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Volumn 134, Issue 4, 2015, Pages 208-214

Numbers of CD8+PD-1+ and CD4+PD-1+ Cells in Peripheral Blood of Patients with Chronic Lymphocytic Leukemia Are Independent of Binet Stage and Are Significantly Higher Compared to Healthy Volunteers

Author keywords

Binet stage; Chronic lymphocytic leukemia; Programmed cell death 1

Indexed keywords

PROGRAMMED DEATH 1 LIGAND 1; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR; TUMOR PROTEIN;

EID: 84930921572     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000381468     Document Type: Article
Times cited : (17)

References (37)
  • 1
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992; 11: 3887-3895.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 12
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N: Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 2002; 99: 12293-12297.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 16
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 Guidelines
    • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H, Hillmen P, Keating MP, Montserrat E, Rai KR, Kipps TJ: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 Guidelines. Blood 2008; 111: 5446-5456.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Dohner, H.6    Hillmen, P.7    Keating, M.P.8    Montserrat, E.9    Rai, K.R.10    Kipps, T.J.11
  • 17
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F: The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009; 144: 3367-3375.
    • (2009) Blood , vol.144 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 19
    • 84877080091 scopus 로고    scopus 로고
    • Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
    • Wienster A: Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2012; 2012: 88-96.
    • (2012) Hematology Am Soc Hematol Educ Program , vol.2012 , pp. 88-96
    • Wienster, A.1
  • 20
    • 84875185728 scopus 로고    scopus 로고
    • Targeting pathological B cell receptor signalling in lymphoid malignancies
    • Young RM, Staudt LM: Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov 2013; 12: 229-243.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 229-243
    • Young, R.M.1    Staudt, L.M.2
  • 24
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freemann GJ: Programmed death-1 ligand interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007; 27: 111-122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freemann, G.J.5
  • 26
    • 33646422454 scopus 로고    scopus 로고
    • Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
    • Yang ZZ, Novak AJ, Stenson MJ, Witzig TE, Ansell SM: Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood 2006; 107: 3639-3646.
    • (2006) Blood , vol.107 , pp. 3639-3646
    • Yang, Z.Z.1    Novak, A.J.2    Stenson, M.J.3    Witzig, T.E.4    Ansell, S.M.5
  • 27
    • 83055164370 scopus 로고    scopus 로고
    • Malignant B cells induce the conversion of CD4+CD25-T cells to regulatory T cells in B-cell non-Hodgkin lymphoma
    • Han Y, Wu J, Bi L, Xiong S, Gao S, Yin L, Jiang L, Chen CH, Yu K, Zhang S: Malignant B cells induce the conversion of CD4+CD25-T cells to regulatory T cells in B-cell non-Hodgkin lymphoma. PloS One 2011; 6:e28649.
    • (2011) PloS One , vol.6 , pp. e28649
    • Han, Y.1    Wu, J.2    Bi, L.3    Xiong, S.4    Gao, S.5    Yin, L.6    Jiang, L.7    Chen, C.H.8    Yu, K.9    Zhang, S.10
  • 29
    • 43549115533 scopus 로고    scopus 로고
    • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
    • Azuma T, Yao S, Zhu G, Flies SJ, Chen L: B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008; 111: 3635-3643.
    • (2008) Blood , vol.111 , pp. 3635-3643
    • Azuma, T.1    Yao, S.2    Zhu, G.3    Flies, S.J.4    Chen, L.5
  • 30
    • 84856515333 scopus 로고    scopus 로고
    • Expansion of a CD8+PD-1+ replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression
    • Nunes CT, Wong R, Mason M, Fegan C, Man S, Pepper C: Expansion of a CD8+PD-1+ replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression. Clin Cancer Res 2012; 18: 678-687.
    • (2012) Clin Cancer Res , vol.18 , pp. 678-687
    • Nunes, C.T.1    Wong, R.2    Mason, M.3    Fegan, C.4    Man, S.5    Pepper, C.6
  • 31
    • 84923183950 scopus 로고    scopus 로고
    • Anti-PD-1-targeted therapies focusing on lymphatic malignancies: Biological rationale, clinical challenges and opportunities
    • Kedmi M, Avigdor A, Nagler A: Anti-PD-1-targeted therapies focusing on lymphatic malignancies: biological rationale, clinical challenges and opportunities. Acta Haematol 2015; 133: 129-135.
    • (2015) Acta Haematol , vol.133 , pp. 129-135
    • Kedmi, M.1    Avigdor, A.2    Nagler, A.3
  • 35
    • 84902489577 scopus 로고    scopus 로고
    • The state of the art in nonsmall cell lung cancer immunotherapy
    • Seetharamu N: The state of the art in nonsmall cell lung cancer immunotherapy. Semin Thorac Cardiovasc Surg 2014; 26: 26-35.
    • (2014) Semin Thorac Cardiovasc Surg , vol.26 , pp. 26-35
    • Seetharamu, N.1
  • 37
    • 84899048777 scopus 로고    scopus 로고
    • Clinical activity, safety and biomarkers of PD-L1 blockade in non-small cell lung cancer (NSCLC): Additional analyses from a clinical study of the engineered antibody MPDL3280A (anti-PDL1)
    • Soria JC, Cruz C, Bahleda R, Delord JP, Horn L, Herbst RS, Gettinger S: Clinical activity, safety and biomarkers of PD-L1 blockade in non-small cell lung cancer (NSCLC): additional analyses from a clinical study of the engineered antibody MPDL3280A (anti-PDL1). Eur Cancer Congr 2013; 49:S798.
    • (2013) Eur Cancer Congr , vol.49 , pp. S798
    • Soria, J.C.1    Cruz, C.2    Bahleda, R.3    Delord, J.P.4    Horn, L.5    Herbst, R.S.6    Gettinger, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.