A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

Journal of Neuroscience

Volumn 33, Issue 24, 2013, Pages 10132-10142

  Thorsell, Annika ^a,c   Tapocik, Jenica D ^a   Liu, Ke ^b   Zook, Michelle ^a   Bell, Lauren ^a   Flanigan, Meghan ^a   Patnaik, Samarjit ^b   Marugan, Juan ^b   Damadzic, Ruslan ^a   Dehdashti, Seameen J ^b   Schwandt, Melanie L ^a   Southall, Noel ^b   Austin, Christopher P ^b   Eskay, Robert ^a   Ciccocioppo, Roberto ^d   Zheng, Wei ^b   Heilig, Markus ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c LINKÖPING UNIVERSITY   (Sweden)

^d UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE; NCGC 00185684; NEUROPEPTIDE S; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVERSION; CALCIUM CELL LEVEL; CENTRAL NUCLEUS (AMYGDALA); CONTROLLED STUDY; DRUG SELF ADMINISTRATION; ENZYME PHOSPHORYLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; IC 50; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOASSAY; RAT; RIGHTING REFLEX; STRESS; WESTERN BLOTTING;

AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING, OPERANT; CRICETINAE; CRICETULUS; CUES; DRUG INTERACTIONS; ETHANOL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; IMIDAZOLES; LOCOMOTION; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHORYLATION; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, NEUROPEPTIDE; REFLEX; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE; SACCHARIN; SELF ADMINISTRATION; SWEETENING AGENTS; TRANSFECTION;

EID: 84878831628     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4742-12.2013     Document Type: Article

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