Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 2, 2011, Pages 358-366

  Dong, Yi Fei ^a   Kataoka, Keiichiro ^a   Tokutomi, Yoshiko ^a   Nako, Hisato ^a   Nakamura, Taishi ^a   Toyama, Kensuke ^a   Sueta, Daisuke ^a   Koibuchi, Nobutaka ^a   Yamamoto, Eiichiro ^a   Ogawa, Hisao ^a   Kim Mitsuyama, Shokei ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; AMLODIPINE; AMLODIPINE PLUS VALSARTAN; ANGIOTENSIN 1 RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; SODIUM CHLORIDE; VALSARTAN;

ADD ON THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD PRESSURE; BRAIN ARTERIOLAR REMODELING; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN DISEASE; BRAIN HYPOXIA; BRAIN INJURY; CELL ACTIVATION; CONTROLLED STUDY; DEATH; ENDOTHELIAL DYSFUNCTION; ENZYME INDUCTION; GLIA CELL; HISTOPATHOLOGY; HYPERTENSION; HYPERTENSIVE STROKE; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION; WHITE MATTER;

AMLODIPINE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD PRESSURE; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CAROTID ARTERIES; DRUG THERAPY, COMBINATION; ENDOTHELIAL CELLS; HYPERTENSION; HYPOXIA-ISCHEMIA, BRAIN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RECEPTOR, ANGIOTENSIN, TYPE 1; SODIUM CHLORIDE, DIETARY; TETRAZOLES; TYROSINE; VALINE;

EID: 80054803069     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.182576     Document Type: Article

References (31)

1. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
2. Briers JD, Richards G, and He XW (1999) Capillary blood flow monitoring using laser speckle contrast analysis (LASCA). J Biomed Opt 4:164-175. (Pubitemid 129694563)
3. Dahlöf B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, et al. (2002) Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359:995-1003. (Pubitemid 34286536)
4. Dalkara T, Yoshida T, Irikura K, and Moskowitz MA (1994) Dual role of nitric oxide in focal cerebral ischemia. Neuropharmacology 33:1447-1452. (Pubitemid 24353740)
5. de Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, and Breteler MM (2002) Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 125:765-772. (Pubitemid 34279772)
6. Dong YF, Liu L, Kataoka K, Nakamura T, Fukuda M, Tokutomi Y, Nako H, Ogawa H, and Kim-Mitsuyama S (2010) Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes. Diabetologia 53:180-191.
7. Erkinjuntti T, Román G, Gauthier S, Feldman H, and Rockwood K (2004) Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke 35: 1010-1017. (Pubitemid 38419819)
8. Forrester KR, Stewart C, Tulip J, Leonard C, and Bray RC (2002) Comparison of laser speckle and laser Doppler perfusion imaging: measurement in human skin and rabbit articular tissue. Med Biol Eng Comput 40:687-697. (Pubitemid 35469958)
9. Förstermann U and Münzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113:1708-1714.
10. Gursoy-Ozdemir Y, Bolay H, Saribas O, and Dalkara T (2000) Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke 31:1974-1980; discussion 1981.
11. Hansson L, Hedner T, Lund-Johansen P, Kjeldsen SE, Lindholm LH, Syvertsen JO, Lanke J, de Faire U, Dahlöf B, and Karlberg BE (2000) Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study. Lancet 356:359-365. (Pubitemid 30487491)
12. Iadecola C (1997) Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20:132-139.
13. Kim-Mitsuyama S, Yamamoto E, Tanaka T, Zhan Y, Izumi Y, Izumiya Y, Ioroi T, Wanibuchi H, and Iwao H (2005) Critical role of angiotensin II in excess saltinduced brain oxidative stress of stroke-prone spontaneously hypertensive rats. Stroke 36:1083-1088.
14. Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P, Zanchetti A, and SCOPE Study Group (2003) The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 21:875-886. (Pubitemid 36677151)
15. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, et al. (2007) 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 25:1751-1762. (Pubitemid 47356612)
16. Meneton P, Jeunemaitre X, de Wardener HE, and MacGregor GA (2005) Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev 85:679-715. (Pubitemid 40404639)
17. Messerli FH, Schmieder RE, and Weir MR (1997) Salt. A perpetrator of hypertensive target organ disease? Arch Intern Med 157:2449-2452. (Pubitemid 27517979)
18. Mochizuki S, Dahlöf B, Shimizu M, Ikewaki K, Yoshikawa M, Taniguchi I, Ohta M, Yamada T, Ogawa K, Kanae K, et al. (2007) Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study. Lancet 369: 1431-1439. (Pubitemid 46635780)
19. Nakamura T, Yamamoto E, Kataoka K, Yamashita T, Tokutomi Y, Dong YF, Matsuba S, Ogawa H, and Kim-Mitsuyama S (2007) Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure. Stroke 38:3016-3022. (Pubitemid 350041562)
20. Nishida Y, Takahashi Y, Sugahara-Kobayashi M, Ishikawa K, and Asai S (2008) Decreased expression of angiotensin II type 1 and type 2 receptors in the brain after long-term administration of antihypertensive drugs in stroke-prone spontaneously hypertensive rat. J Pharmacol Sci 106:663-666. (Pubitemid 351556247)
21. Okamoto K, Yamori Y, and Nagaoka A (1974) Establishment of the stroke-prone spontaneously hypertensive rats (SHR). Circ Res 33/34:I-143-I-153.
22. Parthasarathy AB, Tom WJ, Gopal A, Zhang X, and Dunn AK (2008) Robust flow measurement with multi-exposure speckle imaging. Opt Express 16:1975-1989. (Pubitemid 351240039)
23. Reboldi G, Angeli F, Cavallini C, Gentile G, Mancia G, and Verdecchia P (2008) Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a metaanalysis. J Hypertens 26:1282-1289.
24. Schrader J, Lüders S, Kulschewski A, Hammersen F, Plate K, Berger J, Zidek W, Dominiak P, Diener HC, and MOSES Study Group (2005) Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 36:1218-1226.
25. Shibata M, Ohtani R, Ihara M, and Tomimoto H (2004) White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke 35:2598-2603. (Pubitemid 39458424)
26. Strazzullo P, D'Elia L, Kandala NB, and Cappuccio FP (2009) Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ 339:b4567.
27. Verdecchia P, Reboldi G, Angeli F, Gattobigio R, Bentivoglio M, Thijs L, Staessen JA, and Porcellati C (2005) Angiotensin-converting enzyme inhibitors and calcium channel blockers for coronary heart disease and stroke prevention. Hypertension 46:386-392. (Pubitemid 41099174)
28. Yamamoto E, Kataoka K, Shintaku H, Yamashita T, Tokutomi Y, Dong YF, Matsuba S, Ichijo H, Ogawa H, and Kim-Mitsuyama S (2007a) Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Arterioscler Thromb Vasc Biol 27:2569-2575. (Pubitemid 350158907)
29. Yamamoto E, Tamamaki N, Nakamura T, Kataoka K, Tokutomi Y, Dong YF, Fukuda M, Matsuba S, Ogawa H, and Kim-Mitsuyama S (2008) Excess salt causes cerebral neuronal apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation. Stroke 39:3049-3056.
30. Yamamoto E, Yamashita T, Tanaka T, Kataoka K, Tokutomi Y, Lai ZF, Dong YF, Matsuba S, Ogawa H, and Kim-Mitsuyama S (2007b) Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects. Arterioscler Thromb Vasc Biol 27:556-563.
31. Zakharov P, Völker AC, Wyss MT, Haiss F, Calcinaghi N, Zunzunegui C, Buck A, Scheffold F, and Weber B (2009) Dynamic laser speckle imaging of cerebral blood flow. Opt Express 17:13904-13917.