메뉴 건너뛰기




Volumn 75, Issue 9, 2015, Pages 935-945

The New Era of Drug Therapy for Obesity: The Evidence and the Expectations

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE PLUS NALTREXONE; ANTIOBESITY AGENT; LIRAGLUTIDE; LORCASERIN; PHENTERMINE PLUS TOPIRAMATE; TETRAHYDROLIPSTATIN;

EID: 84930928930     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-015-0410-1     Document Type: Article
Times cited : (48)

References (104)
  • 2
    • 18744433759 scopus 로고    scopus 로고
    • Relation between obesity from childhood to adulthood and the metabolic syndrome: population based study
    • 1:STN:280:DyaK1czltVSnsA%3D%3D 28624 9685277
    • Vanhala M, Vanhala P, Kumpusalo E, Halonen P, Takala J. Relation between obesity from childhood to adulthood and the metabolic syndrome: population based study. BMJ. 1998;317(7154):319.
    • (1998) BMJ , vol.317 , Issue.7154 , pp. 319
    • Vanhala, M.1    Vanhala, P.2    Kumpusalo, E.3    Halonen, P.4    Takala, J.5
  • 3
    • 0030967953 scopus 로고    scopus 로고
    • Predicting obesity in young adulthood from childhood and parental obesity
    • 1:STN:280:DyaK2svjtlSjtg%3D%3D 9302300
    • Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997;337(13):869-73.
    • (1997) N Engl J Med , vol.337 , Issue.13 , pp. 869-873
    • Whitaker, R.C.1    Wright, J.A.2    Pepe, M.S.3    Seidel, K.D.4    Dietz, W.H.5
  • 4
    • 51849146897 scopus 로고    scopus 로고
    • Global burden of obesity in 2005 and projections to 2030
    • 1:STN:280:DC%2BD1cngsVamtQ%3D%3D
    • Kelly T, Yang W, Chen C-S, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008;32(9):1431-7.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.9 , pp. 1431-1437
    • Kelly, T.1    Yang, W.2    Chen, C.-S.3    Reynolds, K.4    He, J.5
  • 5
    • 80053273586 scopus 로고    scopus 로고
    • Four-year weight losses in the Look AHEAD study: factors associated with long-term success
    • 3183129 21779086
    • Wadden TA, Neiberg RH, Wing RR, Clark JM, Delahanty LM, Hill JO, et al. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring). 2011;19(10):1987-98.
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.10 , pp. 1987-1998
    • Wadden, T.A.1    Neiberg, R.H.2    Wing, R.R.3    Clark, J.M.4    Delahanty, L.M.5    Hill, J.O.6
  • 6
    • 84873877246 scopus 로고    scopus 로고
    • Depression as a predictor of weight regain among successful weight losers in the Diabetes Prevention Program
    • 3554307 23002085
    • Price DW, Ma Y, Rubin RR, Perreault L, Bray GA, Marrero D, et al. Depression as a predictor of weight regain among successful weight losers in the Diabetes Prevention Program. Diabetes Care. 2013;36(2):216-21.
    • (2013) Diabetes Care , vol.36 , Issue.2 , pp. 216-221
    • Price, D.W.1    Ma, Y.2    Rubin, R.R.3    Perreault, L.4    Bray, G.A.5    Marrero, D.6
  • 8
    • 77953630340 scopus 로고    scopus 로고
    • The role of gut hormones and the hypothalamus in appetite regulation
    • 1:CAS:528:DC%2BC3cXhtFahsrrK 20424341
    • Suzuki K, Simpson KA, Minnion JS, Shillito JC, Bloom SR. The role of gut hormones and the hypothalamus in appetite regulation. Endocr J. 2010;57(5):359-72.
    • (2010) Endocr J , vol.57 , Issue.5 , pp. 359-372
    • Suzuki, K.1    Simpson, K.A.2    Minnion, J.S.3    Shillito, J.C.4    Bloom, S.R.5
  • 9
    • 84922486127 scopus 로고    scopus 로고
    • Drugs commonly associated with weight change: a systematic review and meta-analysis
    • 1:CAS:528:DC%2BC2MXjtVWqsL4%3D 25590213
    • Domecq JP, Prutsky G, Leppin A, Sonbol MB, Altayar O, Undavalli C, et al. Drugs commonly associated with weight change: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2015;100(2):363-70.
    • (2015) J Clin Endocrinol Metab , vol.100 , Issue.2 , pp. 363-370
    • Domecq, J.P.1    Prutsky, G.2    Leppin, A.3    Sonbol, M.B.4    Altayar, O.5    Undavalli, C.6
  • 10
    • 84861879399 scopus 로고    scopus 로고
    • Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons
    • 1:CAS:528:DC%2BC38XhtVGlsr%2FI 3378066 22436698
    • Roepke TA, Smith AW, Rønnekleiv OK, Kelly MJ. Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons. Am J Physiol Endocrinol Metab. 2012;302(11):E1399-406.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , Issue.11 , pp. E1399-E1406
    • Roepke, T.A.1    Smith, A.W.2    Rønnekleiv, O.K.3    Kelly, M.J.4
  • 11
    • 84902212522 scopus 로고    scopus 로고
    • Involvement of hypothalamic PI3K-STAT3 signalling in regulating appetite suppression mediated by amphetamine
    • 1:CAS:528:DC%2BC2cXpsVKrtrg%3D 24597972
    • Chu S-C, Chen P-N, Hsieh Y-S, Yu C-H, Lin M-H, Lin Y-H, et al. Involvement of hypothalamic PI3K-STAT3 signalling in regulating appetite suppression mediated by amphetamine. Br J Pharmacol. 2014;171(13):3223-33.
    • (2014) Br J Pharmacol , vol.171 , Issue.13 , pp. 3223-3233
    • Chu, S.-C.1    Chen, P.-N.2    Hsieh, Y.-S.3    Yu, C.-H.4    Lin, M.-H.5    Lin, Y.-H.6
  • 12
    • 3242697939 scopus 로고    scopus 로고
    • Alterations in food intake by opioid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens
    • 1:CAS:528:DC%2BD2cXlsl2it78%3D 15262208
    • MacDonald AF, Billington CJ, Levine AS. Alterations in food intake by opioid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens. Brain Res. 2004;1018(1):78-85.
