메뉴 건너뛰기




Volumn 14, Issue 1, 2015, Pages 171-180

Adverse drug reactions associated with the use of liraglutide in patients with type 2 diabetes-focus on pancreatitis and pancreas cancer

Author keywords

Adverse reactions; Cancer; Glucagon like peptide 1; Liraglutide; Pancreas; Pancreatitis; Type 2 diabetes

Indexed keywords

ALBIGLUTIDE; DULAGLUTIDE; EXENDIN 4; GLIMEPIRIDE; HEMOGLOBIN A1C; LIRAGLUTIDE; LIXISENATIDE; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR;

EID: 84918526403     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.975205     Document Type: Review
Times cited : (25)

References (62)
  • 2
    • 70849096647 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide
    • Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M. Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol 2009;68(6):898-905
    • (2009) Br J Clin Pharmacol , vol.68 , Issue.6 , pp. 898-905
    • Jacobsen, L.V.1    Hindsberger, C.2    Robson, R.3    Zdravkovic, M.4
  • 3
    • 78049354214 scopus 로고    scopus 로고
    • Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide
    • Flint A, Nazzal K, Jagielski P, et al. Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide. Br J Clin Pharmacol 2010;70(6):807-14
    • (2010) Br J Clin Pharmacol , vol.70 , Issue.6 , pp. 807-814
    • Flint, A.1    Nazzal, K.2    Jagielski, P.3
  • 4
    • 66149185085 scopus 로고    scopus 로고
    • Nove Nordisk Novo Nordisk European Medicines Agency
    • Nove Nordisk. Summary of product characteristics. Novo Nordisk, European Medicines Agency, 2013
    • (2013) Summary of Product Characteristics
  • 5
    • 82955241439 scopus 로고    scopus 로고
    • Treatment with liraglutide - A once-daily GLP-1 analog - Does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug
    • Jacobsen LV, Vouis J, Hindsberger C, Zdravkovic M. Treatment with liraglutide - A once-daily GLP-1 analog - does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug. J Clin Pharmacol 2011;51(12):1696-703
    • (2011) J Clin Pharmacol , vol.51 , Issue.12 , pp. 1696-1703
    • Jacobsen, L.V.1    Vouis, J.2    Hindsberger, C.3    Zdravkovic, M.4
  • 6
    • 84897852105 scopus 로고    scopus 로고
    • GLP-1 receptor localization in monkey and human tissue: Novel distribution revealed with extensively validated monoclonal antibody
    • Pyke C, Heller RS, Kirk RK, et al. GLP-1 receptor localization in monkey and human tissue: Novel distribution revealed with extensively validated monoclonal antibody. Endocrinology 2014;155(4):1280-90
    • (2014) Endocrinology , vol.155 , Issue.4 , pp. 1280-1290
    • Pyke, C.1    Heller, R.S.2    Kirk, R.K.3
  • 7
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • De Heer J, Rasmussen C, Coy DH, Holst JJ. Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 2008;51(12):2263-70
    • (2008) Diabetologia , vol.51 , Issue.12 , pp. 2263-2270
    • De Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 8
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007;87(4):1409-39
    • (2007) Physiol Rev , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 9
    • 84884583757 scopus 로고    scopus 로고
    • Incretin action in the pancreas: Potential promise possible perils and pathological pitfalls
    • Drucker DJ. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes 2013;62(10):3316-23
    • (2013) Diabetes , vol.62 , Issue.10 , pp. 3316-3323
    • Drucker, D.J.1
  • 10
    • 84881612495 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice
    • Ellenbroek JH, Tons HA, Westerouen van Meeteren MJ, et al. Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice. Diabetologia 2013;56(9):1980-6
    • (2013) Diabetologia , vol.56 , Issue.9 , pp. 1980-1986
    • Ellenbroek, J.H.1    Tons, H.A.2    Westerouen Van Meeteren, M.J.3
  • 11
    • 84860577431 scopus 로고    scopus 로고
    • The human GLP-1 analog liraglutide and the pancreas: Evidence for the absence of structural pancreatic changes in three species
    • Nyborg NC, Mølck A-M, Madsen LW, Knudsen LB. The human GLP-1 analog liraglutide and the pancreas: evidence for the absence of structural pancreatic changes in three species. Diabetes 2012;61(5):1243-9
    • (2012) Diabetes , vol.61 , Issue.5 , pp. 1243-1249
    • Nyborg, N.C.1    Mølck, A.-M.2    Madsen, L.W.3    Knudsen, L.B.4
  • 12
    • 84864674632 scopus 로고    scopus 로고
    • Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidyl-peptidase-4 inhibitors in the outpatient setting
    • Lando HM, Alattar M, Dua AP. Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidyl-peptidase-4 inhibitors in the outpatient setting. Endocr Pract 2012;18(4):472-7
    • (2012) Endocr Pract , vol.18 , Issue.4 , pp. 472-477
    • Lando, H.M.1    Alattar, M.2    Dua, A.P.3
  • 13
    • 70349120958 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation modulates pancreatitisassociated gene expression but does not modify the susceptibility to experimental pancreatitis in mice
    • Koehler JA, Baggio LL, Lamont BJ, et al. Glucagon-like peptide-1 receptor activation modulates pancreatitisassociated gene expression but does not modify the susceptibility to experimental pancreatitis in mice. Diabetes 2009;58(9):2148-61
    • (2009) Diabetes , vol.58 , Issue.9 , pp. 2148-2161
    • Koehler, J.A.1    Baggio, L.L.2    Lamont, B.J.3
  • 14
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    • Vilsbøll T, Zdravkovic M, Le-Thi T, et al. Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care 2007;30(6):1608-10
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1608-1610
    • Vilsbøll, T.1    Zdravkovic, M.2    Le-Thi, T.3
  • 15
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glp-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (lead-1 su
    • Marre M, Shaw J, Brändle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26(3):268-78
    • (2009) Diabet Med , vol.26 , Issue.3 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 16
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The lead (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009;32(1):84-90
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 17
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (lead- 3 mono): A randomised, 52-week, phase iii, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD- 3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;373(9662):473-81
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 18
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (lead-4 met+tzd
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009;32(7):1224-30
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 19
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (lead-5 met +su): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met +SU): a randomised controlled trial. Diabetologia 2009;52(10):2046-55
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 20
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26- week randomised, parallel-group, multinational, open-label trial (lead-6
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26- week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374(9683):39-47
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 21
    • 84868625533 scopus 로고    scopus 로고
    • Dosing rationale for liraglutide in type 2 diabetes mellitus: A pharmacometric assessment
    • Ingwersen SH, Khurana M, Madabushi R, et al. Dosing rationale for liraglutide in type 2 diabetes mellitus: a pharmacometric assessment. J Clin Pharmacol 2012;52(12):1815-23
    • (2012) J Clin Pharmacol , vol.52 , Issue.12 , pp. 1815-1823
    • Ingwersen, S.H.1    Khurana, M.2    Madabushi, R.3
  • 22
    • 83655184782 scopus 로고    scopus 로고
    • Achieving a clinically relevant composite outcome of an HbA1c of 7% without weight gain or hypoglycaemia in type 2 diabetes: A meta-analysis of the liraglutide clinical trial programme
    • Zinman B, Schmidt WE, Moses A, et al. Achieving a clinically relevant composite outcome of an HbA1c of 7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme. Diabetes Obes Metab 2012, 14, 1, 77-82
    • (2012) Diabetes Obes Metab , vol.14 , Issue.1 , pp. 77-82
    • Zinman, B.1    Schmidt, W.E.2    Moses, A.3
  • 23
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • Nauck MA, Kemmeries G, Holst JJ, Meier JJ. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 2011;60(5):1561-5
    • (2011) Diabetes , vol.60 , Issue.5 , pp. 1561-1565
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3    Meier, J.J.4
  • 24
    • 84893046412 scopus 로고    scopus 로고
    • Comparative effects of prolonged and intermittent stimulation of the glucagon-like peptide 1 receptor on gastric emptying and glycemia
