Cardiospheres reverse adverse remodeling in chronic rat myocardial infarction: roles of soluble endoglin and Tgf-β signaling

Basic Research in Cardiology

Volumn 109, Issue 6, 2014, Pages

  Tseliou, Eleni ^a   Reich, Heidi ^a   de Couto, Geoffrey ^a   Terrovitis, John ^b   Sun, Baiming ^a   Liu, Weixin ^a   Marbán, Eduardo ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cardiac fibrosis; Cardiac regeneration; Chronic ischemic cardiomyopathy; Stem cells

Indexed keywords

COLLAGEN TYPE 1; ENDOGLIN; NEUTRALIZING ANTIBODY; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ENDOGLIN PROTEIN, RAT; SIGNAL PEPTIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC STEM CELL; CARDIOSPHERE; CARDIOSPHERE TRANSPLANTATION; CARDIOVASCULAR PARAMETERS; CELL PROLIFERATION; CHRONIC MYOCARDIAL INFARCTION; COCULTURE; COLLAGEN DISEASE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FIBROBLAST; HEART CONTRACTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEFT VENTRICULAR END DIASTOLIC DIAMETER; LEFT VENTRICULAR END SYSTOLIC DIAMETER; MALE; MOLECULAR INTERACTION; MUSCLE REGENERATION; NONHUMAN; PROTEIN SECRETION; RAT; SCAR; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; VASCULARIZATION; ANIMAL; CYTOLOGY; HEART MUSCLE; HEART VENTRICLE REMODELING; PATHOPHYSIOLOGY; PHYSIOLOGY; STEM CELL; WISTAR KYOTO RAT;

ANIMALS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, INBRED WKY; SIGNAL TRANSDUCTION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA; VENTRICULAR REMODELING;

EID: 84929940516     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0443-8     Document Type: Article

References (35)