    • (2004) Brain Res , vol.1018 , Issue.1 , pp. 78-85
    • MacDonald, A.F.1    Billington, C.J.2    Levine, A.S.3
  • 13
    • 70449704068 scopus 로고    scopus 로고
    • Feeding association between the nucleus of the solitary tract and the ventral tegmental area
    • 19748538
    • Kim E-M, Quinn JG, Spanswick D, O'Hare E. Feeding association between the nucleus of the solitary tract and the ventral tegmental area. Appetite. 2009;53(3):457-60.
    • (2009) Appetite , vol.53 , Issue.3 , pp. 457-460
    • Kim, E.-M.1    Quinn, J.G.2    Spanswick, D.3    O'Hare, E.4
  • 14
    • 84888860281 scopus 로고    scopus 로고
    • The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors
    • 1:CAS:528:DC%2BC2cXksVShtg%3D%3D 3882373 24105414
    • Mietlicki-Baase EG, Ortinski PI, Rupprecht LE, Olivos DR, Alhadeff AL, Pierce RC, et al. The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors. Am J Physiol Endocrinol Metab. 2013;305(11):E1367-74.
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , Issue.11 , pp. E1367-E1374
    • Mietlicki-Baase, E.G.1    Ortinski, P.I.2    Rupprecht, L.E.3    Olivos, D.R.4    Alhadeff, A.L.5    Pierce, R.C.6
  • 15
    • 84926455339 scopus 로고    scopus 로고
    • Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
    • 4311629 25688211
    • Poher A-L, Altirriba J, Veyrat-Durebex C, Rohner-Jeanrenaud F. Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance. Front Physiol. 2015;6:4.
    • (2015) Front Physiol , vol.6 , pp. 4
    • Poher, A.-L.1    Altirriba, J.2    Veyrat-Durebex, C.3    Rohner-Jeanrenaud, F.4
  • 17
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • 1:CAS:528:DC%2BD1MXltlSqsro%3D 2859951 19357406
    • Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360(15):1509-17.0
    • (2009) N Engl J Med , vol.360 , Issue.15 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3    Tal, I.4    Rodman, D.5    Goldfine, A.B.6
  • 18
    • 84926463276 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins and energy metabolism
    • 4322621 25713540
    • Busiello RA, Savarese S, Lombardi A. Mitochondrial uncoupling proteins and energy metabolism. Front Physiol. 2015;6:36.
    • (2015) Front Physiol , vol.6 , pp. 36
    • Busiello, R.A.1    Savarese, S.2    Lombardi, A.3
  • 19
    • 84885914497 scopus 로고    scopus 로고
    • Systemic control of brown fat thermogenesis: integration of peripheral and central signals
    • 1:CAS:528:DC%2BC3sXhvVamurbI 3805713 24111913
    • Schulz TJ, Tseng Y-H. Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Ann N Y Acad Sci. 2013;1302:35-41.
    • (2013) Ann N Y Acad Sci , vol.1302 , pp. 35-41
    • Schulz, T.J.1    Tseng, Y.-H.2
  • 20
    • 0026022088 scopus 로고
    • Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism
    • 1:CAS:528:DyaK3MXhtlKks7g%3D 1996719
    • Billington CJ, Briggs JE, Grace M, Levine AS. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am J Physiol. 1991;260(2 Pt 2):R321-7.
    • (1991) Am J Physiol , vol.260 , Issue.2 , pp. R321-R327
    • Billington, C.J.1    Briggs, J.E.2    Grace, M.3    Levine, A.S.4
  • 21
    • 84873362255 scopus 로고    scopus 로고
    • Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN
    • 1:CAS:528:DC%2BC3sXitFeqsL0%3D 23395170
    • Shi Y-C, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, et al. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metab. 2013;17(2):236-48.
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 236-248
    • Shi, Y.-C.1    Lau, J.2    Lin, Z.3    Zhang, H.4    Zhai, L.5    Sperk, G.6
  • 22
    • 84930929490 scopus 로고    scopus 로고
    • Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus
    • Morgan DA, McDaniel LN, Yin T, Khan M, Jiang J, Acevedo MR, et al. Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus. Diabetes. 2015. doi: 10.2337/db14-1257.
    • (2015) Diabetes
    • Morgan, D.A.1    McDaniel, L.N.2    Yin, T.3    Khan, M.4    Jiang, J.5    Acevedo, M.R.6
  • 23
    • 84938739087 scopus 로고    scopus 로고
    • Predicting adult weight change in the real world: a systematic review and meta-analysis accounting for compensatory changes in energy intake or expenditure
    • Dhurandhar EJ, Kaiser KA, Dawson JA, Alcorn AS, Keating KD, Allison DB. Predicting adult weight change in the real world: a systematic review and meta-analysis accounting for compensatory changes in energy intake or expenditure. Int J Obes (Lond). 2014. doi: 10.1038/ijo.2014.184.
    • (2014) Int J Obes (Lond)
    • Dhurandhar, E.J.1    Kaiser, K.A.2    Dawson, J.A.3    Alcorn, A.S.4    Keating, K.D.5    Allison, D.B.6
  • 24
    • 84897116945 scopus 로고    scopus 로고
    • Action and therapeutic potential of oxyntomodulin
    • 1:CAS:528:DC%2BC2cXisVeqsQ%3D%3D 3986661 24749050
    • Pocai A. Action and therapeutic potential of oxyntomodulin. Mol Metab. 2014;3(3):241-51.
    • (2014) Mol Metab , vol.3 , Issue.3 , pp. 241-251
    • Pocai, A.1
  • 25
    • 84898910135 scopus 로고    scopus 로고
    • The future role of gut hormones in the treatment of obesity
    • 1:CAS:528:DC%2BC2cXhs1OntL3J 3871274 24381724
    • Troke RC, Tan TM, Bloom SR. The future role of gut hormones in the treatment of obesity. Ther Adv Chronic Dis. 2014;5(1):4-14.