    • Umapathysivam MM, Lee MY, Jones KL, et al. Comparative effects of prolonged and intermittent stimulation of the glucagon-like peptide 1 receptor on gastric emptying and glycemia. Diabetes 2014;63(2):785-90
    • (2014) Diabetes , vol.63 , Issue.2 , pp. 785-790
    • Umapathysivam, M.M.1    Lee, M.Y.2    Jones, K.L.3
  • 25
    • 84860243253 scopus 로고    scopus 로고
    • Liraglutide: Short-lived effect on gastric emptying - Long lasting effects on body weight
    • Jelsing J, Vrang N, Hansen G, et al. Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight. Diabetes Obes Metab 2012;14(6):531-8
    • (2012) Diabetes Obes Metab , vol.14 , Issue.6 , pp. 531-538
    • Jelsing, J.1    Vrang, N.2    Hansen, G.3
  • 26
    • 84899636658 scopus 로고    scopus 로고
    • Differing effects of liraglutide on gastric emptying in Japanese patients with type 2 diabetes
    • Nagai Y, Hashimoto E, Oikawa R, et al. Differing effects of liraglutide on gastric emptying in Japanese patients with type 2 diabetes. Diabetes Obes Metab 2014;16(6):573-6
    • (2014) Diabetes Obes Metab , vol.16 , Issue.6 , pp. 573-576
    • Nagai, Y.1    Hashimoto, E.2    Oikawa, R.3
  • 27
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002;359(9309):824-30
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 28
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • Kim M, Platt MJ, Shibasaki T, et al. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med 2013;19(5):567-75
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 567-575
    • Kim, M.1    Platt, M.J.2    Shibasaki, T.3
  • 29
    • 84901401785 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: Effect on proatrial natriuretic peptide in healthy males
    • Skov J, Holst JJ, Gøtze JP, et al. Glucagon-like peptide-1: effect on proatrial natriuretic peptide in healthy males. Endocr Connect 2014;3(1):11-16
    • (2014) Endocr Connect , vol.3 , Issue.1 , pp. 11-16
    • Skov, J.1    Holst, J.J.2    Gøtze, J.P.3
  • 30
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide- 1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials
    • Vilsbøll T, Christensen M, Junker AE, et al. Effects of glucagon-like peptide- 1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012;344:d7771
    • (2012) BMJ , vol.344 , pp. d7771
    • Vilsbøll, T.1    Christensen, M.2    Junker, A.E.3
  • 31
    • 84918548603 scopus 로고    scopus 로고
    • European Medicines Agency European Medicines Agency
    • European Medicines Agency. Assessment report Victoza. European Medicines Agency; 2011
    • (2011) Assessment Report Victoza
  • 32
    • 33846799072 scopus 로고    scopus 로고
    • Liraglutide: A once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus
    • Vilsbøll T. Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus. Expert Opin Investig Drugs 2007;16(2):231-7
    • (2007) Expert Opin Investig Drugs , vol.16 , Issue.2 , pp. 231-237
    • Vilsbøll, T.1
  • 33
    • 84908569527 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes friend or foe?
    • Yabe D, Seino Y. Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: friend or foe?. J Diabetes Investig 2014;5(5):475-7
    • (2014) J Diabetes Investig , vol.5 , Issue.5 , pp. 475-477
    • Yabe, D.1    Seino, Y.2
  • 34
    • 84887840117 scopus 로고    scopus 로고
    • Weight maintenance and additional weight loss with liraglutide after lowcalorie- diet-induced weight loss: The scale maintenance randomized study
    • Wadden TA, Hollander P, Klein S, et al. Weight maintenance and additional weight loss with liraglutide after lowcalorie- diet-induced weight loss: the SCALE Maintenance randomized study. Int J Obes(Lond) 2013;37(11):1443-51
    • (2013) Int J Obes(Lond , vol.37 , Issue.11 , pp. 1443-1451
    • Wadden, T.A.1    Hollander, P.2    Klein, S.3
  • 35
    • 84886946727 scopus 로고    scopus 로고
    • Design of the liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (leader) trial
    • e5
    • Marso SP, Poulter NR, Nissen SE, et al. Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial. Am Heart J 2013;166(5):823-30; e5
    • (2013) Am Heart J , vol.166 , Issue.5 , pp. 823-830
    • Marso, S.P.1    Poulter, N.R.2    Nissen, S.E.3
  • 36
    • 84939877797 scopus 로고    scopus 로고
    • Should we still be concerned about the potential side effects of glucagon-like peptide-1 receptor agonists on thyroid C cells?
