Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil

Journal of Biological Chemistry

Volumn 284, Issue 6, 2009, Pages 3619-3627

  Champagne, Kelly ^a   Shishido, Akira ^a   Root, Michael J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RESIDUES; ARTIFICIAL PROTEINS; BINDING ACTIVITIES; BINDING AFFINITIES; BINDING STRENGTH; C TERMINUS; CELLULAR MEMBRANES; COILED COIL; COILED COIL REGIONS; COMPETITIVE BINDING ASSAY; CONFORMATIONAL CHANGE; DESIGN STRATEGIES; HEPTAD REPEAT REGIONS; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; INHIBITORY PEPTIDES; N-TERMINAL; NANOMOLAR AFFINITY; PEPTIDE INHIBITORS; STRUCTURAL TRANSITIONS; STRUCTURE ACTIVITY RELATIONSHIPS; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOMIMETICS; CELL MEMBRANES; LUTETIUM; ORGANIC ACIDS; PEPTIDES;

AMINES;

ENFUVIRTIDE; GLYCOPROTEIN GP 41; VIRUS PROTEIN; BIOMIMETIC MATERIAL; GP41 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; PEPTIDE FRAGMENT; PEPTIDE T20;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; IC 50; MEMBRANE FUSION; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN STRUCTURE; PROTEIN VARIANT; STRUCTURE ACTIVITY RELATION; VIRUS INFECTIVITY; VIRUS STRAIN; WILD TYPE; ANTIVIRAL RESISTANCE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HELA CELL; HUMAN; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; VIRUS ENTRY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BIOMIMETIC MATERIALS; DRUG RESISTANCE, VIRAL; HELA CELLS; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV-1; HUMANS; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; VIRUS INTERNALIZATION;

EID: 63649151400     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809269200     Document Type: Article

References (46)