    • (2014) Ther Adv Chronic Dis , vol.5 , Issue.1 , pp. 4-14
    • Troke, R.C.1    Tan, T.M.2    Bloom, S.R.3
  • 26
    • 84865435072 scopus 로고    scopus 로고
    • Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice
    • 1:CAS:528:DC%2BC38XhtlagtLnL 22822160
    • Caricilli AM, Penteado E, de Abreu LL, Quaresma PGF, Santos AC, Guadagnini D, et al. Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology. 2012;153(9):4401-11.
    • (2012) Endocrinology , vol.153 , Issue.9 , pp. 4401-4411
    • Caricilli, A.M.1    Penteado, E.2    De Abreu, L.L.3    Quaresma, P.G.F.4    Santos, A.C.5    Guadagnini, D.6
  • 27
    • 84907495079 scopus 로고    scopus 로고
    • GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
    • 1:CAS:528:DC%2BC2cXhslWiurjJ 24917578
    • Beiroa D, Imbernon M, Gallego R, Senra A, Herranz D, Villarroya F, et al. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes. 2014;63(10):3346-58.
    • (2014) Diabetes , vol.63 , Issue.10 , pp. 3346-3358
    • Beiroa, D.1    Imbernon, M.2    Gallego, R.3    Senra, A.4    Herranz, D.5    Villarroya, F.6
  • 28
    • 0026753155 scopus 로고
    • Beneficial health effects of modest weight loss
    • 1:STN:280:DyaK38zlsFWruw%3D%3D 1322866
    • Goldstein DJ. Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord. 1992;16(6):397-415.
    • (1992) Int J Obes Relat Metab Disord , vol.16 , Issue.6 , pp. 397-415
    • Goldstein, D.J.1
  • 29
    • 0029363329 scopus 로고
    • Effect of degree of weight loss on health benefits
    • 8581779
    • Blackburn G. Effect of degree of weight loss on health benefits. Obes Res. 1995;3(Suppl 2):211s-6s.
    • (1995) Obes Res , vol.3 , pp. 211s-216s
    • Blackburn, G.1
  • 30
    • 0036945796 scopus 로고    scopus 로고
    • Updated review on the benefits of weight loss
    • 12457296
    • Vidal J. Updated review on the benefits of weight loss. Int J Obes Relat Metab Disord. 2002;26(Suppl 4):S25-8.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. S25-S28
    • Vidal, J.1
  • 31
    • 79960969194 scopus 로고    scopus 로고
    • Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes
    • 1:CAS:528:DC%2BC3MXhtFWlsrbJ 3120182 21593294
    • Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011;34(7):1481-6.
    • (2011) Diabetes Care , vol.34 , Issue.7 , pp. 1481-1486
    • Wing, R.R.1    Lang, W.2    Wadden, T.A.3    Safford, M.4    Knowler, W.C.5    Bertoni, A.G.6
  • 32
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • 1:CAS:528:DC%2BD38XhtVWqurc%3D 11832527
    • Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403.
    • (2002) N Engl J Med , vol.346 , Issue.6 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3    Hamman, R.F.4    Lachin, J.M.5    Walker, E.A.6
  • 33
    • 84921437510 scopus 로고    scopus 로고
    • Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial
    • Look AHEAD Research Group. Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2014;2(10):801-9.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , Issue.10 , pp. 801-809
  • 34
    • 34147223802 scopus 로고    scopus 로고
    • Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis
    • 1856062 17204567
    • Christensen R, Bartels EM, Astrup A, Bliddal H. Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis. 2007;66(4):433-9.
    • (2007) Ann Rheum Dis , vol.66 , Issue.4 , pp. 433-439
    • Christensen, R.1    Bartels, E.M.2    Astrup, A.3    Bliddal, H.4
  • 35
    • 84860330219 scopus 로고    scopus 로고
    • Food and Drug Administration's obesity drug guidance document: a short history
    • 22547756
    • Colman E. Food and Drug Administration's obesity drug guidance document: a short history. Circulation. 2012;125(17):2156-64.
    • (2012) Circulation , vol.125 , Issue.17 , pp. 2156-2164
    • Colman, E.1
  • 37
    • 77956284607 scopus 로고    scopus 로고
    • Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects
    • 1:CAS:528:DC%2BC3cXhtFWjsrnN 20818901
    • James WPT, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP, et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med. 2010;363(10):905-17.
    • (2010) N Engl J Med , vol.363 , Issue.10 , pp. 905-917
    • James, W.P.T.1    Caterson, I.D.2    Coutinho, W.3    Finer, N.4    Van Gaal, L.F.5    Maggioni, A.P.6
  • 38
    • 34249743161 scopus 로고    scopus 로고
    • Dinitrophenol and obesity: an early twentieth-century regulatory dilemma
    • 1:CAS:528:DC%2BD2sXmtVKjs78%3D 17475379
    • Colman E. Dinitrophenol and obesity: an early twentieth-century regulatory dilemma. Regul Toxicol Pharmacol. 2007;48(2):115-7.
    • (2007) Regul Toxicol Pharmacol , vol.48 , Issue.2 , pp. 115-117
    • Colman, E.1
  • 39
    • 0026518794 scopus 로고
    • Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo
    • 1:STN:280:DyaK383ms1KltA%3D%3D 1587072
    • Weintraub M, Sundaresan PR, Madan M, Schuster B, Balder A, Lasagna L, et al. Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo. Clin Pharmacol Ther. 1992;51(5):586-94.
    • (1992) Clin Pharmacol Ther , vol.51 , Issue.5 , pp. 586-594
    • Weintraub, M.1    Sundaresan, P.R.2    Madan, M.3    Schuster, B.4    Balder, A.5    Lasagna, L.6
  • 41
    • 0031602176 scopus 로고    scopus 로고
    • Sibutramine reduces food intake in non-dieting women with obesity
    • 1:CAS:528:DyaK1cXhslWjt7c%3D 9526964
    • Rolls BJ, Shide DJ, Thorwart ML, Ulbrecht JS. Sibutramine reduces food intake in non-dieting women with obesity. Obes Res. 1998;6(1):1-11.
