DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

Cardiovascular Diabetology

Volumn 14, Issue 1, 2015, Pages

  Ma, MingJie ^a   Hasegawa, Yu ^a   Koibuchi, Nobutaka ^a   Toyama, Kensuke ^a   Uekawa, Ken ^a   Nakagawa, Takashi ^a   Lin, Bowen ^a   Kim Mitsuyama, Shokei ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; Brain atrophy; Cerebral ischemia; Cognitive function; Oxidative stress

Indexed keywords

CLAUDIN 5; DIPEPTIDYL PEPTIDASE IV; LINAGLIPTIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; DIPEPTIDYL PEPTIDASE IV INHIBITOR; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ATROPHY; BRAIN BLOOD FLOW; BRAIN NERVE CELL; BRAIN SIZE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; ENZYME INHIBITION; HIPPOCAMPUS; MALE; MICROGLIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TRANSIENT ISCHEMIC ATTACK; ANIMAL; ATROPHY; BRAIN; BRAIN CORTEX; COGNITION; COGNITION DISORDERS; COMMON CAROTID ARTERY; COMPLICATION; DRUG EFFECTS; IMMUNOLOGY; ORGAN SIZE; PATHOLOGY;

ANIMALS; ATROPHY; BRAIN; CAROTID ARTERY, COMMON; CEREBRAL CORTEX; COGNITION; COGNITION DISORDERS; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HIPPOCAMPUS; IMMUNOGLOBULIN G; ISCHEMIC ATTACK, TRANSIENT; LINAGLIPTIN; MICE; MICROGLIA; ORGAN SIZE;

EID: 84931029374     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-015-0218-z     Document Type: Article

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