Cancer Res , vol.14 , Issue.6 , pp. 1814-1822
    • Suvannasankha, A.1    Crean, C.D.2    Shanmugam, R.3
  • 20
    • 79957443436 scopus 로고    scopus 로고
    • The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma
    • COI: 1:CAS:528:DC%2BC3MXmtl2msb0%3D, PID: 2141782
    • Gunn EJ, Williams JT, Huynh DT, et al. The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Leuk Lymphoma, 2011,52(6):1085–1097
    • (2011) Leuk Lymphoma , vol.52 , Issue.6 , pp. 1085-1097
    • Gunn, E.J.1    Williams, J.T.2    Huynh, D.T.3
  • 21
    • 66449097674 scopus 로고    scopus 로고
    • Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions
    • COI: 1:CAS:528:DC%2BD1MXjtVyjsLc%3D, PID: 1927616
    • Gopal YN, Chanchorn E, Van Dyke MW. Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions. Mol Cancer Ther, 2009,8(3):552–562
    • (2009) Mol Cancer Ther , vol.8 , Issue.3 , pp. 552-562
    • Gopal, Y.N.1    Chanchorn, E.2    Van Dyke, M.W.3
  • 22
    • 0037173095 scopus 로고    scopus 로고
    • TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
    • COI: 1:CAS:528:DC%2BD38XltF2htr0%3D, PID: 1206072
    • Naito A, Yoshida H, Nishioka E, et al. TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci USA, 2002,99(13):8766–8771
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.13 , pp. 8766-8771
    • Naito, A.1    Yoshida, H.2    Nishioka, E.3
  • 23
    • 69549116880 scopus 로고    scopus 로고
    • The E3 ligase TRAF6 regulates Akt ubiquitination and activation
    • COI: 1:CAS:528:DC%2BD1MXhtVersr%2FL, PID: 1971352
    • Yang WL, Wang J, Chan CH, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science, 2009,325(5944):1134–1138
    • (2009) Science , vol.325 , Issue.5944 , pp. 1134-1138
    • Yang, W.L.1    Wang, J.2    Chan, C.H.3
  • 24
    • 33947506493 scopus 로고    scopus 로고
    • Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
    • COI: 1:CAS:528:DC%2BD2sXht1Ojsb0%3D, PID: 1713527
    • Lamothe B, Besse A, Campos AD, et al. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem, 2007,282(6):4102–4112
    • (2007) J Biol Chem , vol.282 , Issue.6 , pp. 4102-4112
    • Lamothe, B.1    Besse, A.2    Campos, A.D.3


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