    • (1998) Obes Res , vol.6 , Issue.1 , pp. 1-11
    • Rolls, B.J.1    Shide, D.J.2    Thorwart, M.L.3    Ulbrecht, J.S.4
  • 42
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    • RIO-North America Study Group 1:CAS:528:DC%2BD28XhsFOrs7g%3D 16478899
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J, RIO-North America Study Group. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA. 2006;295(7):761-75.
    • (2006) JAMA , vol.295 , Issue.7 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3    Devin, J.4    Rosenstock, J.5
  • 43
    • 77956017429 scopus 로고    scopus 로고
    • Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial
    • 1:CAS:528:DC%2BC3cXhtVantrzF 20709233
    • Topol EJ, Bousser M-G, Fox KAA, Creager MA, Despres J-P, Easton JD, et al. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet. 2010;376(9740):517-23.
    • (2010) Lancet , vol.376 , Issue.9740 , pp. 517-523
    • Topol, E.J.1    Bousser, M.-G.2    Fox, K.A.A.3    Creager, M.A.4    Despres, J.-P.5    Easton, J.D.6
  • 44
    • 84866415138 scopus 로고    scopus 로고
    • JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities
    • 1:CAS:528:DC%2BC38XhtlajsbzJ 22959249
    • Chorvat RJ, Berbaum J, Seriacki K, McElroy JF. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012;22(19):6173-80.
    • (2012) Bioorg Med Chem Lett , vol.22 , Issue.19 , pp. 6173-6180
    • Chorvat, R.J.1    Berbaum, J.2    Seriacki, K.3    McElroy, J.F.4
  • 45
    • 0026604775 scopus 로고
    • Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin)
    • 1:CAS:528:DyaK38Xht1Sksbc%3D 1728845
    • Hauptman JB, Jeunet FS, Hartmann D. Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin). Am J Clin Nutr. 1992;55(1 Suppl):309S-13S.
    • (1992) Am J Clin Nutr , vol.55 , Issue.1 , pp. 309S-313S
    • Hauptman, J.B.1    Jeunet, F.S.2    Hartmann, D.3
  • 46
    • 37249083878 scopus 로고    scopus 로고
    • Long term pharmacotherapy for obesity and overweight: updated meta-analysis
    • 1:CAS:528:DC%2BD1cXhtFKlsLo%3D 2128668 18006966
    • Rucker D, Padwal R, Li SK, Curioni C, Lau DCW. Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ. 2007;335(7631):1194-9.
    • (2007) BMJ , vol.335 , Issue.7631 , pp. 1194-1199
    • Rucker, D.1    Padwal, R.2    Li, S.K.3    Curioni, C.4    Lau, D.C.W.5
  • 47
    • 1042303480 scopus 로고    scopus 로고
    • Xenical in the Prevention of Diabetes in Obese Subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    • 1:CAS:528:DC%2BD2cXmvV2jug%3D%3D 14693982
    • Torgerson JS, Hauptman J, Boldrin MN, Sjöström L. Xenical in the Prevention of Diabetes in Obese Subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care. 2004;27(1):155-61.
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 155-161
    • Torgerson, J.S.1    Hauptman, J.2    Boldrin, M.N.3    Sjöström, L.4
  • 48
    • 0036845652 scopus 로고    scopus 로고
    • The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial
    • 1:CAS:528:DC%2BD38XpsVChu78%3D 12406041
    • Hanefeld M, Sachse G. The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial. Diabetes Obes Metab. 2002;4(6):415-23.
    • (2002) Diabetes Obes Metab , vol.4 , Issue.6 , pp. 415-423
    • Hanefeld, M.1    Sachse, G.2
  • 49
    • 84896318206 scopus 로고    scopus 로고
    • Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?
    • 1:CAS:528:DC%2BC3sXhvFCjtrvP 3950585
    • Miras AD, le Roux CW. Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery? Int J Obes (Lond). 2014;38(3):325-33.
    • (2014) Int J Obes (Lond) , vol.38 , Issue.3 , pp. 325-333
    • Miras, A.D.1    Le Roux, C.W.2
  • 50
    • 77954635020 scopus 로고    scopus 로고
    • Multicenter, placebo-controlled trial of lorcaserin for weight management
    • 1:CAS:528:DC%2BC3cXptVOgs74%3D 20647200
    • Smith SR, Weissman NJ, Anderson CM, Sanchez M, Chuang E, Stubbe S, et al. Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med. 2010;363(3):245-56.
    • (2010) N Engl J Med , vol.363 , Issue.3 , pp. 245-256
    • Smith, S.R.1    Weissman, N.J.2    Anderson, C.M.3    Sanchez, M.4    Chuang, E.5    Stubbe, S.6
  • 51
    • 80053539943 scopus 로고    scopus 로고
    • A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial
    • 1:CAS:528:DC%2BC3MXhtlyitbnO 21795446
    • Fidler MC, Sanchez M, Raether B, Weissman NJ, Smith SR, Shanahan WR, et al. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab. 2011;96(10):3067-77.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.10 , pp. 3067-3077
    • Fidler, M.C.1    Sanchez, M.2    Raether, B.3    Weissman, N.J.4    Smith, S.R.5    Shanahan, W.R.6
  • 52
    • 84862869642 scopus 로고    scopus 로고
    • Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study
    • 22421927
    • O'Neil PM, Smith SR, Weissman NJ, Fidler MC, Sanchez M, Zhang J, et al. Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study. Obesity (Silver Spring). 2012;20(7):1426-36.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.7 , pp. 1426-1436
    • O'Neil, P.M.1    Smith, S.R.2    Weissman, N.J.3    Fidler, M.C.4    Sanchez, M.5    Zhang, J.6
  • 53
    • 84884478505 scopus 로고    scopus 로고
    • Echocardiographic assessment of cardiac valvular regurgitation with lorcaserin from analysis of 3 phase 3 clinical trials
    • 23661689
    • Weissman NJ, Sanchez M, Koch GG, Smith SR, Shanahan WR, Anderson CM. Echocardiographic assessment of cardiac valvular regurgitation with lorcaserin from analysis of 3 phase 3 clinical trials. Circ Cardiovasc Imaging. 2013;6(4):560-7.