    • Epub ahead of print
    • Cao Y, Liu X-M. Should we still be concerned about the potential side effects of glucagon-like peptide-1 receptor agonists on thyroid C cells?. Endocrine 2014; [Epub ahead of print
    • (2014) Endocrine
    • Cao, Y.1    Liu, X.-M.2
  • 37
    • 0020063847 scopus 로고
    • Experimental induction of C cell tumours in thyroid by increased dietary content of vitamin D3
    • Thurston V, Williams ED. Experimental induction of C cell tumours in thyroid by increased dietary content of vitamin D3. Acta Endocrinol (Copenh) 1982;100(1):41-5
    • (1982) Acta Endocrinol (Copenh , vol.100 , Issue.1 , pp. 41-45
    • Thurston, V.1    Williams, E.D.2
  • 38
    • 77950275036 scopus 로고    scopus 로고
    • Food and Drug Administration Available from
    • Food and Drug Administration. Forteo (teriparatide), medical review 2002: part 3. 2002. Available from: http://www. accessdata.fda.gov/drugsatfda-docs/nda/2002/21-318-FORTEO-Medr-p3.pdf
    • (2002) Forteo (Teriparatide) Medical Review 2002 Part 3
  • 39
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis pancreatic and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011;141(1):150-6
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3
  • 40
    • 84896731936 scopus 로고    scopus 로고
    • Pancreatic safety of incretin-based drugs FDA and EMA assessment
    • Egan AG, Blind E, Dunder K, et al. Pancreatic safety of incretin-based drugs. FDA and EMA assessment. N Engl J Med 2014;370(9):794-7
    • (2014) N Engl J Med , vol.370 , Issue.9 , pp. 794-797
    • Egan, A.G.1    Blind, E.2    Dunder, K.3
  • 41
    • 84903519951 scopus 로고    scopus 로고
    • Risk of pancreatitis in patients treated with incretin-based therapies
    • Meier JJ, Nauck MA. Risk of pancreatitis in patients treated with incretin-based therapies. Diabetologia 2014;57(7):1320-4
    • (2014) Diabetologia , vol.57 , Issue.7 , pp. 1320-1324
    • Meier, J.J.1    Nauck, M.A.2
  • 43
    • 84876063836 scopus 로고    scopus 로고
    • Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: A population-based matched case-control study
    • Singh S, Chang H-Y, Richards TM, et al. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med 2013;173(7):534-9
    • (2013) JAMA Intern Med , vol.173 , Issue.7 , pp. 534-539
    • Singh, S.1    Chang, H.-Y.2    Richards, T.M.3
  • 44
    • 84878352363 scopus 로고    scopus 로고
    • Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Butler AE, Campbell-Thompson M, Gurlo T, et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62(7):2595-604
    • (2013) Diabetes , vol.62 , Issue.7 , pp. 2595-2604
    • Butler, A.E.1    Campbell-Thompson, M.2    Gurlo, T.3
  • 45
    • 0142072036 scopus 로고    scopus 로고
    • Clinicopathological correlates of pancreatic intraepithelial neoplasia: A comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma
    • Andea A, Sarkar F, Adsay VN. Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 2003;16(10):996-1006
    • (2003) Mod Pathol , vol.16 , Issue.10 , pp. 996-1006
    • Andea, A.1    Sarkar, F.2    Adsay, V.N.3
  • 46
    • 84903183754 scopus 로고    scopus 로고
    • Reanalysis of study of pancreatic effects of incretin therapy: Methodological deficiencies
    • Bonner-Weir S, Int Veld PA, Weir GC. Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies. Diabetes Obes Metab 2014;16(7):661-6
    • (2014) Diabetes Obes Metab , vol.16 , Issue.7 , pp. 661-666
    • Bonner-Weir, S.1    Int Veld, P.A.2    Weir, G.C.3
  • 47
    • 84882254410 scopus 로고    scopus 로고
    • An analysis of characteristics of subjects examined for incretin effects on pancreatic pathology
    • Harja E, Lord J, Skyler JS. An analysis of characteristics of subjects examined for incretin effects on pancreatic pathology. Diabetes Technol Ther 2013;15(8):609-18
    • (2013) Diabetes Technol Ther , vol.15 , Issue.8 , pp. 609-618
    • Harja, E.1    Lord, J.2    Skyler, J.S.3
  • 48
    • 84897834466 scopus 로고    scopus 로고
    • Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: A potential confounding factor in the nonclinical assessment of GLP-1-based therapies
    • Chadwick KD, Fletcher AM, Parrula MC, et al. Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies. Diabetes 2014;63(4):1303-14
    • (2014) Diabetes , vol.63 , Issue.4 , pp. 1303-1314
    • Chadwick, K.D.1    Fletcher, A.M.2    Parrula, M.C.3
  • 49
    • 84894494601 scopus 로고    scopus 로고
    • European Medicines Agency. Available from
    • European Medicines Agency. Assessment Report for GLP-1 based therapies. 2013. Available from: http://www.ema. europa.eu/docs/en-GB/document-library/Report/2013/08/WC500147026.pdf
    • (2013) Assessment Report for GLP-1 Based Therapies
  • 50
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study
    • Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care 2009;32(5):834-8
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.L.4
  • 51