1. Behfar A, Crespo-Diaz R, Terzic A, Gersh BJ (2014) Cell therapy for cardiac repair—lessons from clinical trials. Nat Rev Cardiol 11:232–246. doi:10.1038/nrcardio.2014.9
2. Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marbán E (2010) Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res 106:971–980. doi:10.1161/CIRCRESAHA.109.210682
3. Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577–584. doi:10.1038/nature02006
4. Frangogiannis NG (2012) Regulation of the inflammatory response in cardiac repair. Circ Res 110:159–173. doi:10.1161/CIRCRESAHA.111.243162
5. Frey N, Olson EN (2003) Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65:45–79. doi:10.1146/annurev.physiol.65.092101.142243
6. Fujiu K, Nagai R (2013) Contributions of cardiomyocyte-cardiac fibroblast-immune cell interactions in heart failure development. Basic Res Cardiol 108:357. doi:10.1007/s00395-013-0357
7. Hein S, Arnon E, Kostin S, Schönburg M, Elsässer A, Polyakova V, Bauer EP, Klövekorn WP, Schaper J (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107:984–991. doi:10.1161/01.CIR.0000051865.66123.B7
8. Heusch G, Libby P, Gersh B, Yellon D, Bohm M, Lopaschuk G, Opie L (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383:1933–1943. doi:10.1016/S0140-6736(14)60107-0
9. Jeevanantham V, Butler M, Saad A, Abdel-Latif A, Zuba-Surma EK, Dawn B (2012) Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation 126:551–568. doi:10.1161/CIRCULATIONAHA.111.086074
10. Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Lai S, Steenbergen C, Gerstenblith G, Lange R, Marbán E (2009) Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation 120:075–083. doi:10.1161/CIRCULATIONAHA.108.816058
11. Kakkar R, Lee RT (2010) Intramyocardial fibroblast myocyte communication. Circ Res 106:47–57. doi:10.1161/CIRCRESAHA.109.207456
12. Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH (2012) Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation 125:2728–2738. doi:10.1161/CIRCULATIONAHA.111.080002
13. Koitabashi N, Danner T, Zaiman AL, Pinto YM, Rowell J, Mankowski J, Zhang D, Nakamura T, Takimoto E, Kass DA (2011) Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload. J Clin Invest 121:2301–2312. doi:10.1172/JCI44824
14. Laflamme MA, Murry CE (2011) Heart regeneration. Nature 473:326–335. doi:10.1038/nature10147
15. Leask A (2010) Potential therapeutic targets for cardiac fibrosis: TGF beta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res 106:1675–1680. doi:10.1161/CIRCRESAHA.110.217737
16. Li DY, Sorensen LK, Brooke BS, Urness LD, Davis EC, Taylor DG, Boak BB, Wendel DP (1999) Defective angiogenesis in mice lacking endoglin. Science 284:1534–1537. doi:10.1126/science.284.5419.1534
17. Li TS, Cheng K, Lee ST, Matsushita S, Davis D, Malliaras K, Zhang Y, Matsushita N, Smith RR, Marbán E (2010) Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells 28:2088–2098. doi:10.1002/stem.532
18. Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E (2012) Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 379:895–904. doi:10.1016/S0140-6736(12)60195-0
19. Malliaras K, Smith RR, Kanazawa H, Yee K, Seinfeld J, Tseliou E, Dawkins JF, Kreke M, Cheng K, Luthringer D, Ho CS, Blusztajn A, Valle I, Chowdhury S, Makkar RR, Dharmakumar R, Li D, Marbán L, Marbán E (2013) Validation of contrast-enhanced MRI to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction. Circulation 128:2764–2775. doi:10.1161/CIRCULATIONAHA.113.002863
20. McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J (1994) Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 8:345–351. doi:10.1038/ng1294-345
21. Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A (2004) Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 95:911–921. doi:10.1161/01.RES.0000147315.71699.51
22. Mudd JO, Kass DA (2008) Tackling heart failure in the twenty-first century. Nature 451:919–928. doi:10.1038/nature06798
23. Nam YJ, Song K, Luo X, Daniel E, Lambeth K, West K, Hill JA, DiMaio JM, Baker LA, Bassel-Duby R, Olson EN (2013) Reprogramming of human fibroblasts toward a cardiac fate. Proc Natl Acad Sci USA 110:5588–5593. doi:10.1073/pnas.1301019110
24. Nurzynska D, Di Meglio F, Romano V, Miraglia R, Sacco AM, Latino F, Bancone C, Della Corte A, Maiello C, Amarelli C, Montagnani S, Castaldo C (2013) Cardiac primitive cells become committed to a cardiac fate in adult human heart with chronic ischemic disease but fail to acquire mature phenotype: genetic and phenotypic study. Basic Res Cardiol 108:320. doi:10.1007/s00395-012-0320-2
25. Opie LH, Commerford PJ, Gersh BJ, Pfeffer MA (2006) Controversies in ventricular remodelling. Lancet 367:356–367. doi:10.1016/S0140-6736(06)68074-4
26. Papait R, Greco C, Kunderfranco P, Latronico MV, Condorelli G (2013) Epigenetics: a new mechanism of regulation of heart failure? Basic Res Cardiol 108:361. doi:10.1007/s00395-013-0361-1
27. Rosenkranz S, Flesch M, Amann K, Haeuseler C, Kilter H, Seeland U, Schlüter KD, Böhm M (2002) Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1). Am J Physiol Heart Circ Physiol 283:1253–1262. doi:10.1152/ajpheart.00578.2001
28. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I (2007) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446:444–448. doi:10.1038/nature05602
29. Shinde AV, Frangogiannis NG (2014) Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 70:74–82. doi:10.1016/j.yjmcc.2013.11.015
30. Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marbán E (2007) Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 115:896–908. doi:10.1161/CIRCULATIONAHA.106.655209
31. Tseliou E, Pollan S, Malliaras K, Terrovitis J, Sun B, Galang G, Marbán L, Luthringer D, Marbán E (2013) Allogeneic cardiospheres boost cardiac function and attenuate adverse remodeling without eliciting immune reactions post-myocardial infarction in immunologically-mismatched rat strains. J Am Coll Cardiol 61:1108–1119. doi:10.1016/j.jacc.2012.10.052
32. Tseliou E, De Couto G, Terrovitis J, Sun B, Liu W, Marbán L, Marbán E (2014) Angiogenesis, cardiomyocyte proliferation and anti-fibrotic effects underlie structural preservation post-infarction by intramyocardially-injected cardiospheres. PLoS ONE 9:e88590. doi:10.1371/journal.pone.0088590
33. Wang ZF, Wang NP, Harmouche S, Philip T, Pang XF, Bai F, Zhao ZQ (2013) Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats. Basic Res Cardiol 108:318. doi:10.1007/s00395-012-0318-9
34. Whittaker P, Kloner RA, Boughner DR, Pickering JG (1994) Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res Cardiol 89:397–410. doi:10.1007/BF00788278
35. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 13:952–961. doi:10.1038/nm1613