    • (2013) Circ Cardiovasc Imaging , vol.6 , Issue.4 , pp. 560-567
    • Weissman, N.J.1    Sanchez, M.2    Koch, G.G.3    Smith, S.R.4    Shanahan, W.R.5    Anderson, C.M.6
  • 54
    • 24644477445 scopus 로고    scopus 로고
    • Anorectics on trial: a half century of federal regulation of prescription appetite suppressants
    • 16144896
    • Colman E. Anorectics on trial: a half century of federal regulation of prescription appetite suppressants. Ann Intern Med. 2005;143(5):380-5.
    • (2005) Ann Intern Med , vol.143 , Issue.5 , pp. 380-385
    • Colman, E.1
  • 55
    • 0043181917 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures
    • 1:CAS:528:DyaK28XjvVyrtro%3D 8641230
    • Ben-Menachem E, Henriksen O, Dam M, Mikkelsen M, Schmidt D, Reid S, et al. Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures. Epilepsia. 1996;37(6):539-43.
    • (1996) Epilepsia , vol.37 , Issue.6 , pp. 539-543
    • Ben-Menachem, E.1    Henriksen, O.2    Dam, M.3    Mikkelsen, M.4    Schmidt, D.5    Reid, S.6
  • 56
    • 1942436861 scopus 로고    scopus 로고
    • Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist
    • 1:CAS:528:DC%2BD2cXjsVWgs7c%3D 15111016
    • Kaminski RM, Banerjee M, Rogawski MA. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004;46(8):1097-104.
    • (2004) Neuropharmacology , vol.46 , Issue.8 , pp. 1097-1104
    • Kaminski, R.M.1    Banerjee, M.2    Rogawski, M.A.3
  • 57
    • 0034576649 scopus 로고    scopus 로고
    • Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats
    • 1:CAS:528:DC%2BD3MXhtl2mt74%3D 11225714
    • Picard F, Deshaies Y, Lalonde J, Samson P, Richard D. Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats. Obes Res. 2000;8(9):656-63.
    • (2000) Obes Res , vol.8 , Issue.9 , pp. 656-663
    • Picard, F.1    Deshaies, Y.2    Lalonde, J.3    Samson, P.4    Richard, D.5
  • 58
    • 79954561234 scopus 로고    scopus 로고
    • Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial
    • 1:CAS:528:DC%2BC3MXkvVSqtL4%3D 21481449
    • Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377(9774):1341-52.
    • (2011) Lancet , vol.377 , Issue.9774 , pp. 1341-1352
    • Gadde, K.M.1    Allison, D.B.2    Ryan, D.H.3    Peterson, C.A.4    Troupin, B.5    Schwiers, M.L.6
  • 59
    • 84856246606 scopus 로고    scopus 로고
    • Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)
    • 1:CAS:528:DC%2BC38XhsFCmsbo%3D 3270297 22051941
    • Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, et al. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring). 2012;20(2):330-42.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.2 , pp. 330-342
    • Allison, D.B.1    Gadde, K.M.2    Garvey, W.T.3    Peterson, C.A.4    Schwiers, M.L.5    Najarian, T.6
  • 61
    • 0036636368 scopus 로고    scopus 로고
    • Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial
    • 1:CAS:528:DC%2BD38XmtFShsbc%3D 12105285
    • Anderson JW, Greenway FL, Fujioka K, Gadde KM, McKenney J, O'Neil PM. Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial. Obes Res. 2002;10(7):633-41.
    • (2002) Obes Res , vol.10 , Issue.7 , pp. 633-641
    • Anderson, J.W.1    Greenway, F.L.2    Fujioka, K.3    Gadde, K.M.4    McKenney, J.5    O'Neil, P.M.6
  • 62
    • 36849082451 scopus 로고    scopus 로고
    • Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings
    • 1:CAS:528:DC%2BD2sXhsVCksLnM 2359153 17880925
    • Johnson BA. Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem Pharmacol. 2008;75(1):34-56.
    • (2008) Biochem Pharmacol , vol.75 , Issue.1 , pp. 34-56
    • Johnson, B.A.1
  • 64
    • 77956904326 scopus 로고    scopus 로고
    • Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial
    • 1:CAS:528:DC%2BC3cXhs1Wkt7zF 4459776 20559296
    • Wadden TA, Foreyt JP, Foster GD, Hill JO, Klein S, O'Neil PM, et al. Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. Obesity (Silver Spring). 2011;19(1):110-20.
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.1 , pp. 110-120
    • Wadden, T.A.1    Foreyt, J.P.2    Foster, G.D.3    Hill, J.O.4    Klein, S.5    O'Neil, P.M.6
  • 65
    • 84891869792 scopus 로고    scopus 로고
    • Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes
    • 1:CAS:528:DC%2BC3sXhvFaksLvM 3836105 24144653
    • Hollander P, Gupta AK, Plodkowski R, Greenway F, Bays H, Burns C, et al. Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes. Diabetes Care. 2013;36(12):4022-9.
    • (2013) Diabetes Care , vol.36 , Issue.12 , pp. 4022-4029
    • Hollander, P.1    Gupta, A.K.2    Plodkowski, R.3    Greenway, F.4    Bays, H.5    Burns, C.6
  • 66
    • 84879324574 scopus 로고    scopus 로고
    • A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II)
    • 1:CAS:528:DC%2BC3sXpvFaksL0%3D 3739931 23408728
    • Apovian CM, Aronne L, Rubino D, Still C, Wyatt H, Burns C, et al. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring). 2013;21(5):935-43.