1. Peisajovich, S. G., Gallo, S. A., Blumenthal, R., and Shai, Y. (2003) J. Biol. Chem. 278, 21012-21017
2. Liu, S., Jing, W., Cheung, B., Lu, H., Sun, J., Yan, X., Niu, J., Farmar, J., Wu, S., and Jiang, S. (2007) J. Biol. Chem. 282, 9612-9620
3. Fenouillet, E., and Jones, I. M. (1995) J. Gen. Virol. 76, 1509-1514
4. Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15613-15617
5. Root, M. J., and Hamer, D. H. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 5016-5021
6. Lu, M., Blacklow, S. C., and Kim, P. S. (1995) Nat. Struct. Biol. 2, 1075-1082
7. Blacklow, S. C., Lu, M., and Kim, P. S. (1995) Biochemistry 34, 14955-14962
8. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., and Wiley, D. C. (1997) Nature 387, 426-430
9. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
10. Tan, K., Liu, J., Wang, J., Shen, S., and Lu, M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12303-12308
11. Caffrey, M., Cai, M., Kaufman, J., Stahl, S. J., Wingfield, P. T., Covell, D. G., Gronenborn, A. M., and Clore, G. M. (1998) EMBO J. 17, 4572-4584
12. Liu, S., Wu, S., and Jiang, S. (2007) Curr. Pharm. Des. 13, 143-162
13. Wild, C. T., Shugars, D. C., Greenwell, T. K., McDanal, C. B., and Matthews, T. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9770-9774
14. Jiang, S., Lin, K., Strick, N., and Neurath, A. R. (1993) Nature 365, 113
15. Furuta, R. A., Wild, C. T., Weng, Y., and Weiss, C. D. (1998) Nat. Struct. Biol. 5, 276-279
16. Munoz-Barroso, I., Durell, S., Sakaguchi, K., Appella, E., and Blumenthal, R. (1998) J. Cell Biol. 140, 315-323
17. Kilgore, N. R., Salzwedel, K., Reddick, M., Allaway, G. P., and Wild, C. T. (2003) J. Virol. 77, 7669-7672
18. Kilby, J. M., Hopkins, S., Venetta, T. M., DiMassimo, B., Cloud, G. A., Lee, J. Y., Alldredge, L., Hunter, E., Lambert, D., Bolognesi, D., Matthews, T., Johnson, M. R., Nowak, M. A., Shaw, G. M., and Saag, M. S. (1998) Nat. Med. 4, 1302-1307
19. Melikyan, G. B., Markosyan, R. M., Hemmati, H., Delmedico, M. K., Lambert, D. M., and Cohen, F. S. (2000) J. Cell Biol. 151, 413-423
20. Abrahamyan, L. G., Mkrtchyan, S. R., Binley, J., Lu, M., Melikyan, G. B., and Cohen, F. S. (2005) J. Virol. 79, 106-115
21. Reeves, J. D., Gallo, S. A., Ahmad, N., Miamidian, J. L., Harvey, P. E., Sharron, M., Pohlmann, S., Sfakianos, J. N., Derdeyn, C. A., Blumenthal, R., Hunter, E., and Doms, R. W. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16249-16254
22. Lazzarin, A., Clotet, B., Cooper, D., Reynes, J., Arasteh, K., Nelson, M., Katlama, C., Stellbrink, H. J., Delfraissy, J. F., Lange, J., Huson, L., DeMasi, R., Wat, C., Delehanty, J., Drobnes, C., and Salgo, M. (2003) N. Engl. J. Med. 348, 2186-2195
23. Lalezari, J. P., Henry, K., O'Hearn, M., Montaner, J. S., Piliero, P. J., Trottier, B., Walmsley, S., Cohen, C., Kuritzkes, D. R., Eron, J. J., Jr., Chung, J., DeMasi, R., Donatacci, L., Drobnes, C., Delehanty, J., and Salgo, M. (2003) N. Engl. J. Med. 348, 2175-2185
24. Lawless, M. K., Barney, S., Guthrie, K. I., Bucy, T. B., Petteway, S. R., Jr., and Merutka, G. (1996) Biochemistry 35, 13697-13708
25. Liu, S., Lu, H., Niu, J., Xu, Y., Wu, S., and Jiang, S. (2005) J. Biol. Chem. 280, 11259-11273
26. Root, M. J., Kay, M. S., and Kim, P. S. (2001) Science 291, 884-888
27. Hamburger, A. E., Kim, S., Welch, B. D., and Kay, M. S. (2005) J. Biol. Chem. 280, 12567-12572
28. Eckert, D. M., and Kim, P. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 11187-11192
29. Louis, J. M., Bewley, C. A., and Clore, G. M. (2001) J. Biol. Chem. 276, 29485-29489
30. Louis, J. M., Nesheiwat, I., Chang, L., Clore, G. M., and Bewley, C. A. (2003) J. Biol. Chem. 278, 20278-20285
31. Doering, D. S., and Matsudaira, P. (1996) Biochemistry 35, 12677-12685
32. Edelhoch, H. (1967) Biochemistry 6, 1948-1954
33. Steger, H. K., and Root, M. J. (2006) J. Biol. Chem. 281, 25813-25821
34. Wang, Z. X. (1995) FEBS Lett. 360, 111-114
35. Tallarida, R. J. (2000) Drug Synergism and Dose-Effect Data Analysis, pp. 1-55, Chapman and Hall/CRC, London
36. Chou, T. C., and Talalay, P. (1984) Adv. Enzyme Regul. 22, 27-55
37. Luftig, M. A., Mattu, M., Di Giovine, P., Geleziunas, R., Hrin, R., Barbato, G., Bianchi, E., Miller, M. D., Pessi, A., and Carfi, A. (2006) Nat. Struct. Mol. Biol. 13, 740-747
38. Wexler-Cohen, Y., Johnson, B. T., Puri, A., Blumenthal, R., and Shai, Y. (2006) J. Biol. Chem. 281, 9005-9010
39. Rimsky, L. T., Shugars, D. C., and Matthews, T. J. (1998) J. Virol. 72, 986-993
40. Nameki, D., Kodama, E., Ikeuchi, M., Mabuchi, N., Otaka, A., Tamamura, H., Ohno, M., Fujii, N., and Matsuoka, M. (2005) J. Virol. 79, 764-770
41. Lorizate, M., de la Arada, I., Huarte, N., Sanchez-Martinez, S., de la Torre, B. G., Andreu, D., Arrondo, J. L., and Nieva, J. L. (2006) Biochemistry 45, 14337-14346
42. Lorizate, M., Gomara, M. J., de la Torre, B. G., Andreu, D., and Nieva, J. L. (2006) J. Mol. Biol. 360, 45-55
43. Bellamy-McIntyre, A. K., Lay, C. S., Baar, S., Maerz, A. L., Talbo, G. H., Drummer, H. E., and Poumbourios, P. (2007) J. Biol. Chem. 282, 23104-23116
44. Wexler-Cohen, Y., and Shai, Y. (2007) FASEB J. 21, 3677-3684
45. Reeves, J. D., Miamidian, J. L., Biscone, M. J., Lee, F. H., Ahmad, N., Pierson, T. C., and Doms, R. W. (2004) J. Virol. 78, 5476-5485
46. Chan, D. C., and Kim, P. S. (1998) Cell 93, 681-684