Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 22, 2015, Pages E2855-E2864

  Jiao, Junyi ^a,b   Rebane, Aleksander A ^a,b,c   Ma, Lu ^a   Gao, Ying ^a,d   Zhang, Yongli ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c Yale University   (United States)

^d Chinese Academy of Sciences   (China)

Author keywords

Fusion inhibitor; gp41 complex; Optical tweezers; Protein folding; Viral fusion

Indexed keywords

ENFUVIRTIDE; GLYCOPROTEIN GP 41; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PEPTIDE FRAGMENT;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG MECHANISM; ENERGY TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS 1; KINETICS; MEMBRANE FUSION; MICELLE; MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS ENVELOPE; ALGORITHM; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; OPTICAL TWEEZERS; STATISTICAL MODEL; ULTRASTRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ALGORITHMS; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CLONING, MOLECULAR; HIV ENVELOPE PROTEIN GP41; HIV-1; KINETICS; LIKELIHOOD FUNCTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OPTICAL TWEEZERS; PEPTIDE FRAGMENTS; PROTEIN FOLDING; VIRUS INTERNALIZATION;

EID: 84930958573     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424995112     Document Type: Article

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