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.5 , pp. 935-943
    • Apovian, C.M.1    Aronne, L.2    Rubino, D.3    Still, C.4    Wyatt, H.5    Burns, C.6
  • 67
    • 77956057548 scopus 로고    scopus 로고
    • Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
    • 1:CAS:528:DC%2BC3cXhtVGmtbbK 20673995
    • Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376(9741):595-605.
    • (2010) Lancet , vol.376 , Issue.9741 , pp. 595-605
    • Greenway, F.L.1    Fujioka, K.2    Plodkowski, R.A.3    Mudaliar, S.4    Guttadauria, M.5    Erickson, J.6
  • 68
    • 33845875966 scopus 로고    scopus 로고
    • Gut hormones and the regulation of energy homeostasis
    • 1:CAS:528:DC%2BD28XhtlShtrzJ 17167473
    • Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature. 2006;444(7121):854-9.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 854-859
    • Murphy, K.G.1    Bloom, S.R.2
  • 69
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (Liraglutide Effect and Action in Diabetes)-2 study
    • 1:CAS:528:DC%2BD1MXhs1Ggu7g%3D 2606836 18931095
    • Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care. 2009;32(1):84-90.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6
  • 70
    • 84887840117 scopus 로고    scopus 로고
    • Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study
    • 1:CAS:528:DC%2BC3sXhslynsr3I
    • Wadden TA, Hollander P, Klein S, Niswender K, Woo V, Hale PM, et al. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Int J Obes (Lond). 2013;37(11):1443-51.
    • (2013) Int J Obes (Lond) , vol.37 , Issue.11 , pp. 1443-1451
    • Wadden, T.A.1    Hollander, P.2    Klein, S.3    Niswender, K.4    Woo, V.5    Hale, P.M.6
  • 72
    • 84861018492 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: a clinical perspective on cardiovascular effects
    • 22496442
    • Mundil D, Cameron-Vendrig A, Husain M. GLP-1 receptor agonists: a clinical perspective on cardiovascular effects. Diab Vasc Dis Res. 2012;9(2):95-108.
    • (2012) Diab Vasc Dis Res , vol.9 , Issue.2 , pp. 95-108
    • Mundil, D.1    Cameron-Vendrig, A.2    Husain, M.3
  • 73
    • 84914666192 scopus 로고    scopus 로고
    • Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC2cXhsFWhurnK 24980665
    • Ferdinand KC, White WB, Calhoun DA, Lonn EM, Sager PT, Brunelle R, et al. Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus. Hypertension. 2014;64(4):731-7.
    • (2014) Hypertension , vol.64 , Issue.4 , pp. 731-737
    • Ferdinand, K.C.1    White, W.B.2    Calhoun, D.A.3    Lonn, E.M.4    Sager, P.T.5    Brunelle, R.6
  • 74
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide - the FDA's review of a new antidiabetic therapy
    • 1:CAS:528:DC%2BC3cXivV2hu7s%3D 20164475
    • Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide - the FDA's review of a new antidiabetic therapy. N Engl J Med. 2010;362(9):774-7.
    • (2010) N Engl J Med , vol.362 , Issue.9 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 75
    • 72449148137 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?
    • 1:STN:280:DC%2BC3c%2FjvVyitA%3D%3D 2789933 19894028
    • Butler PC, Matveyenko AV, Dry S, Bhushan A, Elashoff R. Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire? Diabetologia. 2010;53(1):1-6.
    • (2010) Diabetologia , vol.53 , Issue.1 , pp. 1-6
    • Butler, P.C.1    Matveyenko, A.V.2    Dry, S.3    Bhushan, A.4    Elashoff, R.5
  • 76
    • 77954671985 scopus 로고    scopus 로고
    • Do incretin-based therapies cause acute pancreatitis?
    • 2825646 20167189
    • Olansky L. Do incretin-based therapies cause acute pancreatitis? J Diabetes Sci Technol. 2010;4(1):228-9.
    • (2010) J Diabetes Sci Technol , vol.4 , Issue.1 , pp. 228-229
    • Olansky, L.1
  • 77
    • 84918526403 scopus 로고    scopus 로고
    • Adverse drug reactions associated with the use of liraglutide in patients with type 2 diabetes - focus on pancreatitis and pancreas cancer
    • 1:CAS:528:DC%2BC2cXitFahtLvF 25363438
    • Chalmer T, Almdal TP, Vilsbøll T, Knop FK. Adverse drug reactions associated with the use of liraglutide in patients with type 2 diabetes - focus on pancreatitis and pancreas cancer. Expert Opin Drug Saf. 2015;14(1):171-80.
    • (2015) Expert Opin Drug Saf , vol.14 , Issue.1 , pp. 171-180
    • Chalmer, T.1    Almdal, T.P.2    Vilsbøll, T.3    Knop, F.K.4
  • 78
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study
    • 2671118 19208917
    • Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32(5):834-8.
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.L.4
  • 79
    • 84896731936 scopus 로고    scopus 로고
    • Pancreatic safety of incretin-based drugs - FDA and EMA assessment
    • 1:CAS:528:DC%2BC2cXjs1ygsb4%3D 24571751
    • Egan AG, Blind E, Dunder K, de Graeff PA, Hummer BT, Bourcier T, et al. Pancreatic safety of incretin-based drugs - FDA and EMA assessment. N Engl J Med. 2014;370(9):794-7.
    • (2014) N Engl J Med , vol.370 , Issue.9 , pp. 794-797
    • Egan, A.G.1    Blind, E.2    Dunder, K.3    De Graeff, P.A.4    Hummer, B.T.5    Bourcier, T.6
  • 80
    • 84875702681 scopus 로고    scopus 로고
    • On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice
    • 23471186
    • Rosol TJ. On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice. Toxicol Pathol. 2013;41(2):303-9.
    • (2013) Toxicol Pathol , vol.41 , Issue.2 , pp. 303-309
    • Rosol, T.J.1
  • 81
    • 0022482362 scopus 로고
    • Brown adipose tissue in patients with phaeochromocytoma
    • 1:STN:280:DyaL2s%2Fgsleitg%3D%3D 3019909
    • Lean ME, James WP, Jennings G, Trayhurn P. Brown adipose tissue in patients with phaeochromocytoma. Int J Obes. 1986;10(3):219-27.