    • 84895787341 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists and pancreatitis: A meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Nardini C, et al. Glucagon-like peptide-1 receptor agonists and pancreatitis: a meta-analysis of randomized clinical trials. Diabetes Res Clin Pract 2014;103(2):269-75
    • (2014) Diabetes Res Clin Pract , vol.103 , Issue.2 , pp. 269-275
    • Monami, M.1    Dicembrini, I.2    Nardini, C.3
  • 52
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369(14):1317-26
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 53
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 2013;369(14):1327-35
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 54
    • 84887295824 scopus 로고    scopus 로고
    • Pancreatitis-diabetes-pancreatic cancer summary of an niddk-nci workshop
    • Andersen DK, Andren-Sandberg Å , Duell EJ, et al. Pancreatitis-diabetes-pancreatic cancer. Summary of an NIDDK-NCI Workshop. Pancreas 2013;42(8):1227-37
    • (2013) Pancreas , vol.42 , Issue.8 , pp. 1227-1237
    • Andersen, D.K.1    Andren-Sandberg Å.2    Duell, E.J.3
  • 55
    • 84899029163 scopus 로고    scopus 로고
    • Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: Systematic review and meta-analysis of randomised and non-randomised studies
    • Li L, Shen J, Bala MM, et al. Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies. BMJ 2014;348:g2366
    • (2014) BMJ , vol.348 , pp. g2366
    • Li, L.1    Shen, J.2    Bala, M.M.3
  • 56
    • 84904560697 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and efficacy of DPP-4 inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes mellitus and renal or hepatic impairment a systematic review of the literature
    • Giorda CB, Nada E, Tartaglino B. Pharmacokinetics, safety, and efficacy of DPP-4 inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes mellitus and renal or hepatic impairment. A systematic review of the literature. Endocrine 2014;46(3):406-19
    • (2014) Endocrine , vol.46 , Issue.3 , pp. 406-419
    • Giorda, C.B.1    Nada, E.2    Tartaglino, B.3
  • 57
    • 84877727819 scopus 로고    scopus 로고
    • Safety and efficacy of liraglutide in patients with type 2 diabetes and endstage renal disease: Protocol for an investigator-initiated prospective, randomised, placebo-controlled, doubleblinded, parallel intervention study
    • Idorn T, Knop FK, Jørgensen M, et al. Safety and efficacy of liraglutide in patients with type 2 diabetes and endstage renal disease: protocol for an investigator-initiated prospective, randomised, placebo-controlled, doubleblinded, parallel intervention study. BMJ Open 2013;3:4
    • (2013) BMJ Open , vol.3 , pp. 4
    • Idorn, T.1    Knop, F.K.2    Jørgensen, M.3
  • 58
    • 84872084453 scopus 로고    scopus 로고
    • Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (duration-6): A randomised open-label study
    • Buse JB, Nauck M, Forst T, et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. Lancet 2013;381(9861):117-24
    • (2013) Lancet , vol.381 , Issue.9861 , pp. 117-124
    • Buse, J.B.1    Nauck, M.2    Forst, T.3
  • 59
    • 84878863716 scopus 로고    scopus 로고
    • Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin
    • Kapitza C, Forst T, Coester H-V, et al. Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin. Diabetes Obes Metab 2013;15(7):642-9
    • (2013) Diabetes Obes Metab , vol.15 , Issue.7 , pp. 642-649
    • Kapitza, C.1    Forst, T.2    Coester, H.-V.3
  • 60
    • 84899585635 scopus 로고    scopus 로고
    • Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (harmony 7): A randomised open-label multicentre non-inferiority phase 3 study
    • Pratley RE, Nauck MA, Barnett AH, et al. Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study. Lancet Diabetes Endocrinol 2014;2(4):289-97
    • (2014) Lancet Diabetes Endocrinol , vol.2 , Issue.4 , pp. 289-297
    • Pratley, R.E.1    Nauck, M.A.2    Barnett, A.H.3
  • 61
    • 84908177336 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus once-daily liraglutide in metformintreated patients with type 2 diabetes (award-6): A randomised open-label phase 3 non-inferiority trial
    • Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformintreated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. Lancet 2014;384(9951):1349-57
    • (2014) Lancet , vol.384 , Issue.9951 , pp. 1349-1357
    • Dungan, K.M.1    Povedano, S.T.2    Forst, T.3
  • 62
    • 84872766753 scopus 로고    scopus 로고
    • Impact of GLP-1 receptor agonists on major gastrointestinal disorders for type 2 diabetes mellitus: A mixed treatment comparison meta-analysis
    • Sun F, Yu K, Yang Z, et al. Impact of GLP-1 receptor agonists on major gastrointestinal disorders for type 2 diabetes mellitus: a mixed treatment comparison meta-analysis. Exp Diabetes Res 2012;2012:230624
    • (2012) Exp Diabetes Res , vol.2012 , pp. 230624
    • Sun, F.1    Yu, K.2    Yang, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.