    • (1986) Int J Obes , vol.10 , Issue.3 , pp. 219-227
    • Lean, M.E.1    James, W.P.2    Jennings, G.3    Trayhurn, P.4
  • 82
    • 0025940707 scopus 로고
    • Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes
    • 1:CAS:528:DyaK38Xmt1Knt7k%3D 453106 1718744
    • Nahmias C, Blin N, Elalouf JM, Mattei MG, Strosberg AD, Emorine LJ. Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 1991;10(12):3721-7.
    • (1991) EMBO J , vol.10 , Issue.12 , pp. 3721-3727
    • Nahmias, C.1    Blin, N.2    Elalouf, J.M.3    Mattei, M.G.4    Strosberg, A.D.5    Emorine, L.J.6
  • 84
    • 0033074328 scopus 로고    scopus 로고
    • Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle
    • 1:CAS:528:DyaK1MXms1GrtQ%3D%3D 9915482
    • Fujimura T, Tamura K, Tsutsumi T, Yamamoto T, Nakamura K, Koibuchi Y, et al. Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle. J Urol. 1999;161(2):680-5.
    • (1999) J Urol , vol.161 , Issue.2 , pp. 680-685
    • Fujimura, T.1    Tamura, K.2    Tsutsumi, T.3    Yamamoto, T.4    Nakamura, K.5    Koibuchi, Y.6
  • 85
    • 84920627180 scopus 로고    scopus 로고
    • Activation of human brown adipose tissue by a β3-adrenergic receptor agonist
    • 1:CAS:528:DC%2BC2MXlvF2itg%3D%3D 25565203
    • Cypess AM, Weiner LS, Roberts-Toler C, Elía EF, Kessler SH, Kahn PA, et al. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015;21(1):33-8.
    • (2015) Cell Metab , vol.21 , Issue.1 , pp. 33-38
    • Cypess, A.M.1    Weiner, L.S.2    Roberts-Toler, C.3    Elía, E.F.4    Kessler, S.H.5    Kahn, P.A.6
  • 86
    • 84908241953 scopus 로고    scopus 로고
    • Thermogenic adipocytes: from cells to physiology and medicine
    • 1:CAS:528:DC%2BC2cXht12nur7M 25107565
    • Diaz MB, Herzig S, Vegiopoulos A. Thermogenic adipocytes: from cells to physiology and medicine. Metab Clin Exp. 2014;63(10):1238-49.
    • (2014) Metab Clin Exp , vol.63 , Issue.10 , pp. 1238-1249
    • Diaz, M.B.1    Herzig, S.2    Vegiopoulos, A.3
  • 87
    • 0037043704 scopus 로고    scopus 로고
    • Gut hormone PYY(3-36) physiologically inhibits food intake
    • 1:CAS:528:DC%2BD38XlvVylt7s%3D 12167864
    • Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002;418(6898):650-4.
    • (2002) Nature , vol.418 , Issue.6898 , pp. 650-654
    • Batterham, R.L.1    Cowley, M.A.2    Small, C.J.3    Herzog, H.4    Cohen, M.A.5    Dakin, C.L.6
  • 89
    • 84872175094 scopus 로고    scopus 로고
    • Unraveling oxyntomodulin, GLP1's enigmatic brother
    • 1:CAS:528:DC%2BC38Xhsl2it7bP 3493657 23019069
    • Pocai A. Unraveling oxyntomodulin, GLP1's enigmatic brother. J Endocrinol. 2012;215(3):335-46.
    • (2012) J Endocrinol , vol.215 , Issue.3 , pp. 335-346
    • Pocai, A.1
  • 90
    • 77954252801 scopus 로고    scopus 로고
    • PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans
    • 1:CAS:528:DC%2BC3cXpsVOlsrg%3D 2889762 20357366
    • Field BCT, Wren AM, Peters V, Baynes KCR, Martin NM, Patterson M, et al. PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans. Diabetes. 2010;59(7):1635-9.
    • (2010) Diabetes , vol.59 , Issue.7 , pp. 1635-1639
    • Field, B.C.T.1    Wren, A.M.2    Peters, V.3    Baynes, K.C.R.4    Martin, N.M.5    Patterson, M.6
  • 91
    • 84868013714 scopus 로고    scopus 로고
    • Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    • 1:CAS:528:DC%2BC38Xhsl2it7rN 3478556 22933116
    • Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, et al. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes. 2012;61(11):2753-62.
    • (2012) Diabetes , vol.61 , Issue.11 , pp. 2753-2762
    • Lockie, S.H.1    Heppner, K.M.2    Chaudhary, N.3    Chabenne, J.R.4    Morgan, D.A.5    Veyrat-Durebex, C.6
  • 92
    • 84864351901 scopus 로고    scopus 로고
    • The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin
    • 1:CAS:528:DC%2BC38XhtFWntL3O 3408645 22421924
    • Kosinski JR, Hubert J, Carrington PE, Chicchi GG, Mu J, Miller C, et al. The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin. Obesity (Silver Spring). 2012;20(8):1566-71.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.8 , pp. 1566-1571
    • Kosinski, J.R.1    Hubert, J.2    Carrington, P.E.3    Chicchi, G.G.4    Mu, J.5    Miller, C.6
  • 93
    • 84925282923 scopus 로고    scopus 로고
    • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
    • 1:CAS:528:DC%2BC2cXitVCks73J 25485909
    • Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med. 2015;21(1):27-36.
    • (2015) Nat Med , vol.21 , Issue.1 , pp. 27-36
    • Finan, B.1    Yang, B.2    Ottaway, N.3    Smiley, D.L.4    Ma, T.5    Clemmensen, C.6
  • 94
    • 81855169560 scopus 로고    scopus 로고
    • A two-year randomized trial of obesity treatment in primary care practice
    • 1:CAS:528:DC%2BC3MXhs1Shsr%2FE 3282598 22082239
    • Wadden TA, Volger S, Sarwer DB, Vetter ML, Tsai AG, Berkowitz RI, et al. A two-year randomized trial of obesity treatment in primary care practice. N Engl J Med. 2011;365(21):1969-79.
    • (2011) N Engl J Med , vol.365 , Issue.21 , pp. 1969-1979
    • Wadden, T.A.1    Volger, S.2    Sarwer, D.B.3    Vetter, M.L.4    Tsai, A.G.5    Berkowitz, R.I.6
  • 95
    • 84907323201 scopus 로고    scopus 로고
    • Assessment and lifestyle management of patients with obesity: clinical recommendations from systematic reviews
    • 1:CAS:528:DC%2BC2cXhs12jt7jF 25182103
    • Kushner RF, Ryan DH. Assessment and lifestyle management of patients with obesity: clinical recommendations from systematic reviews. JAMA. 2014;312(9):943-52.
    • (2014) JAMA , vol.312 , Issue.9 , pp. 943-952
    • Kushner, R.F.1    Ryan, D.H.2
  • 96
    • 84888186784 scopus 로고    scopus 로고
    • Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials
    • 3806364 24149519
    • Gloy VL, Briel M, Bhatt DL, Kashyap SR, Schauer PR, Mingrone G, et al. Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ. 2013;347:f5934.
    • (2013) BMJ , vol.347
    • Gloy, V.L.1    Briel, M.2    Bhatt, D.L.3    Kashyap, S.R.4    Schauer, P.R.5    Mingrone, G.6
  • 97
    • 84907325693 scopus 로고    scopus 로고
    • Long-term follow-up after bariatric surgery: a systematic review
    • 1:CAS:528:DC%2BC2cXhs12jt7nP 4409000 25182102
    • Puzziferri N, Roshek TB, Mayo HG, Gallagher R, Belle SH, Livingston EH. Long-term follow-up after bariatric surgery: a systematic review. JAMA. 2014;312(9):934-42.
    • (2014) JAMA , vol.312 , Issue.9 , pp. 934-942
    • Puzziferri, N.1    Roshek, T.B.2    Mayo, H.G.3    Gallagher, R.4    Belle, S.H.5    Livingston, E.H.6
  • 98
    • 84910010851 scopus 로고    scopus 로고
    • Complications of bariatric surgery: dumping syndrome, reflux and vitamin deficiencies
    • 1:CAS:528:DC%2BC2cXhtlSru7vF 25194187
    • Tack J, Deloose E. Complications of bariatric surgery: dumping syndrome, reflux and vitamin deficiencies. Best Pract Res Clin Gastroenterol. 2014;28(4):741-9.
    • (2014) Best Pract Res Clin Gastroenterol , vol.28 , Issue.4 , pp. 741-749
    • Tack, J.1    Deloose, E.2
  • 99
    • 84910009204 scopus 로고    scopus 로고
    • Obesity and the risk and prognosis of gallstone disease and pancreatitis
    • 1:CAS:528:DC%2BC2cXhtlCktrjL 25194180
    • Bonfrate L, Wang DQ-H, Garruti G, Portincasa P. Obesity and the risk and prognosis of gallstone disease and pancreatitis. Best Pract Res Clin Gastroenterol. 2014;28(4):623-35.
    • (2014) Best Pract Res Clin Gastroenterol , vol.28 , Issue.4 , pp. 623-635
    • Bonfrate, L.1    Wang, D.-H.2    Garruti, G.3    Portincasa, P.4
  • 100
    • 84903212216 scopus 로고    scopus 로고
    • 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society
    • 24239920
    • Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society. J Am Coll Cardiol. 2014;63(25 Pt B):2985-3023.
    • (2014) J Am Coll Cardiol , vol.63 , Issue.25 , pp. 2985-3023
    • Jensen, M.D.1    Ryan, D.H.2    Apovian, C.M.3    Ard, J.D.4    Comuzzie, A.G.5    Donato, K.A.6
  • 102
    • 84922570654 scopus 로고    scopus 로고
    • Pharmacological management of obesity: an Endocrine Society clinical practice guideline
    • 1:CAS:528:DC%2BC2MXjtVWqs7c%3D 25590212
    • Apovian CM, Aronne LJ, Bessesen DH, McDonnell ME, Murad MH, Pagotto U, et al. Pharmacological management of obesity: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100(2):342-62.
    • (2015) J Clin Endocrinol Metab , vol.100 , Issue.2 , pp. 342-362
    • Apovian, C.M.1    Aronne, L.J.2    Bessesen, D.H.3    McDonnell, M.E.4    Murad, M.H.5    Pagotto, U.6
  • 103
    • 84885336333 scopus 로고    scopus 로고
    • Effect of the EndoBarrier gastrointestinal liner on obesity and type 2 diabetes: protocol for systematic review and meta-analysis of clinical studies
    • 3773645 24038010
    • Rohde U, Hedbäck N, Gluud LL, Vilsbøll T, Knop FK. Effect of the EndoBarrier gastrointestinal liner on obesity and type 2 diabetes: protocol for systematic review and meta-analysis of clinical studies. BMJ Open. 2013;3(9):e003417.
    • (2013) BMJ Open , vol.3 , Issue.9
    • Rohde, U.1    Hedbäck, N.2    Gluud, L.L.3    Vilsbøll, T.4    Knop, F.K.5
  • 104
    • 84907332108 scopus 로고    scopus 로고
    • Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: the ReCharge randomized clinical trial
    • 1:CAS:528:DC%2BC2cXhs12jt7nL 25182100
    • Ikramuddin S, Blackstone RP, Brancatisano A, Toouli J, Shah SN, Wolfe BM, et al. Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: the ReCharge randomized clinical trial. JAMA. 2014;312(9):915-22.
    • (2014) JAMA , vol.312 , Issue.9 , pp. 915-922
    • Ikramuddin, S.1    Blackstone, R.P.2    Brancatisano, A.3    Toouli, J.4    Shah, S.N.5    Wolfe, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.